| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:6499822 | IVR | 4000 mg/kg | 4000 mg/kg | Testicular atrophy | Reproductive endocrine-mediated perturbations |
| IVR | 4000 mg/kg | 4000 mg/kg | Changes in haemocrit values | Immunological endocrine-mediated perturbations | |
| IVR | 4000 mg/kg | 4000 mg/kg | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 4000 mg/kg | 4000 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 2000 mg/kg | 2000 mg/kg | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 2000 mg/kg | 2000 mg/kg | Changes in haemocrit values | Immunological endocrine-mediated perturbations | |
| IVR | 2000 mg/kg | 2000 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 2000 mg/kg | 2000 mg/kg | Testicular atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Testicular atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg | 1000 mg/kg | Changes in haemocrit values | Immunological endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Changes in haemocrit values | Immunological endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg | 500 mg/kg | Testicular atrophy | Reproductive endocrine-mediated perturbations | |
| PMID:9114295 | IVR | 1 % | 1 % | Decreased liver weights | Hepatic endocrine-mediated perturbations |
| IVR | 1 % | 1 % | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 1 % | 1 % | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 % | 1 % | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 1 % | 1 % | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| IVR | 1 % | 1 % | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Affects litter size | Reproductive endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| IVR | 2 % | 2 % | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 % | 0.5 % | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 0.5 % | 0.5 % | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.