Bis(2-ethylhexyl) phthalate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:10188194	IVR	750 mg/kg/day	750 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
PMID:10762434	IVR	1 %	1 %	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	2 %	2 %	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	2 %	2 %	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	2 %	2 %	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
PMID:11099646	IVR	750 mg/kg/day	750 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Altered germ cells morphology	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
PMID:11099647	IVR	750 mg/kg/day	750 mg/kg/day	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Changes in mammary gland morphology	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Nipple retention	Reproductive endocrine-mediated perturbations
PMID:12083789	IVR	0.004 M	0.004 M	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.004 M	0.004 M	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	0.0008 M	0.0008 M	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0008 M	0.0008 M	Decreased testis weights	Reproductive endocrine-mediated perturbations
PMID:14692339	IVR	0.00001 M	0.00001 M	Alterations in splenocytes population	Immunological endocrine-mediated perturbations
	IVR	0.00001 M	0.00001 M	Changes in thymus gland morphology	Immunological endocrine-mediated perturbations
PMID:15013064	IVR	750 mg/kg/day	750 mg/kg/day	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Changes in number of nipples	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased inhibin-B levels	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:15229365	IVR	2.6 mmol/kg	2.6 mmol/kg	Affects tryptophan metabolism	Metabolic endocrine-mediated perturbations
PMID:15379967	IVR	2 %	2 %	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	2 %	2 %	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
PMID:15518916	IVR	0.087 M	0.087 M	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	0.087 M	0.087 M	Affects ovulation	Reproductive endocrine-mediated perturbations
	IVR	0.087 M	0.087 M	Affects dopaminergic pathways	Neurological endocrine-mediated perturbations
	IVR	0.087 M	0.087 M	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	0.087 M	0.087 M	Affects insulin signaling	Metabolic endocrine-mediated perturbations
PMID:15620428	IVR	0.087 M	0.087 M	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	0.087 M	0.087 M	Affects neuronal signaling	Neurological endocrine-mediated perturbations
PMID:15883486	IVTH	0.000000001 - 0.001 M	0.000001 - 0.0001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:16400681	IVR	1400 mg/kg	1400 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1400 mg/kg	1400 mg/kg	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	1400 mg/kg	1400 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1400 mg/kg	1400 mg/kg	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	1400 mg/kg	1400 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:16949715	IVR	135 mg	135 mg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.405 mg	0.405 mg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.135 mg	0.135 mg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	45 mg	45 mg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1.22 mg	1.22 mg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	405 mg	405 mg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	15 mg	15 mg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.015 mg	0.015 mg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	5 mg	-	No significant effects observed	-
	IVR	0.045 mg	-	No significant effects observed	-
PMID:17229994	IVR	250 mg/kg	250 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:17286146	IVTH	0 NA	-	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
PMID:17558187	IVR	250 mg/kg	250 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
PMID:17654256	IVR	500 mg/kg	500 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Increased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Increased weights of bulbocavernosus muscles/LABC	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Increased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Increased prostate weights	Reproductive endocrine-mediated perturbations
PMID:17679765	IVR	250 mg/kg	250 mg/kg	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
PMID:18322279	IVR	700 mg/kg/day	700 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	700 mg/kg/day	700 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	1250 mg/kg/day	1250 mg/kg/day	Abnormal development of gonads in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1250 mg/kg/day	1250 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	1250 mg/kg/day	1250 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	1250 mg/kg/day	1250 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	1250 mg/kg/day	1250 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	469 mg/kg/day	469 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	469 mg/kg/day	469 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	469 mg/kg/day	469 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	469 mg/kg/day	469 mg/kg/day	Abnormal development of gonads in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	234 mg/kg/day	234 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	234 mg/kg/day	234 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	938 mg/kg/day	938 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	938 mg/kg/day	938 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:19367084	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Reduced sperm quality	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testosterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased LH levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects testis development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Changes in number of nipples	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Reduced sperm quality	Reproductive endocrine-mediated perturbations
PMID:19428328	IVR	200 mg/kg/day	200 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects fatty acid metabolism	Metabolic endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects cholesterol biosynthesis	Metabolic endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVTH	0.00005 M	0.00005 M	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects cholesterol biosynthesis	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects fatty acid metabolism	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
PMID:19577633	IVR	500 mg/kg/day	500 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
PMID:19781091	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased weights of accessory sex organs	Reproductive endocrine-mediated perturbations
PMID:20568448	IVR	100 mg/kg/day	100 mg/kg/day	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Changes in epididymal morphology	Reproductive endocrine-mediated perturbations
PMID:21636974	IVR	750 mg/kg/day	750 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:21673306	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Affects pancreas development	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Beta cell dysfunction	Metabolic endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
	IVR	1.25 mg/kg/day	1.25 mg/kg/day	Reduced insulin levels	Metabolic endocrine-mediated perturbations
	IVR	6.25 mg/kg/day	6.25 mg/kg/day	Affects pancreas development	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	6.25 mg/kg/day	6.25 mg/kg/day	Beta cell dysfunction	Metabolic endocrine-mediated perturbations
	IVR	6.25 mg/kg/day	6.25 mg/kg/day	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
	IVR	6.25 mg/kg/day	6.25 mg/kg/day	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	6.25 mg/kg/day	6.25 mg/kg/day	Reduced insulin levels	Metabolic endocrine-mediated perturbations
PMID:22279657	IVR	150 mg/kg/day	150 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	150 mg/kg/day	150 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	150 mg/kg/day	150 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	150 mg/kg/day	150 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	150 mg/kg/day	150 mg/kg/day	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	150 mg/kg/day	150 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:22986106	IVR	500 mg/kg	500 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Induce apoptosis of granulosa cells	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg	2000 mg/kg	Induce apoptosis of granulosa cells	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg	2000 mg/kg	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg	2000 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg	2000 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	125 mg/kg	-	No significant effects observed	-
	IVR	500 mg/kg	500 mg/kg	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
PMID:23046697	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Compromised endometrial receptivity	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects the normal functioning of reproductive system	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	-	No significant effects observed	-
	IVR	250 mg/kg/day	-	No significant effects observed	-
PMID:23277027	IVR	0.5 mg/kg	0.5 mg/kg	Lead to obesity	Metabolic endocrine-mediated perturbations
PMID:23536373	IVR	500 mg/kg/day	500 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
PMID:23625783	IVR	0.02 mg/kg	0.02 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Affects ovarian function	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Affects ovarian function	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
PMID:23892333	IVR	0.01 %	0.01 %	Changes in T-cell populations	Immunological endocrine-mediated perturbations
	IVR	0.01 %	0.01 %	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	0.1 %	0.1 %	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.1 %	0.1 %	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	0.1 %	0.1 %	Changes in T-cell populations	Immunological endocrine-mediated perturbations
PMID:24390239	IVR	0.04 mg/kg/day	0.04 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
PMID:24564399	IVR	1 - 300 mg/kg/day	100 - 300 mg/kg/day	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
PMID:24641848	IVR	500 mg/kg	500 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	80 mg/kg	80 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	80 mg/kg	80 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	80 mg/kg	80 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:24675100	IVR	300 mg/kg/day	300 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Alters hypothalamic-pituitary-ovarian axis	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	3000 mg/kg/day	3000 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	3000 mg/kg/day	3000 mg/kg/day	Alters hypothalamic-pituitary-ovarian axis	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	3000 mg/kg/day	3000 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
PMID:24799162	IVR	1 mg/kg/day	1 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects cytokine signaling	Immunological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
PMID:24804967	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Increased spleen weights	Immunological endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
PMID:24811840	IVR	80 mg/kg/day	80 mg/kg/day	Affects the normal functioning of reproductive system	Reproductive endocrine-mediated perturbations
PMID:24950685	IVTH	0.00005 M	0.00005 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00005 M	0.00005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.00005 M	0.00005 M	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	0.000005 M	0.000005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000005 M	0.000005 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000005 M	0.000005 M	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	0.0000005 M	-	No significant effects observed	-
PMID:25016925	IVTH	0.000000001 - 0.000001 M	0.000000001 - 0.000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.000000001 - 0.000001 M	0.000000001 - 0.000001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:25152515	IVR	500 mg/kg	500 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects androgen production	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Affects androgen production	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects androgen production	Reproductive endocrine-mediated perturbations
PMID:25232145	IVR	1 mg/kg/day	1 mg/kg/day	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Elevated insulin levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Elevated insulin levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Elevated insulin levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
PMID:25242624	IVR	500 mg/kg	500 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased weights of accessory sex organs	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Decreased weights of accessory sex organs	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg	100 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Decreased weights of accessory sex organs	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg	1000 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Decreased testis weights	Reproductive
	IVR	20 mg/kg	20 mg/kg	Decreased weights of accessory sex organs
	IVR	20 mg/kg	20 mg/kg	Decreased weights of epididymis
	IVR	100 mg/kg	100 mg/kg	Reduced sperm counts
	IVR	20 mg/kg	20 mg/kg	Affects spermatogenesis
	IVR	100 mg/kg	100 mg/kg	Decreased weights of epididymis
PMID:25280772	IVR	1 mg/kg/day	1 mg/kg/day	Beta cell dysfunction	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Elevated insulin levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Elevated insulin levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Beta cell dysfunction	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Elevated insulin levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Beta cell dysfunction	Metabolic endocrine-mediated perturbations
PMID:25330100	IVR	1 mg/kg/day	1 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
PMID:25352649	IVR	1 mg/kg/day	1 mg/kg/day	Induce neuronal apoptosis	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Oxidative stress in sertoli cells	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Induce neuronal apoptosis	Neurological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Oxidative stress in sertoli cells	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Induce neuronal apoptosis	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Oxidative stress in sertoli cells	Reproductive endocrine-mediated perturbations
PMID:25530038	IVR	1 mg/kg/day	1 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Decreased estrogen levels	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decreased estrogen levels	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects litter size	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
PMID:25766500	IVTH	0.000001 mmol	0.000001 mmol	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
	IVTH	0.000001 mmol	0.000001 mmol	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVTH	0.00000001 mmol	0.00000001 mmol	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
	IVTH	0.00000001 mmol	0.00000001 mmol	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 mmol	0.0000001 mmol	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 mmol	0.0000001 mmol	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
PMID:25853433	IVR	750 mg/kg/day	750 mg/kg/day	Alters mammary gland development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:25870019	IVR	200 mg/kg/day	200 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects spatial memory	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects locomotor activity	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects locomotor activity	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects spatial memory	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects locomotor activity	Neurological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects spatial memory	Neurological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:25881014	IVR	100 mg/kg	100 mg/kg	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
PMID:26035430	IVR	750 mg/kg	750 mg/kg	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:26147211	IVR	750 mg/kg	750 mg/kg	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:26170149	IVR	0.16 mg/kg/day	0.16 mg/kg/day	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg/day	0.04 mg/kg/day	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
PMID:26244509	IVR	300 mg/kg/day	300 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
PMID:26316063	IVR	10 mg/kg	10 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects sertoli cells function	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects leydig cells function	Reproductive endocrine-mediated perturbations
PMID:26372177	IVR	0.05 mg/kg	0.05 mg/kg	Affects testicular development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg	0.05 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg	0.05 mg/kg	Affects testicular function	Reproductive endocrine-mediated perturbations
	IVR	0.005 mg/kg	0.005 mg/kg	Affects testicular development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.005 mg/kg	0.005 mg/kg	Affects testicular function	Reproductive endocrine-mediated perturbations
PMID:26524146	IVR	1 mg/kg/day	1 mg/kg/day	Affects dopaminergic pathways	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased dopamine levels	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects dopaminergic pathways	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects dopaminergic pathways	Neurological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects expression of estrogen receptor-beta (ER-beta)	Reproductive endocrine-mediated perturbations
PMID:26558472	IVR	100 mg/kg	100 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg	-	No significant effects observed	-
PMID:26678702	IVR	200 mg/kg/day	200 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased inhibin-B levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	-	No significant effects observed	-
	IVR	0.2 mg/kg/day	-	No significant effects observed	-
	IVR	20 mg/kg/day	20 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased estradiol/progesterone ratio	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased inhibin-B levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
PMID:26844866	IVR	1 mg/kg/day	1 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
PMID:26845775	IVR	0.02 mg/kg	0.02 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Oxidative stress in ovaries	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Oxidative stress in ovaries	Reproductive endocrine-mediated perturbations
PMID:27040317	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
PMID:27103539	IVR	500 mg/kg/day	500 mg/kg/day	Delayed puberty	Reproductive endocrine-mediated perturbations
PMID:27135907	IVTH	0.000000001 - 0.0000001 M	0.000000001 - 0.0000001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000000001 - 0.0000001 M	0.000000001 - 0.0000001 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
PMID:27405655	IVR	0.02 mg/kg	0.02 mg/kg	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Decreased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg	0.02 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Decreased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
PMID:27472966	IVR	1 mg/kg/day	1 mg/kg/day	Abnormal neuronal distribution	Neurological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Abnormal neuronal distribution	Neurological endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Abnormal neuronal distribution	Neurological endocrine-mediated perturbations
PMID:27639664	IVR	750 mg/kg/day	750 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
PMID:27845755	IVR	500 mg/kg/day	500 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:27849367	IVR	1 mg/kg/day	1 mg/kg/day	Affects thyroid hormone metabolism	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects thyroid hormone metabolism	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects thyroid hormone metabolism	Metabolic endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects thyroid hormone metabolism	Metabolic endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects thyroid hormone metabolism	Metabolic endocrine-mediated perturbations
PMID:27956250	IVR	200 mg/kg	200 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Decreased placental weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Changes in placental morphology	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Changes in placental morphology	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Decreased placental weights	Reproductive endocrine-mediated perturbations
PMID:28025108	IVR	5 mg/kg	5 mg/kg	Affects insulin signaling	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects insulin signaling	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/kg	-	No significant effects observed	-
PMID:28065941	IVR	500 mg/kg/day	500 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decrease in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decrease in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decrease in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
PMID:28082598	IVR	100 mg/kg/day	100 mg/kg/day	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	375 mg/kg/day	375 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	375 mg/kg/day	375 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	375 mg/kg/day	375 mg/kg/day	Affects survival of germ cells	Reproductive endocrine-mediated perturbations
	IVR	375 mg/kg/day	375 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	375 mg/kg/day	375 mg/kg/day	Increased estradiol levels	Reproductive
	IVR	375 mg/kg/day	375 mg/kg/day	Increased LH levels
PMID:28085963	IVR	300 mg/kg/day	300 mg/kg/day	Induce apoptosis in testis	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Alterations in immune responses	Immunological endocrine-mediated perturbations
PMID:28123099	IVR	5 mg/kg	5 mg/kg	Affects sertoli cells function	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Affects skeletal development	Developmental endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Affects sertoli cells function	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
PMID:28199414	IVR	0.4 mg/kg	0.4 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	0.005 mg/kg	0.005 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	0.04 mg/kg	0.04 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
PMID:28286118	IVR	5 mg/kg/day	5 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Affects ovulation	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects ovulation	Reproductive endocrine-mediated perturbations
PMID:28532275	IVR	500 mg/kg/day	500 mg/kg/day	Induce apoptosis in testis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects testicular function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testis weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:28609104	IVR	522 mg/kg/day	522 mg/kg/day	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
	IVR	522 mg/kg/day	522 mg/kg/day	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	522 mg/kg/day	522 mg/kg/day	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
	IVR	522 mg/kg/day	522 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
PMID:28634325	IVR	300 mg/kg/day	300 mg/kg/day	Decreased Alanine aminotransferase (ALT) levels	Hepatic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decreased Alanine aminotransferase (ALT) levels	Hepatic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects testicular morphology	Reproductive endocrine-mediated perturbations
PMID:28871463	IVR	10 mg/kg	10 mg/kg	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Affects development of reproductive system	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Increased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:28915506	IVR	500 mg/kg/day	500 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
PMID:28934723	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.005 mg/kg/day	0.005 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	-	No significant effects observed	-
PMID:28972901	IVR	300 mg/kg/day	300 mg/kg/day	Changes in white blood cell (WBC) populations	Immunological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Pregnancy complications	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Pregnancy complications	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Changes in white blood cell (WBC) populations	Immunological endocrine-mediated perturbations
PMID:29144988	IVR	4 mg/kg	4 mg/kg	Cancer phenotype	Endocrine-mediated cancer
	IVR	4 mg/kg	4 mg/kg	Induce tumor progression	Endocrine-mediated cancer
	IVR	4 mg/kg	4 mg/kg	Alterations in immune responses	Immunological endocrine-mediated perturbations
PMID:29158199	IVR	5 mg/kg/day	5 mg/kg/day	Alterations in number of sertoli cells	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Alterations in number of sertoli cells	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
PMID:29165555	IVR	500 mg/kg/day	500 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Increased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Increased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Increased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
PMID:29225205	IVR	500 mg/kg/day	500 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increase in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Increase in Thyrotropin-releasing hormone (TRH) levels	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg/day	-	No significant effects observed	-
PMID:29228129	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:29280353	IVR	0.05 mg/kg	0.05 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	0.005 mg/kg	0.005 mg/kg	Affects developmental process	Developmental endocrine-mediated perturbations
	IVR	0.005 mg/kg	0.005 mg/kg	Affects expression of androgen receptor (AR)	Reproductive endocrine-mediated perturbations
	IVR	0.005 mg/kg	0.005 mg/kg	Affects the normal functioning of reproductive system	Reproductive endocrine-mediated perturbations
PMID:29385306	IVR	100 mg/kg/day	100 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Induce apoptosis of granulosa cells	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg/day	400 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	1600 mg/kg/day	1600 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	1600 mg/kg/day	1600 mg/kg/day	Induce apoptosis of granulosa cells	Reproductive endocrine-mediated perturbations
	IVR	1600 mg/kg/day	1600 mg/kg/day	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Induce apoptosis of granulosa cells	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
PMID:29458081	IVR	200 mg/kg/day	200 mg/kg/day	Affects uterine morphology	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Endometrial carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
	IVR	20000 mg/kg/day	-	No significant effects observed	-
	IVR	200000 mg/kg/day	200000 mg/kg/day	Endometrial carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	200000 mg/kg/day	200000 mg/kg/day	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
	IVR	200000 mg/kg/day	200000 mg/kg/day	Uterine carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Endometrial carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
PMID:29471507	IVR	500 mg/kg/day	500 mg/kg/day	Affects fertility in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Abnormal estrous cycles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Accelerated onset of puberty in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Accelerated onset of puberty in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects litter size	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects fertility in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Abnormal estrous cycles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects fertility in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects litter size	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Abnormal estrous cycles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Accelerated onset of puberty in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:29472605	IVTH	50 mg/L	50 mg/L	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	50 mg/L	50 mg/L	Causes insulin resistance	Metabolic endocrine-mediated perturbations
	IVTH	50 mg/L	50 mg/L	Decreased triglycerides level	Metabolic endocrine-mediated perturbations
	IVTH	50 mg/L	50 mg/L	Elevated insulin levels	Metabolic endocrine-mediated perturbations
PMID:29606031	IVR	750 mg/kg/day	750 mg/kg/day	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
PMID:29663635	IVR	500 mg/kg/day	500 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
PMID:29689378	IVR	1 mg/kg/day	1 mg/kg/day	Prostate carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	0.01 mg/kg/day	-	No significant effects observed	-
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Prostate carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
PMID:29707687	IVR	1.33 mg/L	1.33 mg/L	Affects litter size	Reproductive endocrine-mediated perturbations
	IVR	1.33 mg/L	1.33 mg/L	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	1.33 mg/L	1.33 mg/L	Decreased uterine weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1.33 mg/L	1.33 mg/L	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.133 mg/L	-	No significant effects observed	-
PMID:29753845	IVR	200 mg/kg	200 mg/kg	Changes in placental morphology	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects placental function	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Reduced insulin levels	Metabolic endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects expression of thyroid receptor (TR)	Metabolic endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Changes in placental morphology	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects placental function	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects expression of thyroid receptor (TR)	Metabolic endocrine-mediated perturbations
PMID:29774754	IVR	30 mg/kg/day	30 mg/kg/day	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Alters hypothalamic-pituitary-gonadal axis (HPG axis)	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
PMID:29777495	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:29805520	IVTH	0.000001 M	0.000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00000001 M	0.00000001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:29842840	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
PMID:29940330	IVR	500 mg/kg/day	500 mg/kg/day	Affects blood-testis barrier (BTB)	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	-	No significant effects observed	-
PMID:29945229	IVR	300 mg/kg	300 mg/kg	Affects testicular function	Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg	300 mg/kg	Increased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg	30 mg/kg	Affects testicular function	Reproductive endocrine-mediated perturbations
PMID:29969652	IVR	25 mg/kg/day	25 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg/day	25 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg/day	25 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg/day	25 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
PMID:30087586	IVR	300 mg/kg/day	300 mg/kg/day	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Abnormal neuronal distribution in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects neuronal density in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
PMID:30243084	IVR	2000 mg/kg/day	2000 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Testicular atrophy	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Alterations in number of sertoli cells	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	2000 mg/kg/day	2000 mg/kg/day	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
PMID:30336312	IVR	300 mg/kg/day	300 mg/kg/day	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decreased estradiol levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decreased estradiol levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	30 mg/kg/day	-	No significant effects observed	-
PMID:30362281	IVR	100 mg/kg/day	100 mg/kg/day	Elevated glucose levels in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	-	No significant effects observed	-
	IVR	1 mg/kg/day	-	No significant effects observed	-
PMID:30543897	IVR	150 mg/kg/day	150 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	-	No significant effects observed	-
PMID:30550969	IVR	5 mg/kg	5 mg/kg	Affects cytokine signaling	Immunological endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	500 mg/kg	500 mg/kg	Affects cytokine signaling	Immunological endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects cytokine signaling	Immunological endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
PMID:30565266	IVR	100 mg/kg/day	100 mg/kg/day	Affects insulin signaling in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased estradiol levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects glycogen metabolism in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased Alanine aminotransferase (ALT) levels in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects gluconeogenesis in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects glucose metabolism in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects glycogen metabolism in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects gluconeogenesis in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects insulin signaling in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Elevated insulin levels in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased Alanine aminotransferase (ALT) levels in offspring	Developmental endocrine-mediat
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased estradiol levels in offspring
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased testosterone levels in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Affects glucose metabolism in offspring
	IVR	100 mg/kg/day	100 mg/kg/day	Elevated insulin levels in offspring
PMID:30597186	IVR	100 mg/kg/day	100 mg/kg/day	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects liver function	Hepatic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Oxidative stress in liver in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects glucose metabolism in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects lipid metabolism in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects the biochemical composition of liver in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects lipid metabolism in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects liver function	Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects glucose metabolism in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects the biochemical composition of liver in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Oxidative stress in liver in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
PMID:30636900	IVR	300 mg/kg/day	300 mg/kg/day	Induce neuronal apoptosis in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Induce neuronal apoptosis in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	30 mg/kg/day	-	No significant effects observed	-
PMID:30649530	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Alters sex ratio	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Alters sex ratio	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	-	No significant effects observed	-
	IVR	0.02 mg/kg/day	-	No significant effects observed	-
PMID:30716676	IVR	300 mg/kg/day	300 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	30 mg/kg/day	30 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
PMID:30755103	IVR	500 mg/kg/day	500 mg/kg/day	Induce apoptosis in testis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Testicular carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Testicular carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Induce apoptosis in testis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Induce apoptosis in testis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Testicular carcinoma	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations
PMID:30769184	IVTH	0.00001 M	0.00001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 M	0.00001 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	-	No significant effects observed	-
PMID:30909102	IVTH	0.00001 M	0.00001 M	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 M	0.00001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00000001 M	0.00000001 M	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	-	No significant effects observed	-
	IVTH	0.0000001 M	-	No significant effects observed	-
	IVTH	0.0000000001 M	-	No significant effects observed	-
	IVTH	0.000000001 M	-	No significant effects observed	-
PMID:30940548	IVR	700 mg/kg/day	700 mg/kg/day	Alterations in vaginal opening of offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	700 mg/kg/day	700 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	700 mg/kg/day	700 mg/kg/day	Increased cholesterol levels in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	700 mg/kg/day	700 mg/kg/day	Alterations in preputial separation in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	700 mg/kg/day	700 mg/kg/day	Elevated glucose levels in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	70 mg/kg/day	70 mg/kg/day	Alterations in vaginal opening of offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	7 mg/kg/day	-	No significant effects observed	-
PMID:30989653	IVR	675 mg/kg/day	675 mg/kg/day	Affects spermatogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	675 mg/kg/day	675 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	675 mg/kg/day	675 mg/kg/day	Changes in morphology of seminiferous tubules in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	675 mg/kg/day	675 mg/kg/day	Induce apoptosis in testis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	675 mg/kg/day	675 mg/kg/day	Affects testicular function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:31022410	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
PMID:31149210	IVR	250 mg/kg/day	250 mg/kg/day	Abnormal estrous cycles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decreased testis weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decreased weights of epididymis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased testis weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Decreased weights of epididymis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	1000 mg/kg/day	1000 mg/kg/day	Abnormal estrous cycles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2500 mg/kg/day	2500 mg/kg/day	Abnormal estrous cycles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:31163220	IVTH	100 mg/L	100 mg/L	Cancer phenotype	Endocrine-mediated cancer
	IVTH	100 mg/L	100 mg/L	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
	IVTH	100 mg/L	100 mg/L	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	200 mg/L	200 mg/L	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	200 mg/L	200 mg/L	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVTH	200 mg/L	200 mg/L	Cancer phenotype	Endocrine-mediated cancer
	IVTH	200 mg/L	200 mg/L	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
	IVTH	50 mg/L	50 mg/L	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVTH	50 mg/L	50 mg/L	Cancer phenotype	Endocrine-mediated cancer
	IVTH	50 mg/L	50 mg/L	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	50 mg/L	50 mg/L	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVTH	100 mg/L	100 mg/L	Affects embryonic development	Developmental endocrine-mediated perturbations
PMID:31181066	IVR	300 mg/kg/day	300 mg/kg/day	Reduced sperm counts in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects sperm motility in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Decreased testis weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	300 mg/kg/day	300 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:31211961	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects expression of estrogen receptor (ER) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects ovarian function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects ovarian function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Oxidative stress in ovaries	Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects ovarian function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	750 mg/kg/day	750 mg/kg/day	Affects expression of estrogen receptor (ER) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects ovarian function in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects expression of estrogen receptor (ER) in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects expression of androgen receptor (AR)	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	20 mg/kg/day	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:31297340	IVR	400 mg/kg	400 mg/kg	Affects cytokine signaling	Immunological endocrine-mediated perturbations
	IVR	400 mg/kg	400 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg	400 mg/kg	Affects the biochemical composition of testis	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg	400 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg	400 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg	400 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	400 mg/kg	400 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
PMID:31369804	IVR	0.05 mg/kg	0.05 mg/kg	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg	0.05 mg/kg	Affects steroidogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg	0.05 mg/kg	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg	0.05 mg/kg	Affects spermatogenesis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.005 mg/kg	-	No significant effects observed	-
PMID:31660453	IVR	0.133 mg/L	0.133 mg/L	Alterations in endometrial morphology	Reproductive endocrine-mediated perturbations
	IVR	0.133 mg/L	0.133 mg/L	Cancer phenotype	Endocrine-mediated cancer
	IVR	1.33 mg/L	1.33 mg/L	Cancer phenotype	Endocrine-mediated cancer
PMID:31771930	IVR	200 mg/kg	200 mg/kg	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg	200 mg/kg	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00002 M	0.00002 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0002 M	0.0002 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0002 M	0.0002 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0005 M	-	No significant effects observed	-
PMID:31904422	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects litter size	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg/day	0.2 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.02 mg/kg/day	0.02 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	-	No significant effects observed	-
	IVR	20 mg/kg/day	20 mg/kg/day	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
PMID:31910153	IVTH	0.000128 M	0.000128 M	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
PMID:31923814	IVR	500 mg/kg/day	500 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	500 mg/kg/day	500 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
PMID:9146736	IVR	5000 mg/L	5000 mg/L	Changes in liver morphology	Hepatic endocrine-mediated perturbations
	IVR	5000 mg/L	5000 mg/L	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	5000 mg/L	5000 mg/L	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	5000 mg/L	5000 mg/L	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	50 mg/L	-	No significant effects observed	-
	IVR	500 mg/L	500 mg/L	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	5 mg/L	-	No significant effects observed	-
	IVR	500 mg/L	500 mg/L	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.