Homosalate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:11333184	IVTH	0.0000001 - 0.00005 M	0.000001 - 0.00005 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00005 M	0.00005 M	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations
PMID:24004914	IVTH	0.00000001 - 0.00001 M	0.000005 - 0.00001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:28879804	IVR	20 mg/L	20 mg/L	Increase in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	20 mg/L	20 mg/L	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	20 mg/L	20 mg/L	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/L	20 mg/L	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	20 mg/L	20 mg/L	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	20 mg/L	20 mg/L	Decrease in TSH levels	Metabolic endocrine-mediated perturbations
PMID:28990245	IVTH	0.00001 M	0.00001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.0000001 M	0.0000001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
PMID:30267922	IVTH	0.0004 M	0.0004 M	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Oxidative stress in placenta	Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Affects placental function	Reproductive endocrine-mediated perturbations
	IVTH	0.00005 M	0.00005 M	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVTH	0.00005 M	0.00005 M	Affects placental function	Reproductive endocrine-mediated perturbations
	IVTH	0.00005 M	0.00005 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVTH	0.00002 M	0.00002 M	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVTH	0.00002 M	0.00002 M	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVTH	0.00002 M	0.00002 M	Oxidative stress in placenta	Reproductive endocrine-mediated perturbations
	IVTH	0.00002 M	0.00002 M	Affects placental function	Reproductive endocrine-mediated perturbations
	IVTH	0.00002 M	0.00002 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVTH	0.0002 M	0.0002 M	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.