| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:31372171 | IVR | 500 mg/kg/day | 500 mg/kg/day | Increased ovarian weights | Reproductive endocrine-mediated perturbations |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2000 mg/kg/day | 2000 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2000 mg/kg/day | 2000 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2000 mg/kg/day | 2000 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2000 mg/kg/day | 2000 mg/kg/day | Induce apoptosis of ovarian follicles | Reproductive endocrine-mediated perturbations | |
| IVR | 2000 mg/kg/day | 2000 mg/kg/day | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Induce apoptosis of ovarian follicles | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.