Tebuconazole

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:17785682	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Changes in number of nipples	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Pregnancy complications	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Increased 17-OH-progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Changes in number of nipples	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Increased progesterone levels	Reproductive endocrine-mediated perturbations
PMID:18067565	IVR	100 mg/kg/day	-	No significant effects observed	-
	IVR	150 mg/kg/day	150 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:20708073	IVTH	0.0000001 - 0.00003 M	0.00001 - 0.00003 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00003 M	0.000003 - 0.00003 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00003 M	0.0000001 - 0.00003 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:29923317	IVR	25 mg/kg/day	25 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	25 mg/kg/day	25 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.