| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| Najafi et al., 2010 | IVR | 112 mg/kg | 112 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 112 mg/kg | 112 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 112 mg/kg | 112 mg/kg | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations | |
| IVR | 112 mg/kg | 112 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 112 mg/kg | 112 mg/kg | Testicular atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 225 mg/kg | 225 mg/kg | Changes in white blood cell (WBC) populations | Immunological endocrine-mediated perturbations | |
| IVR | 225 mg/kg | 225 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 225 mg/kg | 225 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 225 mg/kg | 225 mg/kg | Testicular atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 225 mg/kg | 225 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:21946071 | IVR | 20 mg/kg/day | 20 mg/kg/day | Affects folliculogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects the biochemical composition of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | - | No significant effects observed | - | |
| IVR | 5 mg/kg/day | - | No significant effects observed | - | |
| PMID:22522919 | IVR | 0.5 mg/kg | 0.5 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 2 mg/kg | 2 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg | 8 mg/kg | Increase in the number of abnormal sperms | Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg | 8 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg | 8 mg/kg | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 8 mg/kg | 8 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 8 mg/kg | 8 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 8 mg/kg | 8 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 mg/kg | 0.5 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| PMID:28208233 | IVR | 0.65 mg/kg/day | 0.65 mg/kg/day | Neuronal degeneration | Neurological endocrine-mediated perturbations |
| PMID:28750898 | IVTH | 0.0000001 - 0.00001 M | 0.0000003 - 0.00001 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000001 - 0.00001 M | 0.0000003 - 0.00001 M | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000001 - 0.00001 M | 0.0000003 - 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000001 - 0.00001 M | 0.0000003 - 0.00001 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:31780179 | IVR | 30 mg/L | 30 mg/L | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations |
| IVR | 30 mg/L | 30 mg/L | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/L | 30 mg/L | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/L | 30 mg/L | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/L | 30 mg/L | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 3 mg/L | 3 mg/L | Affects cholesterol transport | Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/L | 3 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/L | 10 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/L | 10 mg/L | Affects cholesterol transport | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/L | 10 mg/L | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 10 mg/L | 10 mg/L | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/L | 30 mg/L | Affects cholesterol transport | Metabolic endocrine-mediated perturbations | |
| IVR | 30 mg/L | 30 mg/L | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 30 mg/L | 30 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.