Equol

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:18656497	IVR	10 mg/kg	10 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
PMID:23220561	IVR	100 mg/kg/day	100 mg/kg/day	Affects the normal functioning of reproductive system	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects the normal functioning of reproductive system	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Increased prolactin levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
PMID:24211351	IVR	100 mg/kg/day	100 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased Dihydroxytestosterone (DHT) levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decreased Dihydroxytestosterone (DHT) levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Increased prolactin levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	250 mg/kg/day	250 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.