| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:31807242 | IVR | 1200 mg/kg/day | 1200 mg/kg/day | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations |
| IVR | 1200 mg/kg/day | 1200 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1200 mg/kg/day | 1200 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1200 mg/kg/day | 1200 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 1200 mg/kg/day | 1200 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | - | No significant effects observed | - | |
| IVR | 20 mg/kg/day | - | No significant effects observed | - | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 320 mg/kg/day | 320 mg/kg/day | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 320 mg/kg/day | 320 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 320 mg/kg/day | 320 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.