2,2',4,4'-Tetrabromodiphenyl ether

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Chemical-gene interaction
• Descriptors
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:17361017	IVR	100 mg/kg/day	100 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Increased uterine weights	Reproductive endocrine-mediated perturbations
PMID:17964624	IVR	100 mg/kg/day	100 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Cancer phenotype	Endocrine-mediated cancer
	IVR	3 mg/kg/day	3 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects thyroid function	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
PMID:18335096	IVR	0.14 mg/kg	0.14 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.14 mg/kg	0.14 mg/kg	Decreased ovarian weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.14 mg/kg	0.14 mg/kg	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.14 mg/kg	0.14 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.7 mg/kg	0.7 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.7 mg/kg	0.7 mg/kg	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	0.7 mg/kg	0.7 mg/kg	Decreased ovarian weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.7 mg/kg	0.7 mg/kg	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.7 mg/kg	0.7 mg/kg	Affects folliculogenesis	Reproductive endocrine-mediated perturbations
PMID:22233939	IVTH	0.00000000000001 - 0.0001 M	0.0000000001 - 0.00000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00000000000001 - 0.0001 M	0.0000000001 - 0.00000001 M	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
PMID:26217518	IVR	1 mg/kg/day	1 mg/kg/day	Affects glucose metabolism	Metabolic endocrine-mediated perturbations
PMID:27449334	IVR	5 mg/kg	5 mg/kg	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Induce apoptosis of ovarian follicles	Reproductive endocrine-mediated perturbations
PMID:28712647	IVR	0.2 mg/kg	0.2 mg/kg	Alterations in immune responses	Immunological endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Abnormal sperm morphology	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Affects testicular function	Reproductive endocrine-mediated perturbations
	IVR	0.2 mg/kg	0.2 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
PMID:29112739	IVR	1 mg/kg	1 mg/kg	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg	-	No significant effects observed	-
PMID:30849655	IVTH	0.000001 M	0.000001 M	Affects liver function	Hepatic endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Affects liver function	Hepatic endocrine-mediated perturbations
	IVTH	0.0000001 M	0.0000001 M	Affects liver function	Hepatic endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.