| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10220851 | IVR | 2 mg/kg/day | 2 mg/kg/day | Decrease in TSH levels | Metabolic endocrine-mediated perturbations |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 15 mg/kg/day | 15 mg/kg/day | Decrease in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 15 mg/kg/day | 15 mg/kg/day | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| PMID:11020651 | IVR | 0.5 mg/kg | 0.5 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations |
| IVR | 2 mg/kg | 2 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Neuronal degeneration | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| PMID:29319366 | IVR | 25 mg/kg/day | 25 mg/kg/day | Reduced insulin levels | Metabolic endocrine-mediated perturbations |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Affects alpha-cells population in islets of Langerhans | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Reduced insulin levels | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects alpha-cells population in islets of Langerhans | Metabolic endocrine-mediated perturbations | |
| PMID:32151602 | IVR | 5 mg/kg | 5 mg/kg | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations |
| IVR | 2.5 - 5 mg/kg | 2.5 - 5 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 2.5 - 5 mg/kg | 2.5 - 5 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 2.5 - 5 mg/kg | 2.5 - 5 mg/kg | Causes inflammation | Immunological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:34233550 | IVR | 1 mg/kg | 1 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Causes inflammation | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:34345841 | IVR | 5 mg/kg/day | 5 mg/kg/day | Affects thyroid hormone metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 2.5 - 5 mg/kg/day | 2.5 - 5 mg/kg/day | Affects thyroid hormone signaling | Metabolic endocrine-mediated perturbations | |
| PMID:36516620 | IVR | 2 ppm | 2 ppm | Decreased body weights | Metabolic endocrine-mediated perturbations |
| IVR | 2 ppm | 2 ppm | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2 ppm | 2 ppm | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 2 ppm | 2 ppm | Decreased gonadotropin-releasing hormone (GnRH) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 2 ppm | 2 ppm | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:37414124 | IVR | 5 mg/kg | 5 mg/kg | Oxidative stress in testis | Reproductive endocrine-mediated perturbations |
| PMID:38629506 | IVR | 1 mg/kg | 1 mg/kg | Causes inflammation | Immunological endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Alterations in number of sertoli cells | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased gonadotropin-releasing hormone (GnRH) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increase in the number of abnormal sperms | Reproductive endocrine-mediated perturbations | |
| PMID:38634348 | IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased hepatic glycogen levels | Hepatic endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Necrosis of liver | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Induce apoptosis in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects lipid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased LDL levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased HDL levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased triglycerides level | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Elevated glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects glucose metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Changes in liver morphology | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased Alanine aminotransferase (ALT) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Causes inflammation | Immunological endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.