| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:19391110 | IVR | 750 mg/kg/day | 750 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects neural development | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Increased Aspartate aminotransferase (AST) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 750 mg/kg/day | 750 mg/kg/day | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| PMID:19577633 | IVR | 250 mg/kg/day | 250 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Nipple retention | Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Abnormal development of gonads in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 125 mg/kg/day | 125 mg/kg/day | Affects anogenital distance in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Abnormal development of gonads in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 125 mg/kg/day | 125 mg/kg/day | Abnormal development of gonads in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | - | No significant effects observed | - | |
| PMID:25637754 | IVR | 500 mg/kg/day | 500 mg/kg/day | Increased inhibin-B levels | Reproductive endocrine-mediated perturbations |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased inhibin-B levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Increased inhibin-B levels | Reproductive endocrine-mediated perturbations | |
| PMID:33983380 | IVR | 75 mg/kg/day | 75 mg/kg/day | Affects cholesterol metabolism | Metabolic endocrine-mediated perturbations |
| IVR | 1 - 9 mg/kg/day | 1 - 9 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 9 mg/kg/day | 1 - 9 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:37274322 | IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Changes in liver morphology | Hepatic endocrine-mediated perturbations |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects fatty acid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects glucose metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 2 - 5 mg/kg | 2 - 5 mg/kg | Changes in haemocrit values | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased Alkaline phosphatase (ALP) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Oxidative stress in liver | Hepatic endocrine-mediated perturbations | |
| IVR | 2 mg/kg | 2 mg/kg | Decreased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increased Lactate dehydrogenase (LDH) levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 2 mg/kg | 1 - 2 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects liver function | Hepatic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Lead to obesity | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 2 mg/kg | 1 - 2 mg/kg | Decreased brain weights | Neurological endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Increased triglycerides level | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.