| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10188194 | IVR | 10 mg/kg/day | - | No significant effects observed | - |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | - | No significant effects observed | - | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Testicular atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Changes in epididymal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| PMID:10910998 | IVR | 100 mg/kg/day | 100 mg/kg/day | Alterations in immune responses | Immunological endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects prostate function | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased weights of bulbocavernosus muscles/LABC | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| PMID:1690464 | IVR | 20 mg/kg | - | No significant effects observed | - |
| IVR | 10 mg/kg | - | No significant effects observed | - | |
| IVR | 40 mg/kg | 40 mg/kg | Affects skeletal development | Developmental endocrine-mediated perturbations | |
| PMID:17686919 | IVR | 10 mg/kg/day | - | No significant effects observed | - |
| IVR | 30 mg/kg/day | - | No significant effects observed | - | |
| IVR | 3 mg/kg/day | - | No significant effects observed | - | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects amino acid metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased cowper's gland weights | Reproductive endocrine-mediated perturbations | |
| PMID:18835618 | IVR | 30 mg/kg | - | No significant effects observed | - |
| IVR | 300 mg/kg | 300 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:19241440 | IVR | 100 mg/kg | 100 mg/kg | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations |
| IVR | 10 mg/kg | 10 mg/kg | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| PMID:28007637 | IVR | 100 mg/kg | 100 mg/kg | Affects anogenital distance | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | - | No significant effects observed | - | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg | 150 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:32171874 | IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Affects survival of live fetus | Reproductive endocrine-mediated perturbations |
| PMID:36410587 | IVR | 5 mg/kg/day | 5 mg/kg/day | Decrease in corticosterone levels | Neurological endocrine-mediated perturbations |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Induce apoptosis in ovary | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg/day | 5 - 25 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Alters hypothalamic-pituitary-gonadal axis (HPG axis) | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects ovarian development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:38000554 | IVTH | 0.0000125 - 0.000025 M | 0.0000125 - 0.000025 M | Increased pregnenolone levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.0000125 - 0.00005 M | 0.0000125 - 0.00005 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000125 - 0.00005 M | 0.0000125 - 0.00005 M | Increase in corticosterone levels | Neurological endocrine-mediated perturbations | |
| IVTH | 0.00005 M | 0.00005 M | Decreased 17-OH-progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000125 - 0.00005 M | 0.0000125 - 0.00005 M | Increase in cortisol levels | Neurological endocrine-mediated perturbations | |
| IVTH | 0.0000063 - 0.00005 M | 0.0000063 - 0.00005 M | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000125 - 0.00005 M | 0.0000125 - 0.00005 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000025 - 0.00005 M | 0.000025 - 0.00005 M | Decreased androstenedione levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000063 - 0.00005 M | 0.0000063 - 0.00005 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000025 - 0.00005 M | 0.000025 - 0.00005 M | Decreased Dehydroepiandrosterone (DHEA) levels | Metabolic endocrine-mediated perturbations | |
| PMID:8480329 | IVR | 200 mg/kg | 200 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.