Chlorpyrifos-methyl

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15147795	IVR	250 mg/kg	250 mg/kg	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	250 mg/kg	250 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	10 mg/kg	-	No significant effects observed	-
	IVR	50 mg/kg	50 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	2 mg/kg	-	No significant effects observed	-
PMID:16472551	IVR	10 mg/kg/day	10 mg/kg/day	Decreased weights of pituitary gland	Neurological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased liver weights in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased weights of adrenal gland in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased spleen weights	Immunological endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased estradiol levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Changes in adrenal gland morphology	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased weights of adrenal gland in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased spleen weights	Immunological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased liver weights in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects anogenital distance in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects implantation	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increase in TSH levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased weights of epididymis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Atrophy in seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased estradiol levels in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:23125134	IVR	100 mg/kg	100 mg/kg	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	4 mg/kg	4 mg/kg	Affects placental development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.