| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:11509742 | IVR | 250 mg/kg/day | 250 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations |
| IVR | 10 mg/kg/day | - | No significant effects observed | - | |
| IVR | 50 mg/kg/day | - | No significant effects observed | - | |
| IVR | 100 mg/kg/day | - | No significant effects observed | - | |
| IVR | 250 mg/kg/day | 250 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1000 mg/kg/day | 1000 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 500 mg/kg/day | 500 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| PMID:17418525 | IVR | 7 - 9 ppm | 7 - 9 ppm | Affects ovulation | Reproductive endocrine-mediated perturbations |
| IVR | 7 - 9 ppm | 7 - 9 ppm | Increased estrone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 7 - 9 ppm | 7 - 9 ppm | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 7 - 9 ppm | 7 - 9 ppm | Decreased E1/E2 ratio | Reproductive endocrine-mediated perturbations | |
| IVR | 7 - 9 ppm | 7 - 9 ppm | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 7 - 9 ppm | 7 - 9 ppm | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 9 ppm | 9 ppm | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 7 - 9 ppm | 7 - 9 ppm | Decreased prolactin levels | Reproductive endocrine-mediated perturbations | |
| IVR | 7 - 9 ppm | 7 - 9 ppm | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 9 ppm | 9 ppm | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 9 ppm | 9 ppm | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 7 - 9 ppm | 7 - 9 ppm | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| PMID:34884750 | IVR | 5 mg/kg | 5 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg | 5 mg/kg | Decreased brain weights | Neurological endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg | 5 - 25 mg/kg | Cognitive impairment | Neurological endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg | 5 - 25 mg/kg | Induce behavioral changes | Neurological endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg | 5 - 25 mg/kg | Altered cell cycle in neurons | Neurological endocrine-mediated perturbations | |
| IVR | 1 - 25 mg/kg | 1 - 25 mg/kg | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg | 5 - 25 mg/kg | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 25 mg/kg | 1 - 25 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 5 - 25 mg/kg | 5 - 25 mg/kg | Affects spatial learning | Neurological endocrine-mediated perturbations | |
| IVR | 1 - 25 mg/kg | 1 - 25 mg/kg | Affects neural development | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.