Colforsin

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:12127262	IVTH	0.00002 M	0.00002 M	Oxidative stress in liver	Hepatic endocrine-mediated perturbations
PMID:15187238	IVTH	0.00001 - 0.00005 M	0.00001 - 0.00005 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.00005 M	0.00001 - 0.00005 M	Affects corticosterone metabolism	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
PMID:15884376	IVTH	0.00003 M	0.00003 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:16935330	IVTH	0.0000001 - 0.00005 M	0.00001 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00005 M	0.00001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00005 M	0.00001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00005 M	0.00001 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:16962624	IVTH	0.0000001 - 0.00003 M	0.0000003 - 0.00003 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00003 M	0.0000003 - 0.00003 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00003 M	0.0000003 - 0.00003 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
PMID:21959537	IVTH	0.0000001 - 0.00001 M	0.0000001 - 0.00001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00000003 - 0.00001 M	0.00000003 - 0.00001 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:23616146	IVTH	0.000001 - 0.01 mmol/L	0.0001 - 0.01 mmol/L	Increase in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.000001 - 0.01 mmol/L	0.0001 - 0.01 mmol/L	Increase in corticosterone levels	Neurological endocrine-mediated perturbations
PMID:33646749	IVTH	0.00001 M	0.00001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 M	0.00001 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:33984659	IVTH	0.00002 M	0.00002 M	Affects sperm motility	Reproductive endocrine-mediated perturbations
PMID:35696490	IVTH	0.000001 - 0.00001 M	0.000001 - 0.00001 M	Increased Dehydroepiandrosterone (DHEA) levels	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased 17-OH-pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.00001 M	0.000001 - 0.00001 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.00001 M	0.000001 - 0.00001 M	Increased 17-OH-progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.00001 M	0.000001 - 0.00001 M	Increased 21-OH-progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 M	0.00001 M	Increase in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.000001 - 0.00001 M	0.000001 - 0.00001 M	Increased estrone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 M	0.00001 M	Increased estriol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 M	0.00001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:35878261	IVR	0.00001 - 0.001 M	0.00001 - 0.001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.00001 - 0.001 M	0.00001 - 0.001 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.0000001 - 0.001 M	0.0000001 - 0.001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.00001 - 0.001 M	0.00001 - 0.001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:37551828	IVR	0.000001 - 5 ppm	0.000001 - 5 ppm	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.000001 - 5 ppm	0.000001 - 5 ppm	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 5 M	0.000001 - 5 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 - 5 ppm	0.5 - 5 ppm	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	5 ppm	5 ppm	Increased weights of adrenal gland	Metabolic endocrine-mediated perturbations
	IVR	0.000001 - 5 ppm	0.000001 - 5 ppm	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 5 M	0.000001 - 5 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 5 M	0.000001 - 5 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:38423186	IVTH	0.000001 M	0.000001 M	Increase in corticosterone levels	Neurological endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased 17-OH-progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increase in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased Dehydroepiandrosterone (DHEA) levels	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Alters aromatase activity	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased androstenedione levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased 11-deoxycortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased epitestosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased estrone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:38901820	IVTH	0.00001 M	0.00001 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:39136868	IVTH	0.0000003 - 0.00003 M	0.0000003 - 0.00003 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00003 M	0.0000001 - 0.00003 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:39243830	IVTH	0.00003 M	0.00003 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:39453121	IVTH	0.0000003 - 0.00003 M	0.0000003 - 0.00003 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.