2,2',4,4',5-Pentabromodiphenyl ether

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:15687051	IVR	0.3 mg/kg	0.3 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	0.06 mg/kg	0.06 mg/kg	Increased spleen weights	Immunological endocrine-mediated perturbations
	IVR	0.06 mg/kg	0.06 mg/kg	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.06 mg/kg	0.06 mg/kg	Affects social behavior	Neurological endocrine-mediated perturbations
PMID:16451854	IVR	10 mg/kg	10 mg/kg	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Decreased weights of pituitary gland in offspring	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Decreased weights of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	10 mg/kg	10 mg/kg	Delayed puberty in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:17964054	IVR	0.3 mg/kg	0.3 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
	IVR	0.06 mg/kg	0.06 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
PMID:20488217	IVR	0.6 mg/kg	0.6 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.6 mg/kg	0.6 mg/kg	Increased Lactate dehydrogenase (LDH) levels	Metabolic endocrine-mediated perturbations
	IVR	1.2 mg/kg	1.2 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1.2 mg/kg	1.2 mg/kg	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	1.2 mg/kg	1.2 mg/kg	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
	IVR	1.2 mg/kg	1.2 mg/kg	Increased Lactate dehydrogenase (LDH) levels	Metabolic endocrine-mediated perturbations
	IVR	1.2 mg/kg	1.2 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.6 mg/kg	0.6 mg/kg	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	0.6 mg/kg	0.6 mg/kg	Affects the biochemical composition of liver	Hepatic endocrine-mediated perturbations
	IVR	0.6 mg/kg	0.6 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:21783486	IVR	452 mg/kg	452 mg/kg	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	452 mg/kg	452 mg/kg	Affects xenobiotic metabolism	Metabolic endocrine-mediated perturbations
PMID:34879533	IVR	2 mg/kg/day	2 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.2 - 2 mg/kg/day	0.2 - 2 mg/kg/day	Decrease in testosterone/LH ratio	Reproductive endocrine-mediated perturbations
	IVR	0.2 - 2 mg/kg/day	0.2 - 2 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.2 - 2 mg/kg/day	0.2 - 2 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Decreased body weights in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.2 - 2 mg/kg/day	0.2 - 2 mg/kg/day	Undescended testes (or cryptorchidism)	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.2 - 2 mg/kg/day	0.2 - 2 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	0.2 - 2 mg/kg/day	0.2 - 2 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.2 - 2 mg/kg/day	0.2 - 2 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
PMID:36963198	IVR	0.2 - 2 mg/kg	0.2 - 2 mg/kg	Affects spermatogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.2 - 2 mg/kg	0.2 - 2 mg/kg	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
PMID:39136868	IVTH	0.00000001 - 0.0000001 M	0.00000001 - 0.0000001 M	Increased testosterone levels	Reproductive endocrine-mediated perturbations

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