| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:34014586 | IVR | 1 - 3 mg/kg/day | 1 - 3 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVR | 1 - 3 mg/kg/day | 1 - 3 mg/kg/day | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 3 mg/kg/day | 3 mg/kg/day | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Induce apoptosis in ovary | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 3 mg/kg/day | 1 - 3 mg/kg/day | Affects embryonic development | Developmental endocrine-mediated perturbations | |
| IVTH | 1 - 5 mg/L | 1 - 5 mg/L | Alters aromatase activity | Reproductive endocrine-mediated perturbations | |
| IVTH | 1 - 5 mg/L | 1 - 5 mg/L | Affects expression of luteinizing hormone receptor (LHR) | Reproductive endocrine-mediated perturbations | |
| IVTH | 1 - 5 mg/L | 1 - 5 mg/L | Affects expression of follicle-stimulating hormone receptor (FSHR) | Reproductive endocrine-mediated perturbations | |
| IVTH | 3 mg/L | 3 mg/L | Oxidative stress in granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVTH | 3 mg/L | 3 mg/L | Induce apoptosis of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 3 mg/kg/day | 1 - 3 mg/kg/day | Oxidative stress in ovaries | Reproductive endocrine-mediated perturbations | |
| IVR | 3 mg/kg/day | 3 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 3 mg/kg/day | 1 - 3 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 3 mg/kg/day | 1 - 3 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 3 mg/kg/day | 1 - 3 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.