Potassium perfluorooctanesulfonate

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:18252804	IVR	1 mg/kg/day	1 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Changes in haemocrit values	Immunological endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Changes in white blood cell (WBC) populations	Immunological endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Changes in B-cell populations	Immunological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Changes in white blood cell (WBC) populations	Immunological endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Alterations in thymocytes population	Immunological endocrine-mediated perturbations
PMID:24440345	IVR	3 mg/kg/day	3 mg/kg/day	Alters hypothalamic-pituitary-adrenal (HPA) axis	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased levels of adrenocortical hormones (ACTH)	Metabolic endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Alters hypothalamic-pituitary-adrenal (HPA) axis	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Alters hypothalamic-pituitary-adrenal (HPA) axis	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased levels of Corticotropin-releasing hormone (CRH)	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased levels of adrenocortical hormones (ACTH)	Metabolic endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased levels of Corticotropin-releasing hormone (CRH)	Neurological endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased levels of adrenocortical hormones (ACTH)	Metabolic endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Alters hypothalamic-pituitary-adrenal (HPA) axis	Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased levels of adrenocortical hormones (ACTH)	Metabolic endocrine-mediated perturbations
PMID:25171141	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Increased noradrenaline levels	Neurological endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased noradrenaline levels	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Increased noradrenaline levels	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased LH levels	Reproductive
	IVR	1 mg/kg/day	1 mg/kg/day	Increased noradrenaline levels
PMID:25623392	IVR	3 mg/kg/day	3 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased 5-HIAA/serotonin (5-HT) ratio	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased 5-HIAA/serotonin (5-HT) ratio	Neurological endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased 5-HIAA/serotonin (5-HT) ratio	Neurological endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased 5-HIAA/serotonin (5-HT) ratio	Neurological endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	0.5 mg/kg/day	0.5 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Increased serotonin (5-HT) levels	Neurological endocrine-mediated perturbations
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased estradiol levels	Reproductive
	IVR	1 mg/kg/day	1 mg/kg/day	Affects sexual behavior
	IVR	1 mg/kg/day	1 mg/kg/day	Decreased LH levels
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased LH levels
	IVR	6 mg/kg/day	6 mg/kg/day	Decreased testosterone levels
PMID:26032630	IVR	3 mg/kg	3 mg/kg	Decreased dopamine levels	Neurological endocrine-mediated perturbations
	IVR	3 mg/kg	3 mg/kg	Decreased estrone levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg	3 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased dopamine levels	Neurological endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased estrone levels	Reproductive endocrine-mediated perturbations
	IVR	6 mg/kg	6 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:29063134	IVTH	0.0000001 - 0.001 M	0.000001 - 0.00001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:35460815	IVR	3 mg/kg/day	3 mg/kg/day	Decrease in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decrease in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects thyroid hormone metabolism	Metabolic endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
PMID:38535903	IVR	5 mg/kg	5 mg/kg	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.