| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:18440200 | IVTH | 0.0625 - 1 mg/L | 0.0625 - 1 mg/L | Decreased progesterone levels | Reproductive endocrine-mediated perturbations |
| PMID:35257354 | IVR | 0.02 mg/kg | 0.02 mg/kg | Increased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.064 mg/kg | 0.064 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.064 mg/kg | 0.064 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| PMID:36907345 | IVR | 0.075 mg/kg/day | 0.075 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations |
| IVR | 0.075 mg/kg/day | 0.075 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.075 mg/kg/day | 0.075 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.15 - 0.3 mg/kg/day | 0.15 - 0.3 mg/kg/day | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.15 - 0.3 mg/kg/day | 0.15 - 0.3 mg/kg/day | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.075 - 0.3 mg/kg/day | 0.075 - 0.3 mg/kg/day | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.075 mg/kg/day | 0.075 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.