| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:10641015 | IVR | 25 mg/kg | 25 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/kg | 25 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| PMID:10876997 | IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Atrophy of mammary gland | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg/day | 4 mg/kg/day | Atrophy of mammary gland | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg/day | 4 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg/day | 4 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg/day | 4 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg/day | 4 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 4 mg/kg/day | 4 mg/kg/day | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| IVR | 0.25 mg/kg/day | - | No significant effects observed | - | |
| PMID:11961216 | IVR | 1 mg/kg/day | 1 mg/kg/day | Increase in T3 levels | Metabolic endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| PMID:15158566 | IVR | 100 mg/kg | 100 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations |
| IVR | 100 mg/kg | 100 mg/kg | Testicular atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Prostate atrophy | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | 10 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Atrophy of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | - | No significant effects observed | - | |
| IVR | 100 mg/kg | 100 mg/kg | Affects morphology of hepatocytes | Hepatic endocrine-mediated perturbations | |
| PMID:16777378 | IVR | 5 mg/kg/day | 5 mg/kg/day | Affects calcium signaling | Metabolic endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | - | No significant effects observed | - | |
| IVR | 200 mg/kg/day | - | No significant effects observed | - | |
| IVR | 40 mg/kg/day | - | No significant effects observed | - | |
| PMID:17443786 | IVR | 0.25 mg | 0.25 mg | Affects neural development | Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations |
| PMID:17558187 | IVR | 5 mg/kg | 5 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations |
| IVR | 250 mg/kg | 250 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | - | No significant effects observed | - | |
| PMID:17679765 | IVR | 25 mg/kg | 25 mg/kg | Hyperplasia in testis | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Hyperplasia in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg | 25 mg/kg | Abnormal proliferation of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Abnormal proliferation of germ cells | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Hyperplasia in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg | 5 mg/kg | Abnormal proliferation of germ cells | Reproductive endocrine-mediated perturbations | |
| PMID:18762243 | IVR | 5 mg/kg/day | 5 mg/kg/day | Affects embryonic development | Developmental endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Induce apoptosis of spermatogenic cells | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:19241440 | IVR | 3 mg/kg | 3 mg/kg | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations |
| PMID:19367084 | IVR | 1 mg/kg/day | 1 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Changes in number of nipples | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects testis development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Changes in number of nipples | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Increased LH levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects testis development | Developm | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased testosterone levels in offspring | ||
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects steroidogenesis | ||
| IVR | 10 mg/kg/day | 10 mg/kg/day | Changes in number of nipples | ||
| PMID:19781091 | IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations | |
| PMID:24211351 | IVR | 100 mg/kg/day | 100 mg/kg/day | Increased 5-alpha-dihydrotestosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects the normal functioning of reproductive system | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects sexual behavior | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:26485406 | IVR | 0.001 - 10 mg/kg/day | 1 - 10 mg/kg/day | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations |
| IVR | 0.001 - 10 mg/kg/day | 1 - 10 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.001 - 10 mg/kg/day | 1 - 10 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:27639664 | IVR | 20 mg/kg/day | 20 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations |
| PMID:29606031 | IVR | 25 mg/kg/day | 25 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 25 mg/kg/day | 25 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| PMID:32171874 | IVR | 3.5 - 25 mg/kg/day | 3.5 - 25 mg/kg/day | Changes in number of nipples | Reproductive endocrine-mediated perturbations |
| IVR | 3.5 - 5 mg/kg/day | 3.5 - 5 mg/kg/day | Undescended testes (or cryptorchidism) | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 3.5 - 25 mg/kg/day | 3.5 - 25 mg/kg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations | |
| PMID:33433340 | IVTH | 0.00000002 - 0.00000005 M | 0.00000002 - 0.00000005 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:34954075 | IVR | 1 mg/day | 1 mg/day | Affects anogenital distance | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/day | 1 mg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:36266662 | IVTH | 0.000001 M | 0.000001 M | Affects leydig cells function | Reproductive endocrine-mediated perturbations |
| IVTH | 0.000001 M | 0.000001 M | Increased Anti-Müllerian hormone (AMH) levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Decreased inhibin-B levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Affects survival of germ cells | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Decreased androstenedione levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Decreased Dehydroepiandrosterone (DHEA) levels | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.000001 M | 0.000001 M | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:37230229 | IVTH | 0.00001 M | 0.00001 M | Alteration in prostate morphology | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00001 M | 0.00001 M | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations | |
| PMID:38360075 | IVR | 2 mg/kg/day | 2 mg/kg/day | Decreased spleen weights | Immunological endocrine-mediated perturbations |
| IVR | 2 mg/kg/day | 2 mg/kg/day | Pregnancy complications | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.