| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:25375936 | IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0075 mg/kg/day | 0.0075 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0075 mg/kg/day | 0.0075 mg/kg/day | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0075 mg/kg/day | 0.0075 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0075 mg/kg/day | 0.0075 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.015 mg/kg/day | 0.015 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 0.00375 mg/kg/day | - | No significant effects observed | - | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| PMID:25497113 | IVR | 0.005 mg/kg | 0.005 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Affects cholesterol metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Reduced glucose levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Decreased triglycerides level | Metabolic endocrine-mediated perturbations | |
| PMID:27608041 | IVR | 0.0075 mg/kg | 0.0075 mg/kg | Cancer phenotype | Endocrine-mediated cancer |
| IVR | 0.03 mg/kg | 0.03 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| IVR | 0.015 mg/kg | 0.015 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:29772511 | IVTH | 1000000 mg/L | 1000000 mg/L | Decreased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVTH | 5000000 mg/L | 5000000 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 5000000 mg/L | 5000000 mg/L | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 10000 mg/L | 10000 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 10000 mg/L | 10000 mg/L | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 1000 mg/L | 1000 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 500000 mg/L | 500000 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 500000 mg/L | 500000 mg/L | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 1000000 mg/L | 1000000 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 100000 mg/L | 100000 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:33798882 | IVR | 0.02 mg/kg | 0.02 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 0.02 mg/kg | 0.02 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| PMID:34030373 | IVR | 0.05475 - 0.073 mg/kg | 0.05475 - 0.073 mg/kg | Changes in morphology of pituitary gland | Neurological endocrine-mediated perturbations |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 0.05475 - 0.073 mg/kg | 0.05475 - 0.073 mg/kg | Changes in hypothalamus morphology | Neurological endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Alters hypothalamic-pituitary-thyroid axis | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Alters hypothalamic-pituitary-gonadal axis (HPG axis) | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Decreased levels of Corticotropin-releasing hormone (CRH) | Neurological endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Decreased levels of adrenocortical hormones (ACTH) | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Decrease in cortisol levels | Neurological endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Decreased gonadotropin-releasing hormone (GnRH) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Alters hypothalamic-pituitary-adrenal (HPA) axis | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.05475 - 0.073 mg/kg | 0.05475 - 0.073 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.073 mg/kg | 0.073 mg/kg | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0365 - 0.05475 mg/kg | 0.0365 - 0.05475 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0365 mg/kg | 0.0365 mg/kg | Decrease in Thyrotropin-releasing hormone (TRH) levels | Metabolic endocrine-mediated perturbati | |
| IVR | 0.0365 - 0.073 mg/kg | 0.0365 - 0.073 mg/kg | Increased LH levels | ||
| PMID:36509348 | IVR | 0.09 mg/kg | 0.09 mg/kg | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations |
| IVR | 0.045 - 0.09 mg/kg | 0.045 - 0.09 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Increased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Increased brain weights | Neurological endocrine-mediated perturbations | |
| IVR | 0.0675 mg/kg | 0.0675 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.045 - 0.09 mg/kg | 0.045 - 0.09 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.045 - 0.09 mg/kg | 0.045 - 0.09 mg/kg | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.045 mg/kg | 0.045 mg/kg | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Decreased gonadotropin-releasing hormone (GnRH) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Increased levels of adrenocortical hormones (ACTH) | Metabolic endocrine-mediated perturbations | |
| IVR | 0.09 mg/kg | 0.09 mg/kg | Decreased levels of Corticotropin-releasing hormone (CRH) | Neurological endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Decrease in corticosterone levels | Neurological endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Affects expression of glucocorticoid receptor (GR) | Neurological endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Alters thyroglobulin levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.09 mg/kg | 0.09 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.045 - 0.09 mg/kg | 0.045 - 0.09 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.045 - 0.09 mg/kg | 0.045 - 0.09 mg/kg | Affects expression of thyroid receptor (TR) | Metabolic endocrine-mediated perturbations | |
| IVR | 0.0675 - 0.09 mg/kg | 0.0675 - 0.09 mg/kg | Changes in brain morphology | Neurological endocrine-mediated perturb | |
| IVR | 0.045 - 0.09 mg/kg | 0.045 - 0.09 mg/kg | Changes in morphology of pituitary gland | ||
| IVR | 0.045 - 0.09 mg/kg | 0.045 - 0.09 mg/kg | Changes in adrenal gland morphology | ||
| PMID:36907345 | IVR | 0.075 - 0.3 mg/kg/day | 0.075 - 0.3 mg/kg/day | Affects uterine morphology | Reproductive endocrine-mediated perturbations |
| IVR | 0.15 - 0.3 mg/kg/day | 0.15 - 0.3 mg/kg/day | Increased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.075 - 0.3 mg/kg/day | 0.075 - 0.3 mg/kg/day | Increase in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.15 - 0.3 mg/kg/day | 0.15 - 0.3 mg/kg/day | Increase in T4 levels | Metabolic endocrine-mediated perturbations | |
| PMID:37690761 | IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Increased levels of Corticotropin-releasing hormone (CRH) | Neurological endocrine-mediated perturbations |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Increased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Decreased Dihydroxytestosterone (DHT) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Alters hypothalamic-pituitary-adrenal (HPA) axis | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Alters hypothalamic-pituitary-gonadal axis (HPG axis) | Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Alters hypothalamic-pituitary-thyroid axis | Metabolic endocrine-mediated perturbations;Neurological endocrine-mediated perturbations | |
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Increased weights of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Decreased weights of adrenal gland | Metabolic endocrine-mediated perturbations | |
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Changes in morphology of pituitary gland | Neurological endocrine-mediated perturbations | |
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Increased levels of adrenocortical hormones (ACTH) | Metabolic endocrine-mediate | |
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Decreased gonadotropin-releasing hormone (GnRH) levels | ||
| IVR | 0.03 mg/kg/day | 0.03 mg/kg/day | Changes in hypothalamus morphology | ||
| IVR | 0.003 - 0.03 mg/kg/day | 0.003 - 0.03 mg/kg/day | Changes in morphology of thyroid gland |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.