Pyriproxyfen

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:31807242	IVR	320 mg/kg/day	320 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	320 mg/kg/day	320 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1200 mg/kg/day	1200 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	40 mg/kg/day	-	No significant effects observed	-
	IVR	600 mg/kg/day	600 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	600 mg/kg/day	600 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg/day	-	No significant effects observed	-
	IVR	1200 mg/kg/day	1200 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	1200 mg/kg/day	1200 mg/kg/day	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	1200 mg/kg/day	1200 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	1200 mg/kg/day	1200 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	320 mg/kg/day	320 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
PMID:32007685	IVTH	0.00001 M	0.00001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.00001 M	0.000001 - 0.00001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.000001 - 0.00001 M	0.000001 - 0.00001 M	Alters estrogen-responsive genes	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00001 M	0.0000001 - 0.00001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:39037111	IVR	0.1 - 1 mg/kg	0.1 - 1 mg/kg	Affects uterine morphology	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Changes in morphology of thyroid gland	Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg	0.1 mg/kg	Affects survival of live fetus	Reproductive endocrine-mediated perturbations
	IVR	0.1 - 1 mg/kg	0.1 - 1 mg/kg	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased weights of thyroid gland	Metabolic endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.