| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:29987898 | IVR | 100 mg/L | 100 mg/L | Decreased testosterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/L | 100 mg/L | Decreased Dihydroxytestosterone (DHT) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/L | 100 mg/L | Affects the biochemical composition of testis | Reproductive endocrine-mediated perturbations | |
| PMID:32197950 | IVTH | 0.0000001 M | 0.0000001 M | Affects estrogen signaling | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00000001 - 0.000001 M | 0.00000001 - 0.000001 M | Induce cancer metastasis | Endocrine-mediated cancer | |
| PMID:33766721 | IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased weights of accessory sex organs | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased weights of bulbocavernosus muscles/LABC | Reproductive endocrine-mediated perturbations | |
| PMID:36757007 | IVR | 1 mg/L | 1 mg/L | Alterations in leydig cell morphology | Reproductive endocrine-mediated perturbations |
| IVR | 1 mg/L | 1 mg/L | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/L | 1 mg/L | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| PMID:37229459 | IVR | 5 ppm | 5 ppm | Elevated glucose levels | Metabolic endocrine-mediated perturbations |
| PMID:39120795 | IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Hyperplasia in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Induce apoptosis in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Causes inflammation | Immunological endocrine-mediated perturbations | |
| PMID:39490100 | IVTH | 0.2 - 1 ppm | 0.2 - 1 ppm | Induce mitochondrial dysfunction in granulosa cells | Reproductive endocrine-mediated perturbations |
| IVR | 0.2 - 1 ppm | 0.2 - 1 ppm | Induce mitochondrial dysfunction in granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.2 ppm | 0.2 ppm | Induce autophagy in granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.01 - 1 ppm | 0.01 - 1 ppm | Abnormal proliferation of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.2 - 1 ppm | 0.2 - 1 ppm | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.01 - 1 ppm | 0.01 - 1 ppm | Affects ovarian development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 - 1 ppm | 0.01 - 1 ppm | Abnormal proliferation of granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 - 1 ppm | 0.1 - 1 ppm | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 - 1 ppm | 0.01 - 1 ppm | Decreased Anti-Müllerian hormone (AMH) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 ppm | 1 ppm | Increased Anti-Müllerian hormone (AMH) levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 - 1 ppm | 0.01 - 1 ppm | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 ppm | 0.1 ppm | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 - 1 ppm | 0.01 - 1 ppm | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 - 1 ppm | 0.01 - 1 ppm | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 0.01 - 1 ppm | 0.01 - 1 ppm | Affects ovarian development | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 1 ppm | 1 ppm | Affects ovarian function | Reproductive endocrine-mediated perturbations | |
| IVR | 0.2 - 1 ppm | 0.2 - 1 ppm | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 ppm | 1 ppm | Induce autophagy in ovary | Reproductive endocrine-mediated perturbations | |
| IVR | 0.01 - 1 ppm | 0.01 - 1 ppm | Altered cell cycle in granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVR | 1 ppm | 1 ppm | Affects folliculogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 ppm | 1 ppm | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive | |
| IVR | 1 ppm | 1 ppm | Affects expression of estrogen receptor-alpha (ER-alpha) | ||
| IVR | 0.1 ppm | 0.1 ppm | Increased estradiol levels | ||
| IVR | 0.01 - 1 ppm | 0.01 - 1 ppm | Abnormal estrous cycles | ||
| PMID:39771102 | IVR | 1 mg/kg | 1 mg/kg | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Causes inflammation | Immunological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Induce apoptosis in thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Changes in morphology of thyroid gland | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Increase in TSH levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects thyroid hormone synthesis | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects thyroid hormone metabolism | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.