Dienestrol

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:30986439	IVR	0.0125 mg/kg/day	0.0125 mg/kg/day	Increased weights of seminal vesicles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0125 mg/kg/day	0.0125 mg/kg/day	Increased weights of epididymis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.0125 mg/kg/day	0.0125 mg/kg/day	Increased prostate weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.00312 mg/kg/day	0.00312 mg/kg/day	Reduced sperm counts in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.00312 mg/kg/day	0.00312 mg/kg/day	Increased Alkaline phosphatase (ALP) levels in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
	IVR	0.00312 mg/kg/day	0.00312 mg/kg/day	Increased weights of seminal vesicles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.00312 mg/kg/day	0.00312 mg/kg/day	Elevated glucose levels in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	0.00625 mg/kg/day	0.00625 mg/kg/day	Reduced sperm counts in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.075 mg/kg/day	0.075 mg/kg/day	Increased weights of epididymis in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg/day	0.05 mg/kg/day	Increased weights of seminal vesicles in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.075 mg/kg/day	0.075 mg/kg/day	Increased prostate weights in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.00625 mg/kg/day	0.00625 mg/kg/day	Increased Alkaline phosphatase (ALP) levels in offspring	Developme
	IVR	0.00625 mg/kg/day	0.00625 mg/kg/day	Abnormal sperm morphology in offspring
	IVR	0.0015 mg/kg/day	0.0015 mg/kg/day	Elevated glucose levels in offspring
	IVR	0.0015 mg/kg/day	0.0015 mg/kg/day	Increased prostate weights in offspring
	IVR	0.0015 mg/kg/day	0.0015 mg/kg/day	Increased liver weights in offspring
	IVR	0.0015 mg/kg/day	0.0015 mg/kg/day	Abnormal sperm morphology in offspring
	IVR	0.0015 mg/kg/day	0.0015 mg/kg/day	Increased weights of seminal vesicles in offspring
	IVR	0.00625 mg/kg/day	0.00625 mg/kg/day	Elevated glucose levels in offspring
	IVR	0.00625 mg/kg/day	0.00625 mg/kg/day	Increased liver weights in offspring
	IVR	0.075 mg/kg/day	0.075 mg/kg/day	Increased weights of seminal vesicles in offspring
	IVR	0.00312 mg/kg/day	0.00312 mg/kg/day	Abnormal sperm morphology in offspring
	IVR	0.0015 mg/kg/day	0.0015 mg/kg/day	Increased weights of epididymis in offspring
	IVR	0.00625 mg/kg/day	0.00625 mg/kg/day	Increased weights of epididymi
	IVR	0.00075 mg/kg/day	0.00075 mg/kg/day
	IVR	0.00075 mg/kg/day	0.00075 mg/kg/day
	IVR	0.00075 mg/kg/day	0.00075 mg/kg/day
	IVR	0.00075 mg/kg/day	0.00075 mg/kg/day
	IVR	0.00075 mg/kg/day	0.00075 mg/kg/day
	IVR	0.00312 mg/kg/day	0.00312 mg/kg/day
	IVR	0.00075 mg/kg/day	0.00075 mg/kg/day
	IVR	0.00075 mg/kg/day	0.00075 mg/kg/day
	IVR	0.00312 mg/kg/day	0.00312 mg/kg/day
	IVR	0.05 mg/kg/day	0.05 mg/kg/day
	IVR	0.00312 mg/kg/day	0.00312 mg/kg/day
	IVR	0.05 mg/kg/day	0.05 mg/kg/day
PMID:32171874	IVR	0.00625 mg/kg/day	0.00625 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.00075 - 0.00625 mg/kg/day	0.00075 - 0.00625 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.