| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:37146712 | IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Increased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Increased Alkaline phosphatase (ALP) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Increased Alanine aminotransferase (ALT) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Oxidative stress in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Induce apoptosis in testis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Induce testicular damage | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 2 mg/kg | 1 - 2 mg/kg | Increased AST/ALT ratio | Hepatic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Decreased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Increased triglycerides level | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Decreased ovarian weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Decreased HDL levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Increased LDL levels | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Increased Aspartate aminotransferase (AST) level | Hepatic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Changes in ovarian morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 2 mg/kg | 1 - 2 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects spermatogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects fertility | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Changes in morphology of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Abnormal estrous cycles | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects ovarian follicles population | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 2 mg/kg | 1 - 2 mg/kg | Affects implantation | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Alterations in preputial separation | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Decreased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Changes in adrenal gland morphology | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Decreased vas deferens weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Altered germ cells morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 8 mg/kg | 1 - 8 mg/kg | Decreased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | mg/kg | - | Decreased weights of adrenal gland | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.