Chloro-tris(1,1,2,2,3,3,4,4,4-nonadeuteriobutyl)stannane

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:32239163	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Abnormal oocyte morphology	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Oxidative stress in ovaries	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Oxidative stress in uterus	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Affects uterine morphology	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Causes inflammation	Immunological endocrine-mediated perturbations
	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
PMID:34902535	IVR	0.0005 mg/kg/day	0.0005 mg/kg/day	Increased body weights	Metabolic endocrine-mediated perturbations
	IVR	0.001 mg/kg/day	0.001 mg/kg/day	Increased adiposity	Metabolic endocrine-mediated perturbations
	IVR	0.0005 - 0.001 mg/kg/day	0.0005 - 0.001 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:36073672	IVR	0.00025 mg/kg/day	0.00025 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.00025 - 0.0025 mg/kg/day	0.00025 - 0.0025 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	0.00025 - 0.025 mg/kg/day	0.00025 - 0.025 mg/kg/day	Changes in brain morphology	Neurological endocrine-mediated perturbations
PMID:38936095	IVTH	0.0000001 - 0.001 M	0.0000001 - 0.001 M	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
	IVTH	0.00000005 - 0.0000001 M	0.00000005 - 0.0000001 M	Altered adipogenesis	Metabolic endocrine-mediated perturbations
	IVTH	0.0000001 M	0.0000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Hyperplasia in mammary glands	Reproductive endocrine-mediated perturbations
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Oxidative stress in mammary gland	Reproductive endocrine-mediated perturbations
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Changes in mammary gland morphology	Reproductive endocrine-mediated perturbations
	IVR	0.001 mg/kg/day	0.001 mg/kg/day	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
	IVR	0.0001 - 0.001 mg/kg/day	0.0001 - 0.001 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	0.0001 mg/kg/day	0.0001 mg/kg/day	Increased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	0.0000001 - 0.001 mg/kg/day	0.0000001 - 0.001 mg/kg/day	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
PMID:39044430	IVTH	0.00000001 - 0.000000025 M	0.00000001 - 0.000000025 M	Altered adipogenesis	Metabolic endocrine-mediated perturbations

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