| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:33980773 | IVR | 5 mg/L | 5 mg/L | Increased HMG-CoA reductase in ovary | Reproductive endocrine-mediated perturbations |
| IVR | 5 mg/L | 5 mg/L | Affects cholesterol transport | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Increased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 - 5 mg/L | 0.5 - 5 mg/L | Affects testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Increased cholesterol levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Increased LDL levels | Metabolic endocrine-mediated perturbations | |
| IVR | 0.5 - 5 mg/L | 0.5 - 5 mg/L | Decreased HDL levels | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Decreased estrogen levels | Reproductive endocrine-mediated perturbations | |
| IVR | 0.5 - 5 mg/L | 0.5 - 5 mg/L | Decreased androgen levels | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Affects expression of estrogen receptor-alpha (ER-alpha) in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Increased HMG-CoA reductase in testis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Affects expression of estrogen receptor-beta (ER-beta) | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Affects expression of estrogen receptor-beta (ER-beta) in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Reduced HMG-CoA reductase in testes in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/L | 5 mg/L | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.