Perfluoro-n-undecanoic acid
No ToxCast endpoints for intended target type: RNA
ToxCast endpoints for intended target type: Protein
| Assay Name | Tissue | Organism | Target Gene ID | Target HGNC Symbol | Response | AC50 Value |
|---|
| CCTE_GLTED_hTTR_0.5uM | | Human | 7276 | TTR | Loss | 1.97 μM |
| BSK_3C_Thrombomodulin | Vascular | Human | 7056 | THBD | Inhibitory | 5.29 μM |
| BSK_3C_TissueFactor | Vascular | Human | 2152 | F3 | Inhibitory | 5.02 μM |
| BSK_BE3C_HLADR | Lung | Human | 3122 | HLA-DRA | Inhibitory | 4.92 μM |
| BSK_BE3C_IL1a | Lung | Human | 3552 | IL1A | Inhibitory | 5.23 μM |
| BSK_BE3C_IP10 | Lung | Human | 3627 | CXCL10 | Inhibitory | 2.29 μM |
| BSK_BE3C_MIG | Lung | Human | 4283 | CXCL9 | Inhibitory | 5.56 μM |
| BSK_BE3C_MMP1 | Lung | Human | 4312 | MMP1 | Inhibitory | 5.54 μM |
| BSK_BE3C_PAI1 | Lung | Human | 5054 | SERPINE1 | Inhibitory | 1.76 μM |
| BSK_BE3C_tPA | Lung | Human | 5327 | PLAT | Inhibitory | 5.38 μM |
| BSK_BE3C_uPA | Lung | Human | 5328 | PLAU | Inhibitory | 5.27 μM |
| BSK_BE3C_uPAR | Lung | Human | 5329 | PLAUR | Inhibitory | 5.59 μM |
| BSK_CASM3C_Thrombomodulin | Vascular | Human | 7056 | THBD | Inhibitory | 0.14 μM |
| BSK_hDFCGF_CollagenIII | Skin | Human | 1281 | COL3A1 | Inhibitory | 3.62 μM |
| BSK_hDFCGF_EGFR | Skin | Human | 1956 | EGFR | Inhibitory | 1.17 μM |
| BSK_hDFCGF_IL8 | Skin | Human | 3576 | CXCL8 | Inhibitory | 6.3 μM |
| BSK_hDFCGF_IP10 | Skin | Human | 3627 | CXCL10 | Inhibitory | 4.7 μM |
| BSK_hDFCGF_MCSF | Skin | Human | 1435 | CSF1 | Inhibitory | 4.97 μM |
| BSK_hDFCGF_MIG | Skin | Human | 4283 | CXCL9 | Inhibitory | 5.08 μM |
| BSK_hDFCGF_PAI1 | Skin | Human | 5054 | SERPINE1 | Inhibitory | 5.09 μM |
| BSK_hDFCGF_TIMP1 | Skin | Human | 7076 | TIMP1 | Inhibitory | 5.31 μM |
| BSK_hDFCGF_VCAM1 | Skin | Human | 7412 | VCAM1 | Inhibitory | 4.25 μM |
| BSK_KF3CT_ICAM1 | Skin | Human | 3383 | ICAM1 | Inhibitory | 4.73 μM |
| BSK_KF3CT_IL1a | Skin | Human | 3552 | IL1A | Inhibitory | 5.06 μM |
| BSK_KF3CT_IP10 | Skin | Human | 3627 | CXCL10 | Inhibitory | 5.25 μM |
| BSK_KF3CT_MCP1 | Skin | Human | 6347 | CCL2 | Inhibitory | 4.55 μM |
| BSK_KF3CT_MMP9 | Skin | Human | 4318 | MMP9 | Inhibitory | 4.19 μM |
| BSK_KF3CT_TIMP2 | Skin | Human | 7077 | TIMP2 | Inhibitory | 6.13 μM |
| BSK_KF3CT_uPA | Skin | Human | 5328 | PLAU | Inhibitory | 5.16 μM |
| BSK_LPS_IL1a | Vascular | Human | 3552 | IL1A | Inhibitory | 0.14 μM |
| BSK_LPS_TNFa | Vascular | Human | 7124 | TNF | Inhibitory | 4.42 μM |
| BSK_SAg_CD40 | Vascular | Human | 958 | CD40 | Inhibitory | 5.27 μM |
| BSK_SAg_CD69 | Vascular | Human | 969 | CD69 | Inhibitory | 2.4 μM |
| BSK_MyoF_ACTA1 | Vascular | Human | 58 | ACTA1 | Inhibitory | 2.55 μM |
| BSK_MyoF_bFGF | Vascular | Human | 2247 | FGF2 | Inhibitory | 6.09 μM |
| BSK_MyoF_VCAM1 | Vascular | Human | 7412 | VCAM1 | Inhibitory | 4.92 μM |
| BSK_MyoF_CollagenI | Vascular | Human | 1277 | COL1A1 | Inhibitory | 2.25 μM |
| BSK_MyoF_CollagenIII | Vascular | Human | 1281 | COL3A1 | Inhibitory | 2.58 μM |
| BSK_MyoF_CollagenIV | Vascular | Human | 1282 | COL4A1 | Inhibitory | 0.96 μM |
| BSK_MyoF_Decorin | Vascular | Human | 1634 | DCN | Inhibitory | 5.16 μM |
| BSK_MyoF_TIMP1 | Vascular | Human | 7076 | TIMP1 | Inhibitory | 5.2 μM |
| BSK_BF4T_MCP1 | Vascular | Human | 6347 | CCL2 | Inhibitory | 5.18 μM |
| BSK_BF4T_Eotaxin3 | Vascular | Human | 10344 | CCL26 | Inhibitory | 3.33 μM |
| BSK_BF4T_VCAM1 | Vascular | Human | 7412 | VCAM1 | Inhibitory | 5.89 μM |
| BSK_BF4T_ICAM1 | Vascular | Human | 3383 | ICAM1 | Inhibitory | 4.51 μM |
| BSK_BF4T_CD90 | Vascular | Human | 7070 | THY1 | Inhibitory | 4.83 μM |
| BSK_BF4T_IL8 | Vascular | Human | 3576 | CXCL8 | Inhibitory | 5.74 μM |
| BSK_BF4T_IL1a | Vascular | Human | 3552 | IL1A | Inhibitory | 6.17 μM |
| BSK_BF4T_Keratin818 | Vascular | Human | 3875 | KRT18 | Inhibitory | 5.17 μM |
| BSK_BF4T_MMP1 | Vascular | Human | 4312 | MMP1 | Inhibitory | 5.66 μM |
| BSK_BF4T_MMP3 | Vascular | Human | 4314 | MMP3 | Inhibitory | 3.33 μM |
| BSK_BF4T_MMP9 | Vascular | Human | 4318 | MMP9 | Inhibitory | 5.37 μM |
| BSK_BF4T_PAI1 | Vascular | Human | 5054 | SERPINE1 | Inhibitory | 6.13 μM |
| BSK_BF4T_tPA | Vascular | Human | 5327 | PLAT | Inhibitory | 5.58 μM |
| BSK_BF4T_uPA | Vascular | Human | 5328 | PLAU | Inhibitory | 6.17 μM |
| BSK_BE3C_ICAM1 | Lung | Human | 3383 | ICAM1 | Inhibitory | 6.33 μM |
| BSK_BE3C_ITAC | Lung | Human | 6373 | CXCL11 | Inhibitory | 2.84 μM |
| BSK_BE3C_IL8 | Lung | Human | 3576 | CXCL8 | Inhibitory | 3.81 μM |
| BSK_BE3C_EGFR | Lung | Human | 1956 | EGFR | Inhibitory | 2.34 μM |
| BSK_BE3C_Keratin818 | Lung | Human | 3875 | KRT18 | Inhibitory | 5.29 μM |
| BSK_BE3C_MMP9 | Lung | Human | 4318 | MMP9 | Inhibitory | 3.33 μM |
| BSK_hDFCGF_MCP1 | Skin | Human | 6347 | CCL2 | Inhibitory | 5.63 μM |
| BSK_hDFCGF_ICAM1 | Skin | Human | 3383 | ICAM1 | Inhibitory | 5.47 μM |
| BSK_hDFCGF_CollagenI | Skin | Human | 1277 | COL1A1 | Inhibitory | 4.47 μM |
| BSK_hDFCGF_ITAC | Skin | Human | 6373 | CXCL11 | Inhibitory | 5.59 μM |
| BSK_hDFCGF_TIMP2 | Skin | Human | 7077 | TIMP2 | Inhibitory | 5.21 μM |
| BSK_KF3CT_IL8 | Skin | Human | 3576 | CXCL8 | Inhibitory | 5.2 μM |
| BSK_KF3CT_MIG | Skin | Human | 4283 | CXCL9 | Inhibitory | 5.48 μM |
| BSK_KF3CT_PAI1 | Skin | Human | 5054 | SERPINE1 | Inhibitory | 4.56 μM |
| BSK_IMphg_CD69 | Vascular | Human | 969 | CD69 | Inhibitory | 0.02 μM |
| BSK_3C_uPAR | Vascular | Human | 5329 | PLAUR | Inhibitory | 4.88 μM |
| BSK_4H_Eotaxin3 | Vascular | Human | 10344 | CCL26 | Inhibitory | 3.33 μM |
| BSK_BE3C_HLADR | Lung | Human | 3122 | HLA-DRA | Inhibitory | 4.71 μM |
| BSK_BE3C_IL1a | Lung | Human | 3552 | IL1A | Inhibitory | 5.25 μM |
| BSK_BE3C_IP10 | Lung | Human | 3627 | CXCL10 | Inhibitory | 2.27 μM |
| BSK_BE3C_MIG | Lung | Human | 4283 | CXCL9 | Inhibitory | 5.09 μM |
| BSK_BE3C_MMP1 | Lung | Human | 4312 | MMP1 | Inhibitory | 5.53 μM |
| BSK_BE3C_PAI1 | Lung | Human | 5054 | SERPINE1 | Inhibitory | 2.27 μM |
| BSK_BE3C_tPA | Lung | Human | 5327 | PLAT | Inhibitory | 5.33 μM |
| BSK_BE3C_uPA | Lung | Human | 5328 | PLAU | Inhibitory | 6.21 μM |
| BSK_BE3C_uPAR | Lung | Human | 5329 | PLAUR | Inhibitory | 5.6 μM |
| BSK_hDFCGF_CollagenIII | Skin | Human | 1281 | COL3A1 | Inhibitory | 5.73 μM |
| BSK_hDFCGF_EGFR | Skin | Human | 1956 | EGFR | Inhibitory | 0.84 μM |
| BSK_hDFCGF_IL8 | Skin | Human | 3576 | CXCL8 | Inhibitory | 6.18 μM |
| BSK_hDFCGF_IP10 | Skin | Human | 3627 | CXCL10 | Inhibitory | 4.76 μM |
| BSK_hDFCGF_MCSF | Skin | Human | 1435 | CSF1 | Inhibitory | 5.03 μM |
| BSK_hDFCGF_MIG | Skin | Human | 4283 | CXCL9 | Inhibitory | 4.94 μM |
| BSK_hDFCGF_MMP1 | Skin | Human | 4312 | MMP1 | Inhibitory | 5.59 μM |
| BSK_hDFCGF_PAI1 | Skin | Human | 5054 | SERPINE1 | Inhibitory | 5.61 μM |
| BSK_hDFCGF_TIMP1 | Skin | Human | 7076 | TIMP1 | Inhibitory | 5.14 μM |
| BSK_hDFCGF_VCAM1 | Skin | Human | 7412 | VCAM1 | Inhibitory | 3.07 μM |
| BSK_KF3CT_ICAM1 | Skin | Human | 3383 | ICAM1 | Inhibitory | 5.0 μM |
| BSK_KF3CT_IL1a | Skin | Human | 3552 | IL1A | Inhibitory | 3.41 μM |
| BSK_KF3CT_IP10 | Skin | Human | 3627 | CXCL10 | Inhibitory | 5.45 μM |
| BSK_KF3CT_MCP1 | Skin | Human | 6347 | CCL2 | Inhibitory | 4.5 μM |
| BSK_KF3CT_MMP9 | Skin | Human | 4318 | MMP9 | Inhibitory | 3.85 μM |
| BSK_KF3CT_TIMP2 | Skin | Human | 7077 | TIMP2 | Inhibitory | 6.15 μM |
| BSK_KF3CT_uPA | Skin | Human | 5328 | PLAU | Inhibitory | 5.47 μM |
| BSK_LPS_CD40 | Vascular | Human | 958 | CD40 | Inhibitory | 1.41 μM |
| BSK_LPS_IL1a | Vascular | Human | 3552 | IL1A | Inhibitory | 0.66 μM |
| BSK_LPS_IL8 | Vascular | Human | 3576 | CXCL8 | Inhibitory | 2.03 μM |
| BSK_LPS_TissueFactor | Vascular | Human | 2152 | F3 | Inhibitory | 3.33 μM |
| BSK_LPS_TNFa | Vascular | Human | 7124 | TNF | Inhibitory | 4.39 μM |
| BSK_SAg_CD38 | Vascular | Human | 952 | CD38 | Inhibitory | 2.78 μM |
| BSK_SAg_CD40 | Vascular | Human | 958 | CD40 | Inhibitory | 5.41 μM |
| BSK_SAg_CD69 | Vascular | Human | 969 | CD69 | Inhibitory | 3.33 μM |
| BSK_MyoF_ACTA1 | Vascular | Human | 58 | ACTA1 | Inhibitory | 2.74 μM |
| BSK_MyoF_bFGF | Vascular | Human | 2247 | FGF2 | Inhibitory | 5.14 μM |
| BSK_MyoF_VCAM1 | Vascular | Human | 7412 | VCAM1 | Inhibitory | 4.85 μM |
| BSK_MyoF_CollagenI | Vascular | Human | 1277 | COL1A1 | Inhibitory | 2.19 μM |
| BSK_MyoF_CollagenIII | Vascular | Human | 1281 | COL3A1 | Inhibitory | 2.59 μM |
| BSK_MyoF_CollagenIV | Vascular | Human | 1282 | COL4A1 | Inhibitory | 0.89 μM |
| BSK_MyoF_IL8 | Vascular | Human | 3576 | CXCL8 | Inhibitory | 6.34 μM |
| BSK_MyoF_Decorin | Vascular | Human | 1634 | DCN | Inhibitory | 5.02 μM |
| BSK_MyoF_PAI1 | Vascular | Human | 5054 | SERPINE1 | Inhibitory | 5.52 μM |
| BSK_MyoF_TIMP1 | Vascular | Human | 7076 | TIMP1 | Inhibitory | 4.33 μM |
| BSK_BF4T_MCP1 | Vascular | Human | 6347 | CCL2 | Inhibitory | 5.55 μM |
| BSK_BF4T_Eotaxin3 | Vascular | Human | 10344 | CCL26 | Inhibitory | 3.14 μM |
| BSK_BF4T_VCAM1 | Vascular | Human | 7412 | VCAM1 | Inhibitory | 4.89 μM |
| BSK_BF4T_ICAM1 | Vascular | Human | 3383 | ICAM1 | Inhibitory | 5.15 μM |
| BSK_BF4T_IL8 | Vascular | Human | 3576 | CXCL8 | Inhibitory | 5.82 μM |
| BSK_BF4T_IL1a | Vascular | Human | 3552 | IL1A | Inhibitory | 5.56 μM |
| BSK_BF4T_Keratin818 | Vascular | Human | 3875 | KRT18 | Inhibitory | 5.05 μM |
| BSK_BF4T_MMP1 | Vascular | Human | 4312 | MMP1 | Inhibitory | 5.11 μM |
| BSK_BF4T_MMP3 | Vascular | Human | 4314 | MMP3 | Inhibitory | 5.26 μM |
| BSK_BF4T_MMP9 | Vascular | Human | 4318 | MMP9 | Inhibitory | 4.36 μM |
| BSK_BF4T_PAI1 | Vascular | Human | 5054 | SERPINE1 | Inhibitory | 5.2 μM |
| BSK_BF4T_tPA | Vascular | Human | 5327 | PLAT | Inhibitory | 4.42 μM |
| BSK_BE3C_ICAM1 | Lung | Human | 3383 | ICAM1 | Inhibitory | 5.73 μM |
| BSK_BE3C_ITAC | Lung | Human | 6373 | CXCL11 | Inhibitory | 2.65 μM |
| BSK_BE3C_IL8 | Lung | Human | 3576 | CXCL8 | Inhibitory | 4.19 μM |
| BSK_BE3C_EGFR | Lung | Human | 1956 | EGFR | Inhibitory | 4.31 μM |
| BSK_BE3C_Keratin818 | Lung | Human | 3875 | KRT18 | Inhibitory | 3.92 μM |
| BSK_BE3C_MMP9 | Lung | Human | 4318 | MMP9 | Inhibitory | 3.77 μM |
| BSK_hDFCGF_MCP1 | Skin | Human | 6347 | CCL2 | Inhibitory | 5.24 μM |
| BSK_hDFCGF_ICAM1 | Skin | Human | 3383 | ICAM1 | Inhibitory | 5.12 μM |
| BSK_hDFCGF_CollagenI | Skin | Human | 1277 | COL1A1 | Inhibitory | 3.03 μM |
| BSK_hDFCGF_ITAC | Skin | Human | 6373 | CXCL11 | Inhibitory | 5.38 μM |
| BSK_hDFCGF_TIMP2 | Skin | Human | 7077 | TIMP2 | Inhibitory | 6.09 μM |
| BSK_KF3CT_IL8 | Skin | Human | 3576 | CXCL8 | Inhibitory | 3.33 μM |
| BSK_KF3CT_PAI1 | Skin | Human | 5054 | SERPINE1 | Inhibitory | 2.66 μM |
| BSK_LPS_CD69 | Vascular | Human | 969 | CD69 | Inhibitory | 3.33 μM |
| CCTE_GLTED_hTBG | | Human | 6906 | SERPINA7 | Loss | 2.7 μM |
| CCTE_GLTED_hTTR_0.125uM | | Human | 7276 | TTR | Loss | 0.78 μM |
| NVS_ADME_hCYP2C9 | | Human | 1559 | CYP2C9 | Loss | 1.58 μM |
| NVS_ENZ_hAKT1 | | Human | 207 | AKT1 | Loss | 1.59 μM |
| NVS_ENZ_hBACE | | Human | 23621 | BACE1 | Loss | 1.51 μM |
| NVS_ENZ_hCASP5 | | Human | 838 | CASP5 | Loss | 3.54 μM |
| NVS_ENZ_hDUSP3 | | Human | 1845 | DUSP3 | Loss | 2.72 μM |
| NVS_GPCR_gLTB4 | Spleen | Guinea pig | 100379538 | Ltb4r | Loss | 4.99 μM |
| NVS_GPCR_hAdoRA2a | | Human | 135 | ADORA2A | Loss | 2.23 μM |
| NVS_GPCR_hAdra2C | | Human | 152 | ADRA2C | Loss | 4.5 μM |
| NVS_NR_hGR | | Human | 2908 | NR3C1 | Loss | 5.36 μM |
| ATG_C_EBP_CIS | Liver | Human | 1051 | CEBPB | Activatory | 172.1 μM |
| ATG_DR5_RAR_CIS | Liver | Human | 5914|5915|5916 | RARA|RARB|RARG | Activatory | 129.49 μM |
| ATG_GATA_CIS | Liver | Human | 2623 | GATA1 | Inhibitory | 148.12 μM |
| ATG_GLI_CIS | Liver | Human | 2735 | GLI1 | Inhibitory | 173.95 μM |
| ATG_GRE_CIS | Liver | Human | 2908 | NR3C1 | Inhibitory | 121.71 μM |
| ATG_Myb_CIS | Liver | Human | 4602 | MYB | Activatory | 153.69 μM |
| ATG_NF_kB_CIS | Liver | Human | 4790 | NFKB1 | Activatory | 95.5 μM |
| ATG_NFI_CIS | Liver | Human | 4774 | NFIA | Activatory | 157.4 μM |
| ATG_NRF1_CIS | Liver | Human | 4899 | NRF1 | Activatory | 161.83 μM |
| ATG_TGFb_CIS | Liver | Human | 7040 | TGFB1 | Activatory | 89.02 μM |
| BSK_KF3CT_MMP9 | Skin | Human | 4318 | MMP9 | Inhibitory | 6.03 μM |
| BSK_KF3CT_TGFb1 | Skin | Human | 7040 | TGFB1 | Inhibitory | 5.59 μM |
| NVS_NR_hPPARg | | Human | 5468 | PPARG | Loss | 6.31 μM |
| CCTE_GLTED_hDIO1 | | Human | 1733 | DIO1 | Loss | 156.53 μM |
| TOX21_ERa_BLA_Antagonist_ratio | Kidney | Human | 2099 | ESR1 | Loss | 1.61 μM |
| TOX21_p450_CYP2C9_Antagonist | | Human | 1559 | CYP2C9 | Loss | 4.33 μM |
No ToxCast endpoints for intended target type: Molecular messenger
ToxCast endpoints for intended target type: Pathway
| Assay Name | Tissue | Organism | Target Gene ID | Target HGNC Symbol | Response | AC50 Value |
|---|
| APR_HepG2_P-H2AX_72hr | Liver | Human | 3014 | H2AX | Activatory | 84.2 μM |
| APR_HepG2_p53Act_72hr | Liver | Human | 7157 | TP53 | Activatory | 79.47 μM |
No ToxCast endpoints for intended target type: Cellular
No ToxCast endpoints for intended target type: Hormone
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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.