DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Enilconazole

ToxCast endpoints for intended target type: RNA

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CLD_CYP1A1_6hr	Liver	Human	1543	CYP1A1	Gain	0.09 μM
CLD_CYP1A2_6hr	Liver	Human	1544	CYP1A2	Gain	0.06 μM
CLD_CYP2B6_6hr	Liver	Human	1555	CYP2B6	Gain	0.02 μM
CLD_CYP3A4_6hr	Liver	Human	1576	CYP3A4	Gain	0.19 μM
CLD_CYP1A1_24hr	Liver	Human	1543	CYP1A1	Gain	1.06 μM
CLD_CYP1A2_24hr	Liver	Human	1544	CYP1A2	Gain	0.51 μM
CLD_CYP2B6_24hr	Liver	Human	1555	CYP2B6	Gain	0.17 μM
CLD_CYP3A4_24hr	Liver	Human	1576	CYP3A4	Gain	6.09 μM
CLD_CYP1A1_48hr	Liver	Human	1543	CYP1A1	Gain	3.84 μM
CLD_CYP1A2_48hr	Liver	Human	1544	CYP1A2	Gain	0.55 μM
CLD_CYP2B6_48hr	Liver	Human	1555	CYP2B6	Gain	0.15 μM
CLD_CYP3A4_48hr	Liver	Human	1576	CYP3A4	Gain	5.76 μM
LTEA_HepaRG_ABCG2	Liver	Human	9429	ABCG2	Inhibitory	2.47 μM
LTEA_HepaRG_BCL2	Liver	Human	596	BCL2	Activatory	13.72 μM
LTEA_HepaRG_CYP1A1	Liver	Human	1543	CYP1A1	Activatory	13.94 μM
LTEA_HepaRG_CYP1A2	Liver	Human	1544	CYP1A2	Activatory	4.54 μM
LTEA_HepaRG_TP53	Liver	Human	7157	TP53	Activatory	14.18 μM

ToxCast endpoints for intended target type: Protein

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
NVS_ADME_hCYP19A1		Human	1588	CYP19A1	Loss	0.47 μM
NVS_ADME_hCYP1A1		Human	1543	CYP1A1	Loss	1.41 μM
NVS_ADME_hCYP1A2		Human	1544	CYP1A2	Loss	1.0 μM
NVS_ADME_hCYP2A6		Human	1548	CYP2A6	Loss	2.52 μM
NVS_ADME_hCYP2B6		Human	1555	CYP2B6	Loss	0.19 μM
NVS_ADME_hCYP2C18		Human	1562	CYP2C18	Loss	0.42 μM
NVS_ADME_hCYP2C19		Human	1557	CYP2C19	Loss	0.06 μM
NVS_ADME_hCYP2C8		Human	1558	CYP2C8	Loss	6.22 μM
NVS_ADME_hCYP2C9		Human	1559	CYP2C9	Loss	0.38 μM
NVS_ADME_hCYP2D6		Human	1565	CYP2D6	Loss	4.45 μM
NVS_ADME_hCYP2J2		Human	1573	CYP2J2	Loss	0.16 μM
NVS_ADME_hCYP3A4		Human	1576	CYP3A4	Loss	0.11 μM
NVS_ADME_rCYP1A1		Rat	24296	Cyp1a1	Loss	7.73 μM
NVS_ADME_rCYP2A1		Rat	24894	Cyp2a1	Loss	0.19 μM
NVS_ADME_rCYP2A2		Rat	24895	Cyp2a2	Loss	0.02 μM
NVS_ADME_rCYP2B1		Rat	24300	Cyp2b1	Loss	0.01 μM
NVS_ADME_rCYP2C11		Rat	29277	Cyp2c11	Loss	0.46 μM
NVS_ADME_rCYP2C12		Rat	25011	Cyp2c12	Loss	1.72 μM
NVS_ADME_rCYP2C13		Rat	171521	Cyp2c13	Loss	0.3 μM
NVS_ADME_rCYP2C6		Rat	293989	Cyp2c6	Loss	0.45 μM
NVS_ADME_rCYP2D1		Rat	266684	Cyp2d1	Loss	2.78 μM
NVS_ADME_rCYP2D2		Rat	25053	Cyp2d2	Loss	0.12 μM
NVS_ADME_rCYP3A1		Rat	25642	Cyp3a23-3a1	Loss	0.71 μM
NVS_ADME_rCYP3A2		Rat	266682	Cyp3a2	Loss	0.86 μM
NVS_ENZ_hMMP1		Human	4312	MMP1	Loss	13.98 μM
NVS_ENZ_hMMP7		Human	4316	MMP7	Loss	10.81 μM
NVS_GPCR_g5HT4	Brain	Guinea pig	100135548	Htr4	Loss	5.39 μM
NVS_GPCR_gH2	Brain	Guinea pig	100135540	Hrh2	Loss	5.75 μM
NVS_GPCR_gOpiateK	Brain	Guinea pig	100135587	Oprk1	Loss	12.22 μM
NVS_GPCR_hM1		Human	1128	CHRM1	Loss	4.27 μM
NVS_GPCR_hM2		Human	1129	CHRM2	Loss	1.7 μM
NVS_GPCR_hM3		Human	1131	CHRM3	Loss	5.02 μM
NVS_GPCR_hM4		Human	1132	CHRM4	Loss	5.11 μM
NVS_GPCR_hOpiate_D1		Human	4985	OPRD1	Loss	4.96 μM
NVS_GPCR_hOpiate_mu		Human	4988	OPRM1	Loss	11.93 μM
NVS_GPCR_rmAdra2B	Brain	Rat	24174	Adra2b	Loss	9.56 μM
NVS_GPCR_rOpiate_NonSelective	Brain	Rat	25601	Oprm1	Loss	9.03 μM
NVS_IC_hKhERGCh		Human	3757	KCNH2	Loss	12.82 μM
NVS_IC_rNaCh_site2	Brain	Rat	81574	Scn1a	Loss	3.69 μM
NVS_MP_hPBR	Intestinal	Human	706	TSPO	Loss	6.85 μM
NVS_MP_rPBR	Kidney	Rat	24230	Tspo	Loss	8.12 μM
NVS_NR_hAR		Human	367	AR	Loss	3.96 μM
NVS_NR_hCAR_Antagonist		Human	9970	NR1I3	Loss	9.8 μM
NVS_OR_gSIGMA_NonSelective	Brain	Guinea pig	100135589	Sigmar1	Loss	3.86 μM
NVS_TR_gDAT	Brain	Guinea pig	100714898	Slc6a3	Loss	12.58 μM
NVS_TR_hDAT		Human	6531	SLC6A3	Loss	9.9 μM
NVS_TR_hNET		Human	6530	SLC6A2	Loss	11.08 μM
NVS_TR_hSERT	Vascular	Human	6532	SLC6A4	Loss	1.87 μM
NVS_TR_rNET	Brain	Rat	83511	Slc6a2	Loss	12.42 μM
NVS_TR_rSERT	Brain	Rat	25553	Slc6a4	Loss	0.48 μM
NVS_TR_rVMAT2	Brain	Rat	25549	Slc18a2	Loss	11.96 μM
ATG_NRF2_ARE_CIS	Liver	Human	4780	NFE2L2	Inhibitory	5.64 μM
ATG_Oct_MLP_CIS	Liver	Human	5451	POU2F1	Inhibitory	3.55 μM
ATG_PXRE_CIS	Liver	Human	8856	NR1I2	Inhibitory	4.84 μM
ATG_SREBP_CIS	Liver	Human	6720	SREBF1	Inhibitory	6.99 μM
ATG_VDRE_CIS	Liver	Human	7421	VDR	Inhibitory	3.43 μM
ATG_RARa_TRANS	Liver	Human	5914	RARA	Gain	3.73 μM
BSK_3C_HLADR	Vascular	Human	3122	HLA-DRA	Inhibitory	13.56 μM
BSK_hDFCGF_PAI1	Skin	Human	5054	SERPINE1	Inhibitory	13.88 μM
BSK_KF3CT_IP10	Skin	Human	3627	CXCL10	Inhibitory	5.82 μM
BSK_LPS_PGE2	Vascular	Human	5732	PTGER2	Inhibitory	0.27 μM
BSK_LPS_TNFa	Vascular	Human	7124	TNF	Inhibitory	0.15 μM
ATG_hERb_XSP1	Liver	Human	2100	ESR2	Gain	7.53 μM
ATG_mPPARg_XSP1	Liver	Human	19016	Pparg	Gain	8.24 μM
ATG_mPXR_XSP1	Liver	Human	8856	NR1I2	Gain	0.95 μM
ATG_mPXR_XSP2	Liver	Human	8856	NR1I2	Gain	1.34 μM
TOX21_Aromatase_LUC_Antagonist	Breast	Human	1588	CYP19A1	Loss	0.41 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881	Breast	Human	367	AR	Loss	14.27 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	6.72 μM
TOX21_p450_CYP3A4_Antagonist		Human	1576	CYP3A4	Loss	0.14 μM
TOX21_p450_CYP2D6_Antagonist		Human	1565	CYP2D6	Loss	4.37 μM
TOX21_p450_CYP2C19_Antagonist		Human	1557	CYP2C19	Loss	0.17 μM
TOX21_p450_CYP2C9_Antagonist		Human	1559	CYP2C9	Loss	0.94 μM
TOX21_p450_CYP1A2_Antagonist		Human	1544	CYP1A2	Loss	1.93 μM
TOX21_Aromatase_LUC_Antagonist	Breast	Human	1588	CYP19A1	Loss	0.39 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	7.66 μM
TOX21_p450_CYP3A4_Antagonist		Human	1576	CYP3A4	Loss	0.15 μM
TOX21_p450_CYP2D6_Antagonist		Human	1565	CYP2D6	Loss	5.67 μM
TOX21_p450_CYP2C19_Antagonist		Human	1557	CYP2C19	Loss	0.15 μM
TOX21_p450_CYP2C9_Antagonist		Human	1559	CYP2C9	Loss	0.84 μM
TOX21_p450_CYP1A2_Antagonist		Human	1544	CYP1A2	Loss	2.02 μM

ToxCast endpoints for intended target type: Molecular messenger

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CEETOX_H295R_11DCORT	Adrenal gland	Human	2908\|4306	NR3C1\|NR3C2	Inhibitory	0.78 μM
CEETOX_H295R_OHPROG	Adrenal gland	Human	5241	PGR	Inhibitory	0.14 μM
CEETOX_H295R_ANDR	Adrenal gland	Human	367	AR	Inhibitory	0.37 μM
CEETOX_H295R_CORTISOL	Adrenal gland	Human	2908\|4306	NR3C1\|NR3C2	Inhibitory	0.12 μM
CEETOX_H295R_ESTRADIOL	Adrenal gland	Human	2099\|2100	ESR1\|ESR2	Inhibitory	0.2 μM
CEETOX_H295R_ESTRONE	Adrenal gland	Human	2099\|2100	ESR1\|ESR2	Activatory	0.28 μM
CEETOX_H295R_PROG	Adrenal gland	Human	5241	PGR	Inhibitory	0.23 μM
CEETOX_H295R_TESTO	Adrenal gland	Human	367	AR	Activatory	0.32 μM

ToxCast endpoints for intended target type: Pathway

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_Antagonist	Bone	Human	367	AR	Loss	11.1 μM

No ToxCast endpoints for intended target type: Cellular

No ToxCast endpoints for intended target type: Hormone

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.