DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Clotrimazole

ToxCast endpoints for intended target type: RNA

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
LTEA_HepaRG_ACLY	Liver	Human	47	ACLY	Activatory	8.91 μM
LTEA_HepaRG_CYP1A2	Liver	Human	1544	CYP1A2	Inhibitory	7.26 μM

ToxCast endpoints for intended target type: Protein

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CCTE_Deisenroth_DEVTOX-GLR_Endo_SOX17	Pluripotent stem cell	Human	64321	SOX17	Inhibitory	4.32 μM
CCTE_Deisenroth_DEVTOX-GLR_Endo_SOX17	Pluripotent stem cell	Human	64321	SOX17	Inhibitory	2.57 μM
NVS_ADME_hCYP1A1		Human	1543	CYP1A1	Loss	3.35 μM
NVS_ADME_hCYP2A6		Human	1548	CYP2A6	Loss	6.26 μM
NVS_ADME_hCYP2B6		Human	1555	CYP2B6	Loss	3.13 μM
NVS_ADME_hCYP2C19		Human	1557	CYP2C19	Loss	1.1 μM
NVS_ADME_hCYP2C9		Human	1559	CYP2C9	Loss	0.58 μM
NVS_ADME_hCYP2D6		Human	1565	CYP2D6	Loss	3.59 μM
NVS_ADME_hCYP3A4		Human	1576	CYP3A4	Loss	0.03 μM
NVS_GPCR_hOpiate_mu		Human	4988	OPRM1	Loss	0.17 μM
NVS_NR_hGR		Human	2908	NR3C1	Loss	0.69 μM
ATG_Ahr_CIS	Liver	Human	196	AHR	Inhibitory	3.89 μM
ATG_DR4_LXR_CIS	Liver	Human	7376\|10062	NR1H2\|NR1H3	Inhibitory	1.48 μM
ATG_EGR_CIS	Liver	Human	1958	EGR1	Activatory	8.64 μM
ATG_ERE_CIS	Liver	Human	2099	ESR1	Activatory	0.44 μM
ATG_NRF2_ARE_CIS	Liver	Human	4780	NFE2L2	Activatory	5.21 μM
ATG_PXRE_CIS	Liver	Human	8856	NR1I2	Inhibitory	0.59 μM
ATG_SREBP_CIS	Liver	Human	6720	SREBF1	Activatory	3.84 μM
ATG_VDRE_CIS	Liver	Human	7421	VDR	Activatory	4.55 μM
ATG_PXR_TRANS	Liver	Human	8856	NR1I2	Gain	0.24 μM
BSK_3C_Thrombomodulin	Vascular	Human	7056	THBD	Inhibitory	8.39 μM
BSK_BE3C_HLADR	Lung	Human	3122	HLA-DRA	Inhibitory	8.22 μM
BSK_BE3C_IL1a	Lung	Human	3552	IL1A	Inhibitory	7.88 μM
BSK_BE3C_PAI1	Lung	Human	5054	SERPINE1	Inhibitory	7.59 μM
BSK_BE3C_TGFb1	Lung	Human	7040	TGFB1	Inhibitory	6.45 μM
BSK_BE3C_tPA	Lung	Human	5327	PLAT	Inhibitory	7.0 μM
BSK_CASM3C_Thrombomodulin	Vascular	Human	7056	THBD	Inhibitory	5.34 μM
BSK_hDFCGF_CollagenIII	Skin	Human	1281	COL3A1	Inhibitory	7.42 μM
BSK_hDFCGF_MCSF	Skin	Human	1435	CSF1	Inhibitory	5.68 μM
BSK_hDFCGF_MIG	Skin	Human	4283	CXCL9	Inhibitory	8.88 μM
BSK_hDFCGF_MMP1	Skin	Human	4312	MMP1	Inhibitory	7.77 μM
BSK_hDFCGF_PAI1	Skin	Human	5054	SERPINE1	Inhibitory	7.76 μM
BSK_hDFCGF_VCAM1	Skin	Human	7412	VCAM1	Inhibitory	8.14 μM
BSK_KF3CT_IP10	Skin	Human	3627	CXCL10	Inhibitory	8.61 μM
BSK_KF3CT_MCP1	Skin	Human	6347	CCL2	Inhibitory	7.25 μM
BSK_KF3CT_MMP9	Skin	Human	4318	MMP9	Inhibitory	5.43 μM
BSK_KF3CT_TGFb1	Skin	Human	7040	TGFB1	Inhibitory	6.57 μM
BSK_LPS_PGE2	Vascular	Human	5732	PTGER2	Inhibitory	7.16 μM
TOX21_Aromatase_LUC_Antagonist	Breast	Human	1588	CYP19A1	Loss	5.3 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	5.71 μM
TOX21_TR_LUC_GH3_Antagonist	Pituitary gland	Rat	7067\|7068	THRA\|THRB	Loss	3.44 μM
TOX21_RORg_LUC_CHO_Antagonist	Ovary	Chinese hamster	6097	RORC	Loss	6.45 μM
TOX21_CAR_LUC_Antagonist	Liver	Human	9970	NR1I3	Loss	2.13 μM
TOX21_p450_CYP3A4_Antagonist		Human	1576	CYP3A4	Loss	0.03 μM
TOX21_p450_CYP2D6_Antagonist		Human	1565	CYP2D6	Loss	0.0 μM
TOX21_p450_CYP2C19_Antagonist		Human	1557	CYP2C19	Loss	6.62 μM
TOX21_p450_CYP2C9_Antagonist		Human	1559	CYP2C9	Loss	1.22 μM
TOX21_p450_CYP1A2_Antagonist		Human	1544	CYP1A2	Loss	7.79 μM
TOX21_Aromatase_LUC_Antagonist	Breast	Human	1588	CYP19A1	Loss	7.37 μM
TOX21_TR_LUC_GH3_Antagonist	Pituitary gland	Rat	7067\|7068	THRA\|THRB	Loss	3.4 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	2.71 μM
TOX21_p450_CYP3A4_Antagonist		Human	1576	CYP3A4	Loss	0.01 μM
TOX21_p450_CYP2C19_Antagonist		Human	1557	CYP2C19	Loss	3.84 μM
TOX21_p450_CYP2C9_Antagonist		Human	1559	CYP2C9	Loss	1.1 μM
TOX21_p450_CYP1A2_Antagonist		Human	1544	CYP1A2	Loss	8.86 μM

ToxCast endpoints for intended target type: Molecular messenger

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CEETOX_H295R_11DCORT	Adrenal gland	Human	2908\|4306	NR3C1\|NR3C2	Activatory	0.11 μM
CEETOX_H295R_OHPREG	Adrenal gland	Human	5241	PGR	Inhibitory	0.01 μM
CEETOX_H295R_OHPROG	Adrenal gland	Human	5241	PGR	Inhibitory	0.07 μM
CEETOX_H295R_ANDR	Adrenal gland	Human	367	AR	Inhibitory	0.15 μM
CEETOX_H295R_CORTIC	Adrenal gland	Human	2908\|4306	NR3C1\|NR3C2	Inhibitory	0.0 μM
CEETOX_H295R_CORTISOL	Adrenal gland	Human	2908\|4306	NR3C1\|NR3C2	Inhibitory	0.04 μM
CEETOX_H295R_DOC	Adrenal gland	Human	2908\|4306	NR3C1\|NR3C2	Inhibitory	0.04 μM
CEETOX_H295R_ESTRADIOL	Adrenal gland	Human	2099\|2100	ESR1\|ESR2	Inhibitory	0.24 μM
CEETOX_H295R_ESTRONE	Adrenal gland	Human	2099\|2100	ESR1\|ESR2	Activatory	0.41 μM
CEETOX_H295R_PROG	Adrenal gland	Human	5241	PGR	Activatory	0.01 μM
CEETOX_H295R_TESTO	Adrenal gland	Human	367	AR	Inhibitory	0.12 μM

ToxCast endpoints for intended target type: Pathway

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
TOX21_ARE_BLA_Agonist_ratio	Liver	Human	4780	NFE2L2	Gain	5.72 μM
TOX21_HSE_BLA_Agonist_ratio	Cervix	Human	3297	HSF1	Gain	6.59 μM
TOX21_H2AX_HTRF_CHO_Agonist_ratio	Ovary	Chinese hamster	3014	H2AX	Gain	139.62 μM

No ToxCast endpoints for intended target type: Cellular

No ToxCast endpoints for intended target type: Hormone

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.