DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Phenylmercuric acetate

ToxCast endpoints for intended target type: RNA

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
LTEA_HepaRG_ABCB1	Liver	Human	5243	ABCB1	Activatory	24.1 μM
LTEA_HepaRG_ABCC2	Liver	Human	1244	ABCC2	Inhibitory	27.21 μM
LTEA_HepaRG_ABCC3	Liver	Human	8714	ABCC3	Activatory	13.02 μM
LTEA_HepaRG_ACLY	Liver	Human	47	ACLY	Inhibitory	23.27 μM
LTEA_HepaRG_ACOX1	Liver	Human	51	ACOX1	Activatory	15.2 μM
LTEA_HepaRG_ADK	Liver	Human	132	ADK	Activatory	31.53 μM
LTEA_HepaRG_AFP	Liver	Human	174	AFP	Activatory	5.0 μM
LTEA_HepaRG_APOA5	Liver	Human	116519	APOA5	Activatory	4.21 μM
LTEA_HepaRG_BAD	Liver	Human	572	BAD	Activatory	15.83 μM
LTEA_HepaRG_BCL2L11	Liver	Human	10018	BCL2L11	Activatory	13.29 μM
LTEA_HepaRG_CASP3	Liver	Human	836	CASP3	Activatory	23.14 μM
LTEA_HepaRG_CASP8	Liver	Human	841	CASP8	Activatory	26.6 μM
LTEA_HepaRG_CAT	Liver	Human	847	CAT	Activatory	18.9 μM
LTEA_HepaRG_CDKN1A	Liver	Human	1026	CDKN1A	Inhibitory	0.17 μM
LTEA_HepaRG_CFLAR	Liver	Human	8837	CFLAR	Activatory	16.75 μM
LTEA_HepaRG_CYP1A2	Liver	Human	1544	CYP1A2	Activatory	5.0 μM
LTEA_HepaRG_CYP2B6	Liver	Human	1555	CYP2B6	Activatory	6.12 μM
LTEA_HepaRG_CYP2C19	Liver	Human	1557	CYP2C19	Activatory	5.0 μM
LTEA_HepaRG_CYP2C8	Liver	Human	1558	CYP2C8	Activatory	5.0 μM
LTEA_HepaRG_CYP2E1	Liver	Human	1571	CYP2E1	Activatory	18.34 μM
LTEA_HepaRG_CYP3A5	Liver	Human	1577	CYP3A5	Activatory	10.92 μM
LTEA_HepaRG_CYP3A7	Liver	Human	1551	CYP3A7	Inhibitory	5.0 μM
LTEA_HepaRG_CYP4A22	Liver	Human	284541	CYP4A22	Activatory	5.0 μM
LTEA_HepaRG_CYP7A1	Liver	Human	1581	CYP7A1	Inhibitory	5.0 μM
LTEA_HepaRG_EGR1	Liver	Human	1958	EGR1	Inhibitory	26.93 μM
LTEA_HepaRG_FABP1	Liver	Human	2168	FABP1	Activatory	17.09 μM
LTEA_HepaRG_FAS	Liver	Human	355	FAS	Inhibitory	22.85 μM
LTEA_HepaRG_FMO3	Liver	Human	2328	FMO3	Activatory	16.87 μM
LTEA_HepaRG_FOXO1	Liver	Human	2308	FOXO1	Activatory	16.82 μM
LTEA_HepaRG_FOXO3	Liver	Human	2309	FOXO3	Inhibitory	14.47 μM
LTEA_HepaRG_GADD45A	Liver	Human	1647	GADD45A	Activatory	16.25 μM
LTEA_HepaRG_GADD45G	Liver	Human	10912	GADD45G	Activatory	82.81 μM
LTEA_HepaRG_GCLC	Liver	Human	2729	GCLC	Activatory	23.07 μM
LTEA_HepaRG_GCLM	Liver	Human	2730	GCLM	Activatory	23.03 μM
LTEA_HepaRG_GSTA2	Liver	Human	2939	GSTA2	Activatory	23.08 μM
LTEA_HepaRG_HMGCS2	Liver	Human	3158	HMGCS2	Activatory	23.34 μM
LTEA_HepaRG_HSPA1A	Liver	Human	3303	HSPA1A	Activatory	50.0 μM
LTEA_HepaRG_IGF1	Liver	Human	3479	IGF1	Inhibitory	23.12 μM
LTEA_HepaRG_IGFBP1	Liver	Human	3484	IGFBP1	Activatory	4.6 μM
LTEA_HepaRG_IL6	Liver	Human	3569	IL6	Inhibitory	16.02 μM
LTEA_HepaRG_IL6R	Liver	Human	3570	IL6R	Inhibitory	19.26 μM
LTEA_HepaRG_JUN	Liver	Human	3725	JUN	Activatory	16.02 μM
LTEA_HepaRG_KRT19	Liver	Human	3880	KRT19	Activatory	4.54 μM
LTEA_HepaRG_LPL	Liver	Human	4023	LPL	Activatory	29.34 μM
LTEA_HepaRG_MMP10	Liver	Human	4319	MMP10	Activatory	15.78 μM
LTEA_HepaRG_MMP3	Liver	Human	4314	MMP3	Activatory	50.0 μM
LTEA_HepaRG_MYC	Liver	Human	4609	MYC	Inhibitory	24.23 μM
LTEA_HepaRG_NFE2L2	Liver	Human	4780	NFE2L2	Inhibitory	23.42 μM
LTEA_HepaRG_NFKB1	Liver	Human	4790	NFKB1	Inhibitory	23.2 μM
LTEA_HepaRG_NQO1	Liver	Human	1728	NQO1	Inhibitory	14.49 μM
LTEA_HepaRG_PDK4	Liver	Human	5166	PDK4	Inhibitory	17.86 μM
LTEA_HepaRG_PEG10	Liver	Human	23089	PEG10	Inhibitory	50.0 μM
LTEA_HepaRG_PPP2R4	Liver	Human	5524	PTPA	Inhibitory	27.95 μM
LTEA_HepaRG_PTEN	Liver	Human	5728	PTEN	Activatory	69.5 μM
LTEA_HepaRG_SDHB	Liver	Human	6390	SDHB	Inhibitory	26.16 μM
LTEA_HepaRG_STAT3	Liver	Human	6774	STAT3	Activatory	16.99 μM
LTEA_HepaRG_SULT2A1	Liver	Human	6822	SULT2A1	Activatory	17.6 μM
LTEA_HepaRG_TGFA	Liver	Human	7039	TGFA	Activatory	23.01 μM
LTEA_HepaRG_TGFB1	Liver	Human	7040	TGFB1	Inhibitory	22.99 μM
LTEA_HepaRG_TIMP1	Liver	Human	7076	TIMP1	Inhibitory	83.74 μM
LTEA_HepaRG_TNFRSF1A	Liver	Human	7132	TNFRSF1A	Activatory	27.62 μM
LTEA_HepaRG_TP53	Liver	Human	7157	TP53	Activatory	0.19 μM
LTEA_HepaRG_UGT1A1	Liver	Human	54658	UGT1A1	Inhibitory	32.53 μM
LTEA_HepaRG_UGT1A6	Liver	Human	54578	UGT1A6	Activatory	18.35 μM
LTEA_HepaRG_XBP1	Liver	Human	7494	XBP1	Activatory	12.63 μM

ToxCast endpoints for intended target type: Protein

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CCTE_Deisenroth_5AR_NBTE_ratio	Kidney	Human	6716	SRD5A2	Inhibitory	49.95 μM
NVS_ADME_hCYP1A1		Human	1543	CYP1A1	Loss	16.03 μM
NVS_ADME_hCYP2B6		Human	1555	CYP2B6	Loss	6.73 μM
NVS_ADME_hCYP2C9		Human	1559	CYP2C9	Loss	9.85 μM
NVS_ENZ_hAChE		Human	43	ACHE	Loss	39.99 μM
NVS_ENZ_hAMPKa1		Human	5562	PRKAA1	Loss	12.0 μM
NVS_ENZ_hCASP3		Human	836	CASP3	Loss	25.0 μM
NVS_ENZ_hCASP8		Human	841	CASP8	Loss	7.84 μM
NVS_ENZ_hEGFR		Human	1956	EGFR	Loss	9.68 μM
NVS_ENZ_hFGFR1		Human	2260	FGFR1	Loss	33.39 μM
NVS_ENZ_hHDAC3		Human	8841	HDAC3	Loss	11.07 μM
NVS_ENZ_hMMP1		Human	4312	MMP1	Loss	5.17 μM
NVS_ENZ_hPTPN1		Human	5770	PTPN1	Loss	11.04 μM
NVS_ENZ_hPTPN12		Human	5782	PTPN12	Loss	15.88 μM
NVS_ENZ_hPTPN13		Human	5783	PTPN13	Loss	5.38 μM
NVS_ENZ_hPTPN9		Human	5780	PTPN9	Loss	17.02 μM
NVS_ENZ_hSIRT1		Human	23411	SIRT1	Loss	6.13 μM
NVS_ENZ_rACFSKBinding	Brain	Rat	64532	Adcy5	Loss	26.77 μM
NVS_ENZ_rMAOBC	Brain	Rat	25750	Maob	Loss	25.0 μM
NVS_GPCR_g5HT4	Brain	Guinea pig	100135548	Htr4	Loss	14.19 μM
NVS_GPCR_gH2	Brain	Guinea pig	100135540	Hrh2	Loss	10.65 μM
NVS_GPCR_gMPeripheral_NonSelective	Bladder	Guinea pig	100379235	Chrm3	Loss	6.0 μM
NVS_GPCR_gOpiateK	Brain	Guinea pig	100135587	Oprk1	Loss	31.41 μM
NVS_GPCR_h5HT2A	Brain	Human	3356	HTR2A	Loss	19.11 μM
NVS_GPCR_hAdoRA1	Brain	Human	134	ADORA1	Loss	25.0 μM
NVS_GPCR_hAdoRA2a		Human	135	ADORA2A	Loss	6.42 μM
NVS_GPCR_hAdra2A		Human	150	ADRA2A	Loss	20.05 μM
NVS_GPCR_hAdra2C		Human	152	ADRA2C	Loss	0.25 μM
NVS_GPCR_hAdrb3		Human	155	ADRB3	Loss	6.02 μM
NVS_GPCR_hAT1	Brain	Human	185	AGTR1	Loss	15.01 μM
NVS_GPCR_hDRD1		Human	1812	DRD1	Loss	0.1 μM
NVS_GPCR_hLTB4_BLT1		Human	1241	LTB4R	Loss	15.67 μM
NVS_GPCR_hNPY2		Human	4887	NPY2R	Loss	8.41 μM
NVS_GPCR_hOpiate_mu		Human	4988	OPRM1	Loss	0.09 μM
NVS_GPCR_hPY2		Human	5028	P2RY1	Loss	6.37 μM
NVS_GPCR_hTXA2		Human	6915	TBXA2R	Loss	5.6 μM
NVS_GPCR_mCKKBCentral	Brain	Mouse	12426	Cckbr	Loss	25.0 μM
NVS_GPCR_r5HT_NonSelective	Brain	Rat	24473	Htr1a	Loss	19.81 μM
NVS_GPCR_r5HT1_NonSelective	Brain	Rat	24473	Htr1a	Loss	16.37 μM
NVS_GPCR_rAdra1_NonSelective	Brain	Rat	29412	Adra1a	Loss	18.81 μM
NVS_GPCR_rAdra1A	Brain	Rat	29412	Adra1a	Loss	25.0 μM
NVS_GPCR_rGABBR	Brain	Rat	81657	Gabbr1	Loss	38.51 μM
NVS_GPCR_rH3	Brain	Rat	85268	Hrh3	Loss	40.18 μM
NVS_GPCR_rmAdra2B	Brain	Rat	24174	Adra2b	Loss	12.35 μM
NVS_GPCR_rmMGluR1	Brain	Rat	24414	Grm1	Loss	10.55 μM
NVS_GPCR_rNK3	Brain	Rat	24808	Tacr3	Loss	14.73 μM
NVS_GPCR_rOpiate_NonSelective	Brain	Rat	25601	Oprm1	Loss	31.9 μM
NVS_GPCR_rOpiate_NonSelectiveNa	Brain	Rat	25601	Oprm1	Loss	30.04 μM
NVS_GPCR_rOXT	Uterus	Rat	25342	Oxtr	Loss	25.0 μM
NVS_GPCR_rSST	Brain	Rat	25033	Sstr1	Loss	5.92 μM
NVS_IC_rCaDHPRCh_L	Brain	Rat	25398	Cacna1a	Loss	40.53 μM
NVS_LGIC_rAMPA	Brain	Rat	50592	Gria1	Loss	10.79 μM
NVS_NR_hAR		Human	367	AR	Loss	16.94 μM
NVS_NR_hPXR		Human	8856	NR1I2	Loss	5.36 μM
NVS_TR_hAdoT		Human	2030	SLC29A1	Loss	11.72 μM
NVS_TR_hDAT		Human	6531	SLC6A3	Loss	11.84 μM
NVS_TR_hNET		Human	6530	SLC6A2	Loss	0.21 μM
ATG_EGR_CIS	Liver	Human	1958	EGR1	Activatory	4.73 μM
ATG_MRE_CIS	Liver	Human	4520	MTF1	Inhibitory	5.86 μM
ATG_RXRb_TRANS	Liver	Human	6257	RXRB	Gain	14.82 μM
BSK_3C_HLADR	Vascular	Human	3122	HLA-DRA	Inhibitory	0.32 μM
BSK_3C_IL8	Vascular	Human	3576	CXCL8	Inhibitory	6.0 μM
BSK_4H_Pselectin	Vascular	Human	6403	SELP	Inhibitory	0.24 μM
BSK_BE3C_HLADR	Lung	Human	3122	HLA-DRA	Inhibitory	0.36 μM
BSK_BE3C_TGFb1	Lung	Human	7040	TGFB1	Inhibitory	0.15 μM
BSK_BE3C_tPA	Lung	Human	5327	PLAT	Inhibitory	0.15 μM
BSK_CASM3C_HLADR	Vascular	Human	3122	HLA-DRA	Inhibitory	0.13 μM
BSK_CASM3C_LDLR	Vascular	Human	3949	LDLR	Inhibitory	0.15 μM
BSK_CASM3C_SAA	Vascular	Human	6288	SAA1	Inhibitory	0.11 μM
BSK_hDFCGF_CollagenIII	Skin	Human	1281	COL3A1	Inhibitory	0.28 μM
BSK_hDFCGF_IL8	Skin	Human	3576	CXCL8	Inhibitory	0.14 μM
BSK_hDFCGF_IP10	Skin	Human	3627	CXCL10	Inhibitory	0.29 μM
BSK_hDFCGF_MIG	Skin	Human	4283	CXCL9	Inhibitory	0.21 μM
BSK_hDFCGF_MMP1	Skin	Human	4312	MMP1	Inhibitory	0.15 μM
BSK_hDFCGF_PAI1	Skin	Human	5054	SERPINE1	Inhibitory	0.18 μM
BSK_hDFCGF_TIMP1	Skin	Human	7076	TIMP1	Inhibitory	0.15 μM
BSK_KF3CT_IP10	Skin	Human	3627	CXCL10	Inhibitory	0.15 μM
BSK_KF3CT_MMP9	Skin	Human	4318	MMP9	Inhibitory	0.19 μM
BSK_KF3CT_TGFb1	Skin	Human	7040	TGFB1	Inhibitory	0.14 μM
BSK_KF3CT_TIMP2	Skin	Human	7077	TIMP2	Inhibitory	0.15 μM
BSK_LPS_IL8	Vascular	Human	3576	CXCL8	Inhibitory	8.21 μM
BSK_LPS_PGE2	Vascular	Human	5732	PTGER2	Inhibitory	0.15 μM
BSK_SAg_Eselectin	Vascular	Human	6401	SELE	Inhibitory	0.31 μM
BSK_SAg_IL8	Vascular	Human	3576	CXCL8	Inhibitory	11.87 μM
CPHEA_Stoker_NIS_Inhibition_RAIU	Kidney	Human	6528	SLC5A5	Loss	50.0 μM
TOX21_AR_BLA_Agonist_ratio	Kidney	Human	367	AR	Gain	6.37 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	0.04 μM
TOX21_AP1_BLA_Agonist_ratio	Cervix	Human	2353\|3725	FOS\|JUN	Gain	5.41 μM
TOX21_TSHR_HTRF_Agonist_ratio	Kidney	Human	7253	TSHR	Gain	6.99 μM
TOX21_TSHR_HTRF_Antagonist_ratio	Kidney	Human	7253	TSHR	Loss	36.16 μM
TOX21_CAR_LUC_Antagonist	Liver	Human	9970	NR1I3	Loss	6.5 μM
TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2	Breast	Human	2099	ESR1	Loss	9.84 μM
TOX21_ERR_LUC_Antagonist	Kidney	Human	2101	ESRRA	Loss	4.0 μM
TOX21_PGC_ERR_LUC_Antagonist	Kidney	Human	2101	ESRRA	Loss	9.36 μM
TOX21_ERb_BLA_Antagonist_ratio	Kidney	Human	2100	ESR2	Loss	4.2 μM
TOX21_p450_CYP3A4_Antagonist		Human	1576	CYP3A4	Loss	10.96 μM
TOX21_p450_CYP2C19_Antagonist		Human	1557	CYP2C19	Loss	10.34 μM
TOX21_p450_CYP2C9_Antagonist		Human	1559	CYP2C9	Loss	4.75 μM
TOX21_p450_CYP1A2_Antagonist		Human	1544	CYP1A2	Loss	25.55 μM
TOX21_hERG_U2OS_Antagonist	Bone	Human	3757	KCNH2	Loss	14.14 μM
TOX21_GNRHR_HEK293_Agonist	Kidney	Human	2798	GNRHR	Gain	21.11 μM
TOX21_AR_BLA_Agonist_ratio	Kidney	Human	367	AR	Gain	38.04 μM
TOX21_ERa_BLA_Agonist_ratio	Kidney	Human	2099	ESR1	Gain	8.14 μM
TOX21_ERa_LUC_VM7_Antagonist_0.5nM_E2	Breast	Human	2099	ESR1	Loss	5.58 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	0.01 μM
TOX21_TR_LUC_GH3_Antagonist	Pituitary gland	Rat	7067\|7068	THRA\|THRB	Loss	0.22 μM
TOX21_TSHR_HTRF_Antagonist_ratio	Kidney	Human	7253	TSHR	Loss	67.58 μM
TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2	Breast	Human	2099	ESR1	Loss	4.4 μM
TOX21_TRHR_HEK293_Agonist	Kidney	Human	7201	TRHR	Gain	22.53 μM
TOX21_TRHR_HEK293_Antagonist	Kidney	Human	7201	TRHR	Loss	17.79 μM
TOX21_p450_CYP3A4_Antagonist		Human	1576	CYP3A4	Loss	6.56 μM
TOX21_p450_CYP2D6_Antagonist		Human	1565	CYP2D6	Loss	0.35 μM
TOX21_p450_CYP2C19_Antagonist		Human	1557	CYP2C19	Loss	10.06 μM
TOX21_p450_CYP1A2_Antagonist		Human	1544	CYP1A2	Loss	17.09 μM
TOX21_hERG_U2OS_Antagonist	Bone	Human	3757	KCNH2	Loss	13.6 μM
TOX21_GNRHR_HEK293_Agonist	Kidney	Human	2798	GNRHR	Gain	42.8 μM
TOX21_KISS1R_HEK293_Agonist	Kidney	Human	84634	KISS1R	Gain	54.5 μM
TOX21_AR_BLA_Agonist_ratio	Kidney	Human	367	AR	Gain	8.49 μM
TOX21_GR_BLA_Agonist_ratio	Cervix	Human	2908	NR3C1	Gain	6.73 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	0.02 μM
TOX21_TR_LUC_GH3_Antagonist	Pituitary gland	Rat	7067\|7068	THRA\|THRB	Loss	0.21 μM
TOX21_AP1_BLA_Agonist_ratio	Cervix	Human	2353\|3725	FOS\|JUN	Gain	7.6 μM
TOX21_TSHR_HTRF_Antagonist_ratio	Kidney	Human	7253	TSHR	Loss	73.6 μM
TOX21_CAR_LUC_Antagonist	Liver	Human	9970	NR1I3	Loss	4.81 μM
TOX21_ERa_LUC_VM7_Antagonist_0.1nM_E2	Breast	Human	2099	ESR1	Loss	8.06 μM
TOX21_PGC_ERR_LUC_Antagonist	Kidney	Human	2101	ESRRA	Loss	4.26 μM
TOX21_TRHR_HEK293_Agonist	Kidney	Human	7201	TRHR	Gain	19.38 μM
TOX21_TRHR_HEK293_Antagonist	Kidney	Human	7201	TRHR	Loss	16.82 μM
TOX21_p450_CYP3A4_Antagonist		Human	1576	CYP3A4	Loss	8.86 μM
TOX21_p450_CYP2C19_Antagonist		Human	1557	CYP2C19	Loss	9.32 μM
TOX21_p450_CYP1A2_Antagonist		Human	1544	CYP1A2	Loss	21.83 μM
TOX21_hERG_U2OS_Antagonist	Bone	Human	3757	KCNH2	Loss	13.01 μM
TOX21_GNRHR_HEK293_Agonist	Kidney	Human	2798	GNRHR	Gain	40.01 μM
TOX21_KISS1R_HEK293_WT	Kidney	Human	84634	KISS1R	Gain	49.94 μM

No ToxCast endpoints for intended target type: Molecular messenger

ToxCast endpoints for intended target type: Pathway

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_Antagonist	Bone	Human	367	AR	Loss	0.29 μM
APR_HepG2_StressKinase_24hr	Liver	Human	3725	JUN	Activatory	82.4 μM
APR_HepG2_p53Act_72hr	Liver	Human	7157	TP53	Inhibitory	4.57 μM
APR_HepG2_StressKinase_72hr	Liver	Human	3725	JUN	Inhibitory	7.33 μM
OT_ERa_GFPERaERE_0120	Cervix	Human	2099	ESR1	Gain	14.95 μM
OT_ERa_GFPERaERE_0480	Cervix	Human	2099	ESR1	Gain	4.11 μM
OT_FXR_FXRSRC1_1440	Kidney	Human	6714\|9971	SRC\|NR1H4	Gain	0.2 μM
OT_NURR1_NURR1RXRa_1440	Kidney	Human	4929\|6256	NR4A2\|RXRA	Gain	0.27 μM
TOX21_p53_BLA_p2_ratio	Intestinal	Human	7157	TP53	Gain	8.1 μM
TOX21_p53_BLA_p4_ratio	Intestinal	Human	7157	TP53	Gain	7.67 μM
TOX21_p53_BLA_p5_ratio	Intestinal	Human	7157	TP53	Gain	4.64 μM
TOX21_HSE_BLA_Agonist_ratio	Cervix	Human	3297	HSF1	Gain	4.56 μM
TOX21_FXR_BLA_Agonist_ratio	Kidney	Human	9971	NR1H4	Gain	7.86 μM
TOX21_PPARd_BLA_Agonist_ratio	Kidney	Human	5467	PPARD	Gain	6.06 μM
TOX21_TSHR_wt_HTRF_Agonist_ratio	Kidney	Human	7253	TSHR	Gain	7.6 μM
TOX21_HDAC_LUC_Antagonist	Colon	Human	3065	HDAC1	Loss	13.44 μM
TOX21_SHH_3T3_GLI3_LUC_Antagonist	Embryo	Mouse	6469	SHH	Loss	0.14 μM
TOX21_p53_BLA_p7_ratio	Intestinal	Human	7157	TP53	Gain	6.43 μM
TOX21_p53_BLA_p2_ratio	Intestinal	Human	7157	TP53	Gain	12.5 μM
TOX21_HDAC_LUC_Antagonist	Colon	Human	3065	HDAC1	Loss	8.72 μM
TOX21_SHH_3T3_GLI3_LUC_Antagonist	Embryo	Mouse	6469	SHH	Loss	0.05 μM
TOX21_p53_BLA_p7_ratio	Intestinal	Human	7157	TP53	Gain	5.08 μM
TOX21_FXR_BLA_Antagonist_ratio	Kidney	Human	9971	NR1H4	Loss	0.3 μM
TOX21_p53_BLA_p4_ratio	Intestinal	Human	7157	TP53	Gain	6.25 μM
TOX21_TSHR_wt_HTRF_Agonist_ratio	Kidney	Human	7253	TSHR	Gain	14.37 μM
TOX21_HDAC_LUC_Antagonist	Colon	Human	3065	HDAC1	Loss	12.89 μM
TOX21_SHH_3T3_GLI3_LUC_Antagonist	Embryo	Mouse	6469	SHH	Loss	0.09 μM
TOX21_p53_BLA_p7_ratio	Intestinal	Human	7157	TP53	Gain	7.17 μM
TOX21_p53_BLA_ms_human_ratio	Intestinal	Human	7157	TP53	Gain	9.82 μM

ToxCast endpoints for intended target type: Cellular

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
APR_HepG2_MicrotubuleCSK_24hr	Liver	Human	7846	TUBA1A	Inhibitory	5.17 μM

No ToxCast endpoints for intended target type: Hormone

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.