IMPPAT Phytochemical information: 
Nicotine

Nicotine
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
Neuronal acetylcholine receptor subunit alpha-7Homo sapiensP36544740 nM|38000 nM|83000 nM|113000 nM|91000 nM|1584.89 nM|4710 nM7600 nM|21000 nM1.06 nM2000 nM|1610 nM|620 nM|7200 nM|6300 nM|630 nM|12000 nM|24000 nM|2110 nM|3000 nM|1000 nM|1023.29 nM|3800 nM|6290 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-7Mus musculusP49582480 nM|244 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicusQ0594154000 nM|13000 nM|109648 nM|108700 nM|43000000 nM|1500 nM|1071.52 nM|23000 nM|47000 nM16 nM130 nM|>10000 nM|668 nM|170 nM|517 nM|4000 nM|610 nM|770 nM|15000 nM|450 nM|234 nM|250 nM|480 nM|460 nM|469 nM|1400 nM|340 nM|1748 nM|6290 nM|750 nM|16000 nM|176 nM|230 nM|400 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-9Rattus norvegicusP431442.4 nM5 nM1000 nMBindingDB
Neuronal acetylcholine receptor; alpha2/beta4Rattus norvegicusP12392= 112.0 nM|= 110.0 nM|= 70.0 nMNPASS
Neuronal acetylcholine receptor; alpha2/beta2Homo sapiensQ15822= 5.5 nMNPASS
Neuronal acetylcholine receptor; alpha2/beta2Rattus norvegicusP12390= 15.0 nM|= 12.0 nM|= 5.5 nMNPASS
Neuronal acetylcholine receptor; alpha2/beta4Homo sapiensQ15822= 103.0 nM|= 70.0 nMNPASS
Neuronal acetylcholine receptor; alpha3/alpha6/beta2/beta3Homo sapiensQ05901= 127.0 nM= 84.8 nMNPASS
Neuronal acetylcholine receptor subunit alpha-6/beta-3Rattus norvegicus= 3.3 nMNPASS
Neuronal acetylcholine receptor subunit beta-4Rattus norvegicusP1239273 nM|= 73.0 nMBindingDB, NPASS
Neuronal acetylcholine receptor subunit alpha-6Gallus gallusP4958120 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4Mus musculusO701747.0 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4/beta-4Rattus norvegicusP09483|P1239240 nM|46 nM|72 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4/beta-4Homo sapiensP30926|P436817100 nM129 nM|23 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4/beta-2Rattus norvegicusP09483|P123904000 nM|590 nM|1000 nM|7.3 nM|10000 nM|14000 nM|591 nM|77 nM|19000 nM3.8 nM1.4 nM|1 nM|1.3 nM|12 nM|10 nM|0.84 nM|1.5 nM|1.1 nM|10.00 nM|9.8 nM|6.8 nM|3 nM|2.3 nM|2 nM|4.0 nM|11.1 nM|1.26 nM|1.01 nM|8.0 nM|0.940000 nM|10.0 nM|35 nM|2.0 nM|1.8 nM|2.8 nM|13 nM|14 nM|4.1 nM|11 nM|5.6 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4/beta-2Mus musculus= 720.0 nM|= 724.44 nMNPASS
Neuronal acetylcholine receptor subunit alpha-4/beta-2Mus musculusO70174|Q9ERK7724 nM|720 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4/beta-2HumanP17787|P436812400 nM370 nM10 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4/beta-2Homo sapiensP17787|P436812100 nM|4000 nM|5000 nM|290 nM|1 nM|3000 nM|295.12 nM|295 nM|9400 nM|6600 nM|300 nM|2400 nM|800 nM430 nM|427 nM|426.58 nM|370 nM|1.2 nM|4.9 nM8.60 nM|2.3 nM|1.2 nM|2.1 nM|2 nM|9.1 nM|4.9 nM|4 nM|1.5 nM|5.5 nM|1.6 nM|>10000 nM|9.46 nM|12.59 nM|0.600000 nM|2.0 nM|10.0 nM|0.045000 nM|1.1 nM|2.2 nM|1.000000 nM|<1.000000 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicusP094831.65 nM>10000 nM|1 nM|0.84 nM|8.3 nM|74 nM|10 nM|40 nM|1.5 nM|7 nM|4 nM|6.0 nM|0.94 nM|22 nM|150 nMBindingDB
Neuronal acetylcholine receptor; alpha3/beta2Homo sapiensP32297= 132000.0 nM= 3.8 nM= 47.0 nM|= 29.0 nMNPASS
Neuronal acetylcholine receptor subunit alpha-4Homo sapiensP436814700 nM|6600 nM1.05 nM|26.25 nM|1 nM|6690 nM|4.9 nM|7.7 nM|4.6 nM|2 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-4Gallus gallusP094821.9 nM|= 1.9 nMBindingDB, NPASS
Neuronal acetylcholine receptor subunit alpha-3/beta-4Rattus norvegicusP04757|P1239286000 nM|24000 nM|35000 nM|1514 nM|1500 nM>10000 nM443 nM|530 nM|481 nM|440 nM|290 nM|288 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-3/beta-4RatP04757|P1239223000 nM>10000 nM440 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-5Rattus norvegicusP20420156 nMBindingDB
Neuronal acetylcholine receptor; alpha3/beta2Rattus norvegicusP12390= 43.0 nM|= 1.0 nM|= 47.0 nM|= 29.0 nMNPASS
Nicotinic acetylcholine receptor alpha 5 subunitMusca domestica11900 nMBindingDB
Neuronal acetylcholine receptor; alpha3/beta4Rattus norvegicusP12392= 86000.0 nM|= 35000.0 nM|= 23000.0 nM|= 24000.0 nM|= 1500.0 nM|= 1513.56 nM> 10000.0 nM= 530.0 nM|= 443.0 nM|= 440.0 nM|= 220.0 nM|= 199.53 nM|= 600.0 nM|= 630.96 nM|= 260.0 nM|= 481.0 nM|= 251.19 nM|= 250.0 nM|= 230.0 nM|= 290.0 nM|= 288.4 nMNPASS
Neuronal acetylcholine receptor subunit alpha-3/beta-4Mus musculus= 167.0 nMNPASS
Transient receptor potential cation channel subfamily A member 1Homo sapiensO7576217000 nM|457088190 nM|457000000 nM|= 17000.0 nM|= 457088189.61 nM|= 2000.0 nMBindingDB, NPASS
StriatumRattus norvegicus= 199.53 nM|= 200.0 nMNPASS
Solute carrier family 22 member 2Rattus norvegicusQ9R0W250500 nM|= 50500.0 nMBindingDB, NPASS
Solute carrier family 22 member 1Rattus norvegicusQ6308964300 nM|= 64300.0 nMBindingDB, NPASS
Soluble acetylcholine receptorAplysia californicaQ8WSF8= 2511.89 nM|= 598.0 nM|= 30.0 nMNPASS
Soluble acetylcholine receptorAplysia californica280 nM|598 nM|2511.89 nM|30 nMBindingDB
Sigma opioid receptorHomo sapiensQ99720> 10000.0 nMNPASS
Transient receptor potential cation channel subfamily A member 1Mus musculusQ8BLA810000 nM|= 10000.0 nMBindingDB, NPASS
Sigma non-opioid intracellular receptor 1Homo sapiensQ99720>10000 nMBindingDB
Serotonin 3 (5-HT3) receptorHomo sapiensQ8WXA8= 71000.0 nMNPASS
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2> 20000.0 nM|> 19952.62 nMNPASS
Neuronal acetylcholine receptor; alpha3/beta4Homo sapiensP32297= 21000.0 nM|= 4300.0 nM|= 51000.0 nM|= 19830.0 nM|= 8000.0 nM|= 7943.28 nM|= 9400.0 nM|= 290.0 nM|= 7000.0 nM|> 1000.0 nM= 430.0 nM|> 1000.0 nM= 320.0 nM|= 530.0 nM|= 394.0 nM|= 400.0 nM|= 260.0 nM|= 261.0 nM|= 1744.44 nMNPASS
Resistance to inhibitors of cholinesterase protein 3Pig roundwormF1L1D96210 nMBindingDB
Potassium voltage-gated channel subfamily H member 2Homo sapiensQ12809245471 nM|244300 nM|245470.89 nMBindingDB
Nicotinic acetylcholine receptor alpha3/betaXHomo sapiensQ05901= 21000.0 nMNPASS
Nicotinic acetylcholine receptor alpha2/beta4Homo sapiensP30926= 10000.0 nMNPASS
Nicotinic acetylcholine receptor alpha-4/beta-2Mus musculusQ8R493= 3.5 nMNPASS
Nicotinic acetylcholine receptor alpha 5 subunitMusca domesticaA9XFY4= 11900.0 nM= 2480.0 nMNPASS
Nicotinic acetylcholine receptorRattus leucopus8.9 nM|125 nM|2 nM|4000 nM|>10000 nM|1 nM|55.3 nM|9.4 nM|1633 nM|55.2 nM|2.31 nM|1.5 nM|6000 nM|22 nM|7.22 nM|0.96 nM|10 nM|5.3 nM|154 nM|960 nM|12 nMBindingDB
Neuronal nicotinic acetylcholine receptorMus musculusQ2MKA5= 4.0 nM= 1.2 nMNPASS
Neuronal acetylcholine receptors; alpha-3/beta-4, alpha-5, beta-2Homo sapiensP30532= 30000.0 nMNPASS
Neuronal acetylcholine receptor; alpha4/beta4Rattus norvegicusP12392= 46.0 nM|= 40.0 nM|= 33.0 nM|= 31.62 nM|= 150.0 nM|= 158.49 nM|= 23.0 nM|= 5.5 nM|= 141.25 nM|= 140.0 nM|= 51.0 nM|= 72.0 nM|= 72.44 nMNPASS
Neuronal acetylcholine receptor; alpha4/beta4Homo sapiensP43681= 7100.0 nM= 129.0 nM|= 23.0 nM|= 70.0 nMNPASS
Neuronal acetylcholine receptor; alpha4/beta2Rattus norvegicusP12390= 4000.0 nM|= 590.0 nM|= 7.3 nM|= 1000.0 nM|= 10000.0 nM|= 67.0 nM|= 67.61 nM|= 220.0 nM|= 210.0 nM|= 14000.0 nM|= 591.0 nM|= 77.0 nM|= 19000.0 nM= 3.8 nM|= 1.65 nM= 1.05 nM|= 0.94 nM|= 12.0 nM|= 1.5 nM|= 1.01 nM|= 1.0 nM|= 1.4 nM|= 10.0 nM|= 8.0 nM|= 1.3 nM|= 2.3 nM|= 0.84 nM|= 2.0 nM|= 0.95 nM|= 35.0 nM|= 1.8 nM|= 4.0 nM|= 0.9333 nM|= 6.2 nM|= 6.31 nM|= 6.8 nM|= 3.0 nM|= 7.0 nM|= 22.0 nM|= 19.95 nM|= 4.9 nM|= 9.8 nM|= 11.1 nM|= 2.83 nM|= 7.586 nM|= 7.6 nM|= 11.0 nM|= 2.1 nM|= 13.0 nM|= 14.13 nM|= 4.1 nM|= 5.6 nMNPASS
Neuronal acetylcholine receptor; alpha4/beta2Homo sapiensP43681= 4000.0 nM|= 5000.0 nM|= 2100.0 nM|= 9332.54 nM|= 9400.0 nM|= 6600.0 nM|= 6606.93 nM|= 4700.0 nM|= 300.0 nM|= 290.0 nM|= 1.0 nM|= 3000.0 nM|= 295.12 nM|= 295.0 nM|= 2400.0 nM|= 316.23 nM|= 800.0 nM= 430.0 nM|= 426.58 nM|= 427.0 nM|= 370.0 nM|= 1.2 nM|= 398.11 nM|= 4.9 nM= 9.1 nM|= 2.3 nM|= 1.2 nM|= 2.0 nM|= 2.1 nM|= 4.0 nM|= 1.6 nM|> 10000.0 nM|= 1.5 nM|= 9.46 nM|= 12.59 nM|= 4.9 nM|= 5.5 nM|= 1.05 nM|= 0.6 nM|= 10.0 nM|= 0.045 nM|= 2.2 nM|< 1.0 nMNPASS
Rattus norvegicusRattus norvegicus= 40.0 nM|= 40000.0 nMNPASS
Neuronal acetylcholine receptor subunit alpha-3/beta-4Homo sapiensP30926|P3229751000 nM|21000 nM|4300 nM|19830 nM172 nM|320 nM|260 nM|261 nM|1744 nM|5.0 nM|530 nMBindingDB
Acetylcholine receptor subunit alphaHomo sapiensP02708180000 nM21000 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-3/beta-2RatP04757|P1239047 nMBindingDB
Cytochrome P450 2A6Homo sapiensP115092.63e+4 nM|579429 nM|> 400000 nM|= 579428.7 nM470000 nM|= 470000.0 nM4400 nM|130000 nM|= 4400.0 nM|= 130000.0 nMBindingDB, NPASS
Cytochrome P450 2A5Mus musculusP20852159956 nM|= 159955.8 nMBindingDB, NPASS
Cytochrome P450 1A2Homo sapiensP051774100000 nM|= 4100000.0 nMBindingDB, NPASS
Cholinergic receptor nicotinic alpha 6 subunitGallus gallus131 nMBindingDB
Canalicular multispecific organic anion transporter 2Homo sapiensO15438> 133000.0 nMNPASS
Canalicular multispecific organic anion transporter 1Homo sapiensQ92887> 133000.0 nMNPASS
Bile salt export pumpHomo sapiensO95342>135000 nM|>1000000 nM|>133000 nM|> 135000.0 nM|> 1000000.0 nM|> 133000.0 nMBindingDB, NPASS
Alpha-bungarotoxinBuus multicinctusP606151700 nM|900 nMBindingDB
AcetylcholinesteraseMusca domesticaQ7YWJ9= 2600000.0 nMNPASS
Acetylcholine-binding proteinLymnaea stagnalisP5815440.7 nM|310 nM|320 nM|316 nM|479 nM|= 478.63 nM|= 320.0 nM|= 316.23 nM83 nM|496 nM|63.1 nM|331.13 nM|316.23 nM|100 nM|= 63.1 nM|= 331.13 nM|= 316.23 nM|= 496.0 nM|= 100.0 nM|= 83.18 nM|= 83.0 nMBindingDB, NPASS
Acetylcholine receptor; alpha1/beta1/delta/gammaHomo sapiensQ07001> 1000.0 nM> 1000.0 nM= 5500.0 nM|= 6270.0 nM|= 1480.0 nMNPASS
Acetylcholine receptor subunit deltaTetronarce californicaP0271820000 nMBindingDB
Acetylcholine receptor subunit beta-like 2Drosophila melanogasterP251624000 nM|= 4000.0 nM2700 nM|= 2700.0 nMBindingDB, NPASS
Acetylcholine receptor subunit alpha/beta/delta/gammaTetronarce californicaP02710|P02712|P02714|P0271860000 nM4 nM|1 nM>10000 nM|6270 nMBindingDB
Acetylcholine receptor subunit alpha/beta/delta/gammaHomo sapiensP02708|P07510|P11230|Q070015500 nMBindingDB
Acetylcholine receptor subunit alpha/Neuronal acetylcholine receptor subunit beta-4Homo sapiensP02708|P3092610000 nMBindingDB
Acetylcholine receptor subunit alphaRattus norvegicusP25108>10000 nMBindingDB
Acetylcholine receptor protein delta chainTorpedo californicaP02718= 160000.0 nMNPASS
Acetylcholine receptor protein alpha chainTorpedo californicaP02710= 23100.0 nMNPASS
Acetylcholine receptor protein alpha chainHomo sapiensP02708= 180000.0 nM= 21000.0 nMNPASS
Acetylcholine receptorTorpedo californicaP02714= 60000.0 nM= 4.0 nM|= 1.0 nM> 10000.0 nM|= 6270.0 nMNPASS
ATP-binding cassette sub-family C member 4Homo sapiensO15439>133000 nMBindingDB
ATP-binding cassette sub-family C member 3Homo sapiensO15438>133000 nMBindingDB
ATP-binding cassette sub-family C member 2Homo sapiensQ92887>133000 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-3/beta-2Rattus norvegicusP04757|P123901 nM|43 nM|47 nMBindingDB
Cytochrome P450 3A4Homo sapiensP086841.424e+5 nMBindingDB
HERGHomo sapiensQ12809= 245470.89 nM|= 244300.0 nM|= 244299.74 nMNPASS
Cytochrome P450 2A13Homo sapiensQ1669654000 nM|= 54000.0 nM72000 nM|= 72000.0 nMBindingDB, NPASS
IMR-32Homo sapiens= 21000.0 nMNPASS
Neuronal acetylcholine receptor subunit alpha-3/beta-2Homo sapiensP17787|P32297132000 nM3.8 nM47 nM|29 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-3Rattus norvegicusP04757475 nM|100 nM|290 nM|47 nM|440 nM|600 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-3Homo sapiensP322979400 nM45 nM|= 45.0 nM>10000 nM|14 nM|187 nM|220 nM|= 220.0 nMBindingDB, NPASS
Neuronal acetylcholine receptor subunit alpha-2/beta-4Rattus norvegicusP12389|P12392112 nM|110 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-2/beta-4RatP12389|P12392110 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-2/beta-4Homo sapiensP30926|Q15822103 nM|70 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-2/beta-2Rattus norvegicusP12389|P1239015 nM|12 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-2/beta-2RatP12389|P1239012 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-2/beta-2Homo sapiensP17787|Q158225.5 nMBindingDB
High affinity choline transporter 1Mus musculusQ8BGY9520115.74 nMBindingDB
Neuronal acetylcholine receptor subunit alpha-2Homo sapiensQ158229900 nMBindingDB
Neuronal acetylcholine receptor protein alpha-9 subunitRattus norvegicusP43144= 2.4 nM= 5.0 nMNPASS
Neuronal acetylcholine receptor protein alpha-7 subunitRattus norvegicusQ05941= 54000.0 nM|= 43000000.0 nM|= 13000.0 nM|= 1500.0 nM|= 1071.52 nM|= 23000.0 nM|= 109647.82 nM|= 108700.0 nM|= 47000.0 nM= 16.0 nM= 4000.0 nM|= 770.0 nM|= 450.0 nM|= 340.0 nM|= 480.0 nM|= 130.0 nM|= 460.0 nM|= 6290.0 nM|= 1748.0 nM|= 750.0 nM|= 234.0 nM|= 1500.0 nM|= 670.0 nM|= 176.0 nM|= 16000.0 nM|= 15848.93 nM|= 469.0 nM|= 1400.0 nM|= 517.0 nM|= 230.0 nM|= 520.0 nM|= 610.0 nM|= 15000.0 nM|= 250.0 nM|= 400.0 nMNPASS
Neuronal acetylcholine receptor subunit alpha-2Rattus norvegicusP123893.6 nM|83 nM|12 nM|110 nMBindingDB
Neuronal acetylcholine receptor protein alpha-7 subunitHomo sapiensP36544= 83000.0 nM|= 38000.0 nM|= 113000.0 nM|= 1584.89 nM|= 91000.0 nM|= 4710.0 nM= 21000.0 nM|= 7600.0 nM= 1.06 nM= 1610.0 nM|= 620.0 nM|= 7200.0 nM|= 6300.0 nM|= 630.0 nM|= 24000.0 nM|= 25118.86 nM|= 12000.0 nM|= 10000.0 nM|= 1000.0 nM|= 2110.0 nM|= 1023.29 nM|= 3000.0 nM|= 3800.0 nM|= 6290.0 nMNPASS
K177cell line= 5000.0 nMNPASS
Neuronal acetylcholine receptor protein alpha-7 subunitMus musculusP49582= 480.0 nM|= 244.0 nMNPASS
Multidrug resistance-associated protein 4Homo sapiensO15439> 133000.0 nMNPASS
Mus musculusMus musculus= 1.41 nMNPASS
Muscarinic acetylcholine receptorRattus norvegicusP10980= 32000.0 nM|= 360000.0 nM|= 28000.0 nM> 5000.0 nM|> 10000.0 nMNPASS
Lycopene cyclasePantoea ananasP21687= 4800.0 nMNPASS
Muscle-type nicotinic acetylcholine receptorHomo sapiensQ04844= 65000.0 nMNPASS
NON-PROTEIN TARGET= 941600.0 nM|= 1963000.0 nM= 5800.0 nM|= 6200.0 nM|= 3700.0 nM|= 3600.0 nMNPASS
Neuronal acetylcholine receptorRattus norvegicusQ05941= 20000.0 nM= 6.6 nM|= 7.0 nM|= 3.0 nM|= 4.0 nM= 4.9e-06 nM|= 0.01 nM|= 430.0 nM|= 11000.0 nM|= 43000000.0 nM|= 0.022 nM|= 10.0 nM|= 5.2 nM|= 45000.0 nM= 8.4 nM|= 2.4 nM|= 1.15 nM|= 1.1 nM|= 13.0 nM|= 27.0 nM|= 1.3 nM|= 1.0 nMNPASS
Neuronal acetylcholine receptor protein alpha-2 subunitRattus norvegicusP12389= 12.0 nMNPASS
Neuronal acetylcholine receptor protein alpha-4 subunitMus musculusO70174= 7.0 nMNPASS
Muscarinic acetylcholine receptor M1/M2/M3/M4/M5Rattus norvegicusP08482|P08483|P08485|P08911|P10980360000 nM|28000 nM|32000 nM>5000 nMBindingDB