| IV Nicotine Induced Changes in Hormone Function, Mood States and Behavior | IV Nicotine Induced Changes in Hormone Function, Mood States and Behavior | NCT01589055 |
| Effect of the Electronic Cigarette on Withdrawal Symptoms | Phase 4 Study to Compare of the Effects of the Electronic Cigarette and Nicotine Inhalator on Tobacco Withdrawal Symptoms Over 24 Hours of Abstinence | NCT01454362 |
| Varenicline in Combination With Nicotine Replacement Therapy for Smoking Cessation | A 26-Week Phase II, Multicentre, Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Varenicline in Combination With Nicotine Replacement Therapy for Smoking Cessation | NCT01444131 |
| Effects of Progesterone on IV Nicotine Induced Changes on BOLD fMRI Signal, Hormones and Subjective Ratings of Stimulant Drugs | | NCT01589068 |
| Guided Self-Change and Nicotine Replacement Therapy for Smoking Cessation | Efficacy of Guided Self-Change, Nicotine Replacement Therapy, and Their Combination for Smoking Cessation in Chronic Obstructive Pulmonary Disease Patients: A Randomized Clinical Trial | IRCT201609271457N11 |
| Effects of Progesterone on IV Nicotine-Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effect | Effects of Progesterone on IV Nicotine-Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effect | NCT01589081 |
| The Effect of Individualized Counseling, Phone Line Follow up, and Nicotine Chewing Gum on Smoking Cessation | The Effect of Individualized Counseling, Phone Line Follow up, and Nicotine chewing Gum on Smoking Cessation in Smokers: A clinical Trial Study | IRCT201011025074N1 |
| Personalized Dosing of Nicotine Replacement (NRT to Effect) | Personalized Dosing of Nicotine Replacement for Smoking Cessation: An Effectiveness Randomized Placebo-controlled Trial | NCT03000387 |
| Bupropion Alone or Combined With Nicotine Gum | Efficacy of Bupropion Alone and in Combination With Nicotine Gum | NCT01621022 |
| A pilot study of the tolerability and effect on smoking urges of flavoured and unflavoured nicotine inhalers that contain either pure nicotine or a nicotine salt, compared to placebo. | A semi-randomised placebo-controlled cross-over pilot study in heavy smokers, of flavoured and unflavoured nicotine base and nicotine lactate pressurised metered-dose formulations, comparing their tolerability and effect on smoking urges . | ACTRN12611001006932 |
| Pharmacokinetic Profile of Toxic Substances and Nicotine in Electronic Cigarettes | Pharmacokinetic Profile of Toxic Substances and Nicotine in Electronic Cigarettes: a Randomised Cross-over Trial KINECIG | NCT01665066 |
| Effects of Progesterone on Smoked Nicotine Induced Changes in Hormones and Subjective Ratings of Stimulant Drug Effects | | NCT01636336 |
| A PROOF OF CONCEPT WITH A NEW NICOTINE INHALER IN COMPARISON WITH NICOTINE INHALER 10 MG- AN EXPLORATORY STUDY IN ADULT HEALTHY SMOKERS | A PROOF OF CONCEPT WITH A NEW NICOTINE INHALER IN COMPARISON WITH NICOTINE INHALER 10 MG- AN EXPLORATORY STUDY IN ADULT HEALTHY SMOKERS | EUCTR2011-002796-41-SE |
| Safety and Tolerability Study of medicinal snuff. | The effect of 6 weeks’ use of the Nicachet 4 mg nicotine powder in pouch on the oral mucosa. A short-term smoking cessation and tolerability study. - Safety and Tolerability Study of medicinal snuff | EUCTR2011-001764-21-SE |
| COMBIVAR. Trial of two parallel groups to evaluate the efficacy of smoking cessation with combined versus monotherapy | COMBIVAR. Randomized double-blind trial of two parallel groups design to evaluate the efficacy of smoking cessation with combined (varenicline plus nicotine patches) versus monotherapy (varenicline) - COMBIVAR | EUCTR2011-004692-36-ES |
| Brain Nicotine Receptor Density & Response to Nicotine Patch | Brain Nicotine Receptor Density & Response to Nicotine Patch | NCT01526005 |
| Using nicotine patches to support smoking cessation among adolescents. | The effectiveness of Nicotine Replacement Therapy for young people aged 12 to 18 years. | NL-OMON22696 |
| Financial Intervention for Smoking Cessation Among Low-Income Smokers | A randomised controlled trial examining the effectiveness of a smoking cessation intervention (financial counselling, free Nicotine Replacement Therapy (NRT) and Quitline support) versus free NRT and Quitline support only on reducing smoking in socioeconomically disadvantaged groups | ACTRN12612000725864 |
| Very Low Nicotine Content Cigarettes and E-Cigarettes in Promoting Smoking Cessation in Daily and Intermittent Cigarette Smokers | Evaluating Concomitant Use of Very Low Nicotine Content Cigarettes and E-Cigarettes Among Daily and Non-Daily Smokers | NCT02964182 |
| Smoked Nicotine Induced Changes in Hormone Function, Mood States and Behaviors | | NCT01636323 |
| Association of Functional COMT Val108/Met Polymorphism With Smoking Cessation in Nicotine Replacement Therapy | Association of Functional COMT Val108/Met Polymorphism With Smoking Cessation in Nicotine Replacement Therapy | NCT01980550 |
| Randomized Controlled Trial of Mailed Nicotine Replacement Therapy to Canadian Smokers | Randomized Controlled Trial of Mailed Nicotine Replacement Therapy to Canadian Smokers | NCT01429129 |
| Nicotine patch preloading for smoking cessation: The Preloading Trial | An open label pragmatic randomised controlled trial of nicotine patch preloading for smoking cessation | ISRCTN33031001 |
| Combination Nicotine Patch / Lorcaserin for Smoking Cessation | Combination Nicotine Patch / Lorcaserin for Smoking Cessation | NCT02906644 |
| Provoked Craving Relief Study by NRT | A Pilot Study to Evaluate Relief of Provoked Acute Craving by Nicotine Mouth Strip, Nicorette ® Nicotine Lozenge and Gum | NCT01476202 |
| Evaluation of the Nicotine Lozenge in Relief of Provoked Acute Craving | Evaluation of the Nicotine Lozenge in Relief of Provoked Acute Craving | NCT01466361 |
| Nicotine Lozenges and Assisted Self-help for Smokeless Tobacco Cessation | Nicotine Lozenges and Assisted Self-help for Smokeless Tobacco Cessation | NCT01341938 |
| Nicotine Reinforcement and Aversion in Young Adult Light Smokers | Nicotine Reinforcement and Aversion in Young Adult Light Smokers | NCT01495819 |
| Nicotine Lozenge Bioequivalence Study | A Single Dose Bioequivalence Study of 2 Different Doses of Mini Cherry Nicotine Lozenges | NCT01536704 |
| A study in U.S. and Germany to show if patients with an early stage of Parkinson's disease could be treated with a nicotine patch. In this study the nicotine patch is being compared to a placebo patch. The placebo patch is identical in appearance to the nicotine patch but does not contain any active ingredients. | A randomized, placebo-controlled, double-blind, multi-center trial to assess the disease-modifying potential of transdermal nicotine in early Parkinson's disease in Germany and the USA (NIC-PD) - NIC-PD | EUCTR2010-020299-42-DE |
| Effects of Contingency Management and Nicotine Replacement Therapy on Youth Smoking | Effects of Contingency Management and Nicotine Replacement Therapy on Youth Smoking | NCT01359709 |
| The Effect of Nicotine Delivery Rate on Reinforcement | The Effect of Nicotine Delivery Rate on Reinforcement | NCT03134339 |
| Nicotine Patch Safety Study | | NCT01655082 |
| Nicotine Replacement Therapy in the Intensive Care Unit | Nicotine Replacement Therapy in the Intensive Care Unit: a Randomized, Controlled Pilot Study | NCT01362959 |
| The Relationship between Genetic Variations of CYP2A6 and Pharmacokinetics of Nicotine and Hair Nicotine Metabolites in Cigarette Smokers Visiting Medical Check-Up Clinic at King Chulalongkorn Memorial Hospital | The relationship between genetic variations of CYP2A6 and pharmacokinetics of nicotine and hair nicotine metabolites in cigarette smokers visiting medical check-up clinic at King Chulalongkorn Memorial Hospital | TCTR20161227002 |
| Effect of transcranial Direct Current Stimulation (tDCS) in cigarette smokers treatment. | Comparison of the trans-cranial Direct Current Stimulation (tDCS) and Bupropion on treatment of nicotine-dependent smokers. | IRCT2016072629093N1 |
| Effects of Acute Nicotine Treatment on Neuroplasticity and Memory in Patients With Schizophrenia | Effects of Acute Nicotine on Long-term Potentiation in the Dorsolateral Prefrontal Cortex of Patients With Schizophrenia and Healthy Controls | NCT01465074 |
| Provoked Craving Assessment | Evaluation of the Nicotine Mini Lozenge in Relief of Provoked Acute Craving | NCT01506908 |
| Can we improve how health providers support smoking cessation in Aboriginal and Torres Strait Islander pregnant women? - a pilot study | The Indigenous Counselling and Nicotine (ICAN) QUIT in Pregnancy Step-Wedge Pilot Study: feasibility of training health providers in evidence based smoking cessation care for Australian Indigenous pregnant smokers. | ACTRN12616001603404 |
| Preloading Trial | An open label pragmatic randomised controlled trial of nicotine patch preloading for smoking cessation. - Preloading Trial | EUCTR2011-005134-19-GB |
| PMCAN for Smokers at Smoking Hotspots | Proactive Minimal Cessation Advice Plus Nicotine Replacement Therapy (PMCAN) for Smoking Cessation in Smokers at Smoking Hotspots: a Pilot Randomized Controlled Trial | NCT02935231 |
| Varenicline alone or with nicotine e-cigarettes for smoking cessation in people with mental illness and drug and/or alcohol dependence. | A randomised controlled clinical trial to evaluate the effectiveness and safety of combining varenicline with nicotine e-cigarettes on smoking abstinence in people with co-existing mental health and drug and alcohol dependence conditions. | ACTRN12616001355460 |
| Medicinal Nicotine for Preventing Stress Induced Craving and Withdrawal Symptoms | Medicinal Nicotine for Preventing Stress Induced Craving and Withdrawal Symptoms | NCT01522963 |
| A Four-Part Study to Determine the Safety, Tolerability and Pharmacokinetics of the Oxette (Registered Trademark) Nicotine Inhaler, Including a Comparison with the Nicorette (Registered Trademark) Inhaler | A Four-Part Study to Determine the Safety, Tolerability and Pharmacokinetics of the Oxette (Registered Trademark) Nicotine Inhaler, Including a Comparison with the Nicorette (Registered Trademark) Inhaler | ACTRN12612000088842 |
| A Two-Arm, Open-Label, Multi-Location, Single Center Study of the Craving Profile of the Nicotine Replacement Therapy Chrono Quit Smoking Solution (CQSS2; 21 mg) versus NiQuitin (registered trademark) Patch (21 mg) for Smoking Cessation in Treatment Seeking Subjects | A Two-Arm, Open-Label, Multi-Location, Single Center Study of the Craving Profile of the Nicotine Replacement Therapy Chrono Quit Smoking Solution (CQSS2; 21 mg) versus NiQuitin (registered trademark) Patch (21 mg) for Smoking Cessation in Treatment Seeking Subjects | ACTRN12616001529437 |
| Sensorimotor Replacement With Electronic and De-nicotinised Cigarettes | The Effect of Non-nicotine Sensorimotor Replacement on Withdrawal and Craving: Studies With Electronic and De-nicotinised Cigarettes | NCT01414998 |
| Open label randomised trial of nicotine replacement therapy and oral smokeless tobacco (snus) in smoking cessation - STONES | Open label randomised trial of nicotine replacement therapy and oral smokeless tobacco (snus) in smoking cessation - STONES | EUCTR2006-004461-34-GB |
| Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers | Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers | NCT02989038 |
| Clinical Trial to Evaluate the Efficacy of Smoking Cessation | Randomized Double-blind Trial of Two Parallel Groups Design to Evaluate the Efficacy of Smoking Cessation With Combined (Varenicline Plus Nicotine Patches) Versus Monotherapy (Varenicline Plus Placebo Patches) | NCT01538394 |
| Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder | Reduced Nicotine Cigarettes in Smokers With and Without Alcohol Use Disorder | NCT02990455 |
| Disease-modifying Potential of Transdermal NICotine in Early Parkinson's Disease | A Randomized, Placebo-controlled, Double-blind, Multi-center Trial to Assess the Disease-modifying Potential of Transdermal Nicotine in Early Parkinson's Disease in Germany and the USA | NCT01560754 |
| Tobacco Harm Reduction with Vaporised Nicotine (THRiVe): Feasibility Study | Tobacco Harm Reduction with Vaporised Nicotine (THRiVe): An uncontrolled feasibility study of novel nicotine replacement products among people living with HIV (PLHIV) who smoke | ACTRN12616001641482 |
| Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels | Nicotine Related Brain Activity: The Influence of Smoking History and Blood Nicotine Levels, an Exploratory Study | NCT01588561 |
| Nicotine Withdrawal Symptoms and Smoking Relapse | Identifying Neurobiological Mechanisms That Underlie Acute Nicotine Withdrawal and Drive Early Relapse in Smokers | NCT01511614 |
| Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers | Project 2, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Opioid Abusers | NCT02250664 |
| e-Cigarettes Versus NRT Gum for Smoking Cessation | e-Cigarettes Versus Nicotine Replacement Therapy for Smoking Cessation | NCT01925781 |
| Nicotine Patch - Multidose Bioequivalence Study | | NCT01658215 |
| Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement | Efficacy and Neural Correlates of Personalized Treatment With Transdermal Nicotine Replacement: A Randomized, Controlled Pilot Study in Motivated Smokers Unable to Quit With Standard Dosing | NCT02439944 |
| Project 2: Strategies for Reducing Nicotine Content in Cigarettes | Project 2: Strategies for Reducing Nicotine Content in Cigarettes | NCT02139930 |
| Examination of mechanism of action of pre-quit use of nicotine patch and varenicline for smoking cessation | Effect of treatment with pre-quit nicotine patch or pre-quit varenicline or standard nicotine patch for regular daily smokers aged over 18 on abstinence at four weeks | ACTRN12614000329662 |
| The Effects of Nicotine Chewing Gum in Parkinson's Disease | The Effects of Nicotine Chewing Gum on Acute Low Blood Pressure in Parkinson's Disease | NCT02452125 |
| In-patient Smoking Cessation Intervention Using Counseling, Spirometry and Nicotine Replacement Therapy | In-patient Smoking Cessation Intervention Using Counseling, Spirometry and Nicotine Replacement Therapy | NCT02470923 |
| Electronic Nicotine Delivery Systems as a Smoking Cessation Treatment | Electronic Nicotine Delivery Systems (ENDS) as a Smoking Cessation Treatment | NCT02487953 |
| Motivating Smokers at Outdoor Public Smoking Hotspots to Have Quit Attempt With Nicotine Replacement Therapy Sampling | Motivating Smokers at Outdoor Public Smoking Hotspots to Have Quit Attempt With Nicotine Replacement Therapy Sampling: A Randomized Controlled Trial | NCT02491086 |
| COMPARING MOTIVATIONAL INTERVIEWING-BASED TREATMENT AND ITS COMBINATION WITH NICOTINE REPLACEMENT THERAPY ON SMOKING CESSATION IN PRISONERS: A RANDOMIZED CONTROLLED CLINICAL TRIAL | COMPARING MOTIVATIONAL INTERVIEWING-BASED TREATMENT AND ITS COMBINATION WITH NICOTINE REPLACEMENT THERAPY ON SMOKING CESSATION IN PRISONERS: A RANDOMIZED CONTROLLED CLINICAL TRIAL | TCTR20150724001 |
| Pharmacokinetics and Acute Effects of Multiple Dose of Nicotine: Electronic Cigarette and Cigarette | Pharmacokinetics and Acute Effects of Multiple Dose of Nicotine Administered by Electronic Cigarette and Cigarette | NCT02511704 |
| Switching to Reduced Oxidant or Nicotine Content Cigarettes in Smokers | Switching to Reduced Nicotine Content Cigarettes or Reduced Reactive Oxygen/Reactive Nitrogen Species Cigarettes in Smokers | NCT02415270 |
| The Use of Nicotine Patches Together With E-cigarettes (With and Without Nicotine) for Smoking Cessation | A Randomised-controlled Clinical Trial to Evaluate the Effectiveness and Safety of Combining Nicotine Patches With E-cigarettes (With and Without Nicotine) Plus Behavioural Support, on Smoking Abstinence | NCT02521662 |
| TDCS and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence | Transcranial Direct Current Stimulation (TDCS) and Cognitive Retraining to Augment Pharmacotherapy for the Treatment of Nicotine Dependence | NCT02534454 |
| Nicotine Patch - Bioequivalence Study | | NCT02089308 |
| "Uptake of nicotine following a single use of ""Heat Not Burn"" (HNB) 1.2 and a cigarette" | "An assessment of the biological uptake of nicotine among healthy adult smokers following a single controlled use of ""Heat Not Burn"" (HNB) 1.2 and a combustible cigarette" | ISRCTN88682435 |
| Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers | Evaluation of Very Low Nicotine Content Cigarettes in Adolescent Smokers | NCT02587312 |
| Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers | Effects of Nicotine Reduction on Smoking Behavior in ADHD Smokers | NCT02599571 |
| â??Effect of behavioural counseling, Behavioural counseling and Bupropion and Behavioural Counseling, Bupropion and Nicotine chewing Gums in tobacoo cessation. | â??Efficacy of different models of tobacco cessation intervention- A Randomised Controlled Trial | CTRI/2015/11/006346 |
| Control Systems Approach to Predicting Individualized Dynamics of Nicotine Cravings | Using Control Systems to Predict Individualized Dynamics of Nicotine Cravings | NCT02643914 |
| What Are the Effects of Varenicline Compared With Nicotine Replacement Therapy on Long Term Smoking Cessation and Clinically Important Outcomes? | | NCT02681848 |
| Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Menthol Electronic Cigarettes vs Combustible Menthol Cigarettes and Nicotine Gum | A Single-Center, Randomized, Open-Label, Crossover Study to Assess Elements of Abuse Liability for Three Menthol Electronic Cigarettes | NCT02664012 |
| A pilot study of the potential acceptability of vaporised nicotine products for smoking cessation or long-term substitution among smokers | A phase 1 study of acceptability and preferences of vaporised nicotine replacement products [18mg/mL nicotine administered by vaporisers (Innokin iTaste VV4 and Cool Fire IV)] compared to standard nicotine replacement products (gum, patch, dissolvable oral strip, mouthspray, inhalator)] or vaporised nicotine-free solution [0% nicotine] in smokers living with HIV. | ACTRN12615000829516 |
| Can free nicotine replacement therapy (NRT) increase smoking cessation before scheduled surgery? | Can free nicotine replacement therapy (NRT) increase smoking cessation before scheduled surgery? | ACTRN12616000073404 |
| A Pharmacokinetic and Safety Study of the Chrono Nicotine Replacement Therapy System in male smokers. | A pharmacokinetic and safety study of the Chrono Nicotine Replacement Therapy System in male smokers. | ACTRN12615000304538 |
| Pilot Study of Nicotine Nasal Spray and Varenicline on Smoking in Methadone-Maintained Patients | A Pilot Randomized, Placebo-Controlled, Crossover Study of the Effect of the Nicotine Nasal Spray and Varenicline on Cigarette Smoking Following Methadone Dosing in Methadone-Maintained Patients | NCT02147132 |
| Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women | Project 1, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Childbearing Age Women | NCT02250534 |
| Comparison of Nicotine Plasma Concentrations and Subjective Effects for Three Electronic Cigarettes vs Combustible Cigarettes and Nicotine Gum | A Single-Center, Randomized, Open-Label, Crossover Study to Assess Elements of Abuse Liability for Three Electronic Cigarettes | NCT02269514 |
| Prevention of nicotine abstinence symptoms in critically ill patients | """Prevention of nicotine abstinence in critically ill patients after major surgery"" - NIKOTIN" | EUCTR2014-003720-43-CZ |
| Effect of Nicotine and Consulting on smoking cessation and pulmonary indexes in patients candidate for heart surgery | Comparison of Nicotine Replacement Therapy (NRT) and Nursing consulting on smoking cessation and Spiro metric indexes of smokers candidate for Coronary Artery Bypass Graft (CABG) | IRCT2014071518499N1 |
| Contingency Management, Quitting Smoking, and ADHD | Smoking/Nicotine Dependence in Attention Deficit Hyperactivity Disorder (ADHD) | NCT02266784 |
| Does Sweet Taste Potentiate Nicotine Cue Reactivity? | Does Sweet Taste Potentiate Nicotine Cue Reactivity? | NCT02499757 |
| Effects of Nicotine-Free Hookah Smoking on Blood Flow to the Heart, Muscle and Skin | Effects of Nicotine-Free Hookah Smoking on Blood Flow to the Heart, Muscle and Skin | NCT02310373 |
| Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum | A Randomized, Controlled Study to Assess Biomarkers of Tobacco Exposure and Nicotine Pharmacokinetics in Smokers After a 5-Day In-Clinic Confinement Switch to an Electronic Cigarette or Nicotine Gum | NCT02323438 |
| Transdermal Nicotine Replacement in Smokers With Acute Aneurysmal Subarachnoid Hemorrhage | Transdermal Nicotine Replacement in Smokers With Acute Aneurysmal Subarachnoid Hemorrhage | NCT02350335 |
| Assessment of three e-cigarette nicotine blends,when used by current smokers. | A Four-Way Crossover Study Comparing Nicotine Pharmacokinetics and Exhaled Carbon Monoxide Levels of a Traditional Tobacco Cigarette and Three Nicotine-Based eLiquid Blends Delivered via e-Cigarette, Following Single Use in Healthy Male Smokers. | ACTRN12614000522617 |
| Medicinal Nicotine for Preventing Cue Induced Craving | | NCT02347605 |
| Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders | Project 3, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in People With Current Affective Disorders | NCT02232737 |
| Very-Low Nicotine Cigarettes and Non-Daily Smokers | The Effect of Very-Low Nicotine Cigarettes on Smoking in Non-Daily Smokers | NCT02228824 |
| Characterization of Nicotine Exposure and Urge-to-Smoke Following Use of Electronic and Conventional Cigarettes | Characterization of Nicotine Exposure and Urge-to-Smoke Following a Single Controlled Administration and Short-Term Ad Lib Use of Electronic Cigarettes and Conventional Cigarettes in Adult Smokers | NCT02210754 |
| Study to Determine the Efficacy and Safety of a Novel Nicotine Replacement Therapy | A Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel Group Study Using a Naturalistic Clinical Model to Measure the Efficacy and Safety of a Novel Nicotine Replacement Therapy in Smokers Motivated to Quit | NCT02355665 |
| Comparison of Pharmacokinetic Profiles of 3 New Nicotine Gum Formulations With a Reference Gum | A Pilot, Open Label, Randomised, Single Dose, Four-Period, Four-Treatment, Four-Sequence, Four Way Crossover Comparative Pharmacokinetic Study of Three Different 4 mg Nicotine Chewing Gum Test Formulations of Fertin Pharma A/S, Denmark With Nicorette Freshmint 4 mg Medicated Chewing Gum of McNeil Denmark ApS as Reference Formulation in Healthy, Adult, Human Smokers Under Fasting Conditions | NCT02356913 |
| Effect of nicotine patch in Cognitive function improvement in Parkinson's disease | Effect of nicotine patch in Cognitive function improvement in Parkinson's disease - Effect of nicotine patch in Cognitive function improvement | JPRN-UMIN000016664 |
| Electronic cigarettes: Nicotine delivery in users | Electronic cigarettes - nicotine delivery in users: A crossover study | ISRCTN39500419 |
| Reward Sensitivity and Pharmacotherapy for Smoking Cessation | The Effects of Behavioral Counseling Plus Nicotine Replacement Therapy (NRT) or Varenicline on Smoking Cessation Among Smokers High and Low in Intrinsic Reward Sensitivity | NCT02162849 |
| Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers | Smoking Cessation Versus Long-term Nicotine Replacement Among High-risk Smokers | NCT02148445 |
| Effect of Nicotine on Brain Reward Pathways | Effect of Nicotine on Brain Reward Pathways | NCT02346539 |
| Nicotine absorption from electronic cigarettes | Nicotine absorption from electronic cigarette use: comparison between experienced and naive users | ISRCTN69827722 |
| Behavioral Activation Therapy and Nicotine Replacement Therapy in Increasing Smoking Cessation | Low Reward Sensitivity and Behavioral Activation Therapy for Smoking Cessation | NCT02697227 |
| The non-concealed placebo: a randomized trial on smoking cessation | An open-label randomized interventional study to assess the effect of placebo smoking cessation patches versus no treatment on nicotine dependence scores of adult Filipino smokers | ISRCTN64013828 |
| Pilot Pharmacokinetic Study of Investigational Sublingual Nicotine Tablet Versus COMMIT Nicotine Lozenge | A Randomized, 2 Way Crossover, Pilot Pharmacokinetic Study of Investigational Sublingual Nicotine Tablets ( Pharmaceutical Productions Inc.) Versus COMMIT Smoking Lozenge ( GLAXOSMITHKLINE) in Healthy Smoking Volunteers | NCT01887847 |
| Comparison of Pharmacokinetic Profiles of Two Nicotine Gum Formulations | A Pharmacokinetic Study Comparing Two Nicotine Gum Formulations in a Single Dose Design | NCT01847443 |
| D-cycloserine (DCS) Pretreatment + CBT + Nicotine Replacement Therapy for Smoking Cessation (DCS) | D-cycloserine (DCS) Pretreatment + Cognitive Behavioral Therapy and Nicotine Replacement Therapy for Smoking Cessation | NCT01842334 |
| Acute and Chronic Nicotine Modulation of Reinforcement Learning | Acute and Chronic Nicotine Modulation of Reinforcement Learning | NCT01830842 |
| Nicotine, Non-Smokers With and Without ADHD, and Genetics Study | Nicotine, Non-Smokers With and Without ADHD, and Genetics Study | NCT01819259 |
| Sublingual Nicotine Tablets Compared With Swedish Snus | Elevated Dose of Sublingual Nicotine Tablets Compared With Swedish Snus. Nicotine Pharmacokinetics and Subjective Effects of Single Doses. | NCT01838460 |
| Nicotine Treatment of Cognitive Decline in Down Syndrome | Nicotinic Treatment of Age-Related Cognitive Decline in Down Syndrome: An Open Label Pilot Trial | NCT01778946 |
| Varenicline or Nicotine Patch in Promoting Smoking Cessation Among Current Smokers | Pilot Study of Varenicline vs. Nicotine Patch Delivered by a Telephone Quitline to Promote Smoking Cessation | NCT01771627 |
| Cognitive Behaviour Therapy and Nicotine Replacement to Increase Tobacco Cessation | Efficacy of Cognitive Behaviour Therapy Associated to Nicotine Replacement in Tobacco Cessation: a Randomised Open Label Clinical Trial | NCT01734330 |
| A Cost-effectiveness Study of Nicotine Patches Distributed Through a Quitline | A Cost-effectiveness Study of Nicotine Patches Distributed Through a Quitline | NCT01889771 |
| Early Smoking Reduction or Cessation by Means of no Nicotine Electronic Cigarette Added to Standard Counselling. | Evaluation of Early Smoking Reduction or Cessation by Means of no Nicotine Electronic Cigarette Added to Standard Counselling. | NCT01733706 |
| Effects of Electronic Cigarettes on Nicotine Concentrations | Effects of Electronic Cigarettes on Nicotine Concentrations Before and 5, 10, 15, 20 and 30 Minutes After Use | NCT01775787 |
| A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers | A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers | NCT01702519 |
| Nicotine Mouth Film for Craving Relief. | A Study to Evaluate Relief of Provoked Acute Craving by Nicotine Mouth Film and Nicotine Lozenge | NCT01702532 |
| Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes | Project 1, Study 1: Investigating the Impact of Nicotine Using Spectrum Cigarettes | NCT01681875 |
| Motivation and Nicotine Patch Treatment for Under-served Smokers | Motivation and Nicotine Patch Treatment for Under-served Smokers | NCT01684995 |
| Nicotine Reduction Pilot StudyTo determine if a price differential based on nicotine content reduces cigarette consumption in smokers who are unmotivated to quit. | Nicotine Reduction Study using very low nicotine content cigarettes (VLNC) in smokers who are unmotivated to quit | ACTRN12612000914864 |
| Pharmacokinetic Study of 4 mg Nicotine Lozenge. | A Randomized, Cross-Over, Single Dose Pharmacokinetic Study of 4mg Nicotine Lozenges. | NCT01669122 |
| Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging | Nicotine Dependence, Withdrawal and Replacement Therapy Assessed by PET Imaging | NCT01664741 |
| Nicotine Gum Recovery After Colorectal Surgery | Does Nicotine Gum Enhance Bowel Recovery After Colorectal Surgery? | NCT01662115 |
| Providing Free Nicotine Patches to Quitline Smokers | Distribution of Voucher vs. Direct Mailing of Nicotine Patches to Quitline Smokers | NCT01736085 |
| Evaluation of short-term safety and use patterns of an e-cigarette | An open-label evaluation of plasma nicotine, carbon monoxide, heart rate, craving and withdrawal after acute use of the NJOY King e-cigarette in the clinic, following a one-week actual use pilot study | ISRCTN95345566 |
| Nicotine Metabolism and Low Nicotine Cigarettes | Nicotine Metabolism and Low Nicotine Cigarettes | NCT01898507 |
| Smoking Cessation in Women With Gynecological Conditions | Immediate Smoking Cessation for Patients at Risk for Cervical Dysplasia, Cervical Cancer and Lower Genital Tract Dysplasia and Cancer - A Feasibility Study Comparing Nicotine Replacement Therapy With the Electronic Nicotine Delivery System. | NCT01989923 |
| Memory Improvement Through Nicotine Dosing (MIND) Study | Long-Term Nicotine Treatment of Mild Cognitive Impairment | NCT02720445 |
| PHARMACODYNAMIC EFFECTS OF NICOTINE MOUTH SPRAY AND CYTISINE TABLET. A STUDY IN HEALTHY SMOKERS. | PHARMACODYNAMIC EFFECTS OF NICOTINE MOUTH SPRAY AND CYTISINE TABLET. A STUDY IN HEALTHY SMOKERS. | EUCTR2016-001267-36-SE |
| Facilitating Smoking Cessation With Reduced Nicotine Cigarettes | Facilitating Smoking Cessation With Reduced Nicotine Cigarettes | NCT02796391 |
| A Single-Center, Randomized, Open-Label, Two-Period, Cross Over, Pharmacokinetic Study to Assess the Relative Bioavailability of Nicotine Delivered by the Chrono Quit Smoking Solution (CQSS1) versus NicoDerm (Registered Trademark) CQ (Registered Trademark) Patch | A Single-Center, Randomized, Open-Label, Two-Period, Cross Over, Pharmacokinetic Study to Assess the Relative Bioavailability of Nicotine Delivered by the Chrono Quit Smoking Solution (CQSS1) versus NicoDerm (Registered Trademark) CQ (Registered Trademark) Patch in Smokers | ACTRN12616000824460 |
| Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study) | Depressed Mood Improvement Through Nicotine Dosing (Depressed MIND Study) | NCT02816138 |
| Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use | Abuse Liability of Reduced Nicotine Content Cigarettes in the Context of Concurrent E-Cigarette Use | NCT02870218 |
| Nicotine Replacement Therapy in Nicotine-dependent Arrestees | Nicotine Replacement Therapy in Nicotine-dependent Arrestees: a Monocentric Randomized Simple Blind Study | NCT02905734 |
| Neural Mechanisms Underlying Nicotine and Alcohol Combinations | Neural Mechanisms Underlying Nicotine and Alcohol Combinations | NCT02049268 |
| A study of providing adult smokers, who smoke at least one cigarette per day, the opportunity to sample a range of nicotine replacement therapies (NRTs) in everyday non-medical community locations, to determine if this is acceptable to smokers, and whether it increases their motivation to quit smoking, encourages them to use NRTs, and helps them to quit smoking and remain abstinent for three months. | A pilot uncontrolled single arm non-randomised open-label trial of the acceptability and effect on motivation to quit and compliance with use of nicotine replacement therapy of supplying nicotine replacement therapies to smokers in community locations regardless of their motivation to quit smoking. | ACTRN12614000054617 |
| Transdermal Nicotine and Melatonin Patches for Postoperative Pain Relief | Comparative Study Between Transdermal Nicotine and Melatonin Patches on Postoperative Pain Relief After Laparoscopic Cholecystectomy, a Double-blind, Placebo-controlled Trial | NCT02747628 |
| A Bioavailability Study of Nicotine Delivered by an Electronic Vapour Product | A Randomised, Crossover, Relative Bioavailability Study of Nicotine Delivered by an Electronic Vapour Product, a Nicotine Inhalator and a Conventional Cigarette | NCT02032212 |
| Very Low Nicotine Cigarettes in Smokers With Schizophrenia | Very Low Nicotine Cigarettes in Smokers With Schizophrenia | NCT02019459 |
| Electronic Cigarettes or Nicotine Inhaler for Smoking Cessation | Electronic Nicotine Delivery Devices (ENDDs) or Nicotine Inhaler for Smoking Cessation | NCT02004171 |
| Very Low-Nicotine Cigarettes in Smokers With SUD | Very Low-Nicotine Cigarettes in Smokers With SUD: Smoking, Substance Use Effects | NCT01989507 |
| The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users | Menthol's Effects on Nicotine Reinforcement in Smokers | NCT02102100 |
| Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products | Cardiovascular Assessment of the Effects of Tobacco and Nicotine Delivery Products | NCT01964807 |
| Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status | Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status | NCT01928719 |
| Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders | Reduced Nicotine Cigarettes in Smokers With Mood and Anxiety Disorders | NCT01928758 |
| Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers | Evaluation of Moclobemide, a Reversible MAO-A Inhibitor, as an Adjunct to Nicotine Replacement Therapy in Female Smokers | NCT01926626 |
| Pharmacokinetics of Nicotine Film in Smokers | Pharmacokinetics of Nicotine Film in Smokers | NCT02239770 |
| Effects of Nicotine Replacement Therapy and D-cycloserine on Nicotine Treatment Seekers | Effects of Nicotine Replacement Therapy and D-cycloserine on Nicotine Treatment Seekers | NCT01907594 |
| Nicotine Patch Bioequivalence Study | | NCT01658202 |
| A randomised controlled trial to evaluate the effectiveness of a smoking cessation intervention for people with chronic hepatitis C | A randomised controlled trial to evaluate the effectiveness of a smoking cessation intervention (Quitline and Nicotine Replacement Therapy) versus Quitline Intervention only for people with chronic hepatitis C to stop or reduce smoking in this group. | ACTRN12611000346976 |
| Evaluation de l'efficacité des traitements substitutifs nicotiniques (dispositifs transdermiques délivrant la nicotine pendant 16h/24h) chez 400 femmes enceintes fumeuses. Essai multicentrique, national, randomisé, contre placebo. - SNIPP | Evaluation de l'efficacité des traitements substitutifs nicotiniques (dispositifs transdermiques délivrant la nicotine pendant 16h/24h) chez 400 femmes enceintes fumeuses. Essai multicentrique, national, randomisé, contre placebo. - SNIPP | EUCTR2006-005894-22-FR |
| Nicotine Patch for Marijuana Withdrawal | Nicotine for Marijuana Withdrawal | NCT01400243 |
| Examining the Effect of the Nicotine Patch in Male and Female Smokers - 3 | Effects of Transdermal Nicotine on Tobacco Withdrawal and the Effects of Smoking-related Stimuli in Men and Women | NCT00390559 |
| Nicotine as an Adjuvant Analgesic for Third Molar Surgery | Effect of Nicotine on Pain After Third Molar Extraction. | NCT00385216 |
| A pilot study of the pharmacokinetics, efficacy, and acceptability of a novel nicotine inhaler in smokers | A pilot study of the pharmacokinetics, affect on Smoking Urges, and acceptability of a novel nicotine inhaler in smokers | ACTRN12606000423516 |
| The Effects of Nicotine on Cognition in Schizophrenia | A Double Blind Placebo Controlled Trial of the Effects of Transdermal Nicotine on Cognitive Function in Non-Smokers With and Without Schizophrenia | NCT00383747 |
| The Effects of Nicotine Withdrawal on Reward Responsivity in Schizophrenia | A Double-Blind, Placebo-Controlled Trial of Reward Responsivity During Nicotine Withdrawal in Smokers With Schizophrenia and Normal Controls | NCT00373126 |
| Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking | Comparing the Lozenge to the Patch for Smoking Cessation | NCT00365508 |
| Comparison of Standard Versus Extended Nicotine Patch Therapy for Smoking Cessation | Comparison of Standard Versus Extended Nicotine Patch Therapy for Smoking Cessation | NCT00364156 |
| Phase I Study: Stop Smoking Therapy for Ontario Patients (STOP) | The STOP (Stop Smoking Therapy for Ontario Patients) Study: The Effectiveness of Nicotine Replacement Therapy in Ontario Smokers. | NCT00356993 |
| Stop Smoking Therapy for Ontario Patients | The STOP (Stop Smoking Therapy for Ontario Patients) Study: The Effectiveness of Nicotine Replacement Therapy in Ontario Smokers PHASE II | NCT00352781 |
| Effectiveness of Nicotine Replacement Therapy in Reducing the Risk of Nicotine Exposure in Pregnant Minority Smokers | Nicotine Replacement Therapy Methods for Pregnant Women | NCT00341432 |
| A multi-component intervention for smoking cessation among Australian male prison inmates | A randomised trial of nortriptyline, nicotine replacement therapy,and brief cognitive behavioural therapy (CBT) vs. placebo, nicotine replacement therapy, and brief cognitive behavioural therapy for smoking cessation among prison inmates. | ACTRN12606000229572 |
| The evaluation of the efficacy and safety of a transdermal delivery system of nicotine/mecamylamine in cigarette smokers | | ISRCTN43027384 |
| Bio-Behavioral Predictors of the Efficacy of Nicotine Replacement Therapy (NRT) | Bio-Behavioral Predictors of the Efficacy of Nicotine Replacement Therapy - Transdisciplinary Tobacco Use Research Center (TTURC), Project 2 | NCT00326781 |
| Smoking Relapse Prevention in Schizophrenia | A Trial of the Effects of Bupropion, Nicotine Replacement Therapy and CBT on Smoking Cessation and Smoking Relapse in Patients With Schizophrenia | NCT00320697 |
| Nicotine Replacement Therapy for Smoking Cessation in Schizophrenia | Nicotine Replacement Therapy Added to Cognitive Behavioral Therapy for Smoking Cessation in Patients With Major Mental Illness | NCT00320723 |
| Computer-Assisted Counseling in Helping African American Smokers Stop Smoking | Treatment of Nicotine Dependence Among African Americans | NCT00310141 |
| Nicotine Patch and Bupropion to Reduce Smoking Rates in Younger, Low-Income, and Minority Individuals | Clinical Trial of Two Medications on Smoking Cessation | NCT00308763 |
| Safety and Effectiveness of Sustained Release Bupropion in Treating Individuals With Schizophrenia Who Smoke | Nicotine and Smoking Cessation in Schizophrenia | NCT00307203 |
| Group Therapy for Nicotine Dependence: Mindfulness and Smoking | Group Therapy for Nicotine Dependence | NCT00297479 |
| Nicotine Skin Patch in Treating Patients With Kaposi's Sarcoma | Treatment of Classical Kaposi Sarcoma With Nicotine Dermal Patch: A Phase II Trial | NCT00295984 |
| Smoking cessation by nurses with smokelesstobacco buccal tabltes, nicotine buccal tablets, nicotine patches with repeated thearapy every 6 months for 2 years | Smoking cessation by nurses with smokelesstobacco buccal tabltes, nicotine buccal tablets, nicotine patches with repeated thearapy every 6 months for 2 years | EUCTR2005-004626-10-DK |
| Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction | Evaluating Nicotine Lozenges for Treatment of Smokeless Tobacco Addiction | NCT00392379 |
| A cross-over trial of the acceptability and effect on smoking reduction of snus, novel nicotine pouch substitute, and nicotine gum in heavy New Zealand smokers | A cross-over trial of the acceptability and effect on smoking reduction of snus, novel nicotine pouch (sachet) substitute, and nicotine gum in heavy New Zealand smokers | ACTRN12606000463572 |
| NicoNovum Evaluation of Withdrawal Relief Study Part 1 | A phase III, single blind, randomised, cross-over trial of the effects of a novel nicotine replacement therapy (NicoNovum pouch)in the treatment of withdrawal relief in smokers. | ACTRN12606000489594 |
| Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia | Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia | NCT00407277 |
| Functional Magnetic Resonance Imaging (fMRI) Investigation of Nicotine Withdrawal Symptoms | Simultaneous fMRI/EEG of the 4 mg Nicotine Lozenge in Relief of Cognitive Impairment Associated With Nicotine Withdrawal | NCT00657020 |
| A Single Dose Bioequivalence Study OfTwo Formulations Of Nicotine Lozenges | A Single Dose Bioequivalence Study of 2mg and 4mg Nicotine Lozenges | NCT00651352 |
| Nicotine Replacement and Counseling In Adolescents | A Randomized Trial of the Nicotine Nasal Spray in Adolescent Smokers | NCT00625794 |
| Nicotine Patch Pretreatment for Smoking Cessation in PTSD | Nicotine Patch Pre-treatment for Smoking Cessation in PTSD | NCT00625131 |
| Social Cognition,Attentional Network and Nicotine Drug Dependency - A Pharmacological Clinical Trail | Social Cognition,Attentional Network and Nicotine Drug Dependency - A Pharmacological Clinical Trail | NCT00618280 |
| Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement Therapy | Do Treatments for Smoking Cessation Affect Alcohol Drinking? Study 1: Nicotine Replacement Therapy | NCT00699556 |
| Pilot Study: Preoperative Nicotine Lozenges | The Role of Nicotine Lozenges in Reducing Preoperative Exposure to Cigarette Smoke | NCT00586482 |
| Nicotine and Behavior in Adult ADHD | Nicotine and Behavioral Regulation in Adult ADHD | NCT00573248 |
| Evaluation of pharmokinetics. tobacco withdrawal relief and acceptability of an electronic inhaled nicotine delivery device (Ruyan e-cigarette). | Evaluation of pharmokinetics. tobacco withdrawal relief and acceptability of an electronic inhaled nicotine delivery device (Ruyan e-cigarette). | ACTRN12607000587404 |
| Nicotine replacement thrapy as a secondary prevention strategy in post-operative coronary bypass patients | An examination of the effectiveness of transdermal nicotine replacment therapy as a secondary prevention strategy in patients admitted to hospital for coronary artery bypass grafting | ACTRN12607000572460 |
| An evaluation of the 4 mg nicotine mint lozenge for the relief of cognitive impairment associated with nicotine withdrawal. | An evaluation of the 4 mg nicotine mint lozenge for the relief of cognitive impairment associated with nicotine withdrawal. | EUCTR2005-005307-42-GB |
| Study of Nicotine for the Prevention of PONV | The Role of Transcutaneous Nicotine in the Prevention of Postoperative Nausea and Vomiting in Non-smokers | NCT00553709 |
| First Time in Human Study With GSK1018921 | Single-Blind, Randomised, Placebo-controlled First Time in Human Study to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Oral Escalating Doses of GSK1018921 in Healty Volunteers and a Randomized, Double-blind, Double Dummy, Placebo Controlled, Three-way Crossover Study in a Separate Cohort of Healthy Volunteers to Test the Effect of Single Doses of GSK1018921 and Nicotine on qEEG and MMN in Healthy Volunteers | NCT00527020 |
| Simultaneous fMRI/EEG of the 4 mg nicotine lozenge in relief of cognitive impairment associated with nicotine withdrawal | Simultaneous fMRI/EEG of the 4 mg nicotine lozenge in relief of cognitive impairment associated with nicotine withdrawal | EUCTR2007-002374-55-GB |
| Study of Nicotine Patch in Pregnancy (SNIPP) | Assessment of the Effectiveness of Nicotine Replacement Therapies (Nicotine Patches Delivering Nicotine 16 h/24 h) in 400 Pregnant Smokers. Randomized, Placebo-controlled, Multicenter, National Study. The SNIPP. | NCT00507975 |
| """Influencia de la fase del ciclo hormonal en la efectividad de nicotina y bupropion para ayudar a dejar de fumar""""Influence of the fase of the hormone´s cicle in the efectivity of nicotine and Bupropion in smoking cessation""" | """Influencia de la fase del ciclo hormonal en la efectividad de nicotina y bupropion para ayudar a dejar de fumar""""Influence of the fase of the hormone´s cicle in the efectivity of nicotine and Bupropion in smoking cessation""" | EUCTR2006-007060-28-ES |
| Effect of Nicotine on Chronic Pelvic Pain | Effect of Nicotine on Chronic Pelvic Pain | NCT00440505 |
| Nicotine Patch as an Analgesic Adjuvant After Surgery | Study to Determine Whether the Use of a Nicotine Patch During the Day of Surgery Improves Postoperative Pain and Reduces Opioid Requirement. | NCT00440830 |
| Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers | Effect Of Nicotine on Neurocognitive Performance of Cigarette Smokers: A Double-Blind, Within-Subjects, Placebo-Controlled Study | NCT00429208 |
| NicoNovum Evaluation of Withdrawal Relief Study Part 2 | A phase III, single blind, randomised, cross-over trial of the effects of a novel nicotine replacement therapy (NicoNovum mouthspray and lozenge)in the treatment of withdrawal relief in smokers. | ACTRN12607000086460 |
| "Nicotine in Treating ""Hunger Pain"" in Patients With Malignant Bowel Obstruction Caused By Cancer" | "A Pilot Study of Nicotine for ""Hunger Pain"" in Patients With Bowel Obstruction From Incurable Cancer" | NCT00425906 |
| Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day | A Randomized Trial to Compare Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day | NCT03060083 |
| A Randomized Trial of Internet Access to Nicotine Patches | iQuit Smoking: A Randomized Trial of Internet Access to Nicotine Patches | NCT00534404 |
| General practice study of Nicotine Replacement Therapy (NRT) assisted smoking cessation | | ISRCTN05689186 |
| Adjustment of DOses of NIcotine in Smoking Cessation (ADONIS) | Does Dose Adjustment of Nicotine Replacement Therapies According to Saliva Cotinine Increase Efficacy of These Treatments of Assistance To the Nicotinic Weaning Of the High-Risk Patients? | NCT00235313 |
| Anesthesia and Postoperative Pain | Intranasal Nicotine for Postoperative Pain Treatment: A Comparison of Its Effects in the Context of Isoflurane-induced Anesthesia Versus Propofol Anesthesia | NCT00232817 |
| Comparison of Nicotine Inhaler and/or Bupropion in Helping People to Stop Smoking and Prevent the Recurrence of Smoking | Phase III Trial Comparing Nicotine Inhaler Versus Bupropion Versus Nicotine Inhaler Plus Bupropion For Smoking Cessation Efficacy And Relapse Prevention | NCT00033592 |
| Computer-Assisted Scheduling of Nicotine Inhaler Use in Participants Who Plan to Stop Smoking | Computerized Scheduling of Nicotine Inhaler Use | NCT00021138 |
| Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation | Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation | NCT00018148 |
| Naltrexone and Patch for Smokers | Naltrexone and Nicotine Replacement Effects on Cue Reactivity of Smokers | NCT00018213 |
| Behavioral Counseling for Alcohol Dependent Smokers (Nicotine Patch) | Mood Management Training for Alcohol Dependent Smokers | NCT00004551 |
| Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch) | Behavioral/Pharmacological Treatments for Alcohol-Nicotine Dependence | NCT00000447 |
| Timing of Smoking Intervention in Alcohol Treatment (Nicotine Patch) | Timing of Smoking Intervention in Alcohol Treatment | NCT00000444 |
| Tobacco Dependence in Alcoholism Treatment (Nicotine Patch/Naltrexone) | Nalmefene in Nicotine and Alcohol Dependence | NCT00000437 |
| CASCAID Study: Cytisine as a smoking cessation aid | A single-blind randomised controlled non-inferiority clinical trial to evaluate the efficacy and safety of cytisine compared to usual care (21mg, 14mg, or 7mg nicotine patch, 4mg or 2mg nicotine gum or 2mg or 1mg nicotine lozenge nicotine replacement therapy (NRT) plus behavioural support) as a treatment for people who wish to stop smoking | ACTRN12610000590066 |
| Cytisine Compared to Combination NRT in Relapsed Smokers | Pilot RCT of Cytisine Compared to Combination Nicotine Replacement Therapy to Reduce Cigarette Consumption in Relapsed Smokers | NCT04286295 |
| Nicotine Patch for Nicotine Dependence in Individuals With Schizophrenia or Schizoaffective Disorder - 1 | High-Dose Versus Regular-Dose Nicotine Patch for Nicotine Dependence in Individuals With Schizophrenia or Schizoaffective Disorder | NCT00046813 |
| Cytisine for nicotine-containing electronic cigarette and tobacco cigarette cessation: a randomized placebo-controlled trial | Cytisine for nicotine-containing electronic cigarette and tobacco cigarette cessation: a randomized placebo-controlled trial - CYT03-2021 | CTIS2023-504708-27-00 |
| Hormones and Reduction in Co-users of Marijuana and Nicotine | Sex Differences and Progesterone: Association With Impulsivity and Marijuana Reduction in Co-Users of Marijuana and Nicotine Cigarettes | NCT02579421 |
| Progesterone and Brain Imaging Study | Multimodal Imaging of Progesterone/Neurosteroid Effects in Nicotine Addiction | NCT01954966 |
| Effect of Progesterone on Smoking Behavior in Male and Female Smokers | Progesterone and the Effects of Nicotine | NCT00271206 |
| Does Nicotine Influence the Risk of Preeclampsia? | Does Nicotine Influence the Risk of Preeclampsia? A Prospective Study | NCT06645340 |
| Determination of Carcinogens Nicotine in Electronic Cigarettes Users | Determination of Carcinogens Nicotine in Electronic Cigarettes Users | NCT02897401 |
| ENtiCe Project - Encouragement for Nicotine Cessation in pregnant smokers | In a community sample of pregnant women who are current smokers, does receipt of a larger Personal-Financial Incentive compared to a smaller Personal-Financial Incentive and no Personal-Financial Incentive illustrate a trend in increasing cessation rates: A Proof-Of-Concept trial | ACTRN12612000399897 |
| Role of Metabolites in Nicotine Dependence (1) - 1 | Role of Metabolites in Nicotine Dependence (1) | NCT00000284 |
| Role of Metabolites in Nicotine Dependence (2) - 5 | Role of Metabolites in Nicotine Dependence (2) | NCT00000288 |
| Role of Metabolites in Nicotine Dependence (4) - 13 | Role of Metabolites in Nicotine Dependence (4) | NCT00000296 |
| Investigation of Nicotine Seeking Behavior in Current Smokers | Neuropharmacological Investigation of Frontostriatal Network Function and Nicotine Seeking Behavior in Current Smokers | NCT03670212 |
| Progesterone Augmentation of Nicotine Replacement Therapy Study | Progesterone Augmentation of Nicotine Replacement Therapy Study | NCT02685072 |
| Efficacy of Nicotine Acid on Dyslipidaemia in Patients With Metabolic Syndrome | Placebokontrollierte Untersuchung Zur Wirkung Von Nikotinsäure Auf Die Dyslipidämie Bei Metabolischem Syndrom Und Das Arterioskleroserisiko (Placebo Controlled Investigation of Efficacy of Nicotine Acid on Dyslipidaemia in Patients With Metabolic Syndrome and the Risk of Atherosclerosis) | NCT00659321 |
| Combination Nicotine Replacement for Alcoholic Smokers | Combination Nicotine Replacement for Alcoholic Smokers | NCT00064844 |
| Nicotine Treatment of Mild Cognitive Impairment (MCI) | Double-Blind Treatment of Mild Cognitive Impairment (MCI) With Transdermal Nicotine or Transdermal Placebo | NCT00091468 |
| Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use | Treatment of Smokeless Tobacco Users: Use of Nicotine Replacement Products to Reduce Smokeless Tobacco Use | NCT00218244 |
| Effectiveness of the Nicotine Patch in Suppressing Nicotine Withdrawal Symptoms in Women Versus Men - 1 | Effects of Nicotine Patch in Men and Women | NCT00218140 |
| Effects of Transdermal Nicotine on Smoking, Craving and Withdrawal in People With Schizophrenia | Transdermal Nicotine and Bupropion for Smoking in Schizophrenics (Study 1) | NCT00218218 |
| Nicotine Lozenge to Reduce Smokeless Tobacco Use | Treatment of Smokeless Tobacco Users | NCT00218283 |
| A comparison of Nicotine Replacement Therapy and Nicotine Replacement Therapy combined with the Minimal Intervention Strategy for smoking cessation in cardiovascular outpatients. | A comparison of Nicotine Replacement Therapy and Nicotine Replacement Therapy combined with the Minimal Intervention Strategy for smoking cessation in cardiovascular outpatients. | ISRCTN22579361 |
| A Trial of Pre-Quitting Nicotine Replacement Therapy | A single blind randomised controlled trial comparing the use of Nicotine Replacement Therapy (NRT) while still smoking for 2 weeks prior to quitting followed by usual NRT practice, with usual NRT cessation practice on smoking abstinence at 6 months. | ACTRN12605000373673 |
| A Pilot Drug Trial That Evaluates the Whitening Potential of Nicotine Gum | An Open-label Study on Nicorette Freshmint Gum, 2 MG AND 4 MG in Smokers With Visible Teeth Staining Motivated to Quit | NCT00174499 |
| Smoking cessation program using nicotine replacement therapy for adolescent smokers: A randomized trial | Smoking cessation program using nicotine replacement therapy for adolescent smokers: A randomized trial - Smoking cessation program using nicotine replacement therapy for adolescent smokers: A randomized trial | JPRN-C000000024 |
| Pre-treatment of nicotine for one month before quitting smoking: a randomised trial | Nicotine gum treatment before smoking cessation, a randomised trial | ISRCTN60585119 |
| Examining the Effectiveness of the Nicotine Patch in Male and Female Smokers - 2 | Effects of Transdermal Nicotine on Tobacco Withdrawal and the Effects of Smoking in Men and Women | NCT00135746 |
| Smoking Cessation Treatment With Transdermal Nicotine Replacement Therapy - 1 | Smoking Cessation Treatment With Transdermal Nicotine Replacement Therapy | NCT00067158 |
| Nurse Smoking Cessation of Patients With Chronic Obstructive Pulmonary Disease (COPD) With Nicotine Replacement Therapy (NRT) and Behavioral Support | Smoking Cessation of Patients With COPD: A Multi-Center, Randomized, Placebo Controlled Nurse Conducted Smoking Cessation Trial | NCT00132236 |
| Nicotine Replacement Treatment for Pregnant Smokers - 1 | Nicotine Replacement Treatment for Pregnant Smokers | NCT00115687 |
| Double-blind, randomised, placebo-controlled trial of nicotine replacement therapy in pregnancy - Smoking, Nicotine and Pregnancy (SNAP) Trial | Double-blind, randomised, placebo-controlled trial of nicotine replacement therapy in pregnancy - Smoking, Nicotine and Pregnancy (SNAP) Trial | EUCTR2004-002621-46-GB |
| Non-Nicotine Agents for Smoking Cessation | Non-Nicotine Agents for Smoking Cessation | NCT00108537 |
| Nicotine Delivery Systems: Research & Treatment | Nicotine Delivery Systems: Research and Treatment | NCT00108342 |
| Comparision of single-dose nicotine pharmacokinetics of three variants of nicotine oral drops 2 mg and of Nicorette Gum 2 mg in healthy smokers | Comparision of single-dose nicotine pharmacokinetics of three variants of nicotine oral drops 2 mg and of Nicorette Gum 2 mg in healthy smokers | EUCTR2005-000917-37-SE |
| A randomised, controlled trial in primary care of a nicotine replacement therapy (NRT) assisted cessation intervention amongst adult smokers with established vascular disease to confirm effectiveness, safety and genetic influences | | ISRCTN27140757 |
| AN OPEN-LABEL, MULTICENTER STUDY WITH FOLLOW-UP EVALUATING THE SAFETY AND EFFICACY OF VARENICLINE TARTRATE IN COMPARISON TO TRANSDERMAL NICOTINE PATCH FOR SMOKING CESSATION - N/A | AN OPEN-LABEL, MULTICENTER STUDY WITH FOLLOW-UP EVALUATING THE SAFETY AND EFFICACY OF VARENICLINE TARTRATE IN COMPARISON TO TRANSDERMAL NICOTINE PATCH FOR SMOKING CESSATION - N/A | EUCTR2004-001607-35-GB |
| PERCEPTION AND TOLERABILITY OF NICOTINE FILMS FOR USE IN THE MOUTH. A RANDOMIZED, CROSSOVER, PHASE-II, STUDY IN HEALTHY SMOKERS. | PERCEPTION AND TOLERABILITY OF NICOTINE FILMS FOR USE IN THE MOUTH. A RANDOMIZED, CROSSOVER, PHASE-II, STUDY IN HEALTHY SMOKERS. | EUCTR2004-004575-11-SE |
| PHARMACOKINETICS OF NICOTINE FILM FOR USE IN THE MOUTH. A RANDOMIZED, CROSSOVER, PHASE-I, COMPARATIVE STUDY IN HEALTHY SMOKERS. | PHARMACOKINETICS OF NICOTINE FILM FOR USE IN THE MOUTH. A RANDOMIZED, CROSSOVER, PHASE-I, COMPARATIVE STUDY IN HEALTHY SMOKERS. | EUCTR2004-003016-30-SE |
| Acute effects of smoking and oral nicotine on blood haemostatis using thromboelastography | Acute effects of smoking and oral nicotine on blood haemostatis using thromboelastography | ISRCTN63224732 |
| Treating Nicotine Dependence in Schizophrenic Individuals: Effectiveness of Bupropion - 1 | Optimizing Treatment for Schizophrenic Smokers | NCT00124683 |
| Oral Tolerability Of Two Nicotine Dosage Forms | A Randomized, Open Label Study to Evaluate the Oral Tolerability of a Nicotine Prototype | NCT00682461 |
| A phase II multicenter, randomised, double-blind, parallel group, placebo-controlled, study to evaluate the effectiveness of EVT 302 in smoking cessation, effect on its own and in combination with open label nicotine replacement | A phase II multicenter, randomised, double-blind, parallel group, placebo-controlled, study to evaluate the effectiveness of EVT 302 in smoking cessation, effect on its own and in combination with open label nicotine replacement | EUCTR2008-002472-99-DE |
| Effet de la Nicotine transdermique sur les symptomes moteurs de la maladie de Parkinson avancée (une administration quotidienne) .Etude contrôlée, randomisée, en deux groupes parallèles et en simple insu sur 40 patients. - NICOPARK2 | Effet de la Nicotine transdermique sur les symptomes moteurs de la maladie de Parkinson avancée (une administration quotidienne) .Etude contrôlée, randomisée, en deux groupes parallèles et en simple insu sur 40 patients. - NICOPARK2 | EUCTR2008-001336-13-FR |
| Pharmacokinetics With a New Oral Nicotine Replacement Product and Nicorette® Gum | Single-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product and Nicorette® Gum. A Study in Healthy Smokers. | NCT01152736 |
| Bioequivalence Between an Oral Nicotine Replacement Product and Nicorette® Gum | Bioequivalence Between an Oral Nicotine Replacement Product and Nicorette® Gum. A Study in Healthy Smokers. | NCT01152749 |
| Effect of nicotine on cognition of schizophrenics | Effects of nicotine on visuospatial deficits in schizophrenia | IRCT138903142999N2 |
| The effect of nicotine on attention. | The Neurobiological Basis of Disengagement: A Mechanism Implicated in Visuospatial Attention. | NL-OMON29186 |
| Bioequivalence Between Nicotine Replacement Products and Nicorette® Gum | Bioequivalence Between Oral Nicotine Replacement Products and Nicorette® Gum - A Study in Healthy Smokers | NCT01113424 |
| Nicotine nasal spray for smoking cessation in primary care | Randomised placebo controlled trial of nicotine nasal spray for smoking cessation in primary care | ISRCTN03150596 |
| Effect of Daily Nicotine Patch Application on Mechanical Ventilation Weaning in Smoking Patients | Multicentric Evaluation of a Daily Nicotine Patch Administration on Mechanical Ventilation Weaning in Smoking Patients Hospitalized in Intensive Care Unit | NCT01104896 |
| An fMRI-study on the effects of NicVAX® and placebo on Central Nervous System activation and behaviour following a nicotine challenge. | An fMRI-study on the effects of NicVAX® and placebo on Central Nervous System activation and behaviour following a nicotine challenge. - fMRI study NicVAX | NL-OMON36778 |
| Testing the feasibility of nicotine-assisted reduction to stop in pharmacies | Testing the feasibility of nicotine-assisted reduction to stop in pharmacies: a 2x2 factorial trial | ISRCTN54805841 |
| an fMRI study on the effects of NicVAX and placebo on Central Nervous System activation and behaviour following a nicotine challenge - NicVAX fMRI study | an fMRI study on the effects of NicVAX and placebo on Central Nervous System activation and behaviour following a nicotine challenge - NicVAX fMRI study | EUCTR2010-019381-90-NL |
| Pharmacokinetics With Two New Oral Nicotine Replacement Products and Nicorette® Gum | Single-dose Pharmacokinetics With Two New Oral Nicotine Replacement Products and Nicorette® Gum. A Study in Healthy Smokers. | NCT01152723 |
| Nicotine Patch Trial in Syrian Primary Care Settings | Transdermal Nicotine Therapy as an Adjunct to Behavioral Smoking Cessation Counseling in Syrian Primary Care Settings | NCT01085032 |
| Single-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product | Single-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product. A Study in Healthy Smokers | NCT01084603 |
| Early Effects of a New Oral Nicotine Replacement Product and NiQuitin™ Lozenge | Nicotine Pharmacodynamics With a New Oral Nicotine Replacement Product and NiQuitin™ Lozenge: A Study in Healthy Smokers | NCT01075659 |
| Novel Determinants and Measures of Smokeless Tobacco Use: Study 2 | Novel Determinants and Measures of Smokeless Tobacco Use: Study 2 Effects of Switching Levels of Nicotine and TSNA in Products on Smokeless Tobacco Use | NCT01067599 |
| A research study to investigate the absorption of nicotine from a number of Tobacco Products and an Over the Counter (OTC) Nicotine Gum | A Randomised, Pharmacokinetic Study of Multiple Tobacco Products and an Over the Counter (OTC) Nicotine Product in Healthy Subjects | ISRCTN11703777 |
| Comparison of Low Yield Cigarettes in African Americans vs. Whites | Nicotine Regulation/Response to Low Yield Cigarettes in African-Americans vs. Whites | NCT01058876 |
| Supplemental Nicotine Administration for Smoking Cessation in Posttraumatic Stress Disorder (PTSD) | Supplemental Nicotine Administration for Smoking Cessation in PTSD | NCT01055886 |
| The effectiveness of Nicotine Replacement Therapy for young people aged 12 to 18 years | The effectiveness of Nicotine Replacement Therapy for young people aged 12 to 18 years | EUCTR2009-017862-22-NL |
| Innovative Interventions for Smoking Cessation | Innovative Interventions for Smoking Cessation: Comparison of Very Low Nicotine Content Cigarettes Plus Nicotine Patch; Very Low Nicotine Content Cigarettes Alone or Nicotine Patch Alone | NCT01050569 |
| Neurobiology of Nicotine and Non-nicotine Components of Tobacco Addiction | Neurobiology of Nicotine and Non-nicotine Components of Tobacco Addiction | NCT01056926 |
| Nicotine Replacement Therapy (NRT) and Bupropion Mechanisms of Effectiveness in Smokers | NRT & Bupropion Mechanisms of Effectiveness in Smokers: Phase IV Trial | NCT01048944 |
| Multiple-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product. | Multiple-dose Nicotine Pharmacokinetics With a New Oral Nicotine Replacement Product. A Study in Healthy Smokers. | NCT01084707 |
| An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence | An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence | NCT01047527 |
| Outcome of nicotine replacement therapy in the patients admitted to Intensive Care Unit | Outcome of nicotine replacement therapy in the patients admitted to Intensive Care Unit: a randomised case-control double blinded prospective trial | ISRCTN66928309 |
| The Effect of Nicotine on Arousal, Cognition and Social Cognition in Young and Elderly Healthy Subjects. | A Double-Blind, Placebo-Controlled, Randomized Three-Way Crossover Study to Investigate The Effect of Nicotine on Arousal, Standard Cognitive Tasks And Social Cognition in Young and Elderly Healthy Subjects | NCT01181934 |
| Nicotine Effects on Endophenotypes of Schizophrenia | Nicotine Effects on Endophenotypes of Schizophrenia | NCT01315002 |
| Pharmacogenetics of Nicotine Addiction Treatment | Pharmacogenetics of Nicotine Addiction Treatment (PNAT) | NCT01314001 |
| NICOTINE PHARMACODYNAMICS WITH A NEW ORAL NICOTINE REPLACEMENT PRODUCT AND NICOTINE GUM 4 MG. A STUDY IN HEALTHY SMOKERS. | NICOTINE PHARMACODYNAMICS WITH A NEW ORAL NICOTINE REPLACEMENT PRODUCT AND NICOTINE GUM 4 MG. A STUDY IN HEALTHY SMOKERS. | EUCTR2010-023268-42-SE |
| Study to Determine if a New Nicotine Replacement Therapy Can Safely Help Smokers to Quit Smoking | A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, 26-Week Trial to Measure the Efficacy and Safety of a Novel Nicotine Replacement Therapy in Smokers in a Naturalistic Environment | NCT01296698 |
| Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence | Cognitive Behavioral Therapy and the Nicotine Transdermal Patch for Cannabis Dependence and Nicotine Dependence | NCT01292642 |
| Smoking Cessation With the Nicotine Patch: A Pilot Study of Patch Messaging | Smoking Cessation With the Nicotine Patch: A Pilot Study of Patch Messaging | NCT01287377 |
| Bioequivalence Between Two Oral Nicotine Sublingual Tablets, 2 mg and 4 mg | Bioequivalence Between Two Oral Nicotine Sublingual Tablets, 2 mg and 4 mg - A Study in Healthy Smokers | NCT01238627 |
| Single-dose Nicotine Pharmacokinetics With Four Oral Nicotine Replacement Products | Single-dose Nicotine Pharmacokinetics With Four Oral Nicotine Replacement Products. A Study in Healthy Smokers. | NCT01234896 |
| Single-dose Nicotine Pharmacokinetics With Three Oral Nicotine Replacement Products. A Study in Healthy Smokers. | Single-Dose Nicotine Pharmacokinetics With Three Oral Nicotine Replacement Products - A Study in Healthy Smokers | NCT01234792 |
| The Effects of Nicotine withdrawal on Panic-like Response to Breath Holding: A Placebo-Controlled, Double-Blind, Cross-Over Patch Study - Nicotine and BH | The Effects of Nicotine withdrawal on Panic-like Response to Breath Holding: A Placebo-Controlled, Double-Blind, Cross-Over Patch Study - Nicotine and BH | EUCTR2010-022835-13-IT |
| 4 mg Nicotine Polacrilex Gum and Swedish Portion Snus | Nicotine Delivery and Subjective Effects of 4 mg Nicotine Polacrilex Chewing Gum Compared With Swedish Portion Snus | NCT01182129 |
| Single-dose Pharmacokinetics of Oral Nicotine Replacement Products | Single-dose Pharmacokinetics of Oral Nicotine Replacement Products - An Exploratory Study in Healthy Volunteers | NCT01228617 |
| A study on implementing a smoking reduction programme through General Practices | A randomised controlled trial testing the feasibility of nicotine assisted reduction to stop in General Practice | ISRCTN03732457 |
| ASCEND: A Study of Cessation using Electronic Nicotine Devices | A three arm single blind parallel group randomised controlled clinical trial to evaluate the efficacy, acceptability, utilisation and safety of an electronic cigarette (ENDS) as a smoking cessation aid (ASCEND) | ACTRN12610000866000 |
| Effects of Nicotine Replacement and Repeated Cue Exposure on Cigarette Craving | Effects of Nicotine Replacement and Repeated Cue Exposure on Cigarette Craving | NCT01329614 |
| Nicotine Treatment of Impulsivity in Parkinson's Disease | Nicotine Treatment of Impulsivity in Parkinson's Disease: A Pilot Study | NCT01216904 |
| Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia | Biological and Behavioral Mechanisms of Smoking in Schizophrenia | NCT01213524 |
| Safety, Tolerability and Efficacy of the Nicotine Patch and Gum for the Treatment of Adolescent Tobacco Dependence | Safety, Tolerability and Efficacy of the Nicotine Patch and Gum for the Treatment of Adolescent Tobacco Dependence | NCT01208935 |
| Smoking Cessation and Reduction With an Electronic Nicotine Delivery Device (ENDD) | Effect of an Electronic Nicotine Delivery Device (ENDD) on Smoking Cessation and Reduction: a Pilot Study | NCT01195597 |
| Nicotine Administration and Post-operative Opioid Use With Bariatric Surgery | A Randomized, Double Blind, Study to Evaluate the Efficacy of Nasal Nicotine Spray to Reduce Post-Operative Opioid Requirements in Nonsmokers in Elective Laparoscopic Bariatric Surgical Patients | NCT01194089 |
| The Effect of Nicotine on Arousal, Cognition and Social Cognition in Schizophrenic Patients | A Double-Blind, Placebo-Controlled, Randomized Three-Way Crossover Study to Investigate The Effect of Nicotine on Arousal, Standard Cognitive Tasks And Social Cognition in Patients With Schizophrenia (Smoking and Non-Smoking) | NCT01186471 |
| Combination of Nicotine Replacement Therapy (NRT) and Varenicline to Increase Cessation of Tobacco (CONVICT Study) | Effects of a Combination of Varenicline and Transdermal Nicotine Patch on Post-quitting Urges to Smoke | NCT01184664 |
| Comparative Pharmacokinetic Study of New Oral Nicotine Replacement Therapy Products. | Comparative Pharmacokinetic Study of New Oral Nicotine Replacement Therapy Products - A Study in Healthy Smokers. | NCT01227720 |
| Multiple-dose Nicotine Pharmacokinetics With Three Oral Nicotine Replacement Products | Multiple-dose Nicotine Pharmacokinetics With Three Oral Nicotine Replacement Products. A Study in Healthy Smokers. | NCT01321931 |
| Effects of Nicotine on Brain Opioid Receptors | Functional Characterization of OPRM1 A118G in Nicotine Dependence: IV Nicotine Study | NCT01040338 |
| Nicotine Lozenge or Tobacco-Free Snuff for Smokeless Tobacco Reduction | A Pilot Study to Compare the Nicotine Lozenge and Tobacco-Free Snuff for Smokeless Tobacco Reduction | NCT01018394 |
| Extinction Based Treatment for Nicotine Dependence | Brain Substrates of Extinction Based Treatment for Nicotine Dependence | NCT00831155 |
| Effect of Smoking, Abstention and Nicotine Replacement Therapy on Wound Healing | Effect of Smoking, Abstention and Nicotine Replacement Therapy on Wound Healing | NCT00825851 |
| Anopen label, randomised, two-way crossover bioequivalence study in healthy sokers of Zonnic 1,5 mg nicotine gum versus Nicorette 4 mg nicotine chewing gum Classic flavour | Anopen label, randomised, two-way crossover bioequivalence study in healthy sokers of Zonnic 1,5 mg nicotine gum versus Nicorette 4 mg nicotine chewing gum Classic flavour | EUCTR2008-007238-23-SE |
| Contingency Management for Smoking in Substance Abusers | Contingent Vouchers for Smoking in Substance Abusers as Adjunct to Nicotine Patch | NCT00807742 |
| Efficacy and safety following use of a novel nicotine replacement therapy. A multicenter, randomized, double blind, placebo-controlled, parallel group, 52-week study in smokers motivated to quit. | Efficacy and safety following use of a novel nicotine replacement therapy. A multicenter, randomized, double blind, placebo-controlled, parallel group, 52-week study in smokers motivated to quit. | EUCTR2008-006845-13-DK |
| Relapse Prevention Study in Newly Abstinent Smokers | A Study to Investigate the Effects of GSK598809 in Newly Abstinent Nicotine-dependent Subjects. | NCT00793468 |
| Preemptive Use of the Nicotine Patch for Postoperative Pain Relief After Open Abdominal Surgery | Preemptive Use of Nicotine Patch for Postoperative Pain Relief in Open Abdominal Surgery | NCT00790829 |
| Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking | Varenicline Versus Nicotine Replacement for Methadone-Maintained Smokers | NCT00790569 |
| Investigation to explore whether there is a synergistic effect between nicotine replacement therapy and guided bodyscanning on cigarette cravings and withdrawal symptoms | Investigation to explore whether there is a synergistic effect between nicotine replacement therapy and guided bodyscanning on cigarette cravings and withdrawal symptoms | ISRCTN52104724 |
| Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine | Study 2: Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine | NCT00777569 |
| Smoking Reduction or Cessation With Nicotine Replacement Therapy | Smoking Reduction or Cessation With Nicotine Replacement Therapy. A Placebo Controlled Double Blind Trial With Nicotine Gum or Inhaler. | NCT00840242 |
| Transdermal Nicotine in Female Patients at High Risk for Post Operative Nausea and/or Vomiting (PONV) | Transdermal Nicotine in Female Patients at High Risk for PONV | NCT00775749 |
| The efficacy of Hypericum perforatum extract (Ze117), nicotine patches and combination Hypericum perforatum/nicotine patches for smoking cessation. | A clinical trial assessing the efficacy and neural mechanisms of Remotiv (Ze117), nicotine patches and combination Remotiv/nicotine patches for smoking cessation. | ACTRN12608000500358 |
| Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study | Topiramate Alone and in Combination With the Nicotine Patch for Smoking Cessation: A Pilot Study | NCT00755716 |
| Nicotine Patches in Reducing Hand-Foot Syndrome in Patients Who Are Receiving Capecitabine For Metastatic Breast Cancer | Pilot Study of Nicotine Patches to Reduce Hand-Foot Syndrome Associated With Capecitabine Chemotherapy in Patients With Metastatic Breast Cancer | NCT00751101 |
| RELIQ Study: Reduced levels of nicotine in cigarettes to increase quitting | A single-blind randomised controlled trial of nicotine-free cigarettes as an adjunct to usual nicotine replacement therapy (NRT)-based cessation practice (patch, gum and/or lozenge), in people who wish to stop smoking. | ACTRN12608000410358 |
| Concurrent Nicotine Patch / Denicotinized Cigarette Therapy for Smoking Cessation II | Concurrent Nicotine Patch / Denicotinized Cigarette Therapy for Smoking Cessation II | NCT00734617 |
| Attention Deficit Hyperactivity Disorder (ADHD) Smoking Cessation Study | Lis-dexamphetamine (LDX/SPD489)as a Treatment for Smoking Cessation in Nicotine Dependent Individuals With ADHD | NCT00736255 |
| Clinical Study of Smoke-Break Liquid Cigarettes | Phase II Study to Measure Effectiveness and to Monitor Side Effects of Smoke-Break Nicotine Delivery Device | NCT00715871 |
| Efficacy of Oral Tobacco Products Compared to a Medicinal Nicotine | Oral Tobacco as a Harm Reduction Product: Study 2 - Efficacy of Oral Tobacco Products Compared to Medicinal Nicotine for Complete Cigarette Substitution and Among Non-abstainers, for Reduction in Cigarette Smoking | NCT00710034 |
| PILOT STUDY ON USAGE PATTERNS OF A NOVEL NICOTINE REPLACEMENT THERAPY - A MULTI-CENTER, OPEN, 3-WEEK RANDOMIZED LOW INTERVENTION STUDY OF TWO DIFFERENT DIRECTIONS FOR USE IN SMOKERS MOTIVATED TO QUIT | PILOT STUDY ON USAGE PATTERNS OF A NOVEL NICOTINE REPLACEMENT THERAPY - A MULTI-CENTER, OPEN, 3-WEEK RANDOMIZED LOW INTERVENTION STUDY OF TWO DIFFERENT DIRECTIONS FOR USE IN SMOKERS MOTIVATED TO QUIT | EUCTR2008-002498-11-GB |
| Study of Nicotine Patches in Patients With Sarcoidosis | Modulation of Pulmonary Sarcoidosis by Nicotinic Acetylcholine Receptors | NCT00701207 |
| Combination Medications vs. Patch Alone for Medically-Ill Smokers | Flexibly-Dosed Combination Pharmacotherapy Versus Standard-Dosed Nicotine Patch Alone for Smokers With Medical Illness | NCT00770666 |
| Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers | Effects of Nicotine on Elements of Attentions in Smokers and Nonsmokers | NCT01034020 |
| Telephone Counseling and the Distribution of Nicotine Patches to Smokers | The Efficacy of Telephone Counseling and the Centralized Distribution of Nicotine Replacement Therapy Through a Smoking Cessation Quitline | NCT00851357 |
| Efficacy of Transdermal Nicotine, on Motor Symptoms in Advanced Parkinson's Disease | Efficacy of Transdermal Nicotine, on Motor Symptoms in Advanced Parkinson's Disease(One Daily Administration).A Controlled Randomised Study, in Two Parallel Groups and Single Blind in 40 Patients. | NCT00873392 |
| Nicotine pharmacodynamics with a new oral nicotine replacement product and NiQuitin Lozenge. A study in healthy smokers. | Nicotine pharmacodynamics with a new oral nicotine replacement product and NiQuitin Lozenge. A study in healthy smokers. | EUCTR2009-015870-36-SE |
| Trial of Nicotine Nasal Spray as an Aid for Smoking Cessation in Schizophrenia | Double-Blind, Placebo-Controlled Trial of Nicotine Nasal Spray as an Aid for Smoking Cessation in Schizophrenia | NCT01010477 |
| A randomised controlled trial of a high intensity smoking intervention for pregnant Indigenous women | The effect of a multifaceted high intensity culturally specific intervention incorporating advice, support and nicotine replacement on smoking cessation rates in pregnant Indigneous women: a randomised controlled trial. | ACTRN12609000929202 |
| Nicotine Vaccination and Nicotinic Receptor Occupancy | 123I-5-IA SPECT Imaging of Nicotinic Receptors and Effects of Nicotine Vaccine | NCT00996034 |
| The Safety of Transdermal Nicotine Immediately Following an Acute Coronary Syndrome | The Safety of Transdermal Nicotine Immediately Following an Acute Coronary Syndrome: The STADIA Pilot Study | NCT00990197 |
| Efficacy and Safety Study of Nicotine Mint Lozenge (2mg and 4mg) in Smoking Cessation | A Multi-center, Randomized, Double-blind, Parallel, Placebo-controlled Clinical Study to Evaluate Efficacy and Safety of Nicotine Mint Lozenge (2mg and 4mg) in Smoking Cessation | NCT00985985 |
| Sensitivity to Intravenous Nicotine: Genetic Moderators | Sensitivity to Intravenous Nicotine: Genetic Moderators | NCT00969137 |
| Cumulative Skin Irritation Potential of a New 25 mg Nicotine Patch | Study on the Cumulative Skin Irritation Potential of a Newly Developed 25 mg Nicotine Transdermal Therapeutic System. A Double Blind, Randomized, Repeat Patch Test, Single Center Study in 42 Healthy Male and Female Subjects | NCT00967174 |
| Cumulative Skin Irritation Potential of a New 15 mg Nicotine Patch | Study on the Cumulative Skin Irritation Potential of a Newly Developed 15 mg Nicotine Transdermal Therapeutic System. A Double Blind, Randomized, Repeat Patch Test, Single Center Study in 42 Healthy Male and Female Subjects | NCT00965913 |
| Photoirritation and Photoallergic Potential of a New Nicotine Patch | Assessment of Photoirritation and Photoallergic Potential of a Newly Developed Nicotine Transdermal Therapeutic System (TTS) After Single and Multiple Application and Multiple UV Exposure in Healthy Subjects. A Standard Photocontact Allergenicity Assay. | NCT00966901 |
| Nicotine Substitute Prescribed at Hourly Intake or ad Libitum for Heavy Smokers Willing to Quit | Use of Nicotine Substitute Prescribed at Hourly Intake or ad Libitum for Heavy Smokers Willing to Quit: a Randomized Controlled Trial | NCT00861276 |
| Skin Sensitization Potential of a New Nicotine Patch | Study on the Skin Sensitization Potential of a New Nicotine Transdermal Therapeutic System (TTS). A Double Blind, Randomized, Repeat Patch Test, Single Center Phase I Study | NCT00967070 |
| Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes | Gender Differences in Response to Nicotine Replacement Therapy and De-Nicotinized Cigarettes | NCT00960778 |
| Nicotine Patch, Blood Flow and Oxidative Stress Study | The Effect Of Nicotine On Indices Of Arterial Function And Oxidative Stress | NCT00954096 |
| Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine | Assessment of High Dose Transdermal Nicotine for Fast Metabolizers of Nicotine | NCT00956943 |
| Highdose Nicotine Patch Therapy for Smokeless Tobacco Use | Highdose Nicotine Patch Therapy for Smokeless Tobacco Use | NCT00939029 |
| Does nicotine improve selective attention more than placebo in healthy volunteers and what does this tell us about mechanisms of attention? | Does nicotine improve selective attention more than placebo in healthy volunteers? | ACTRN12609000511235 |
| Randomised controlled trial of Zonnic and nicotine patch (ZAP) in smoking cessation | Randomised placebo-controlled trial of Zonnic and nicotine patch in heavy smokers for smoking cessation | ACTRN12609000482268 |
| Nicotine inhaler plus nicotine patch for smoking cessation | Pulmonary nicotine inhaler plus nicotine transdermal patch for 6-month smoking cessation in heavy smokers | ACTRN12609000481279 |
| A randomised controlled trial examining the efficacy of a smoking cessation intervention initiated during psychiatric hospitalisation on post-discharge smoking reduction, nicotine dependence and abstinence. | The effect of an integrated smoking care program on the reduction and abstinence of smoking in mental health inpatients following discharge from hospital. | ACTRN12609000465257 |
| A Pilot Study Evaluating Nicotine Lozenges and Self Help | A Pilot Study to Assess the Effectiveness of the Nicotine Lozenge for Smokeless Tobacco Users | NCT00888459 |
| Pharmacogenetics of Nicotine Metabolism in African-Americans | Pharmacogenetics of Nicotine Metabolism in African-Americans | NCT00879918 |
| Varenicline Versus Transdermal Nicotine Patch for Smoking Cessation in Patients With Coronary Heart Disease | Varenicline Versus Transdermal Nicotine Patch for Smoking Cessation in Patients With Coronary Heart Disease: a Pilot Randomized Trial | NCT00959972 |
| E-cigarettes and Cardiovascular Function | Impact on Cardiovascular Function in Smokers Making a Quit Attempt Using E-cigarettes Compared With Smokers Making a Quit Attempt With Prescription Nicotine-Replacement Therapy | NCT03061253 |
| Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age | Low Nicotine Content Cigarettes in Vulnerable Populations: Women of Reproductive Age | NCT04092387 |
| Nicotine Virtual Reality Conditioned Place Preference | Effect of Nicotine on Acquisition and Extinction of a Conditioned Place Preference in a Virtual Reality Environment | NCT06259630 |
| E-cigarette support for smoking cessation: Identifying the effectiveness of intervention components in an online randomised optimisation experiment | An online randomised experiment to identify effective tailored interventions on flavours, device, nicotine strength, and text message support and brief information to assist smokers to stop smoking using e-cigarettes (TASSE) | ISRCTN54776958 |
| Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Students | Multi-method Pilot Study to Evaluate the Interest of Music Therapy Associated to Nicotine Replacement Therapy (NRT) Versus NRT Alone on Craving Related to Smoking Cessation in Students. | NCT05589220 |
| Nicotine Influence on the Retina Following the Use of Electronic Cigarette | Nicotine Influence on Vascularization and Retinal Metabolism Following Electronic Cigarette Use | NCT05801419 |
| Nicotine pharmacokinetics and subjective effects assessment of e-cigarettes(1.8%,4%) compared with conventional cigarettes and nicotine gum in Chinese adult smokers | Nicotine pharmacokinetics and subjective effects assessment of e-cigarettes(1.8%,4%) compared with conventional cigarettes and nicotine gum in Chinese adult smokers | ChiCTR2200063802 |
| Effects on oral health from the usage of ZYN Dry and ZYN Moist nicotine pouches | Effects of two types of nicotine pouch (NP) products on oral health, specifically focusing on dental caries, soft tissues, and periodontal health in current, daily tobacco-based snus users transitioning to NPs | ISRCTN13243849 |
| Investigating the long-term impact of nicotine replacement products on tobacco smoking cessation for low-socioeconomic status smokers | Investigating the long-term impact of nicotine replacement products on tobacco smoking cessation for low-socioeconomic status smokers | ACTRN12622001147774 |
| Messages About Reduced Nicotine in Combusted Tobacco Products | Messages About Reduced Nicotine in Combusted Tobacco Products: An Online Randomized Controlled Trial | NCT05506046 |
| Overcoming Nicotine Dependence to Enable Quitting | A Mechanistic Test of Treatment Strategies to Foster Practice Quitting | NCT05513872 |
| A study to investigate the safety, tolerability and concentration in the blood of nicotine compared between different types of nicotine replacement therapies (NRTs) | A randomised open-label, 3-way crossover, relative bioavailability study of nicotine delivered by an electronic inhaler, Nicorette® Inhalator and Nicorette® QuickMist | ISRCTN17715270 |
| Systemic nicotine uptake and side effect by all-white nicotine pouches | Systemic nicotine uptake and side effect by all-white nicotine pouches - Nicotide Pouches | DRKS00026244 |
| Laser Acupuncture for Smokeless Tobacco Cessation | EFFICACY OF AURICULAR LASER ACUPUNCTURE AND BEHAVIOURAL COUNSELING IN REDUCING NICOTINE DEPENDENCE AMONG DENTAL PATIENTS USING SMOKELESS TOBACCO - A RANDOMIZED CONTROLLED TRIAL - LASC | CTRI/2022/07/044503 |
| Online survey on risk perception, use behavior, and motivation to use among nicotine product users | Online survey on risk perception, use behavior, and motivation to use among nicotine product users - NiQuiz | DRKS00026603 |
| Preloaded Combination Nicotine Replacement Therapy on Smoking Cessation of Adult Population in Kazakhstan | Effectiveness of Preloaded Combination Nicotine Replacement Therapy on Smoking Cessation of Adult Population in Kazakhstan- A Randomized Controlled Trial | NCT05484505 |
| Use of Nicotine to stop tobacco addiction in tuberculosis patients | Effectiveness of Nicotine Replacement inclusive Therapy on Tobacco Cessation of Tuberculosis Patients: An Open Label Before-After Non-Control Quasi Experimental Clinical Trial | CTRI/2022/06/043045 |
| Effect of E-Liquid Flavor on Respiratory Symptoms in People Using Electronic Nicotine Delivery Systems | A Randomized, Parallel-group Open-label Trial of ENDS Users Switching From Flavors of Potentially High-toxicity Profile to Flavors of Potentially Low-toxicity Profile (CRoFT_3.2) | NCT05423340 |
| A study to understand and compare the concentration of nicotine in the blood in healthy male and female participants who are current daily users of any tobacco and/or non-medicinal electronic nicotine delivery products using a Logic compact device with associated e-liquid pods of similar nicotine concentration with and without nicotine salts | A single-centre, single-blinded, randomized, crossover study to assess the nicotine pharmacokinetic profile following the use of two variants of the commercially available e-cigarette logic compact in adult healthy electronic cigarette users | ISRCTN97168882 |
| To compare the two methods counselling alone and nicotine replacement therapy (to replace Tobacco with Nicotine an addictive substance in tobacco) plus counselling in quitting of Tobacco. | Evaluation of abstinence of tobacco use with counselling alone and NRT plus counselling. | CTRI/2022/04/042253 |
| Acute effects of different nicotine applications on small airway stiffness, maximal exercise capacity, and arterial vessel stiffness during and after exercise situations on a bicycle | Acute effects of different nicotine applications on small airway stiffness, maximal exercise capacity, and arterial vessel stiffness during and after exercise situations on a bicycle | DRKS00030564 |
| Exenatide for Smoking Cessation and Prevention of Weight Gain | A Randomized Controlled Trial of Exenatide as an Adjunct to Nicotine Patch for Smoking Cessation and Prevention of Post-Cessation Weight Gain | NCT05610800 |
| Free Samples for Health | Effectiveness of Nicotine Replacement Therapy Sampling in Dental Practices | NCT05627596 |
| Levels of biomarkers of exposure in users of tobacco/nicotine products. | Assessing biomarkers of exposure in plasma and urine in current, daily users of nicotine pouches, tobacco-based snus, or combustible cigarettes, or nonusers of tobacco/nicotine products. | ISRCTN38557348 |
| Use of Nicotine Pouches Among Daily Smokers | Randomized Placebo-controlled Trial of Nicotine Pouches in Smokers | NCT06043362 |
| Treating Caregivers Who Smoke at AFCH | Treating Nicotine Addiction in Caregivers of Children at American Family Children's Hospital | NCT06051474 |
| Comparison of Nicotine Replacement Therapy and Electronic Cigarettes for Smoking Cessation in Pakistan | A Randomized Controlled Trial (RCT) to Compare Efficacy of Nicotine Replacement Therapy (NRT) Versus Electronic Cigarettes (EC) for Quitting Tobacco Smoking in Pakistan | NCT06063421 |
| Nicotine and Pavlovian Bias | Effects of Acute Nicotine Administration on Motivational Mechanisms | NCT06027723 |
| Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine | Comparative Pharmacokinetics and Pharmacodynamics of Synthetic Nicotine | NCT05962229 |
| Effect of orexin system on nicotine addiction and its neural mechanism | Effect of orexin system on nicotine addiction among smokers and its neural mechanism | ChiCTR2300072930 |
| Effect of Orexin System on Nicotine Addiction and Its Neural Mechanism | Effect of Orexin System on Nicotine Addiction Among Smokers and Its Neural Mechanism | NCT05947162 |
| Study on nicotine uptake in smokers using electronic nicotine delivery systems compared to combustible cigarette | A two-part, open label, randomized, controlled, crossover study to characterize nicotine pharmacokinetics of a new generation of JUUL Electronic Nicotine Delivery System (ENDS) device compared to a commercially available ENDS device and the subjects’ usual brand of combustible cigarette | ISRCTN60504239 |
| A study measuring nicotine uptake to the bloodstream from novel tobacco-free oral nicotine pouches compared to combustible cigarettes and nicotine gum | A randomized, open-label, crossover study to characterize nicotine pharmacokinetic parameters following use of novel nicotine-containing products for oral use compared to combustible cigarettes and nicotine gum in healthy adult smokers | ISRCTN53244525 |
| Nicotine Replacement Therapy Sampling for Smokers in the Community | "Building Capacity and Promoting Smoking Cessation in the Community Via ""Quit to Win"" Contest 2023: a Randomised Controlled Trial of 1-week Nicotine Replacement Therapy Sampling" | NCT05881083 |
| Assessing the Use of Nicotine Gum to Decrease Betel Nut Chewing in Saipan | Assessing the Use of Nicotine Gum to Decrease Betel Nut Chewing in Saipan | NCT05758298 |
| A double blind, investigator initiated study of four different Nicotine gums. | A double blind, randomized, five treatment, five period, five way crossover, investigator initiated, comparative bioavailability and craving assessment study of four different Nicotine gums as test formulations (T1, T2, T3, T4) with Paan Masala/Tobacco Mixture as reference (R) in 20 normal, healthy, adult, human tobacco and pan masala chewers under fasting conditions. | CTRI/2023/02/049880 |
| Depressed Mood Improvement Through Nicotine Dosing 3 | Nicotinic Modulation of the Cognitive Control System in Late-Life Depression (R33 Phase) | NCT05746273 |
| Depressed Mood Improvement Through Nicotine Dosing-3 (Depressed MIND3) Extension | Open Label Extension Study of Depressed Mood Improvement Through Nicotine (Depressed MIND3) | NCT05746546 |
| Examining the Impact of Nicotine Pouches in Rural Ohio and Ohio Appalachia | Examining the Impact of Nicotine Pouches in Rural Ohio and Ohio Appalachia | NCT05730439 |
| Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes | Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes | NCT05706701 |
| Electronic Cigarettes and Nicotine Pouches for Smoking Cessation | Electronic Cigarettes and Nicotine Pouches for Smoking Cessation in Pakistan: A Randomized Controlled Trial | NCT05715164 |
| A Study to compare Aromatherapy with nicotine replacement therapy on nicotine dependence for transgenders . | Comparing the effectiveness of indigenous aromatherapy with conventional nicotine replacement therapy for nicotine dependency on transgenders of Pondicherry - ARO | CTRI/2022/12/048385 |
| Impact of E-cigarette Nicotine Concentration on Compensation | Impact of E-cigarette Nicotine Concentration on Compensation, Cigarette Smoking, and Biomarkers of Exposure and Harm in Diverse Smokers | NCT05887947 |
| A single-dose, randomised, crossover study to assess the nicotine pharmacokinetics of oral nicotine products in healthy adult users of smokeless pouch products | Pharmacokinetics study assessing nicotine uptake of nicotine smokeless pouches | ISRCTN12265853 |
| A study to assess the processing of nicotine by the body and subjective effects of oral nicotine products in healthy adult users of cigarettes and smokeless pouch products | A single dose, randomised, crossover study to assess the nicotine pharmacokinetics and product subjective effects of oral nicotine products in healthy adult users of cigarettes and smokeless pouch products | ISRCTN10633589 |
| "Acute Pharmacokinetic and Pharmacodynamic Effects of ""Tobacco-Free"" Oral Nicotine Pouches in Smokers" | "Acute Pharmacokinetic and Pharmacodynamic Effects of ""Tobacco-Free"" Oral Nicotine Pouches in Smokers" | NCT05335915 |
| Effect of immediate vs gradual reduction in nicotine content of cigarettes on smoke behaviors: an ecological momentary assessment study | Effect of immediate vs gradual reduction in nicotine content of cigarettes on smoke behaviors: an ecological momentary assessment study | ChiCTR2100048216 |
| Effect of immediate ruduction in nicotine content of cigarettes vs re-consolidation time window combined with immediate ruduction in nicotine content of cigarettes on Smoke behaviors in patients with COPD | Effect of immediate ruduction in nicotine content of cigarettes vs re-consolidation time window combined with immediate ruduction in nicotine content of cigarettes on Smoke behaviors in patients with COPD | ChiCTR2100048158 |
| Research and Innovation to Stop E-cigarette/Vaping in Young Adults | Young Adult Vaping Cessation: A Randomized Trial Examining Phone Coaching, Text-based Digital Intervention, and Nicotine Replacement Therapy | NCT04974580 |
| Using Nicotine to Reverse Age-related Auditory Processing Deficits | Using Nicotine to Reverse Age-related Auditory Processing Deficits: Human Psychophysics and Electrophysiology | NCT04971954 |
| Evaluation of Different Smoking Cessation Protocols: Nicotine Replacement, Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT) or Hypnotherapy in Cancer Patients Scheduled for Surgery | Pilot Study in Cancer Patients Scheduled for Surgery Evaluating Different Smoking Cessation Protocols : Nicotine Replacement, Motivational Interviewing (MI), Cognitive Behavioural Therapy (CBT) or Hypnotherapy | NCT04899492 |
| Quit Nicotine: E-Cig Cessation Intervention | Quit Nicotine: E-Cig Cessation Intervention | NCT04898075 |
| A study to assess if nicotine delivered via an e-cigarette can have an effect on cognitive function in healthy adult smokers | An exploratory, randomised, crossover study to investigate the effect of nicotine on cognitive function in healthy adult smokers who use an electronic cigarette, after a period of smoking abstinence | ISRCTN35376793 |
| Galantamine for Cognition in People With Schizophrenia | Effect of Nicotine Agonist Galantamine Added to High Potency Medications for Cognitive Function in Patients With Schizophrenia and Schizoaffective Disorder | NCT00320736 |
| The effect of nicotine on Parkinson's disease. | The effect of nicotine rich diet with / without redistribution of dietary protein on motor indices in patients with Parkinson's disease | IRCT20210618051612N1 |
| Acute Effects of Vaping Nicotine on Cognition in Young Adults | Acute Effects of Vaping Nicotine on Reward Processing and Inhibitory Control in Young Adults | NCT04901208 |
| A study to assess markers of exposure and potential harm in users of Lyft nicotine pouch products | A cross-sectional study to assess biomarkers of exposure and biomarkers of potential harm in solus users of Lyft nicotine pouch products | ISRCTN16988167 |
| Smoking, nicotine and pregnancy 2 trial | Impact of the ‘Baby, Me & NRT’ intervention on pregnant women’s adherence to nicotine replacement therapy (NRT): a randomised controlled trial | ISRCTN16830506 |
| COMPARISON OF EFFICACY OF 4MG NICOTINE GUM AND 4MG NICOTINE LOZENGES IN REDUCTION OF TOBACCO CRAVING, WITHDRAWAL SYMPTOMS AND TOBACCO SELF CONTROL RATE AMONG SMOKELESS TOBACCO CHEWERS AGED 20 â?? 35 YEARS IN DAVANGERE â?? A CONCURRENT PARALLEL RANDOMISED CONTROLLED TRIAL. | COMPARISON OF EFFICACY OF 4MG NICOTINE GUM AND 4MG NICOTINE LOZENGES IN REDUCTION OF CRAVING, WITHDRAWAL SYMPTOMS AND TOBACCO ABSTINENCE RATE AMONG SMOKELESS TOBACCO USERS AGED 20 â?? 35 YEARS IN DAVANGERE â?? A CONCURRENT PARALLEL RANDOMISED CONTROLLED TRIAL. | CTRI/2021/03/032000 |
| Study on the kinetics of nicotine metabolism of cigarettes/e-cigarettes in Chinese healthy subjects and the effect of complete/partial replacement of cigarettes with e-cigarettes on human biomarkers, tolerance and satisfaction survey of e-cigaret | Study on the kinetics of nicotine metabolism of cigarettes/e-cigarettes in Chinese healthy subjects and the effect of complete/partial replacement of cigarettes with e-cigarettes on human biomarkers, tolerance and satisfaction survey of e-cigaret | ChiCTR2100044062 |
| A study to assess if nicotine delivered via an e-cigarette can have an effect on appetite in healthy adult smokers | An exploratory randomised crossover study to investigate the effect of nicotine on appetite in healthy adult smokers, who use an e-cigarette, after a period of smoking abstinence | ISRCTN72435551 |
| HARMONY: Harm reduction for Opiates, Nicotine and You. | A trial of the effectiveness of vaporised nicotine products for tobacco smoking cessation amongst NSW opiate agonist treatment clients | ACTRN12621000148875 |
| Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior | Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior | NCT04805515 |
| A study investigating the uptake to the blood circulation and subjective effects of nicotine from tobacco-free nicotine pouches | Nicotine plasma concentrations, pharmacokinetics and pharmacodynamics of single doses of flavored non-tobacco-based nicotine pouches (ZYN ULTRA) in current, daily snus users | ISRCTN66329631 |
| Nicotine salts | Sensory appeal and puffing intensity of e-cigarette use: influence of nicotine salts versus free-base nicotine in e-liquids | NL-OMON20501 |
| A Study of Nicotine Freshmint Mouthspray in E-cigarette Users Willing to Quit | A Multicenter, Parallel group, Double-blind, Placebo-controlled, Randomized, Efficacy and Safety Study of Nicotine Freshmint Mouthspray in E-cigarette Users Willing to Quit - CCSSMC005220 | CTIS2023-505036-35-00 |
| Reduced Nicotine Cigarette Purchasing Decisions | Reduced Nicotine Cigarette Purchasing Decisions | NCT04999644 |
| Using ANDS to Reduce Harm for Low SES Cigarette Smokers | Using Alternative Nicotine Delivery Systems (ANDS) to Reduce Harm for Low SES Cigarette Smokers. (Tri-PEC Study) | NCT05327439 |
| Cigarette and E-cigarette Nicotine Content in an Electronic Tobacco Marketplace (ETM) | The Impact of Cigarette Nicotine Content, E-Cigarette Nicotine Content and E-Cigarette Flavoring on Smoking Behavior in an Electronic Tobacco Marketplace | NCT05320887 |
| Effects of an Oral Nicotine Product in Smokeless Tobacco Users | Effects of an Oral Nicotine Product in Smokeless Tobacco Users | NCT05280769 |
| Systems neuropharmacology of nicotine in aversive learning in humans | Systems neuropharmacology of nicotine in aversive learning in humans - NICO3 | DRKS00025233 |
| The effect of nicotine on cognitive function | The Effect of Nicotine on Cognitive functions and Positive Affection in individual with Mild Cognitive Impairment | IRCT20190418043313N1 |
| Appeal of Nicotine Pouches Versus Cigarettes in the Ohio Appalachia Population | Examining the Appeal of Nicotine Pouches in Ohio Appalachia | NCT05236894 |
| Usage behavior and nicotine kinetics during ad libitum use of tobacco heating systems, e-cigarettes, and tobacco cigarettes | Usage behavior and nicotine kinetics during ad libitum use of tobacco heating systems, e-cigarettes, and tobacco cigarettes - Nicotide 2 | DRKS00024751 |
| Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures | Assessing the Effect of Nicotine Reduction on ENDS User's Addiction and Exposures | NCT05205382 |
| Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type | Comparison of the Substitution Between Different Tobacco/Nicotine Products as a Function of Tobacco-user Type | NCT05177848 |
| Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex | Effects of Nicotine and Attention on Frequency Tuning in Auditory Cortex | NCT05018117 |
| Effects of flavors in oral tobacco-derived nicotine pouches on nicotine exposure | Nicotine plasma concentrations, pharmacokinetics, and pharmacodynamics following single doses of flavored oral tobacco-derived nicotine pouches in current, daily oral tobacco/nicotine users | ISRCTN91637022 |
| IV Pulsed-Nicotine As a Model of Smoking: the Effects of Dose and Delivery Rate | IV Pulsed-Nicotine As a Model of Smoking: the Effects of Dose and Delivery Rate | NCT05176418 |
| ROLE OF NICOTINE GUMS, NICOTINE PATCHES AND BEHAVIOURAL COUNSELLING IN QUITTING TOBACCO HABIT | EFFECTIVENESS OF NICOTINE REPLACEMENT THERAPY AND BEHAVIOURAL INTERVENTION IN TOBACCO CESSATION - A TERTIARY HOSPITAL BASED RANDOMISED CONTROLLED TRIAL | CTRI/2021/10/037366 |
| Impact of Nicotine Messaging on Beliefs and Behavior | Study 2: Impact of Nicotine Messaging on Nicotine Beliefs and Tobacco Use Behavior | NCT05108649 |
| Smoking, Nicotine and Pregnancy 3 Trial | Open-label randomized controlled trial of enhanced support and nicotine replacement therapy (NRT) offered for preloading, lapse recovery and smoking reduction: impact on smoking in pregnancy | ISRCTN84798566 |
| Tobacco quitting therapy with or without m-cessation among Indian smokers | Efficacy of Nicotine replacement therapy in combination with Behavioural counselling & m-cessation as compared to only Behavioural counselling & m-cessation on tobacco abstinence rate among Indian smokers: A Randomized Controlled Trial | CTRI/2021/09/036425 |
| Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study] | Comparing Nicotine Delivery, Subjective Effects, and Sensory Experiences of Tobacco Users Using Oral Nicotine Products and Electronic Cigarettes [ZYN Study] | NCT05030194 |
| Nicotine delivery in venous blood during the use of tobacco heating devices within the acute phase. | Nicotine delivery in venous blood during the use of tobacco heating devices within the acute phase. - Nicotide Heat | DRKS00024596 |
| Treatment for Nicotine Addiction in Women | COMT Inhibition as a Novel Treatment for Nicotine Addiction in Women | NCT02448654 |
| Nicotine Differences in Smokers | Nicotine Discrimination in Smokers | NCT05159934 |
| A study investigating the extraction of nicotine and flavors from tobacco-free nicotine pouches | In vivo extraction of nicotine and flavor compounds from a single dose of non-tobaccobased nicotine pouches (ZYN Moist) | ISRCTN30119403 |
| Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a SMART Study | Effect of Flavored on!® Nicotine Pouch Products on Smoking Behaviors: a Sequential Multiple Assignment Randomized Controlled Trial | NCT06072547 |
| Effectiveness of electronic cigarettes compared with combination nicotine replacement therapy for smoking cessation in patients with chronic obstructive pulmonary disease and effect on lung health (ECAL Trial). | Effectiveness of electronic cigarettes compared with combination nicotine replacement therapy for smoking cessation in patients with chronic obstructive pulmonary disease and effect on lung health (ECAL Trial). | ISRCTN82413824 |
| To understand the Efficacy and safety of Varenicline, Bupropion and Nicotine Replacement Therapy for Smokeless Tobacco Cessation in India: A Randomized Controlled Trial | Evaluating the Effectiveness and safety of Varenicline over Bupropion and Nicotine Replacement Therapy for Smokeless Tobacco Cessation in India: A Randomized Controlled Trial - NIL | CTRI/2025/04/085862 |
| Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy | Clinical Research Evaluating Smoking Cessation With E-Cigarettes and Nicotine Therapy | NCT06948058 |
| Study of the effects of Biperiden drug on reducing the desire to quit smoking | Study of the acute effects of Biperiden on nicotine cravings: double-blind, placebo-controlled study | RBR-7qtvbh3 |
| Combination of Acupuncture, Auricular Acupressure and Nicotine Replacement Therapy for Smoking Cessation | Combination of Acupuncture, Auricular Acupressure and Nicotine Replacement Therapy for Smoking Cessation: A Randomized Controlled Trial | NCT06931054 |
| Comparing nicotine exposure from nicotine pouches and tobacco-based snus: a three-part study. | Examining the effects of nicotine content in nicotine pouches on nicotine exposure under controlled settings and during ad libitum use: a comprehensive three-part study | ISRCTN24482911 |
| Very low nicotine content (VLNC) tobacco use trial | A pilot randomised trial exploring the intentions of people who smoke, to seek illicit tobacco if very low nicotine content (VLNC) cigarettes were the only tobacco available in New Zealand | ISRCTN37490746 |
| Effects of single doses of tobacco-based snus and 3 mg nicotine pouches on plasma nicotine levels, nicotine metabolism, and effects on the body | Effects of single doses of tobacco-based snus and 3 mg nicotine pouches on plasma nicotine, pharmacokinetics, and pharmacodynamics | ISRCTN16677198 |
| Puff vs Pill: Break the Habit Study: Effect of Nicotine Vaping Products vs Varenicline on Smoking Cessation Among People Experiencing Social Disadvantage. | Effect of Nicotine Vaping Product vs Varenicline on Smoking Cessation Among People Experiencing Social Disadvantage: A Randomised Controlled Trial | ACTRN12625000179437 |
| Nicotine Patch Plus Nicotine Mouth Spray Versus Nicotine Reduction for Vaping Cessation | The New Zealand Quit Vaping Trial: Combination Nicotine Replacement Therapy Versus Nicotine Reduction. | NCT06832098 |
| effects of pH on nicotine uptake and risk potential, and systemic inflammation markers after use of nicotine pouches | effects of pH on nicotine uptake and risk potential, and systemic inflammation markers after use of nicotine pouches - Pouches 2 | DRKS00035978 |
| iCanQuit Smoking Cessation Among Hispanic Adults | Providing Nicotine Replacement Therapy to Enhance the Efficacy of a Smoking Cessation Smartphone App for Hispanic Adults | NCT06811038 |
| A comparative study of single doses of tobacco and nicotine pouches on plasma nicotine levels, nicotine metabolism, and effects on the body | A comparative study on the effects of single doses of tobacco-based snus and nicotine pouches: Plasma nicotine concentrations, pharmacokinetics, and pharmacodynamics | ISRCTN86618385 |
| Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation | Combination Nicotine Replacement Therapy, Cytisine, or Varenicline for Smoking Cessation: A Randomized Controlled Trial | NCT06832085 |
| Smoking Cessation for Fathers of Sick Children | mHealth-based Motivational Counselling Integrate With a Sample of Nicotine Replacement Therapy for Fathers of Sick Children Who Smoke Cigarettes: A Pilot Randomized Controlled Trial | NCT07014124 |
| Oral Nicotine Pouches Versus Nicotine Replacement Therapy to Reduce Cigarette Use for Smokers in Rural Appalachia | Testing Oral Nicotine Pouches to Reduce Smoking-Related Cancer in Rural Appalachia | NCT06763536 |
| Study protocol of the U-Niko trial: a cluster randomized controlled trial of a municipal-based tobacco and nicotine cessation intervention among adolescents and young adults | Study protocol of the U-Niko trial: Evaluating the feasibility and efficacy of a cluster randomized controlled trial of a municipal-based tobacco and nicotine cessation intervention among adolescents and young adults | ACTRN12624001470583 |
| Opioids, Low Nicotine Cigarettes, and Chronic Pain | Targeting Reinforcement Mechanisms for Smoking Cessation Using Very Low Nicotine Content Cigarettes in Individuals With Opioid Use Disorder and Chronic Pain | NCT06747871 |
| Assessing the feasibility of using nicotine replacement therapy (NRT) to enable disadvantaged parents to create a smoke-free home | A pilot randomised control trial of an intervention to reduce children’s exposure to second-hand smoke in the home in disadvantaged communities in Scotland | ISRCTN79307718 |
| Evaluation of Acute and Subacute Effects of Nicotine Free Electronic Cigarette(NCFE) Vapors | "EVALUATION OF ACUTE AND SUBACUTE EFFECTS OF NICOTINE FREE ELECTRONIC CIGARETTE (NFEC) VAPORS -Aim 2.1 of ""Adverse Effects of Inhaled Nicotine From Tobacco and E-cigarettes""." | NCT02585791 |
| Effect of Nicotine Replacement Therapy on Delirium and Cognitive Function After Surgery in Tobacco Users: A Double-Blind Randomized Trial | Nicotine Replacement Therapy reduces the incidence of Delirium and Cognitive Dysfunction in Post Operative period in abstinent tobacco smokers: A Double Blind Randomized Controlled Trial - NA | CTRI/2025/05/087578 |
| The Design and Application of an Automatic Detection and Analysis Instrument for Nicotine and Addictive Drugs in Urine | The Design and Application of an Automatic Detection and Analysis Instrument for Nicotine and Addictive Drugs in Urine | ChiCTR2500103515 |
| The effect of oxytocin in smokers with schizophrenia | The effect of oxytocin on nicotine craving, cognitive disorder, clinical symptoms, and sleep quality in smokers with schizophrenia | IRCT20250517065767N1 |
| Homeopathic treatment of nicotine dependence | A double-blind randomized placebo controlled clinical trial evaluating efficacy of anti-craving homoeopathic medicines in nicotine dependence | CTRI/2018/04/013329 |
| Homoeopathic management of nicotine dependence of smokers | Effectiveness Of Individualized Homoeopathic Medicine Selected Through Kents Repertory In The Management Of Nicotine Dependence of Smokers | CTRI/2018/03/012653 |
| A PHASE I , Randomized, Double-Blind, Placebo-Controlled Pharmacokinetic Study of the Chrono Nicotine Replacement Therapy System | A Randomized, Double-Blind, Placebo-Controlled Pharmacokinetic Study of the Chrono Nicotine Replacement Therapy System for adult male smokers | ACTRN12615001287527 |
| Interactive Effects of IV Ethanol and IV Nicotine | A Laboratory Study on the Interactive Effects of IV Ethanol and IV Nicotine on Subjective Effects and Cognition | NCT01814410 |
| Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans | Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans | NCT00616746 |
| A Nicotine Pharmacokinetics and Smoking Behaviour Study Examining Cigarette Ingredients | A Randomised, Controlled, Double-Blind Study to Examine Nicotine Pharmacokinetics and Smoking Behaviour in Healthy Smokers When Smoking Cigarettes Containing Different Commonly Used Ingredients | NCT03272295 |
| Evaluating Selected Constituents in the Exhaled Breath Samples | An Open-Label, Multi-Center Study to Evaluate Selected Constituents in the Exhaled Breath Samples From the Use of JUUL Nicotine Salt Pod System Product (5% and 3% Virginia Tobacco, Mint, Mango, Menthol) Users and Conventional Cigarettes (Non-Menthol and Menthol Flavors) | NCT04143256 |
| Evaluation of the Effectiveness of Routine Nurse Education in Prescribing Nicotine Replacement Therapy for Hospitalized Smokers in a University Hospital | Evaluation of the Effectiveness of Routine Nurse Education in Prescribing Nicotine Replacement Therapy for Hospitalized Smokers in a University Hospital | NCT06789536 |
| Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by ENDS Consumers | A Randomized, Open-Label, Multi-Center, Cross-Over Study of Adult Electronic Nicotine Delivery Systems (ENDS) Consumers to Assess Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With RELX Infinity ENDS | NCT04620616 |
| A Randomized, Single-Blind, Two-Arm, Cross-Over Study to Compare Use of Two Tobacco and Two Menthol Flavor e-Liquids in Electronic Nicotine Delivery System Users | A Randomized, Single-Blind, Two-Arm, Cross-Over Study to Compare Use of Two Tobacco and Two Menthol Flavor e-Liquids in Electronic Nicotine Delivery System Users | NCT05134415 |
| Studies on new nicotine innovation products | Studies on new nicotine innovation products - NicAcc | DRKS00036192 |
| Effect of crocin in cigarette smokers | The effects of crocin on nicotine dependence, depression, anxiety and metabolic biomarkers in cigarette smokers | IRCT20170420033551N11 |
| Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms | Nicotine Reinforcement and Smoking-Cue Reactivity: Association With Genetic Polymorphisms | NCT02921282 |
| An open observational study investigating the effect on oral health when using tobacco free nicotine pods | Oral Safety Study: Open observational study of oral health associated with use of a non-tobacco based nicotine pouch (ZYN®) among current daily snus users | ISRCTN16087707 |
| Low-Dose Galantamine to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine | The Use of Low-Dose Galantamine to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine | NCT02420327 |
| A Study to Help People Quit Smoking. | Cholinergic Enhancement as a Treatment for Nicotine Addiction | NCT01880099 |
| Effect of perioperative high-dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing thoracic surgery: A randomized controlled pilot study. | Effect of perioperative high-dose transdermal nicotine patch on pain sensitivity among male abstinent tobacco smokers undergoing thoracic surgery: A randomized controlled pilot study | ChiCTR2500104070 |
| Characterization of Product Use in Smokers Switching From Cigarettes to a RELX Electronic Nicotine Delivery System | A Randomized, Multi-Center, Open-Label, Parallel-Cohort Study to Characterize Product Use in Smokers Switching From Combustible Cigarettes to a RELX Electronic Nicotine Delivery System (ENDS) | NCT04708106 |
| Comparing the Success of Two Methods to Help People Quit Tobacco in Delhi: Counseling with Nicotine Gum and Health Risk Information vs. Counseling with Nicotine Gum Alone | EFFECTIVENESS OF MOTIVATIONAL TOOL BASED ON BIOMEDICAL RISK ASSESSMENT AS AN ADJUNCT FOR TOBACCO CESSATION TREATMENT AMONG TOBACCO USERS IN DELHI: RANDOMIZED CONTROL TRIAL | TCTR20241130001 |
| Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches | Evaluation of Low and High Nicotine Tobacco Free Nicotine Pouches As a Harm Reducing Substitute for Combustible Cigarettes - (Pack2Pouch) | NCT06678789 |
| A study to characterize nicotine delivery of the JUUL2 electronic nicotine delivery system in adults as compared to a commercially available e-cigarette and combustible cigarette | A two-part, randomized, controlled, crossover study to characterize nicotine pharmacokinetics of the JUUL2 Electronic Nicotine Delivery System (ENDS), in two flavors and two nicotine strengths, compared to a commercially available ENDS product and the subjects’ usual brand of combustible cigarette | ISRCTN29801527 |
| Role of nicotine gum and behavioural counselling in quitting smokeless tobacco habit | Efficacy of nicotine gum for intervention of smokeless tobacco cessation in adults in a dental setting: A randomized control trial - NIL | CTRI/2024/03/064840 |
| Evaluating the Delivery and Effects of THC Vaping Liquids in the Bloodstream | Acute Effects of Sequential Nicotine Vaping on the Pharmacokinetic and Pharmacodynamic Properties of Vaped THC: A Double-Blind, Placebo-Controlled, Randomized Within-Subject Crossover Study | NCT06334016 |
| CSD231005 Nicotine Pouch Biomarkers of Exposure | A Multi Site, Open Label, Parallel Group Study to Assess Changes in Tobacco Related Biomarkers of Exposure Following Switching From Smoking of Combustible Cigarettes to Exclusive Use of Nicotine Pouches in Adult Smokers | NCT06303115 |
| Informing Oral Nicotine Pouch Regulations to Promote Public Health | Informing Oral Nicotine Pouch Regulations to Promote Public Health | NCT06315881 |
| Effectiveness of Combined Tobacco Treatment in Hospitalized Subjects | Effectiveness of Combined Treatment of Bupropion and Nicotine Replacement Therapy in Hospitalized Subjects With Active Smoking in a Reference Center | NCT06254001 |
| Intervention study to find the Nicotine dependence among Smokeless Tobacco users | Effectiveness of Behavioural Intervention on level of Nicotine dependence among Smokeless Tobacco users - NIL/NOT APPLICABLE | CTRI/2024/01/061447 |
| Pharmacokinetics of Miist Nicotine Inhaler in healthy smokers | An open-label Phase 1 study to investigate the pharmacokinetics, safety and tolerability, and pharmacodynamics of nicotine administered in single and multiple inhalations via a novel Miist Nicotine Inhaler in healthy male smokers | ACTRN12623001317684 |
| Plasma nicotine concentrations following single doses of new-format nicotine pouches | Nicotine plasma concentrations, pharmacokinetics, and pharmacodynamics following single doses of nicotine pouches with a new format in current, daily oral tobacco/nicotine pouch users | ISRCTN13589495 |
| Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers | Alternative Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers | NCT06372899 |
| Role of Individualized Homoeopathic Medicines against Daphne Indica in Smokeless Nicotine Dependence. | A Single Blind Randomized Controlled Trial to Compare the Effectiveness of Individualized Homoeopathic Medicines against Daphne Indica in Smokeless Nicotine Dependence | CTRI/2022/06/043134 |
| Two arm, placebo controlled, randomized Clinical Study To Evaluate The Effect Of Nicotine Polacrilex Lozenge 2 mg In healthy human Tobacco Users including smokers. | A Randomized, Double-Blind, Placebo controlled, Two period, Two sequence, Crossover study to evaluate the effect of Test product Nicotine Polacrilex Lozenge 2 mg (Equivalent to Nicotine 2 mg) onUrges for Tobacco Consumption in Healthy Adult Tobacco Users. - NA | CTRI/2023/11/059845 |
| Study to Evaluate Music Therapy and Nicotine Replacement Therapy on Craving Related to Smoking Cessation in Health Staff | Multi-method Pilot Study to Evaluate the Interest of Music Therapy Associated to Nicotine Replacement Therapy (NRT) Versus NRT Alone on Craving Related to Smoking Cessation in Health Staff. | NCT06130423 |
| A Clinical Study To Evaluate The Effect Of Nicotine Polacrilex Gum USP 4 mg In Tobacco Users. | A Randomized, Double-Blind, Placebo controlled, Two period, Two sequence, Crossover study toevaluate the effect of Test product Nicotine Polacrilex Gum USP 4 mg (Equivalent to Nicotine 4 mg) on Urges for Tobacco Consumption in Healthy Adult Tobacco Users. - NA | CTRI/2023/10/058915 |
| A Clinical Study To Evaluate The Effect Of Nicotine Polacrilex Gum USP 2 mg In Tobacco Users. | A Randomized, Double-Blind, Placebo controlled, Two period, Two sequence, Crossover study to evaluate the effect of Test product Nicotine Polacrilex Gum USP 2 mg (Equivalent to Nicotine 2 mg) onUrges for Tobacco Consumption in Healthy Adult Tobacco Users - NA | CTRI/2023/10/058889 |
| Addictive Threshold of Nicotine | Addictive Threshold of Nicotine | NCT06096714 |
| CAN-DOSE Study: Cessation With Augmented Nicotine for Dual Use Of Smoking and E-cigarettes | Comparing the Effects of Augmented Doses of Nicotine Replacement Therapy on Quitting Cigarettes and E-cigarettes | NCT06087328 |
| Nicotine Pharmacokinetic Study of Heated Tobacco and Heated Herbal Products | A Randomised, Cross-Over, Nicotine Pharmacokinetic and Pharmacodynamic Study of Heated Tobacco and Heated Herbal Products Compared With Combustible Cigarettes | NCT06093659 |
| "The ""Quit-for-Kids"" Project: to Increase Abstinence and Protect Children from Tobacco Smoke Exposure" | An Integrated Smoking Cessation Intervention Model of Brief Advice, Nicotine Replacement Therapy and Mobile Health Support for Smoking Parents to Increase Abstinence and Protect Children from Tobacco Smoke Exposure: a Randomized Controlled Trial | NCT06127589 |
| Max Up - Comparing uptake of lung cancer screening and smoking cessation outcomes in Quitline clients receiving 3 months vs 12 months of smoking cessation Nicotine Replacement Therapy and counselling. | Max Up – A randomised controlled trial of biochemically verified smoking cessation abstinence testing 3 months vs 12 months of NRT and counselling in Quitline clients eligible for lung cancer screening who complete a low dose chest CT scan. | ACTRN12623001212640 |
| Effects of E-cigs vs Pouches on Cigarette Smoking and Addiction | Evaluating The Effects Of E-cigarettes Versus Oral Nicotine Pouches and Product Constituents (Menthol Flavor, Nicotine Concentration) On Adult Cigarette Smoking and Addiction | NCT06077240 |
| Understanding Role of Nicotine Vaping Products in Smoking Cessation: A Qualitative Study | Understanding experiences of smokers and ex-smokers use of nicotine vaping products (NVPs) for smoking cessation. | ACTRN12624000506594 |
| Comparison of effectiveness of Bupropion and Nicotine gum for smokers dependent on Opioids | Effectiveness of Nicotine Replacement Therapy (NRT) and Bupropion for Smoking Cessation amongst opioid dependent subjects on agonist maintenance treatment: A Randomized Open-Label, Parallel-Group Trial - NIL | CTRI/2024/05/067468 |
| Addiction Potential of Very Low Nicotine Filtered Little Cigars | Addiction Potential of Very Low Nicotine Filtered Little Cigars | NCT06630728 |
| Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes | A Randomized Controlled Trial of Reduced Nicotine Cigarettes and E-cigarettes Among Dual Users | NCT06614504 |
| Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids | Compensatory Behavior of E-cig Users in Response to Reduced Nicotine E-liquids | NCT06602492 |
| The Options 2 Study | A Randomized Comparative Effectiveness Trial of Nicotine Pouches for Cigarette Substitution: A Question of Public Health | NCT06595459 |
| Effects of Nicotine Pouch Characteristics on Perceptions and Behavior | Effect of Product Characteristics on the Appeal and Sensory Attributes of Nicotine Pouches | NCT06597435 |
| A Clinical Trial to compare the effectiveness of herbal hard candy lozenges and Nicotine lozenges to help in tobacco cessation and healing of tobacco related oral lesions. | Development of a novel innovative herbal formulation to reduce tobacco withdrawal symptoms and promote healing of tobacco related oral lesions. - NIL | CTRI/2024/08/072674 |
| Comparing effect Of Nicotine Replacement Therapy, Laser Therapy and Behavioural Counselling for quitting tobacco -A Parallel Randomized Clinical Trial. | Comparative evaluation of effect Of pharmacotherapy, laser therapy and behavioural counselling on tobacco cessation-A parallel randomized clinical trial. | CTRI/2024/07/071001 |
| A Study on Visual Vs. Standard Nicotine Replacement Therapy for Smokeless Tobacco Users | A Pilot Randomized Controlled Trial Comparing Visually Aided Nicotine Replacement Therapy and Standard Nicotine Replacement Therapy In Smokeless Tobacco Users. - NIL | CTRI/2024/07/070901 |
| The efficacy of transdermal nicotine patches for post-operative pain relief in Arthroscopic Shoulder Surgical patients at Phramongkutklao Hospital | The efficacy of transdermal nicotine patches for post-operative pain relief in Arthroscopic Shoulder Surgical patients at Phramongkutklao Hospital | TCTR20160804001 |
| Effects of Oral Nicotine and Caffeine Pouches on Anaerobic Performance, Autonomic Function, Cognition, and Behavior | Effects of Oral Nicotine and Caffeine Pouches on Anaerobic Performance, Autonomic Function, Cognition, and Behavior | NCT06529055 |
| Abuse Liability and Appeal of Oral Nicotine Products | The Effect of Flavor and Nicotine Strength on the Abuse Liability and Appeal of Oral Nicotine Products | NCT06506162 |
| A clinical study to evaluate the contents of exhaled breath after use of the JUUL2 electronic nicotine delivery system and conventional cigarettes | An open-label, single-center clinical study to evaluate selected chemical constituents in the exhaled breath with the use of the JUUL2 Electronic Nicotine Delivery System (ENDS) and conventional cigarettes | ISRCTN16176441 |
| Galantamine Effects on Nicotine Responses in Smokers | Galantamine Effects on Nicotine Responses in Smokers | NCT01417429 |
| Biomarkers, Smoking Topography, Nicotine Kinetics, and Subjective Smoking Experience with Flavored, Nicotine-Containing HTP Products Based on Rooibos by the Brand glo | Biomarkers, Smoking Topography, Nicotine Kinetics, and Subjective Smoking Experience with Flavored, Nicotine-Containing HTP Products Based on Rooibos by the Brand glo - Nicotide veo | DRKS00034338 |
| Preoperative Nicotine Cessation for Women With Breast Cancer Recommended for Reconstruction | Preoperative Nicotine Cessation for Women With Breast Cancer Recommended for Reconstruction | NCT06461650 |
| Transcranial Magnetic Stimulation for Nicotine Dependence: An Effectiveness-Implementation Trial | Integrating Transcranial Magnetic Stimulation as a Treatment for Nicotine Dependence in the Clinic: A Pragmatic, Hybrid Effectiveness-Implementation Trial | NCT06534047 |
| Motivational interviewing vs Nicotine replacement therapy vs Combination for Smoking Cessation | Effectiveness of three different tobacco smoking cessation interventions among patients visiting a dental institute in Bangalore : A Randomized Clinical Trial - NIL | CTRI/2024/06/068508 |
| A study to assess nicotine pharmacokinetics for heated tobacco products and cigarettes | A single-centre, open-label, randomised, crossover study to assess the nicotine pharmacokinetics following use of heated tobacco products and combustible cigarettes | ISRCTN11517760 |
| A study to characterize nicotine delivery of the JUUL2 electronic nicotine delivery system as compared to a commercially available e-cigarette and combustible cigarette | An open-label, randomized, controlled, crossover study to characterize nicotine pharmacokinetics of the JUUL2 Electronic Nicotine Delivery System (ENDS) in two flavors as compared to a commercially available ENDS product and the subjects’ usual brand of combustible cigarette | ISRCTN34837836 |
| Impact of Low Nicotine Cigarette Messaging on Perceptions and Cigarette Choices | Impact of Low Nicotine Cigarette Messaging on Risk Perceptions and Hypothetical Tobacco and Nicotine Product Choices. | NCT04740008 |
| A study to assess in-the-moment product liking of a heating device with two variants of an alternative non-tobacco, nicotine-containing consumable in healthy adult heated tobacco product users | A randomised, controlled, single-centre, open-label study to assess elements of abuse liability and nicotine pharmacokinetics for a glo heating device with two variants of an alternative non-tobacco, nicotine-containing consumable in healthy adult heated tobacco product users | ISRCTN13625876 |
| A study comparing a 4 mg nicotine gum with a gum without nicotine to understand the effect of nicotine in the body.A study in healthy smokers willing to quit | DOUBLE-BLIND, PLACEBO CONTROLLED STUDY OF PHARMACODYNAMIC EFFECTS OF 4 MG NICOTINE GUM. A STUDY IN HEALTHY SMOKERS WILLING TO QUIT - Redbull Study - CCSSMC000766 | EUCTR2018-004229-10-PL |
| A study to evaluate if providing vape as a smokefree support product to service users in an acute inpatient mental health unit is acceptable to both service users and staff. | Feasibility, acceptability and impact on agitation and aggression of providing nicotine vaporisers in a closed Adult Mental Health Service unit.The eCIMUS study (Use of electronic Cigarettes in Inpatient Mental health service Users who Smoke) | ACTRN12619001128189 |
| A study to examine the delivery of nicotine into the blood of people when they use Juul e-cigarettes with different pod designs | An open label, randomized, controlled, crossover study to measure nicotine pharmacokinetics using the JUUL ENDS with existing and new vaporization pods and a combustible cigarette in healthy adult subjects | ISRCTN18302793 |
| Single-Dose Bioequivalence Study Comparing Two 4 mg Nicotine Lozenges | A Single-Center, Single-Dose, Open-Label, Laboratory-Blind, Randomized, Two-Period Crossover Study to Determine the Bioequivalence of Two Nicotine Resinate Lozenge Formulations Containing Nicotine 4 mg in up to 42 Healthy Male and Female Smokers Under Fasting Conditions | NCT03432312 |
| Single-Dose Bioequivalence Study Comparing Two 2 mg Nicotine Lozenges | A Single-Center, Single-Dose, Open-Label, Laboratory-Blind, Randomized, Two-Period Crossover Study to Determine the Bioequivalence of Two Nicotine Resinate Lozenge Formulations Containing Nicotine 2 mg in up to 42 Healthy Male and Female Smokers Under Fasting Conditions | NCT03432273 |
| Nicotinic Hepatic Metabolism on Neuroreceptor Substrates of Nicotine Addiction | The Influence of Nicotinic Hepatic Metabolism on Neuroreceptor Substrates of Nicotine Addiction | NCT03442413 |
| Vaping High vs. Low Nicotine E-Liquid | Vaping High vs. Low Nicotine E-Liquid | NCT04047836 |
| Low Nicotine Cigarettes Plus Electronic Cigarettes | Randomized Trial of Low Nicotine Cigarettes Plus Electronic Cigarettes in Smokers | NCT04058717 |
| Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use | Feasibility of PET/CT to Detect the Oral/Pulmonary Distribution of Nicotine Following E-cigarette Use | NCT03491059 |
| The QuitNic Study: A pilot study of electronic nicotine devices for smoking cessation with drug and alcohol clients | New solutions for reducing harm of tobacco smoking with highly addicted smokers: A pilot study of electronic nicotine devices for smoking cessation with drug and alcohol clients | ACTRN12617000849392 |
| Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families | Nicotine Patch as an Adjunctive Intervention to Reduce Secondhand Smoke Among NICU Families | NCT04045964 |
| Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes | Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes | NCT04038515 |
| Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women | Project 4, Study 2: Extended Exposure to Low Nicotine Content Cigarettes in Pregnant Women | NCT04033237 |
| Intake behavior of nicotine in venous blood in electric cigarettes in the acute phase | Intake behavior of nicotine in venous blood in electric cigarettes in the acute phase - Nico-Tide | DRKS00017432 |
| Effects of Nicotine Salt Aerosol on Cigarette Smokers | Effects of Nicotine Salt Aerosol on Cigarette Smokers | NCT03974152 |
| A randomized controlled trial of telecare and face to face consultation with CA-F17 based on the standard smoking cessation program for nicotine dependence. | A randomized controlled trial of telecare and face to face consultation with CA-F17 based on the standard smoking cessation program for nicotine dependence. - A randomized controlled trial of telecare and face to face consultation with CA-F17 based on the standard smoking cessation program for nicotine dependence. | JPRN-UMIN000031620 |
| Effects of Prazosin on the Attention-Enhancing Effects of Nicotine | The Effects of Prazosin on the Attention-Enhancing Effects of Nicotine in Healthy Non-Smokers | NCT03416569 |
| A Study to Evaluate Changes in Smokers Using An Oral Tobacco-Derived Nicotine Product | A Randomized, Controlled, Parallel Group Clinical Study of Cigarette Smokers Using an Innovative Oral Tobacco-derived Nicotine Product to Determine Impact on Cigarette Consumption and Biomarkers of Exposure | NCT04079933 |
| REN-Project 2 Cigarette and E-cigarette Nicotine Content and E-liquid Flavors | Project 2: The Impact of Cigarette Nicotine Content, E-cigarette Nicotine Content, and E-cigarette Flavoring on Smoking Behavior | NCT03185546 |
| Electronic Hookah and Endothelial Cell Function | The Effects of Electronic Hookah on Endothelial Cell Function: The Role of Nicotine | NCT04133376 |
| Comparative Effectiveness of Cystine Versus Nicotine Replacement Therapy | Comparative Effectiveness of Cystine Versus Nicotine Replacement Therapy (NRT) in the National Smoking Cessation Program of Mongolia: A Pragmatic Non-Inferiority Trial | NCT04126135 |
| Preferences for Reduced Nicotine Cigarettes in Smokers | PRINCESS Study : Preferences for Reduced Nicotine Cigarettes in Smokers | ACTRN12617000590369 |
| Behavioral Pharmacology of Cannabis and Nicotine | Behavioral Pharmacology of Cannabis and Nicotine | NCT04124432 |
| Cognition and Smoking Relapse (HCS) | Understanding the Role of Cognitive Dysfunction in the Treatment of Nicotine Dependence Among HIV-infected Smokers | NCT03169101 |
| Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to JUUL ENDS | A Randomized, Open Label, Parallel Group Study in Adult Smokers to Evaluate Changes in Biomarkers of Cigarette Smoke Exposure After Switching Either Exclusively or Partly to Using JUUL Electronic Nicotine Delivery Systems With Two Different Nicotine Concentrations | NCT04107779 |
| Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder | Low Nicotine Content Cigarettes in Vulnerable Populations: Opioid Use Disorder | NCT04092101 |
| A Study to Assess the Nicotine Pharmacokinetics, Tolerability and Safety With a New Oral Nicotine Replacement Product in Healthy Japanese Smokers | A Single-dose and Repeated-dose, Open-label, Randomized, Cross-over Study to Assess the Nicotine Pharmacokinetics, Tolerability and Safety With A New Oral Nicotine Replacement Product in Healthy Japanese Smokers. | NCT03398876 |
| Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders | Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders | NCT04090879 |
| A Bioequivalence Study of Two Nicotine Lozenges in Fasting Conditions in Healthy Smokers | A Single Dose Bioequivalence Study of a 2 mg Prototype Mini Nicotine Lozenge vs 2 mg Nicotine Mini Lozenge (Nicorette Minis) Healthy Smokers Under Fasting Conditions | NCT03541044 |
| Study to Characterize Puffing Topography With Use of JUUL Electronic Nicotine Delivery Systems (ENDS) in Adult, Closed-System ENDS Consumers | A Randomized, Open-Label, Cross-Over Study to Characterize Puffing Topography With Use of JUUL Electronic Nicotine Delivery Systems (ENDS) in Adult, Closed-System ENDS Consumers | NCT04088175 |
| Impact of Alternative Nicotine-Delivery Products on Combustible Cigarette Use | Understanding the Real-World Impact of the Use of Three Alternate Nicotine-Delivery Products on Combustible Cigarette Use | NCT04084210 |
| Effectiveness of NRT and Video assisted NRT on tobacco cessation and addiction level among adults attending Deaddiction Clinic AIIMS Rishikesh. | A Randomized Controlled Trial to assess the effectiveness of Nicotine Replacement Therapy and Video Assisted Nicotine Replacement Therapy on Tobacco Cessation and Addiction Level among adults attending Deaddiction Clinic at AIIMS, Rishikesh, Uttarakhand. | CTRI/2019/08/021008 |
| Increasing the dose of nicotine replacement treatment to individual needs | Increasing the dose of Nicotine Replacement Treatment to individual needs: A pilot study | ISRCTN24872175 |
| EFFECTIVENESS OF BEHAVIORAL COUNSELLING VERSUS BEHAVIOURAL COUNSELLING WITH NICOTINE GUM ALONE FOR QUITTING TOBACCO USAGE AMONG TUBERCULOSIS PATIENTS VISITING DOTS CENTRES, DELHI. | EFFECTIVENESS OF TWO METHODS OF TOBACCO CESSATION AMONG TUBERCULOSIS PATIENTS VISITING DOTS CENTRES, DELHI | CTRI/2019/08/020968 |
| A randomized controlled trial of CA-F17 in standard smoking cessation program for nicotine dependence | A randomized controlled trial of CA-F17 in standard smoking cessation program for nicotine dependence - A randomized controlled trial of CA-F17 in standard smoking cessation program for nicotine dependence | JPRN-UMIN000031589 |
| Exploratory research for comparison of E-cigarette liquid mixture smoke with conventional cigarette smoke effects to arterial plasma nicotine concentration and CoHb | Exploratory research for comparison of E-cigarette liquid mixture smoke with conventional cigarette smoke effects to arterial plasma nicotine concentration and CoHb | KCT0002285 |
| Treating Nicotine Addiction | Efficacy of Nicotine Replacement Therapy, Bupropion and Both for Treating Nicotine Addiction | PACTR201904758098529 |
| Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco | Impact of Nicotine Reduction on Adolescent Cigarette Use, Alternative Tobacco Use, and Harm From Tobacco | NCT03860077 |
| Brief Advice, Nicotine Replacement Therapy Sampling and Active Referral (BANSAR) for Smoking Fathers | A Combined Cessation Intervention of Brief Advice, Nicotine Replacement Therapy Sampling and Active Referral (BANSAR) for Smoking Fathers: a Multicenter, Single-blinded, Pragmatic Randomised Controlled Trial | NCT03671707 |
| A study to assess nicotine uptake into the blood from and liking of two tobacco heating products compared to cigarettes and a nicotine replacement therapy | An assessment of nicotine kinetics and liking profiles of two tobacco heating products in comparison to combustible cigarettes and a nicotine replacement therapy | ISRCTN13439529 |
| Effectiveness of Behavioral Counselling with Nicotine Gum versus Behavioral Counselling alone for quitting tobacco usage among patients at a Tobacco Cessation Clinic in Delhi. | Effectiveness of Behavioral Counselling with Nicotine Gum versus Behavioral Counselling among patients visiting Tobacco Cessation Clinic in Delhi: a Randomized Clinical Trial. | CTRI/2018/03/012867 |
| Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers | Does Switching to Nicotine Containing Electronic Cigarettes Reduce Health Risk Markers | NCT03625986 |
| Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes | Measuring Neuroadaptations in Response to Very Low Nicotine Content Cigarettes | NCT03612960 |
| Randomized Trial of Electronic Cigarettes With or Without Nicotine in Smoking Cessation. | A Randomized, Placebo Controlled, Double Blind, Double Dummy, Multicenter Trial Comparing Electronic Cigarettes With Nicotine to Varenicline and to Electronic Cigarettes Without Nicotine. | NCT03630614 |
| Effects of Random Nicotine Delivery on Smoking Cessation | Effects of Random Nicotine Delivery on Smoking Cessation | NCT03674970 |
| Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol | Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol | NCT03580525 |
| The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products | The Role of Nicotine Dose and Route of Delivery in Affecting Adoption of E-cigarettes and Reducing Exposure to Toxic Combustion Products | NCT03492463 |
| Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes | Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes With Characterization of Nicotine Exposure Profiles in Adult Smokers | NCT03559751 |
| Evaluation of Abuse Liability of Very Low Nicotine (VLN) Mentholated Cigarettes | Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Mentholated Cigarettes With Characterization of Nicotine Exposure Profiles in Adult Smokers | NCT03559725 |
| Assessment of the JUUL 5% Nicotine Salt Based ENDS Product, When Used by Current Smokers. | A Five-sequence, Partially Randomized Crossover Pilot Study Comparing Nicotine Pharmacokinetics of a Traditional Tobacco Cigarette and JUUL 5% Nicotine Salt Based ENDS Product, in Healthy Adult Male Smokers | ACTRN12618000849291 |
| Assessment of JUUL 5% nicotine salt based Electronic Nicotine Delivery System (ENDS) products, when used by healthy adult smokers | A Six-sequence, Randomized Crossover Study Comparing Nicotine Pharmacokinetics of Traditional Cigarettes and JUUL 5% Nicotine Salt Based ENDS Products, in Healthy Adult Smokers | ACTRN12618000800224 |
| To Assess the Bioequivalence of the 4mg Prototype Mini Nicotine Lozenge to the Reference Product (Nicorette) in Healthy Smokers | A Single Dose Bioequivalence Study of a 4 mg Prototype Mini Nicotine Lozenge vs 4 mg Nicotine Mini Lozenge (Nicorette Minis) in Healthy Smokers Under Fasting Conditions | NCT03543137 |
| A Study to Assess Changes in Cigarette Consumption During a Switch to Very Low Nicotine Cigarettes | A Longitudinal Ambulatory Study to Assess Changes in Cigarette Consumption and Biomarkers of Exposure During a 6-week Switch to Very Low Nicotine Cigarettes | NCT03571724 |
| Young Adults and Low Nicotine Cigarettes | Young Adults and Low Nicotine Cigarettes | NCT03699865 |
| A study investigating the uptake to the blood circulation of nicotine from tobacco free nicotine pods compared to tobacco-based Swedish snus and American moist snuff | Nicotine plasma concentrations and pharmacokinetics of single doses of non-tobacco-based nicotine pouches (ZYN®) compared with conventional, tobacco-based Swedish snus and American moist snuff among current, daily snus users | ISRCTN77807609 |
| Use of Nicotine Replacement Therapy (NRT) Sample and Brief Smoking Cessation Advice for Recruiting Smokers | Use of Nicotine Replacement Therapy (NRT) Sample and Brief Smoking Cessation Advice for Recruiting Smokers to Smoking Cessation Services and Motivating Quit Attempts | NCT03717051 |
| Effects of Transdermal Nicotine on Response Inhibition to Emotional Cues in Schizophrenia | Effects of Transdermal Nicotine on Response Inhibition to Emotional Cues in Schizophrenia | NCT03838484 |
| Comparing the Effectiveness of Combined NRT With Single NRT in Primary Care Clinics in Hong Kong | Comparing the Effectiveness of Nicotine Patch With Gum Versus Nicotine Patch Alone in Smoking Cessation in Hong Kong Primary Care Clinics | NCT03836560 |
| Cessation and Relapse Prevention (CARP) Trial: Nicotine vaporisers compared to standard nicotine replacement therapy for smoking cessation among people with co-morbidities. | A pragmatic randomised partial crossover clinical trial of nicotine vaporisers added to standard care for smoking cessation and relapse prevention (CARP) among priority populations with comorbidities | ACTRN12618000408280 |
| Comprehensive Ayurvedic Management in Nicotine Addiction. | A Prospective Standard Controlled Clinical Study For Evaluation of Comprehensive Ayurvedic Management in Nicotine based Substance Use Disorder. | CTRI/2019/01/017236 |
| Gender Differences in Switching From Smoking Regular Cigarettes to E-Cigarettes | Gender Differences in Standardized Research E-Cigarette (SREC) Product Use, Acceptability, Reinforcement, and Nicotine Dependence Symptoms | NCT03856515 |
| Cytisine versus nicotine for smoking cessation in hospitalized psychiatric patients. | Cytisine versus nicotine for smoking cessation in hospitalized psychiatric patients. | IRCT20100127003210N16 |
| Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers | Effects of E-Cigarette Power and Nicotine Content in Dual Users and Vapers | NCT03830892 |
| Stop for the Op and stop for life; Can smoking cessation be increased before elective-surgery by an offer of free mailed nicotine replacement therapy (NRT) and Quitline counselling to smokers waiting for surgery? | Reducing cardiovascular risk through smoking cessation before elective surgery. A randomized control trial of mailed nicotine replacement therapy (NRT) and behavioural support and relapse-prevention. | ACTRN12619000032156 |
| A Study to Evaluate the Pharmacokinetic Profiles of Cigarettes and E-Cigarettes With Nicotine Salt Formulations | A Randomized, Open-label, Cross-over Clinical Study to Evaluate the Pharmacokinetic Profiles of Cigarettes and E-Cigarettes With Nicotine Salt Formulations in Adult Smokers | NCT03822546 |
| Smoking quit rates among pulmonary tuberculosis patients undergoing brief advice with or without nicotine replacement therapy | Effectiveness of Smoking Cessation among Pulmonary Tuberculosis Patients Undergoing Directly Observed Therapy Short Course- A Randomized Controlled Trial | CTRI/2018/11/016457 |
| A study to investigate the delivery of nicotine in the blood stream from two variants of e-cigarette devices and a conventional cigarette | A randomised controlled single centre open-label pharmacokinetic study to examine nicotine delivery from different variants of an e-cigarette and a conventional cigarette in healthy subjects | ISRCTN55307091 |
| Varenicline and nicotine replacement therapy for smokers admitted to hospitals | Evaluating the efficacy and safety of varenicline as a sole pharmacotherapy vs. in combination with nicotine replacement therapy (NRT) lozenges in assisting smoking cessation among hospitalised smokers: study protocol for a randomised controlled trial | ACTRN12618001792213 |
| Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy (COMBO) | A Comparison of the Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy Versus Varenicline Alone for Smoking Cessation: a Pilot Study | NCT03722966 |
| United States Pre-Market Tobacco Application Pharmacokinetics | A Randomized, Open-Label, Cross-Over Study to Assess Nicotine Uptake and Subjective Measures With Use of JUUL 5% Electronic Nicotine Delivery Systems (ENDS) Compared to Usual Brand Combustible Cigarettes, a Comparator E-Cigarette, and Nicotine Gum in Healthy Adult Smokers | NCT03719391 |
| Comparing NicoBloc to Nicotine Lozenges | A Pilot Trial Comparing NicoBloc to Nicotine Lozenges: Initial Acceptability and Feasibility Trial | NCT03720899 |
| Pilot Trial of Transnasal Nicotine in Parkinson Disease | Uncontrolled Pilot Trial of Transnasal Nicotine in Parkinson Disease | NCT03865121 |
| A randomized controlled trial of preoperative nicotine patch on postoperative pain in nicotine dependent patients | A randomized controlled trial of preoperative nicotine patch on postoperative pain in nicotine dependent patients | ChiCTR-IOR-17013591 |
| N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers | N-Acetyl Cysteine Plus Behavioral Therapy for Nicotine Dependent Pathological Gamblers | NCT00967005 |
| A Single-Center, Open-Label Pharmacokinetic (PK) Study to Assess the PK Profile of Nicotine Delivered by the Chrono Quit Smoking Solution (CQSS2) | A Single-Center, Open-Label Pharmacokinetic (PK) Study in male smokers to Assess the PK Profile of Nicotine Delivered by the Chrono Quit Smoking Solution (CQSS2) | ACTRN12617001258347 |
| Vaporized Nicotine and Autonomic Control | Vaporized Nicotine and Autonomic Control | NCT04613609 |
| A study to investigate chemical compounds in healthy adults' exhaled breath following e-cigarette use | An exploratory research study to evaluate the concentration of volatile organic compounds in exhaled breath following use of the logic compact e-cigarette and tobacco flavour pod in healthy males and females who are current daily users of any tobacco and/or non-medicinal electronic nicotine delivery products. | ISRCTN83014658 |
| Depressed Mood Improvement Through Nicotine Dosing 2 | Nicotinic Modulation of the Cognitive Control System in Late-life Depression | NCT04433767 |
| Efficacy of Nicotine in Preventing COVID-19 Infection | Efficacy of Nicotine in Preventing COVID-19 Infection | NCT04583410 |
| Feasibility of Electronic Nicotine Devices for Smoking Cessation With Alcohol and Other Drug Treatment Clients | The QuitENDs Study: A Feasibility Pilot Study of Electronic Nicotine Devices for Smoking Cessation With Alcohol and Other Drug Treatment Clients | ACTRN12617000905369 |
| Nurse-led stop smoking service versus standard doctor counselling for Inflammatory Bowel Disease (IBD) patients. | Nurse-led smoking cessation service utilising motivational interviewing and nicotine replacement therapy (NRT) versus standard of care counselling in IBD patients: A pilot study | ACTRN12620000679987 |
| Study of Nicotine for Pain Associated With Chemotherapy-Induced Peripheral Neuropathy | Phase 2 Study of Nicotine for the Treatment of Pain Associated With Chemotherapy-Induced Peripheral Neuropathy | NCT04468230 |
| Effects of Flavors on Nicotine Reinforcement in Smokers | Effects of Flavors on Nicotine Reinforcement in Smokers | NCT03243630 |
| Oral Mucosal Effects In Adult Smokers Associated With Two Nicotine Lozenge Formulations | Randomized, Parallel-Group, Assessor Blind Study To Evaluate Oral Mucosal Effects In Healthy Adult Smokers Associated With 3 Week Use Of Nicotine Bi-tartrate 4mg Mint Lozenges Relative To The Use Of Nicotine Polacrilex 4mg Mint Lozenges | NCT03087786 |
| Changes in Oral Health in Tobacco Cigarettes Smokers After Switching to Combustion-Free Nicotine Delivery Systems | International Randomized Controlled Trial Evaluating Changes in Oral Health in Smokers After Switching to Combustion-Free Nicotine Delivery Systems: SMILE Study Protocol | NCT04649645 |
| A study to find whether laser acupuncture is beneficial for reducing dependence to smoking . | Comparative evaluation of urinary cotinine levels, Fagerstrom test scores before and after treatment with laser acupuncture , counseling and laser acupuncture with counseling for nicotine dependence due to smoking â??A randomized controlled trial | CTRI/2017/08/009317 |
| Do Flavors Increase the Addiction Potential of Nicotine? | Do Flavors Increase the Addiction Potential of Nicotine?: A Pilot Laboratory Study | NCT04696380 |
| Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With Use of RELX ENDS Products by Smokers | A Randomized, Open-Label, Single-Center, Cross-Over Study of Adult Smokers to Assess Nicotine Uptake, Measures of Abuse Liability, and Puffing Topography With RELX Infinity Electronic Nicotine Delivery Systems (ENDS) | NCT04640285 |
| Identification of biomarkers specific to different nicotine product categories | Identification of biomarkers specific to different nicotine product categories - BoEx nicotine product user groups | DRKS00022428 |
| Targeting Mailed Nicotine Patch Distribution Interventions to Rural Regions of Canada | Targeting Mailed Nicotine Patch Distribution Interventions to Rural Regions of Canada: Randomized Controlled Trial | NCT04606797 |
| Smoking by IV Pulsed Nicotine | Modeling Tobacco Smoking by IV Pulsed Nicotine in Smokers | NCT04488744 |
| Effects of Exercise and Nicotine on Cognition in Smokers | The Acute Effects of Moderate Intensity Exercise and Nicotine on Cognition in Smokers | NCT03091699 |
| A study investigating the uptake to the blood circulation of nicotine from tobacco-free nicotine pouches compared to American moist snuff pouches | Nicotine plasma concentrations and pharmacokinetics of single doses of non-tobacco-based nicotine pouches (ZYN Moist and ZYN Dry Mini) and conventional, tobacco-based US moist snuff pouches among current, daily snus users | ISRCTN13527565 |
| Influences of different nicotine applications on peripheral and central hemodynamic as well as on arterial stiffness and endothelial dysfunction | Influences of different nicotine applications on peripheral and central hemodynamic as well as on arterial stiffness and endothelial dysfunction - EZig | DRKS00012919 |
| The Cardiovascular Impacts of Electronic Cigarettes in Comparison to the Use of Nicotine Replacement Patches | The Cardiovascular Impacts of Electronic Cigarettes to the Use of Nicotine Replacement Patches | NCT03358953 |
| Efficacy of nicotine in preventing COVID-19 infection | Efficacy of nicotine in preventing COVID-19 infection - NICOVID-PREV | EUCTR2020-003722-23-FR |
| Nicotine's Potential Abuse With Menthol | Impact of Menthol on the Abuse Potential of Nicotine | NCT04535362 |
| Offering Nicotine Patches to All Households in a Municipality With High Smoking Rates | Offering Nicotine Patches to All Households in a Municipality With High Smoking Rates: Test of an Idea to Promote Large Increases in Tobacco Cessation | NCT04534231 |
| Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Hospitalized Patients | Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Hospitalized Patients | NCT04608201 |
| Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace | "Impact of Very Low Nicotine Content Cigarettes in a Complex Marketplace Part of ""Evaluating New Nicotine Standards for Cigarettes""" | NCT03272685 |
| Nicotine Replacement Therapy, Counseling, Varenicline, and Bupropion for Smoking Cessation, the PISCES I Trial | PISCES I: Precision Implemented Smoking Cessation Evaluation Study | NCT04604509 |
| E-cigarettes, Nicotine Inhaler, and Blood Vessel Function | The Effects of Electronic Cigarettes on Endothelial Function and Oxidative Stress | NCT03072628 |
| Investigating the use of nicotine for treating complications of levodopa therapy in Parkinsons disease | Investigating the role of nicotinic neuromodulation in levodopa-induced dyskinesias â?? a multimodal study. | CTRI/2020/12/029965 |
| To compare the effectiveness of using nicotine chewing gum with behavioral counselling versus doing yoga with behavioral counselling in quitting tobacco among Delhi government bus drivers: Cluster Randomized Trial | Effectiveness of behavioral counselling with nicotine gum versus behavioral counselling with Yoga on tobacco cessation among Delhi Government Bus Drivers: Cluster Randomized Trial - YITC | CTRI/2020/04/024462 |
| Helping pregnant smokers quit: a multi-centre study of electronic cigarettes and nicotine patches | Helping pregnant smokers quit: a multi-centre RCT of electronic cigarette and nicotine patches | ISRCTN62025374 |
| A study to investigate the delivery of nicotine in the bloodstream from three variants of tobacco-free oral pouches (modern oral products), for comparison to four commercial products and a conventional cigarette | A single-dose, randomised, crossover study to assess the pharmacokinetics of oral nicotine products and a cigarette in healthy adults who smoke combustible cigarettes and use smokeless pouch products | ISRCTN17828518 |
| The efficacy and safety of acupuncture and nicotine replacement therapy for smoking cessation: a randomized parallel controlled trial | The efficacy and safety of acupuncture and nicotine replacement therapy for smoking cessation: a randomized parallel controlled trial | ITMCTR2100004361 |
| A study investigating the uptake to the blood circulation and subjective effects of nicotine from tobacco free nicotine pods compared to tobacco based Swedish snus | Nicotine pharmacokinetics and subjective effects of a single dose of a non-tobacco-based nicotine pouch (ZYN®) compared with conventional, tobacco-based Swedish snus among current, daily snus users | ISRCTN14866695 |
| The efficacy and safety of acupuncture and nicotine replacement therapy for smoking cessation: a randomized parallel controlled trial | The efficacy and safety of acupuncture and nicotine replacement therapy for smoking cessation: a randomized parallel controlled trial | ChiCTR2100042912 |
| A three-month Electronic Nicotine Delivery System (ENDS)-based intervention in a homeless context: efficacy, challenges and opportunities | A 3-month Electronic Nicotine Delivery System (ENDS)-based intervention in a homeless context: efficacy, challenges and opportunities | ISRCTN14767579 |
| Addressing Smoking in Sheltered homeless with Intensive Smoking Treatment | A feasibility study examining the safety of varenicline, combination nicotine replacement therapy and counselling in male adult tobacco smokers at risk or experiencing homelessness. | ACTRN12619001564145 |
| Vaporised nicotine products versus nicotine replacement therapy for tobacco smoking cessation among low-socioeconomic status smokers: A randomised controlled trial. | Vaporised nicotine products versus nicotine replacement therapy for tobacco smoking cessation among low-socioeconomic status smokers: A randomised controlled trial. | ACTRN12621000076875 |
| A study to investigate the delivery of nicotine in the bloodstream from seven variants of tobacco-free oral nicotine pouches (Modern oral products), for comparison to a commercial snus product | A multi-centre, randomised, cross-over, pharmacokinetic study of 8 oral nicotine products | ISRCTN18038559 |
| Exposure to nicotine and tobacco products during pregnancy | Maternal exposure to carcinogens, toxicants and nicotine during pregnancy among e-cigarette users, smokers, nicotine replacement therapy users and among those who have never used nicotine or tobacco products | ISRCTN13835237 |
| A study investigating the extraction of nicotine and flavors from tobacco free nicotine pods compared to tobacco based Swedish snus | The in-vivo extraction of nicotine and flavor compounds from a single dose of a non-tobacco-based nicotine pouch (ZYN®) compared with conventional, tobacco-based Swedish snus among current, daily snus users | ISRCTN44913332 |
| Metabolic Syndrome in Diabetic Smokers Using Cigarettes & Combustion-Free Nicotine Delivery Systems | A Randomised Controlled International Multicentre Study Evaluating Changes in Metabolic Syndrome in Smokers With Type 2 Diabetes Mellitus After Switching From Tobacco Cigarettes to Combustion-Free Nicotine Delivery Systems: DIASMOKE Study | NCT04231838 |
| Project NEAT: NicotinE As Treatment for tobacco smoking following discharge from residential withdrawal services. | Project NEAT: A randomized controlled trial to examine the efficacy of Vaporised nicotine products and telephone quit line support compared with nicotine replacement therapy and telephone quit line support when used following discharge from a residential withdrawal services. | ACTRN12619001787178 |
| Effect on nicotine glue in increasing gastric mucus movements after appendectomy surgery | The effect of Nicotine Patch in reducing post Appendectomy Illeus | IRCT2017082535889N1 |
| The effect of nicotine patch on reducing nausea and vomiting and postoperative pain | The effect of nicotine patch on reduction of nausea and vomiting and pain following bile duct surgery using laparoscopic method | IRCT2017092336328N1 |
| Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Intensive Care Unit Patients | Evaluation of the Efficacy of Nicotine Patches in SARS-CoV2 (COVID-19) Infection in Intensive Care Unit Patients | NCT04598594 |
| A study characterizing nicotine uptake to the bloodstream from novel tobacco-free oral nicotine pouches compared to Swedish portion snus and nicotine gum | A randomized, open-label, crossover study to characterize nicotine pharmacokinetic parameters following the use of novel nicotine-containing products (Nordic Spirit) for oral use compared to Swedish portion snus and nicotine gum, in healthy adult snus users | ISRCTN75583947 |
| Concentration Impact Nicotine Salt | Impact of the Nicotine Concentration on the Efficacy of a Nicotine Salt Vape Pod System as Smoking Cessation Tool | NCT04725656 |
| Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study | Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids[SALTVAPE Study] | NCT04231539 |
| Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors | Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors | NCT04258852 |
| The Interaction of Flavor With Nicotine Form in Adult Smokers | The Interaction of Flavor With Nicotine Form in Adult Smokers | NCT04262817 |
| End Nicotine Dependence Clinic | End Nicotine Dependence (END) Clinic | NCT03290430 |
| Smoking Cessation After Acute Coronary Syndrome | Nicotine Replacement Therapy After Acute Coronary Syndrome | NCT03209622 |
| Effect of cash incentives on preoperative nicotine replacement therapy use and smoking cessation before elective surgery. | Effectiveness of Cash incentives on Abstinence of elective Surgery Smokers at Hospitalisation: a randomised feasibility trial. | ACTRN12620000130965 |
| Effects of nicotine on the vision and cognition of nonsmokers | Effects of nicotine gum on early-stage visual processing and cognition in healthy nonsmokers | RBR-46tjy3 |
| Vaporised nicotine products versus oral forms of nicotine replacement therapy (NRT) products for tobacco smoking cessation among low-socioeconomic status (low-SES) smokers | Vaporised nicotine products versus oral forms of nicotine replacement therapy (NRT) products for tobacco smoking cessation among low-socioeconomic status (low-SES) smokers | ACTRN12617001324303 |
| Long-term Effectiveness of Mailed Nicotine Replacement Therapy: A 5-year Follow-up | Long-term Effectiveness of Mailed Nicotine Replacement Therapy: A 5-year Follow-up | NCT03097445 |
| A study to assess the nicotine uptake of three oral nicotine products in healthy adult smokers | Single dose, randomized, crossover study to assess the pharmacokinetics of three oral nicotine products in healthy adult smokers under fasting conditions | ISRCTN65708311 |
| Cigarette Smoking Among Young Adults | Impact of a Reduced Nicotine Standard on Young Adult Appeal for Menthol and Non-menthol Cigarettes | NCT04340947 |
| The Use of AVL-3288 to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine | The Use of AVL-3288 to Potentiate the Attention-Enhancing Effects of Low-Dose Nicotine | NCT03281694 |
| Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking | Impact of Exclusive Use of Low Nicotine Cigarettes on Compensatory Smoking | NCT03311646 |
| Effect of Nicotine Replacement Therapy on abstinent smokers undergoing spine surgery | EFFECT OF NICOTINE REPLACEMENT THERAPY ON PERI-OPERATIVE OPIOID REQUIREMENT IN ABSTINENT TOBACCO SMOKERS UNDERGOING SPINAL SURGERY: A DOUBLE BLIND RANDOMIZED CONTROLLED TRIAL | CTRI/2020/09/027664 |
