IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Gamma-aminobutyric acid receptor subunit alpha-5	Homo sapiens	P31644				8.7 nM	BindingDB
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2	Homo sapiens	P18507\|P31644\|P47870	230 nM\|234 nM				BindingDB
Gamma-aminobutyric acid receptor subunit gamma-1	Rattus norvegicus	P23574		33 nM			BindingDB
Gamma-aminobutyric acid receptor subunit alpha-6	Homo sapiens	Q16445				77.62 nM	BindingDB
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2	Homo sapiens	P18507\|P28472\|Q16445	1500 nM				BindingDB
Sodium- and chloride-dependent taurine transporter	Homo sapiens	P31641	= 354000.0 nM				NPASS
Gamma-aminobutyric acid receptor subunit rho-1	Homo sapiens	P24046	270 nM\|269 nM\|800 nM\|1190 nM\|1000 nM\|339 nM\|340 nM				BindingDB
Gamma-aminobutyric acid receptor subunit alpha-5/beta-2/gamma-2	Homo sapiens		= 230.0 nM\|= 234.42 nM				NPASS
Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2	Homo sapiens		= 3700.0 nM\|= 3715.35 nM				NPASS
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3	Homo sapiens		= 4500.0 nM				NPASS
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/theta	Homo sapiens		= 3400.0 nM				NPASS
Gamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2	Homo sapiens	P18507\|P28472\|P34903	28000 nM				BindingDB
Gamma-aminobutyric acid receptor subunit alpha-3/beta-2/gamma-2	Homo sapiens	P18507\|P34903\|P47870	920 nM\|912 nM				BindingDB
Gamma-aminobutyric acid receptor subunit alpha-3	Homo sapiens	P34903				50.11 nM	BindingDB
Gamma-aminobutyric acid receptor subunit alpha-2/beta-2/gamma-2	Homo sapiens	P18507\|P47869\|P47870	650 nM\|661 nM				BindingDB
Gamma-aminobutyric acid receptor subunit alpha-2	Rattus norvegicus	P23576		22 nM			BindingDB
Gamma-aminobutyric acid receptor subunit alpha-2	Homo sapiens	P47869				22.9 nM	BindingDB
Gamma-aminobutyric acid receptor subunit rho-3	Homo sapiens	A8MPY1				580 nM	BindingDB
Gamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2	Homo sapiens	P14867\|P18507\|P28472	80000 nM				BindingDB
Gamma-aminobutyric acid receptor subunit alpha-4/beta-2/gamma-2	Homo sapiens	P18507\|P47870\|P48169	3715 nM\|3700 nM				BindingDB
Gamma-aminobutyric acid type B receptor subunit 1	Homo sapiens	Q9UBS5	1700 nM				BindingDB
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
Gamma-aminobutyric acid type B receptor subunit 1/2	Homo sapiens	O75899\|Q9UBS5	530 nM	25 nM			BindingDB
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2	Homo sapiens	P14867\|P18507\|P47870	43000 nM\|1800 nM\|1778 nM\|51000 nM\|3700 nM\|3802 nM				BindingDB
Sodium- and chloride-dependent betaine transporter	Homo sapiens	P48065		36000 nM\|17700 nM\|181000 nM\|165959 nM\|27542 nM\|27500 nM\|3890 nM\|17783 nM\|10000 nM			BindingDB
Sodium- and chloride-dependent GABA transporter 3	Mus musculus	P31650		8128 nM\|11482 nM\|33113 nM			BindingDB
Sodium- and chloride-dependent GABA transporter 3	Homo sapiens	P48066		7000 nM\|11000 nM			BindingDB
Sodium- and chloride-dependent GABA transporter 2	Rattus norvegicus	P31646		5000 nM			BindingDB
Sodium- and chloride-dependent GABA transporter 2	Mus musculus	P31649		27542 nM\|7079 nM			BindingDB
Sodium- and chloride-dependent GABA transporter 2	Homo sapiens	Q9NSD5		26000 nM			BindingDB
Sodium- and chloride-dependent GABA transporter 1/GABA transporter 2/GABA transporter 3/betaine transporter	Rattus norvegicus	P23978\|P31646\|P31647\|P48056		2000 nM\|3000 nM			BindingDB
Sodium- and chloride-dependent GABA transporter 1	Rattus norvegicus	P23978		2500 nM\|2600 nM\|2750 nM\|2880 nM\|1800 nM\|2730 nM\|7244 nM\|30200 nM			BindingDB
Sodium- and chloride-dependent GABA transporter 1	Mus musculus	P31648		7244 nM\|5000 nM			BindingDB
Sodium- and chloride-dependent GABA transporter 1	Homo sapiens	P30531		5000 nM\|3000 nM\|3311 nM\|10000 nM			BindingDB
Sigma non-opioid intracellular receptor 1	Rattus norvegicus	Q9R0C9				>10000 nM	BindingDB
Rattus norvegicus	Rattus norvegicus			= 70.0 nM\|= 2600.0 nM\|= 2000.0 nM\|= 8600.0 nM\|= 3600000.0 nM			NPASS
Proton-coupled amino acid transporter 1	Homo sapiens	Q7Z2H8				4000000 nM\|= 4000000.0 nM	BindingDB, NPASS
Platelet glycoprotein VI (GPVI)	Homo sapiens	Q9HCN6			= 41.1 nM		NPASS
Platelet glycoprotein VI	Homo sapiens	Q9HCN6			41 nM		BindingDB
Histone deacetylase	Homo sapiens	Q969S8				= 8190.0 nM	NPASS
Histone deacetylase	Homo sapiens	O15379\|P56524\|Q13547\|Q8WUI4\|Q92769\|Q969S8\|Q96DB2\|Q9BY41\|Q9UBN7\|Q9UKV0\|Q9UQL6				8190 nM	BindingDB
Heat shock factor protein 1	Mus musculus	P38532	>195000 nM\|> 195000.0 nM				BindingDB, NPASS
Gamma-aminobutyric acid type B receptor subunit 1/2		O88871\|Q9Z0U4		40 nM\|17 nM\|60 nM\|30 nM			BindingDB
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus	P62813	10000 nM				BindingDB
GABA-A receptor; alpha-2/beta-3/gamma-2	Homo sapiens	P47869	= 40000.0 nM				NPASS
Gamma-aminobutyric acid (GABA) B receptor 1	Rattus norvegicus					38 nM\|33 nM	BindingDB
GABA transporter	Rattus norvegicus	P48056		= 2000.0 nM\|= 3000.0 nM			NPASS
GABA receptor rho-1 subunit	Homo sapiens	P24046	= 1190.0 nM\|= 800.0 nM\|= 269.15 nM\|= 270.0 nM\|= 1000.0 nM\|= 340.0 nM\|= 338.84 nM				NPASS
GABA receptor gamma-1 subunit	Rattus norvegicus	P23574		= 33.0 nM			NPASS
GABA receptor alpha-2 subunit	Rattus norvegicus	P23576		= 22.0 nM			NPASS
GABA receptor alpha-1 subunit	Rattus norvegicus	P62813	= 10000.0 nM				NPASS
GABA B receptor	Rattus norvegicus	O88871		= 17.0 nM\|= 60.0 nM\|= 30.0 nM\|= 40.0 nM			NPASS
GABA A receptor alpha-4/beta-3/gamma-2	Homo sapiens	P48169	= 50000.0 nM				NPASS
GABA A receptor alpha-4/beta-3/gamma-2	Homo sapiens	P18507\|P28472\|P48169	50000 nM				BindingDB
GABA transporter 1	Homo sapiens	P30531		= 5000.0 nM\|= 3311.31 nM\|= 3000.0 nM\|= 10000.0 nM			NPASS
GABA A receptor alpha-3/beta-2/gamma-2	Homo sapiens	P34903	= 912.01 nM\|= 920.0 nM				NPASS
GABA A receptor alpha-1/beta-1/gamma-2	Homo sapiens	P18505	= 43000.0 nM\|= 42657.95 nM				NPASS
D(2) dopamine receptor	Rattus norvegicus	P61169				>10000 nM	BindingDB
D(1A) dopamine receptor	Rattus norvegicus	P18901				>10000 nM	BindingDB
Cannabinoid receptor 1	Hirudo medicinalis					1000 nM	BindingDB
CB1 cannabinoid receptor-interacting protein 1	Theromyzon tessulatum					1000 nM	BindingDB
Betaine transporter	Homo sapiens	P48065	= 36000.0 nM	= 36000.0 nM\|= 17782.79 nM\|= 25000.0 nM\|= 3981.07 nM\|= 851.14 nM\|= 1548.82 nM\|= 4168.69 nM\|= 16218.1 nM\|= 3630.78 nM\|= 7585.78 nM\|= 5495.41 nM\|= 2187.76 nM\|= 6606.93 nM\|= 5370.32 nM\|= 7943.28 nM\|= 15135.61 nM\|= 5128.61 nM\|= 9549.93 nM\|= 13182.57 nM\|= 7413.1 nM\|= 14125.38 nM\|= 4000.0 nM\|= 1000.0 nM\|= 2000.0 nM\|= 5000.0 nM\|= 17000.0 nM\|= 8000.0 nM\|= 6000.0 nM\|= 3000.0 nM\|= 9000.0 nM\|= 7000.0 nM\|= 16000.0 nM\|= 11000.0 nM\|= 13000.0 nM\|= 10715.19 nM\|= 10232.93 nM\|= 3311.31 nM\|= 27542.29 nM\|= 39000.0 nM\|= 165958.69 nM\|= 181000.0 nM\|= 3890.45 nM\|= 10000.0 nM			NPASS
5-hydroxytryptamine receptor 7	Rattus norvegicus	P32305				>10000 nM	BindingDB
Gamma-aminobutyric acid receptor subunit alpha-1	Homo sapiens	P14867				77.62 nM\|57.54 nM\|21.37 nM	BindingDB
GABA A receptor alpha-2/beta-2/gamma-2	Homo sapiens	P47869	= 660.69 nM\|= 650.0 nM				NPASS
GABA transporter 1	Rattus norvegicus	P23978		= 2600.0 nM\|= 1800.0 nM\|= 2880.0 nM\|= 2150.0 nM\|= 1970.0 nM\|= 1790.0 nM\|= 2500.0 nM\|= 1620.0 nM\|= 2750.0 nM\|= 2120.0 nM\|= 2730.0 nM\|= 1830.0 nM\|= 2640.0 nM			NPASS
GABA transporter 1	Mus musculus	P31648		= 7244.36 nM\|= 5011.87 nM\|= 5000.0 nM\|= 30199.52 nM			NPASS
GABA transporter 2	Rattus norvegicus	P31646		= 5000.0 nM			NPASS
GABA-C receptor	Homo sapiens	P24046			= 1700.0 nM		NPASS
GABA-B receptor 1	Homo sapiens	Q9UBS5	= 1700.0 nM				NPASS
GABA-B receptor	Homo sapiens	O75899	= 530.0 nM	= 25.0 nM			NPASS
GABA-A receptor; anion channel	Rattus norvegicus	Q9ES14		= 128.0 nM\|= 50000.0 nM\|= 33.0 nM\|= 30.0 nM\|= 29.0 nM\|= 18.0 nM\|= 20.0 nM\|= 100.0 nM\|= 15.0 nM\|= 25.0 nM\|= 13.0 nM\|= 24.0 nM		= 25.0 nM\|= 49.0 nM\|= 2100000.0 nM	NPASS
GABA-A receptor; anion channel	Rattus norvegicus	O09028\|P15431\|P18506\|P18508\|P19969\|P20236\|P23574\|P23576\|P28471\|P28473\|P30191\|P62813\|P63079\|P63138\|Q91ZM7\|Q9ES14				= 98.0 nM	NPASS
GABA-A receptor; anion channel	Mus musculus	P16305	= 14300.0 nM				NPASS
GABA-A receptor; anion channel	Homo sapiens	Q16445		= 25.0 nM\|= 1450.0 nM		= 200.0 nM\|= 33.0 nM	NPASS
GABA-A receptor; alpha-6/beta-3/gamma-2	Homo sapiens	Q16445	= 1500.0 nM				NPASS
GABA transporter 2	Homo sapiens	Q9NSD5		= 26000.0 nM			NPASS
GABA-A receptor; alpha-5/beta-3/gamma-2	Homo sapiens	P18507\|P28472\|P31644	3000 nM				BindingDB
GABA-A receptor; alpha-5/beta-3/gamma-2	Homo sapiens	P31644	= 3000.0 nM				NPASS
GABA-A receptor; alpha-2/beta-3/gamma-2	Homo sapiens	P18507\|P28472\|P47869	40000 nM				BindingDB
GABA-A receptor; alpha-1/beta-3/gamma-2	Homo sapiens	P28472	= 80000.0 nM				NPASS
GABA-A receptor; alpha-1/beta-2/gamma-2	Rattus norvegicus	P63138	= 2300.0 nM				NPASS
GABA-A receptor; alpha-1/beta-2/gamma-2	Homo sapiens	P18507	= 1778.28 nM\|= 1800.0 nM\|= 51000.0 nM\|= 3700.0 nM\|= 3801.89 nM				NPASS
GABA-A receptor; agonist GABA site	Homo sapiens	Q16445	= 21100.0 nM\|= 990.0 nM\|= 16500.0 nM				NPASS
GABA transporter 4	Mus musculus	P31650		= 8128.31 nM\|= 11481.54 nM\|= 33113.11 nM			NPASS
GABA transporter 3	Mus musculus	P31649		= 27542.29 nM\|= 7079.46 nM			NPASS
GABA transporter 3	Homo sapiens	P48066		= 7000.0 nM\|= 3981.07 nM\|= 4000.0 nM\|= 1000.0 nM\|= 11000.0 nM			NPASS
GABA-A receptor; alpha-3/beta-3/gamma-2	Homo sapiens	P34903	= 28000.0 nM				NPASS

a curated database

IMPPAT Phytochemical information:
gamma-Aminobutyric acid

Bioactivity information

IMPPAT Phytochemical information: gamma-Aminobutyric acid

Bioactivity information

IMPPAT Phytochemical information:
gamma-Aminobutyric acid