IMPPAT Phytochemical information: 
Piperine
Piperine
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
MDA-MB-231Homo sapiens= 58.45 ug.mL-1NPASS
Leishmania donovaniLeishmadonovani= 752000.0 nM|= 2558000.0 nMNPASS
MCF7Homo sapiens= 99000.0 nM|= 990.0 nM|= 12960.0 nMNPASS
Monoamine oxidase AHomo sapiensP21397= 58980.0 nMNPASS
Leishmania amazonensisLeishmaamazonensis= 14500.0 nMNPASS
Hepatitis B virusHepatitis B virus= 140000.0 nM|= 150000.0 nMNPASS
IMR-32Homo sapiens= 89000.0 nM|= 10190.0 nMNPASS
Histone deacetylase 6Homo sapiensQ9UBN7= 1044.0 nMNPASS
HepatocyteMus musculus= 12000.0 nMNPASS
Monoamine oxidase AMus musculusQ64133= 19000.0 nMNPASS
L929Mus musculus= 42000.0 nMNPASS
Monoamine oxidase ARattus norvegicusP21396= 404.0 nM= 49300.0 nMNPASS
Vanilloid receptorHomo sapiensQ8NER1= 3162.28 nMNPASS
Monoamine oxidase BMus musculusQ8BW75= 3190.0 nMNPASS
Monoamine oxidase BRattus norvegicusP19643= 260.0 nM= 91300.0 nMNPASS
P-glycoprotein 1Homo sapiensP08183= 15500.0 nM|= 74100.0 nMNPASS
PC-3Homo sapiens> 50000.0 nMNPASS
SARS-CoV-2Severe acute respiratory syndrome coronavirus 2> 20000.0 nM|> 19952.62 nMNPASS
SW480Homo sapiens< 200000.0 nMNPASS
Staphylococcus aureusStaphylococcus aureus= 72300.0 nMNPASS
Transient receptor potential cation channel subfamily V member 1Homo sapiensQ8NER13162.28 nMBindingDB
Trypanosoma cruziTrypanosoma cruzi= 7360.0 nM|= 4910.0 nM|= 7310.0 nM|= 5000.0 nM|= 233000.0 nMNPASS
WI-38Homo sapiens= 8800.0 nMNPASS
Monoamine oxidase BHomo sapiensP27338= 483.0 nM|= 1050.0 nMNPASS
HepG2Homo sapiens> 10000.0 nMNPASS
Polyunsaturated fatty acid 5-lipoxygenaseHomo sapiensP0991754000 nMBindingDB
HUVECHomo sapiens= 100000.0 nMNPASS
A549Homo sapiens= 11890.0 nMNPASS
ATP-dependent translocase ABCB1Homo sapiensP0818315500 nM|74100 nMBindingDB
Amine oxidase [flavin-containing] AHomo sapiensP2139758980 nMBindingDB
Amine oxidase [flavin-containing] AMus musculusO75477 Q6413319000 nMBindingDB
Amine oxidase [flavin-containing] ARattus norvegicusP21396404 nM49300 nMBindingDB
Amine oxidase [flavin-containing] BHomo sapiensP27338483 nM|1050 nMBindingDB
Amine oxidase [flavin-containing] BMus musculusQ8BW753190 nMBindingDB
HeLaHomo sapiens= 950.0 nM|= 19210.0 nMNPASS
Arachidonate 5-lipoxygenaseHomo sapiensP09917= 54000.0 nMNPASS
Bel-7402Homo sapiens> 10000.0 nMNPASS
COLO 205Homo sapiens= 46000.0 nMNPASS
Amine oxidase [flavin-containing] BRattus norvegicusP19643260 nM91300 nMBindingDB
Carbonic anhydrase 2Homo sapiensP009182.000e+6 nMBindingDB
HEp-2Homo sapiens= 70000.0 nMNPASS
HCT-116Homo sapiens< 200000.0 nMNPASS
Carbonic anhydrase 1Homo sapiensP009156.0000e+7 nMBindingDB
GABA-A receptor; alpha-1/beta-2/gamma-2Homo sapiensP18507= 52400.0 nMNPASS
GABA-A receptor; alpha-1/beta-2/gamma-2Homo sapiensP14867|P47870|P18507= 5800.0 nMNPASS
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2Homo sapiensP14867|P18507|P4787052400 nMBindingDB
Dihydroorotate dehydrogenaseHomo sapiensQ02127= 880.0 nM= 710.0 nMNPASS
DU-145Homo sapiens> 50000.0 nMNPASS
DLD-1Homo sapiens< 200000.0 nMNPASS
Cathepsin DHomo sapiensP0733942300 nM|= 42300.0 nMBindingDB, NPASS
Dihydroorotate dehydrogenase (quinone), mitochondrialHomo sapiensQ02127880 nM710 nMBindingDB