IMPPAT Phytochemical information: 
Piperine

Piperine
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
curcumin-piperine supplementation in children with none- alcoholic fatty liver diseaseThe effect of curcumin-piperine supplementation on glycemic indices, lipid profiles, anthropometric indices and liver function in children with none- alcoholic fatty liver diseaseIRCT20171107037302N2
Curcumin-piperine supplementation in children with none- alcoholic fatty liver diseaseThe effect of curcumin-piperine supplementation on inflammatory and oxidative stress factors, sonographic findings and symptom of depression, anxiety and stress in children with nonalcoholic fatty liver diseaseIRCT20121216011763N54
Evaluation of the effect of curcumin-piperine supplement in septic patientsEvaluation of the effect of curcumin-piperine supplement on damage indicators in septic patients admitted to the intensive care unitIRCT20201220049774N3
Evaluation of the effect of curcumin-piperine supplement in patients with acute ischemic strokeEvaluation of the effect of curcumin-piperine supplement administration on the severity of injury and function in patients with acute ischemic strokeIRCT20201220049774N4
Effect of Curcumin-Piperine (Compounds from turmeric and pepper) and Probiotics in patients with Knee OsteoarthritisEffect of Curcumin-Piperine and Probiotic Supplementation in patients with Early Knee OsteoarthritisCTRI/2022/07/043621
Effect of curcumin piperine in patients with non-proliferative diabetic retinopathyThe effect of curcumin-piperine supplementation on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy.IRCT20201129049534N5
Evaluation of the patients with severe traumatic brain injury receiving the curcumin-piperine supplementEvaluation of the injury severity and organ dysfunction in patients with severe traumatic brain injury receiving the curcumin-piperine supplementIRCT20201220049774N5
To study the safety of curcumin capsulesAn Open Label Balanced Randomized Single Dose Two Treatment Two Sequence Two Period Two Way Crossover Oral Relative Bioavailability Study Of Curcumin Capsules 200 mg Manufactured By Laila Nutraceuticals Vijayawada India With Curcumin C3 Complex® 1000 mg + Bioperine® (standardized to 95% Piperine) 5 mg Capsules in Healthy Adult Human Male Subjects Under Fasting Conditions - NILCTRI/2023/10/058584
The effect of curcumin on metabolic syndrome in childrenThe effect of curcumin plus piperine on metabolic syndrome in childrenIRCT20181022041407N4
Action of Curcuma Longa and Piperine on the oxidative and inflammatory profile of patients with Inflammatory Bowel Disease: a randomized, double-blind, placebo-controlled studyEffect of supplementation with Curcuma Longa (extract) and Piperine on inflammatory markers, oxidative stress and glycoxidation in patients with Inflammatory Bowel Disease treated at a Teaching Hospital in AlagoaRBR-89q4ydz
Synergistic effect of Combination of curcumin and piperine supplementation as an adjuvant treatment to the usual treatment method using Bevacizumab in patients with neovascular age-related macular degenerationComparing the synergistic effect of Combination of curcumin and piperine supplementation as an adjuvant treatment to the usual treatment method using Bevacizumab in patients with neovascular age-related macular degenerationIRCT20230614058480N1
Absorption and availability of NCT023 extract in blood in healthy volunteersA study to determine comparative bioavailability of NCT023 extracts Vs Curcuma longa extract with Piperine in healthy volunteers. - NILCTRI/2023/10/058565
Comparing the effectiveness of the combination of caffeine, L-theanine and piperin compared to placebo and pure caffeine in increasing attentionInvestigating the effectiveness of capsules containing the combination of caffeine, L-theanine and piperin compared to pure caffeine and placebo in improving attention in healthy peopleIRCT20160306026938N19
The effects of curcumin-piperine supplementation along with manual therapy on Frozen Shoulder PatientsThe effects of curcumin supplementation along with manual therapy on Metabolic Parameters, Inflammatory Markers, Oxidative Stress, and Electromyography in Frozen Shoulder Patients: A Randomized Clinical TrialIRCT20121216011763N64
Effect of curcumin-piperine supplementation on nthropometric indexes in hemodialysisEvaluation of the effect of curcumin-piperine supplementation on anthropometric indexes and handgrip in patients undergoing hemodialysis: a double-blind clinical trial studyIRCT20240809062699N1
Evaluation of the effects of curcumin-piperine in reducing Pseudomonas infection and improving clinical outcome in patients with cystic fibrosisEvaluation of the effects of curcumin-piperine in reducing Pseudomonas infection and improving clinical outcome in patients with cystic fibrosisIRCT20221229056976N1
Evaluation of the effect of curcumin-piperine in the treatment of rheumatoid arthritisThe effect of curcumin-piperine supplementation on inflammatory factors and clinical signs in patients with rheumatoid arthritis: a double-blind clinical trial studyIRCT20121216011763N53
Curcumin and Piperine in Patients on Surveillance for Monoclonal Gammopathy, Smoldering Myeloma or Prostate CancerEfficacy of Curcumin and Piperine in Patients on Active Surveillance for Either Monoclonal Gammopathy of Unknown Significance (MGUS), Low-risk Smoldering Multiple Myeloma (SMM) or Early Stage Prostate Cancer: A Pilot StudyNCT04731844
Evaluation of the effect of curcumin in coronary hospitalized patientsEvaluation of the effect of curcumin-piperine supplementation in patients with coronavirus admitted to the intensive care unit (ICU): a double-blind clinical trial studyCommunity Verified iconIRCT20121216011763N52
The impact of the herbal compound of Turmeric- Black pepper and ginger extract on Sudden sensorineural hearing loss in diabetic patientsThe impact of the herbal compound of corcomin- piperin and gingerol on Sudden sensorineural hearing loss in diabetic patients referred to Tehran Amir Alam and Khomeini HospitalsIRCT2017012332132N1
Studying the influence of curcumin and piperine on tamoxifen exposureThe effects of curcumin and piperine on the pharmacokinetics of tamoxifen in patients with breast cancer ¡®the ELDORADO study¡¯NL-OMON25193
The effect of curcumin and piperine on tamoxifen metabolism in patients breast cancer ‘the ELDORADO study’The effect of curcumin and piperine on the pharmacokinetics of tamoxifen in patients with estrogen receptor positive breast cancer ‘the ELDORADO study’EUCTR2016-004008-71-NL
Comparison of Piperine, Vitamin E, and Piperine with Vitamin E Oral Capsules Effects on Premenstrual SyndromeComparison of Piperine, Vitamin E, and Piperine with Vitamin E Oral Capsules Effects on Premenstrual Syndrome among Dormitory StudentsIRCT201508022172N19
Curcumin and Piperine in Reducing Inflammation for Ureteral Stent-Induced Symptoms in Patients With CancerPhase 1 Pilot Study of Curcumin and Piperine to Derive a Safe, Optimal Biologic Dose for Ureteral Stent-Induced Symptoms in Cancer PatientsNCT02598726
"""Turmeric as an additive agent to treat Fibrosis of cheeks""""""Evaluate the efficacy of Curcumin & Piperine as an antioxidant adjuvant to intralesional dexamethasone injections in the management of Oral Submucous Fibrosis"""CTRI/2015/07/006001
Piperine effect on caffeine salivary concentrationThe role of piperine on the salivary concentration of caffeine as a main CYP1A2 probeIRCT201209239271N3
Combination therapy in vitiligoThe effect of topical piperine combined with narrow band UVB on vitiligo treatment: A clinical trial studyIRCT2016061527802N2
The effect of piperine on Midazolam concentrationThe role of piperine on Midazolam plasma concentration in healthy volunteersIRCT201203129271N1
Effect Of Piperine In Patients With Oropharyngeal DysphagiaEffect of Natural Agonists of TRPV1 in the Treatment of Functional Oropharyngeal Dysphagia in Neurological Diseases and the Elderly: PiperineNCT01383694
Resveratrol With or Without Piperine to Enhance Plasma Levels of ResveratrolA Randomized, Double-Blind Pilot Trial of Resveratrol With or Without Piperine to Enhance Plasma Levels of ResveratrolNCT01324089
The effects of curcumin-piperne supplementation on CABG patientEvaluation of the effectiveness of curcumin-piperine supplementation on inflammatory factors, cardiac biomarkers, atrial fibrillation and clinical outcomes after coronary artery bypass graft surgery (CABG): A randomized double-blind, placebo-controlled, dose–response studyIRCT20201129049534N4
Cerebral Blood Flow Effects of Resveratrol and Piperine in HumansEffects of Resveratrol Alone or in Combination With Piperine on Cerebral Blood Flow Parameters and Cognitive Performance in HumansNCT01331382
Evaluation of the effect of curcumin in improving patients with covid -19Investigating the effect of curcumin-piperine supplementation in accelerating the recovery period of patients with covid-19IRCT20200514047445N1
Investigating the effect of curcumin-piperine supplementation on interleukin 6 and oxidative stress index in diabetic nephropathy patientsInvestigating the effect of curcumin-piperine supplementation on interleukin 6 and oxidative stress index in diabetic nephropathy patientsIRCT20230823059232N2
Evaluation the effect of curcumin-piperine supplementation on Oxidized LDL and oxidative stress index in patients with type 2 diabetic with high LDLEvaluation the effect of curcumin-piperine supplementation on Oxidized LDL and oxidative stress index in patients with type 2 diabetic with high LDLIRCT20230823059232N1
Comparative evaluation of the effect of Risorine in Patients with Newly Diagnosed Sputum Smear Positive Pulmonary Tuberculosis:Efficacy and Safety Study of Risorine (FDC of Rifampicin 200mg + Isoniazid 300mg + Piperine 10mg) in Patients with Newly Diagnosed Sputum Smear Positive Pulmonary Tuberculosis: a Randomized, Single-blind, Comparative Clinical TrialCTRI/2012/06/002742
To study the effect of 3 different formulations of curcumin (Any one of the 3 curcumin formulations - 1.CONVENTIONAL, 2.SELF NANO EMULSIFYING, AND 3. With PIPERINE FORMULATION) taken as add-on therapy for a period of 90 days in Hyperlipidemic patients on the levels of Lipid profile.A randomised placebo control comparative study of 3 Curcumin formulations (1.Conventional Curcumin, 2.Self Nano emulsifying Curcumin, and 3.Curcumin with Piperine formulation) as an Add-on therapy in Hyperlipidemic human patients and evaluating their effect on the Lipid profile.CTRI/2018/09/015714
Effect of curcumin-piperine supplementation on inflammatory markers in hemodialysisEvaluation of the effect of curcumin-piperine supplementation on inflammatory markers in Patients on Hemodialysis: a double-blind clinical trial studyIRCT20240809062699N3
Effect of Curcumin-Piperine in Fatty LiverThe effect of Curcumin-Piperine supplementation on cardiometabolic factors, hepatic steatosis and fibrosis of fibroscan results and liver function in patients with non-alcoholic fatty liver disease: a randomized double-blind clinical trialIRCT20121216011763N42
Effect of curcumin-piperine in patients with ischemic strokeThe effects of curcumin-piperine supplementation on inflammatory, oxidative stress and metabolic indicators in patients with ischemic stroke in the rehabilitation phase: a double-blind clinical trial studyIRCT20121216011763N48
Effect of Curcumin-Piperine in moderate-to-high hepatic steatosisThe effects of curcumin plus piperine supplementation on cardiometabolic risk factors and fibroscan findings in patients with moderate-to-high hepatic steatosis : a randomized double blind placebo-controlled trialIRCT20121216011763N47
Effect of curcumin-piperine in patients with coronavirus (COVID-19)Effect of curcumin-piperine supplementation on disease duration, severity and clinical signs, and inflammatory factors in patients with coronavirus (COVID-19): A randomized, double-blind, placebo-controlled clinical trial studyIRCT20121216011763N46
Influence of Piperine on the bioavailability of epicatechin and epigallocatechin - a pilot studyInfluence of Piperine on the bioavailability of epicatechin and epigallocatechin - a pilot study - E-Pip-PilotDRKS00020741
Effect of curcumin-piperine supplementation on oxidative stress in hemodialysisEvaluation of the effect of curcumin-piperine supplementation Oxidative Stress markers in Patients on Hemodialysis: a double-blind clinical trial studyIRCT20240809062699N2
The effect of curcumin-piperine dietary supplement in people with type 2 diabetes and hypertriglyceridemiaThe effect of curcumin-piperine dietary supplement on lipid profile, glycemic, inflammatory and blood pressure indicators in people with type 2 diabetes and hypertriglyceridemia: randomized double-blind clinical trialIRCT20121216011763N50
Evaluation of the effect of curcumin piperine supplementation in patients with sepsis admitted to the intensive care unit (ICU): a double-blind randomized controlled clinical trialThe effect of curcumin piperine supplementation on inflammation, length of stay, and 28-day mortality in patients with sepsis admitted to the intensive care unit (ICU): a double-blind randomized controlled clinical trialIRCT20150613022681N4
Effect of piperine supplement in patients with non alcoholic fatty liver diseaseInvestigation of the effect of piperine supplement on anthropometric indices, ultrasonographic findings, biochemical parameters and quality of life in patients with nonalcoholic fatty liver diseaseIRCT20180802040678N2
Effect of TABATA and Piperine and Capsaicin on Nitric Oxide and Creatine KinaseComparison of the effect of Piperine and Capsaicin on Nitric Oxide and Creatine Kinase after 8 weeks Tabata bodybuilding execrciseIRCT20171210037809N3
3 PERIOD FASTING STUDY IN HEALTHY, ADULT, MALES, RANDOMLY DOSED IN EACH PERIOD WITH 2000mg OF CURCUMINOIDS FROM LIQUID CURCUMIN or with CURCUMINOID POWDER WITH TURMERIC ESSENTIAL OIL IN VEGETARIAN CAPSULES OR WITH CURCUMINOID POWDER WITH PIPERINE IN VEGETARIAN CAPSULESAn open-label, balanced, randomized, single-dose, three-treatment, three-period, three-sequence, three-way crossover, oral relative bioavailability study of 2000mg of Curcuminoids from Liquid Curcumin of Halcyon Bioscience Pty Ltd, Sydney, Australia with 2000mg of Curcuminoids from reference product 1 (R1) - Curcuminoid Powder with Turmeric essential oil in vegetarian capsules and 2000mg of Curcuminoids from reference product 2 (R2) - Curcuminoid powder with Piperine in vegetarian capsules in normal, healthy, adult, human male subjects under fasting condition. - NACTRI/2019/04/018513
The effect of curcumin on rheumatoid arthritisThe effect of curcumin-piperine supplementation on anthropometric indices and clinical signs in patients with rheumatoid arthritis A double-blind clinical trial studyIRCT20120701010149N3
Effect of Piperine on the antibiotic AmikacinEvaluation of piperine as a possible bio-enhancer on the pharmacokinetic profile of amikacin: A randomized controlled clinical trialCTRI/2019/09/021031