IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
Plasmodium berghei	Plasmodium berghei			= 20000.0 nM			NPASS
Pancreatic triacylglycerol lipase	Sus scrofa	P00591		>100000 nM\|> 100000.0 nM			BindingDB, NPASS
PC-3	Homo sapiens			= 50000.0 nM\|= 65170.0 nM\|= 68600.0 nM			NPASS
PANC-1	Homo sapiens			= 87000.0 nM			NPASS
Ornithine decarboxylase	Homo sapiens	P11926		26000 nM\|= 26000.0 nM			BindingDB, NPASS
Oxysterols receptor LXR-beta	Homo sapiens	P55055		22000 nM			BindingDB
Oxysterols receptor LXR-alpha	Homo sapiens	Q13133		31000 nM			BindingDB
No relevant target				= 10160.0 nM\|= 88770.0 nM\|= 1230730.0 nM			NPASS
P-glycoprotein 1	Homo sapiens	P08183			= 26302.68 nM		NPASS
Neuraminidase	InflueA virus (strain A/Puerto Rico/8/1934 H1N1)	P03468		77100 nM\|77700 nM			BindingDB
RAW	Mus musculus			= 18100.0 nM			NPASS
Prostaglandin G/H synthase 1	Homo sapiens	P23219		80000 nM			BindingDB
Proteasome Macropain subunit MB1	Homo sapiens	P28074		= 9260.0 nM\|= 65000.0 nM			NPASS
Proteasome subunit beta type-5	Homo sapiens	P28074		9260 nM\|65000 nM			BindingDB
Protein kinase C alpha	Homo sapiens	P17252		> 100000.0 nM			NPASS
Protein kinase C alpha type	Homo sapiens	P17252		1.5e+4 nM\|>100000 nM			BindingDB
Protein kinase Pfmrk	Plasmodium falciparum	P90584		= 93000.0 nM			NPASS
Proto-oncogene tyrosine-protein kinase Src	Homo sapiens	P12931		>10000 nM\|>100000 nM\|75000 nM			BindingDB
RAC-alpha serine/threonine-protein kinase	Homo sapiens	P31749		>70000 nM			BindingDB
Neuraminidase	InflueA virus (A/WSN/1933(H1N1))	P03470		83300 nM\|134400 nM\|77100 nM			BindingDB
Plasmodium falciparum	Plasmodium falciparum			= 38200.0 nM\|= 4.1 ug.mL-1\|= 2.0 ug.mL-1			NPASS
Neuraminidase	InflueA virus (A/Puerto Rico/8/1934(H1N1))	P03468		= 20.84 ug.mL-1			NPASS
Maltase-glucoamylase	Homo sapiens	O43451		2610 nM\|10400 nM\|= 10400.0 nM\|= 2610.0 nM		10400 nM\|= 10400.0 nM	BindingDB, NPASS
NON-PROTEIN TARGET			= 99600.0 nM\|= 44480.0 nM\|= 28.0 nM\|= 97000.0 nM\|= 403000.0 nM	= 300000.0 nM\|= 47000.0 nM\|= 11000.0 nM\|= 183900.0 nM\|= 489000.0 nM\|= 0.54 ug.mL-1\|= 6.99 ug.mL-1\|= 6720.0 nM\|= 690.0 nM			NPASS
K562	Homo sapiens			= 17560.0 nM			NPASS
KOPN-8	Homo sapiens		> 86206.9 nM				NPASS
LN-229	Homo sapiens			= 44000.0 nM			NPASS
LNCaP	Homo sapiens			= 30650.0 nM\|= 37400.0 nM\|= 24000.0 nM\|= 31700.0 nM\|= 10000.0 nM			NPASS
LXR-alpha	Homo sapiens	Q13133		= 31000.0 nM			NPASS
LXR-beta	Homo sapiens	P55055		= 22000.0 nM			NPASS
Leishmania donovani	Leishmadonovani			= 73000.0 nM			NPASS
LoVo	Homo sapiens			= 15880.0 nM			NPASS
MCF7	Homo sapiens			= 15100.0 nM\|= 77000.0 nM\|= 11000.0 nM\|> 30000.0 nM\|= 1000.0 nM\|= 62710.0 nM\|= 50.0 nM			NPASS
MDA-MB-231	Homo sapiens			= 43000.0 nM			NPASS
Neuraminidase	InflueA virus	B4URF0		= 77100.0 nM\|= 134400.0 nM\|= 83300.0 nM			NPASS
MO15-related protein kinase Pfmrk	Plasmodium falciparum			93000 nM			BindingDB
Melan-a	Mus musculus			= 57830.0 nM			NPASS
Mitogen-activated protein kinase 14	Homo sapiens	Q16539		6.14e+4 nM			BindingDB
Monoamine oxidase	Bos taurus			= 95000.0 nM			NPASS
Monoamine oxidase	Homo sapiens	P27338		= 900.0 nM			NPASS
Monoamine oxidase A	Homo sapiens	P21397		= 2520.0 nM\|= 3900.0 nM\|= 9700.0 nM			NPASS
Monoamine oxidase A	Rattus norvegicus	P21396		= 40000.0 nM			NPASS
Monoamine oxidase B	Homo sapiens	P27338		= 6800.0 nM\|= 4100.0 nM\|= 6810.0 nM\|= 650.0 nM			NPASS
Mus musculus	Mus musculus			> 100000.0 nM			NPASS
NCI-H460	Homo sapiens			= 47000.0 nM			NPASS
NIH3T3	Mus musculus			= 24000.0 nM			NPASS
RAW264.7	Mus musculus			= 26500.0 nM\|= 26000.0 nM\|= 19100.0 nM\|> 50000.0 nM\|= 11400.0 nM\|> 1000.0 nM			NPASS
Radical scavenging activity				> 1000.0 nM			NPASS
Solute carrier family 2, facilitated glucose transporter member 4	Mus musculus	P14142		= 20000.0 nM			NPASS
SEM	Homo sapiens		= 59338.0 nM				NPASS
Tyrosine-protein kinase ABL1/ABL2	Homo sapiens	P00519\|P42684		>10000 nM			BindingDB
Tyrosine-protein kinase BMX	Homo sapiens	P51813		= 67990.0 nM			NPASS
Tyrosine-protein kinase CSK	Homo sapiens	P41240		>5.0e+4 nM			BindingDB
Tyrosine-protein kinase FYN	Homo sapiens	P06241		= 58180.0 nM			NPASS
Tyrosine-protein kinase Fyn	Homo sapiens	P06241		58180 nM			BindingDB
Tyrosine-protein kinase SRC	Homo sapiens	P12931		> 10000.0 nM\|= 75000.0 nM\|> 100000.0 nM			NPASS
Tyrosine-protein kinase SYK	Homo sapiens	P43405		39000 nM\|= 39000.0 nM			BindingDB, NPASS
U-87 MG	Homo sapiens			= 55000.0 nM			NPASS
U-937	Homo sapiens			> 100000.0 nM\|= 72000.0 nM\|= 48000.0 nM			NPASS
UoC-B1	Homo sapiens		= 35695.8 nM				NPASS
Vero	Chlorocebus aethiops			= 32900.0 nM			NPASS
Voltage-dependent L-type calcium channel subunit alpha-1C	Cavia porcellus	O35505		20000 nM\|= 20000.0 nM			BindingDB, NPASS
Voltage-dependent L-type calcium channel subunit alpha-1C	Rattus norvegicus	P22002		11000 nM			BindingDB
Voltage-gated L-type calcium channel alpha-1C subunit	Rattus norvegicus	P22002		= 11000.0 nM\|= 57500.0 nM			NPASS
WiDr	Homo sapiens			= 27700.0 nM			NPASS
Xanthine dehydrogenase	Bos taurus	P80457		= 1730.0 nM			NPASS
Xanthine dehydrogenase	Homo sapiens	P47989		= 232500.0 nM\|> 1000000.0 nM\|= 3530.0 nM			NPASS
Xanthine dehydrogenase/oxidase	Bos taurus	P80457		1730 nM			BindingDB
Xanthine dehydrogenase/oxidase	Homo sapiens	P47989		232500 nM\|>1000000 nM			BindingDB
cAMP-dependent protein kinase catalytic subunit alpha	Homo sapiens	P17612		>1.00e+5 nM			BindingDB
Isoform 1 of Steroid hormone receptor ERR2 (ERRbeta2-delta10)	Homo sapiens	O95718		395 nM			BindingDB
Tyrosine-protein kinase ABL1	Homo sapiens	P00519		3.9e+4 nM\|10000 nM			BindingDB
Tyrosine-protein kinase ABL	Homo sapiens	P42684		> 10000.0 nM			NPASS
Tyrosine-protein kinase ABL	Homo sapiens	P00519		= 10000.0 nM			NPASS
Tyrosinase	Mus musculus	P11344		>500000 nM\|> 500000.0 nM			BindingDB, NPASS
SK-BR-3	Homo sapiens			= 96700.0 nM			NPASS
SK-MEL-2	Homo sapiens			= 36000.0 nM			NPASS
SUP-B15	Homo sapiens		> 86206.9 nM				NPASS
Serine/threonine-protein kinase AKT	Homo sapiens	P31749		> 70000.0 nM			NPASS
Serotonin 2a (5-HT2a) receptor	Homo sapiens	P28223		= 10469.0 nM		= 2991.0 nM	NPASS
Serotonin 2c (5-HT2c) receptor	Homo sapiens	P28335		= 14910.0 nM		= 7806.0 nM	NPASS
Sex hormone-binding globulin	Homo sapiens	P04278			39811 nM		BindingDB
Sialidase	Clostridium perfringens	P10481		12050 nM\|= 12050.0 nM			BindingDB, NPASS
Sialidase 2	Homo sapiens	Q9Y3R4		= 380000.0 nM			NPASS
Sialidase-2	Homo sapiens	Q9Y3R4		380000 nM			BindingDB
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
Signal transducer and activator of transcription 3	Homo sapiens	P40763		24800 nM\|= 24800.0 nM			BindingDB, NPASS
Solute carrier organic anion transporter family member 1B3	Homo sapiens	Q9NPD5		3890 nM\|= 3890.45 nM		2960 nM\|= 2960.0 nM	BindingDB, NPASS
Solute carrier organic anion transporter family member 2B1	Homo sapiens	O94956		= 5300.0 nM\|= 5248.07 nM			NPASS
Steroid hormone receptor ERR1	Homo sapiens	P11474		10 nM			BindingDB
T47D	Homo sapiens			= 48000.0 nM			NPASS
T98G	Homo sapiens			= 89410.0 nM			NPASS
Testis-specific androgen-binding protein	Homo sapiens	P04278			= 39810.72 nM		NPASS
Thromboxane-A synthase	Homo sapiens	P24557		= 7720.0 nM			NPASS
Tissue alpha-L-fucosidase	Bos taurus	Q2KIM0		54000 nM			BindingDB
Transthyretin	Homo sapiens	P02766		= 7800.0 nM			NPASS
Trypanosoma brucei brucei	Trypanosoma brucei brucei			= 4200.0 nM			NPASS
Solute carrier organic anion transporter family member 1B1	Homo sapiens	Q9Y6L6		9120 nM\|= 9120.11 nM		5000 nM\|= 5000.0 nM	BindingDB, NPASS
Ishikawa	Homo sapiens			= 510.0 nM			NPASS
Hepatitis B virus	Hepatitis B virus		= 33000.0 nM				NPASS
Human immunodeficiency virus type 1 integrase	Human immunodeficiency virus 1	Q7ZJM1		> 20000.0 nM\|= 1100.0 nM			NPASS
Alpha-glucosidase MAL62	Saccharomyces cerevisiae	P07265		6998 nM			BindingDB
Alpha-mannosidase	Canavalia ensiformis	C0HJB3		49000 nM\|= 49000.0 nM			BindingDB, NPASS
Amine oxidase [flavin-containing] A	Homo sapiens	P21397		3900 nM\|9700 nM			BindingDB
Amine oxidase [flavin-containing] A	Rattus norvegicus	P21396		40000 nM			BindingDB
Amine oxidase [flavin-containing] A/B	Bos taurus	P21398\|P56560		95000 nM			BindingDB
Androgen Receptor	Homo sapiens	P10275		= 1300000.0 nM			NPASS
Androgen Receptor	Rattus norvegicus	P15207		= 85113.8 nM			NPASS
Androgen receptor	Homo sapiens	P10275		1300000 nM			BindingDB
Androgen receptor	Rattus norvegicus	P15207		85113.8 nM			BindingDB
Arachidonate 15-lipoxygenase	Oryctolagus cuniculus	P12530		= 9033.0 nM			NPASS
Aromatase	Homo sapiens	P11511				100000 nM	BindingDB
Aryl sulfotransferase	Rattus norvegicus	P17988		= 290.0 nM			NPASS
B16-F10	Mus musculus			= 79210.0 nM			NPASS
BJ	Homo sapiens		> 86206.9 nM				NPASS
BT-20	Homo sapiens			= 46000.0 nM			NPASS
BV-2	Mus musculus			= 28400.0 nM			NPASS
BXPC-3	Homo sapiens			= 30000.0 nM\|= 79000.0 nM			NPASS
Balb/MK	Mus musculus			= 9100.0 nM			NPASS
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens	Q9UNQ0		8800 nM\|6900 nM			BindingDB
Butyrylcholinesterase	Rattus norvegicus	Q9JKC1		> 50000.0 nM			NPASS
COLO 201	Homo sapiens			= 73000.0 nM			NPASS
Alpha-glucosidase MAL32	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P38158		100000 nM			BindingDB
COLO357	Homo sapiens			= 50000.0 nM			NPASS
Alpha-amylase 1A	Homo sapiens	P0DUB6					BindingDB
Aldose reductase	Rattus norvegicus	P07943		= 44979.0 nM			NPASS
17-beta-hydroxysteroid dehydrogenase type 1	Homo sapiens	P14061		2210 nM			BindingDB
17-beta-hydroxysteroid dehydrogenase type 2	Homo sapiens	P37059		16500 nM			BindingDB
17-beta-hydroxysteroid dehydrogenase type 3	Homo sapiens	P37058		3.03e+4 nM			BindingDB
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	Plasmodium falciparum			7000 nM			BindingDB
A-431	Homo sapiens		= 108000.0 nM\|= 278000.0 nM				NPASS
A549	Homo sapiens			= 43090.0 nM\|= 64000.0 nM			NPASS
AGS	Homo sapiens			= 41670.0 nM			NPASS
ANN-1	Mus musculus			= 8000.0 nM			NPASS
ATP-binding cassette sub-family G member 2	Homo sapiens	Q9UNQ0		= 6900.0 nM\|= 8800.0 nM			NPASS
ATP-dependent translocase ABCB1	Homo sapiens	P08183			26303 nM		BindingDB
Acetylcholinesterase	Rattus norvegicus	P37136		> 50000.0 nM			NPASS
Adenosine A1 receptor	Homo sapiens	P30542		= 19904.0 nM		= 11611.0 nM	NPASS
Adenosine A1 receptor	Rattus norvegicus	P25099				= 5000.0 nM	NPASS
Adenosine A2a receptor	Homo sapiens	P29274		= 17442.0 nM		= 9792.0 nM	NPASS
Adenosine A2a receptor	Rattus norvegicus	P30543				= 36000.0 nM	NPASS
Adenosine receptor A1	Rattus norvegicus	P25099				5000 nM	BindingDB
Adenosine receptor A2a	Rattus norvegicus	P30543				36000 nM	BindingDB
Alcohol sulfotransferase	Rattus norvegicus	P15709		= 34000.0 nM			NPASS
Aldehyde oxidase	Homo sapiens	Q06278		340 nM\|= 340.0 nM\|= 5.0 nM			BindingDB, NPASS
Aldo-keto reductase family 1 member B1	Homo sapiens	P15121		20000 nM			BindingDB
Aldose reductase	Homo sapiens	P15121		= 20000.0 nM			NPASS
Alpha-L-fucosidase 1	Bos taurus	Q2KIM0		= 54000.0 nM			NPASS
Caco-2	Homo sapiens			> 100000.0 nM			NPASS
Amine oxidase [flavin-containing] B	Homo sapiens	P27338		6800 nM\|4100 nM			BindingDB
Casein kinase 2	Rattus norvegicus			= 32000.0 nM			NPASS
Epidermal growth factor receptor erbB1	Homo sapiens	P00533		= 1000.0 nM\|= 2600.0 nM\|= 0.7 ug.mL-1\|= 0.1 ug.mL-1\|= 0.2 ug.mL-1\|= 25120.0 nM\|= 600.0 nM			NPASS
Estradiol 17-beta-dehydrogenase 1	Homo sapiens	P14061		= 2210.0 nM			NPASS
Estradiol 17-beta-dehydrogenase 2	Homo sapiens	P37059		= 16500.0 nM			NPASS
Estrogen receptor	Homo sapiens	P03372	956 nM\|48 nM\|20 nM\|810 nM\|950 nM\|240 nM	1145 nM\|1973 nM\|3920 nM\|4.68e+3 nM\|1300 nM\|300 nM\|395 nM\|92 nM\|29.4 nM\|9.7 nM\|580 nM\|6100 nM\|4660 nM\|2150 nM\|4735 nM\|= 990.0 nM		370 nM	BindingDB, NPASS
Estrogen receptor alpha	Homo sapiens	P03372	= 3920.0 nM\|= 48.0 nM\|= 20.0 nM\|= 950.0 nM\|= 810.0 nM\|= 501.19 nM\|= 240.0 nM	= 1300.0 nM\|= 6100.0 nM\|= 395.0 nM\|= 92.0 nM\|= 4660.0 nM\|= 29.4 nM\|= 1973.0 nM\|= 1145.0 nM\|= 2150.0 nM\|= 9.7 nM\|= 580.0 nM\|= 300.0 nM\|= 135.0 nM\|= 4680.0 nM\|= 4735.0 nM		= 370.0 nM\|= 39.0 nM	NPASS
Estrogen receptor beta	Homo sapiens	P03372\|Q92731		990 nM			BindingDB
Estrogen receptor beta	Homo sapiens	Q92731	73 nM\|4.1 nM\|6 nM\|28 nM\|200 nM\|2.4 nM\|= 200.0 nM\|= 4.1 nM\|= 1.7 nM\|= 6.0 nM\|= 73.0 nM\|= 956.0 nM\|= 28.0 nM\|= 19.95 nM\|= 2.4 nM	25 nM\|61 nM\|200 nM\|98.7 nM\|18 nM\|10 nM\|4 nM\|9.7 nM\|1.3 nM\|395 nM\|6.8 nM\|390 nM\|83 nM\|98.70 nM\|45900 nM\|78 nM\|= 83.0 nM\|= 390.0 nM\|= 10.0 nM\|= 4.0 nM\|= 98.7 nM\|= 9.7 nM\|= 1.3 nM\|= 61.0 nM\|= 25.0 nM\|= 45900.0 nM\|= 395.0 nM\|= 6.8 nM\|= 18.0 nM\|= 2.88 nM\|= 78.0 nM		24 nM\|= 24.0 nM\|= 0.594 nM	BindingDB, NPASS
Estrogen-related receptor alpha	Homo sapiens	P11474		= 10.0 nM			NPASS
Estrogen-related receptor beta	Homo sapiens	O95718		= 395.0 nM			NPASS
Fatty acid synthase	Plasmodium falciparum	Q965D7		= 7000.0 nM			NPASS
Epidermal growth factor receptor	Homo sapiens	P00533		1e+3 nM\|1000 nM\|740 nM\|2590 nM\|25120 nM\|2600 nM			BindingDB
Filobasidiella neoformans	Cryptococcus neoformans			> 50.0 ug.mL-1			NPASS
Glucose transporter	Homo sapiens	P11166				= 7000.0 nM	NPASS
Glycogen synthase kinase-3 beta	Homo sapiens	P49841	>300000 nM				BindingDB
HCT-116	Homo sapiens			= 34900.0 nM			NPASS
HT-29	Homo sapiens			= 52780.0 nM\|= 50000.0 nM			NPASS
Candida albicans	Candida albicans			> 100.0 ug.mL-1\|> 50.0 ug.mL-1			NPASS
HepG2	Homo sapiens		= 67694.5 nM	> 100000.0 nM			NPASS
Integrase	Human immunodeficiency virus 1			1100 nM\|>20000 nM			BindingDB
Hepatitis C virus	Hepatitis C virus		= 14400.0 nM				NPASS
Histone deacetylase 6	Homo sapiens	Q9UBN7		= 1885.0 nM			NPASS
Human immunodeficiency virus 1	Human immunodeficiency virus 1		= 13.9 ug.mL-1				NPASS
Giardia intestinalis	Giardia intestinalis			> 5.0 ug.mL-1			NPASS
Dual specificity mitogen-activated protein kinase kinase 4	Homo sapiens	P45985		400 nM\|= 400.0 nM			BindingDB, NPASS
HUVEC	Homo sapiens			= 88000.0 nM			NPASS
Dipeptidyl peptidase IV	Homo sapiens	P27487		= 480.0 nM			NPASS
Cavia porcellus	Cavia porcellus		= 194984.46 nM				NPASS
Cruzipain	Trypanosoma cruzi	P25779		>400000 nM\|82700 nM\|> 400000.0 nM\|= 82700.0 nM			BindingDB, NPASS
Cyclin-dependent kinase 1/cyclin B1	Homo sapiens	P14635		= 370000.0 nM			NPASS
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1	Homo sapiens	P11802\|P24385		250000 nM			BindingDB
Cyclin-dependent kinase 4/cyclin D1	Homo sapiens	P24385		= 250000.0 nM			NPASS
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1	Homo sapiens	P06493\|P14635		370000 nM			BindingDB
Cyclooxygenase-1	Homo sapiens	P23219		= 80000.0 nM			NPASS
Dopamine transporter	Homo sapiens	Q01959		= 16918.0 nM		= 13442.0 nM	NPASS
Cystic fibrosis transmembrane conductance regulator	Rattus norvegicus	P34158			40000 nM\|= 40000.0 nM		BindingDB, NPASS
Cytochrome P450 19A1	Homo sapiens	P11511				= 123000.0 nM\|= 100000.0 nM	NPASS
Cytoplasmic tyrosine-protein kinase BMX	Homo sapiens	P51813		67990 nM			BindingDB
Cystic fibrosis transmembrane conductance regulator	Homo sapiens	P13569	8200 nM\|8480 nM\|6170 nM\|14200 nM\|= 14200.0 nM\|= 8480.0 nM\|= 8200.0 nM\|= 6170.0 nM\|= 7000.0 nM				BindingDB, NPASS
DNA (cytosine-5)-methyltransferase 1	Homo sapiens	P26358		30000 nM\|= 30000.0 nM			BindingDB, NPASS
DLD-1	Homo sapiens			= 50000.0 nM			NPASS
Dipeptidyl peptidase 3	Homo sapiens	Q9NY33		3.66e+4 nM			BindingDB
Death-associated protein kinase 1	Homo sapiens	P53355		98000 nM\|= 98000.0 nM			BindingDB, NPASS
DU-145	Homo sapiens			= 47290.0 nM\|> 100000.0 nM			NPASS
Dipeptidyl peptidase 4	Homo sapiens	P27487		480 nM			BindingDB
DNMT3A2/3L complex	Homo sapiens	Q9UJW3		> 100000.0 nM			NPASS
DNA topoisomerase II alpha	Homo sapiens	P11388		= 30.0 ug.mL-1			NPASS
DNA topoisomerase 2-alpha	Homo sapiens	P11388		111000 nM			BindingDB
DNA polymerase eta	Homo sapiens	Q9Y253		= 92400.0 nM			NPASS

a curated database

IMPPAT Phytochemical information:
Genistein

Bioactivity information

IMPPAT Phytochemical information: Genistein

Bioactivity information

IMPPAT Phytochemical information:
Genistein