IMPPAT Phytochemical information: 
Genistein

Genistein
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
Treatment of non-alcoholic fatty liver diseaseThe effect of genistein supplementation on inflammatory and oxidative indices and lipid profile in non-alcoholic fatty liver patientsIRCT201312132480N5
Phase I/II a Study of Decitabine in Combination With Genistein in Pediatric Relapsed or Refractory MalignanciesA Phase I/IIa Study of Decitabine in Combination With Genistein in Pediatric Patients With Relapsed or Refractory Solid Tumors and LeukemiaNCT02499861
Comparing the effect of curcumin and genistein to treatment with Ivacaftor in CF patients with a class III mutationComparing the effect of curcumin and genistein to treatment with Ivacaftor in CF patients with a class III mutation - TICTAC-studyEUCTR2014-000817-30-NL
Genistein and Interleukin-2 in Treating Patients With Metastatic Melanoma or Kidney CancerA Pilot Study of the Effect of Genistein in Combination With High-Dose Interleukin-2 on Cell Expansion and Gene Expression in Patients With Metastatic Melanoma or Renal Cell CarcinomaNCT00276835
Genistein as an add-on treatment for CF?Genistein as an add-on treatment for CF? - TRIO studyNL-OMON45929
Study of Genistein in Pediatric Oncology Patients (UVA-Gen001)A Randomized, Placebo-Controlled Pilot Study of Genistein Supplementation in Pediatric Cancer Patients Receiving Myelosuppressive ChemotherapyNCT02624388
Effect of Enteral Genistein Supplementation in SepsisEffect of Enteral Genistein Supplementation on Inflammatory Cytokines, Morbidity and Mortality in Patients With SepsisNCT02796794
Genistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate CancerGenistein Supplementation to Mitigate Cardiometabolic Dysfunction in Patients Undergoing Androgen Deprivation Therapy for Prostate CancerNCT02766478
Effects of Genistein Aglycone in Glucocorticoid Induced OsteoporosisMetabolic, Endocrine, and Central Effects of Genistein Aglycone in Glucocorticoid Induced OsteoporosisNCT03040531
Effect of genistein supplementation on serum level of homocystein and PAI-1 (Plasminogen Activator Inhibitor-1) in postmenopausal women with type-2 diabetes mellitus.Effect of genistein supplementation on serum level of homocystein and PAI-1 (Plasminogen Activator Inhibitor-1) in postmenopausal women with type-2 diabetes mellitus.IRCT20100408003664N23
Genistein Stimulates Insulin Sensitivity Through Gut MicrobiotaGenistein Stimulates Insulin Sensitivity Through Gut Microbiota Reshaping and Skeletal Muscle AMPK Activation in Obese SubjectsNCT04105023
Efficacy and safety of topical genistein nutraceutical products on skin in postmenopausal womenEfficacy and safety of topical genistein nutraceutical products on skin in postmenopausal womenTCTR20220209010
Genistein in trAnSthyretin recePtor Amyloid caRdiomyopathyCardiovascular Genistein Therapy for Heart Failure InflammationNCT06634108
Cardiovascular Genistein Therapy for Heart Failure InflammationA Pilot Clinical Trial of Cardiovascular Genistein Therapy for Heart Failure InflammationNCT06501768
Genistein on Post-myocardial Infarction Patient With Elevated hsCRPA Clinical Trial to Evaluate the Anti-inflammatory Effect of Genistein on Post-myocardial Infarction Patients With Elevated hsCRPNCT06689566
Protein Analysis in patients with Chronic PancreatitisProteomic Profiling of Patients with Chronic Pancreatitis Following Genistein (Soybean Extract) Administration: A 6-Month Study on Pain-Associated Biomarkers - NILCTRI/2025/01/078868
Treatment of non-alcoholic fatty liver diseaseThe effect of genistein supplementation on glycemic state, insulin resistance and adipose tissue in non alcoholic fatty liver patientsIRCT201506222480N6
The effect of curcumin and genistein in CF patients with a class III mutationThe effect of curcumin and genistein in CF patients with a class III mutationNL-OMON23234
Genistein in Treatment of Metastatic Colorectal CancerGenistein Combined With FOLFOX or FOLFOX-Avastin for Treatment of Metastatic Colorectal Cancer: Phase I/II Pilot StudyNCT01985763
High Dose Genistein in Sanfilippo SyndromeA Phase III, Double Blinded, Randomised, Placebo Controlled Clinical Trial of High Dose Oral Genistein Aglycone in Patients with Sanfilippo Syndrome (Mucopolysaccharidosis III) - High Dose Genistein in Sanfilippo SyndromeEUCTR2013-001479-18-GB
Genistein, Gemcitabine, and Erlotinib in Treating Patients With Locally Advanced or Metastatic Pancreatic CancerPhase II Trial of Novasoy®, Gemcitabine, and Erlotinib in Locally Advanced or Metastatic Pancreatic CancerNCT00376948
Monoclonal Antibody Therapy in Treating Patients With Recurrent Acute Lymphoblastic Leukemia or Non-Hodgkin's LymphomaA Phase I Study of B43-Genistein Immunoconjugate in Recurrent B-Lineage Acute Lymphoblastic Leukemia and Non Hodgkin's LymphomaNCT00004858
Genistein in Treating Patients With Stage II, Stage III, or Stage IV Prostate CancerPhase I Single and Multiple-Dose Safety and Pharmacokinetic Clinical Study of Genistein in Normal Volunteers and in Prostate Neoplasia (Multiple Dose Safety and Pharmacokinetic Clinical Study of Genistein in Prostate Neoplasia)NCT00005827
Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis)A Pilot Trial of Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous Cystic Fibrosis PatientsNCT00016744
Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo Radical ProstatectomyA Phase II Study Of Genistein In Patients With Localized Prostate Cancer (Molecular Correlates of Soy In Humans)NCT00058266
Vascular and Skeletal Protective Effects of Genistein in Postmenopausal WomenNCT00355953
Effect of Genistein in Women With Metabolic SyndromeGenistein Use in Postmenopausal Women With Metabolic SyndromeNCT00541710
Genistein in Preventing Breast or Endometrial Cancer in Healthy Postmenopausal WomenPhase I Multiple Dose Clinical Study of Soy Isoflavones in Healthy, Post-Menopausal WomenNCT00099008
Phase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder CancerPhase II Study of Isoflavone G-2535 (Genistein) in Patients With Bladder CancerNCT00118040
Gemcitabine Hydrochloride and Genistein in Treating Women With Stage IV Breast CancerPhase II Trial of Gemcitabine and Genistein in Metastatic Breast Cancer Patients With Biomarker AssaysNCT00244933
Soy Isoflavone in Combination With Radiation Therapy and Cisplatin in SCC of the Head and NeckA Pilot Study of Soy Isoflavone, Genistein, in Combination With Radiation Therapy and Cisplatin in Locally Advanced Squamous Cell Carcinoma of the Head and NeckNCT02075112
Effects of GCP on Prostate Cancer.Effects of a Genistein Combined Polysaccharide (GCP) on Patients With a Diagnosis of Prostate Cancer on Active Surveillance.NCT00269555
Isoflavones and the Coronary Circulation in Men and Women With Coronary Artery DiseaseThe Effect of Genistein (Supro®) on Coronary Artery Diameter and Blood Flow in Men and Women With Coronary Heart DiseaseNCT00287690
Postmenopausal Facial Skin After Estradiol and Genistein Topical TreatmentHyaluronic Acid Concentration in Postmenopausal Facial Skin After Estradiol and Genistein Topical Treatment: Double-blind and Randomized Clinical Trial of EfficacyNCT01553773
Genistein in Preventing Breast Cancer in Women at High Risk for Breast CancerPhase IIB Trial of G-2535 (Unconjugated Isoflavones-100) in Women at High Risk for Breast CancerNCT00290758
A Pharmacokinetic Study of Genistein, a Tyrosine Kinase InhibitorA Pharmacokinetic Study of Genistein, a Tyrosine Kinase InhibitorNCT00001696
Synthetic Genistein (BONISTEIN™) in Patients Who Are Undergoing Surgery for Prostate CancerEffects of Synthetic Genistein Supplementation on Blood and Tissue Biomarkers in Patients With Localized Prostate CancerNCT00546039
Effect of Genistein (a soyabean extract) in patients suffering from Ulcerative ColitisEffect of Genistein on Fecal Microbial Diversity, Modified Mayo Score, and Biomarkers in Patients with Ulcerative Colitis: A Placebo-Controlled Study. - NILCTRI/2025/03/083415
Prostate Cancer Prevention Trial With Quercetin and GenisteinClinical Trial on the Effectiveness of the Flavonoids Genistein and Quercetin in Men With Rising Prostate-specific AntigenNCT01538316
Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis)A Pilot Trial of Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygous Cystic Fibrosis PatientsNCT00590538
Third Year Evaluation on Genistein Efficacy and SafetySafety Profile and Bone Efficacy of the Phytoestrogen Genistein in a Cohort of Osteopenic, Postmenopausal Women After Three Years of Treatment: a Follow-up StudyNCT00626769
Genistein in Treating Patients Undergoing External-Beam Radiation Therapy for Bone MetastasesPhase I-II Trial of Genistein in Subjects Receiving Palliative External Beam Radiation Therapy for Osseous Metastases: A Study of Palliation of Symptoms and Quality of LifeNCT00769990
Genistein in Treating Patients With Pancreatic Cancer That Can Be Removed by SurgeryA Pre-Surgical, Randomized Clinical Trial of Genistein in Resectable Pancreatic AdenocarcinomaNCT00882765
Genistein in Treating Patients With Prostate CancerPhase 2 Trial of Genistein in Men With Circulating Prostate Cancer CellsNCT01126879
Cholecalciferol and Genistein Before Surgery in Treating Patients With Early Stage Prostate CancerPhase IIA, Randomized Placebo-Controlled Trial of Single High Dose Cholecalciferol and Daily Genistein (G-2535) Versus Placebo in Men With Early Stage Prostate Cancer Undergoing ProstatectomyNCT01325311
Study of Genistein in Reducing Side Effects of Superficial Bladder Cancer TreatmentPhase II Randomized Placebo-Controlled Clinical Trial of Genistein in Reducing the Toxicity and Improving the Efficacy of Intravesical TherapyNCT01489813
Effects of a Genistein Concentrated Polysaccharide (GCP) for Prostate Cancer on Active Surveillance.Effects of a Genistein Concentrated Polysaccharide (GCP) on Patients With a Diagnosis of Prostate Cancer on Active Surveillance.NCT00584532
MTD Determination, Safety and Efficacy of the Decitabine-Genistein Drug Combination in Advanced Solid Tumors and Non-Small Cell Lung CancerA Phase I/IIa Dose-Escalation Study of the Decitabine-Genistein Drug Combination in Advanced Solid Tumors and Non-Small Cell Lung Cancer (NSCLC) SubjectsNCT01628471
Effects of Genistein in Postmenopausal Women With Metabolic SyndromeRole of Genistein on Metabolic Syndrome in Post-menopausal WomenNCT01664650
Genistein as a Possible Treatment for Alzheimer's Disease.Effect of Activation of the Receptor PPARg/RXR as a Possible Treatment for Alzheimer's Disease. Role of Genistein.NCT01982578
The Clinical Study on Isoflavone Genistein in Restructuring the Gut Microbiota of Hyperlipidemia PatientsShenzhen Hospital of Southern Medical UniversityNCT06895954