IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
quadruplex DNA	Homo sapiens				= 9900.0 nM		NPASS
Potassium voltage-gated channel subfamily H member 2	Homo sapiens	Q12809		3100 nM\|66069.34 nM			BindingDB
Peroxisome proliferator-activated receptor delta	Homo sapiens	Q03181	= 14000.0 nM				NPASS
Peroxisome proliferator-activated receptor alpha	Homo sapiens	Q07869	= 580.0 nM			= 730.0 nM	NPASS
PC-3	Homo sapiens			= 21500.0 nM			NPASS
Neuraminidase	InflueA virus (strain A/USSR/90/1977 H1N1)	P03469		38500 nM\|32200 nM\|= 38500.0 nM\|= 32200.0 nM			BindingDB, NPASS
NAD(+) hydrolase SARM1	Homo sapiens	Q6SZW1		140000 nM\|110000 nM\|77000 nM		130000 nM	BindingDB
Neuraminidase	InflueA virus (A/Puerto Rico/8/1934(H1N1))	P03468				= 14300.0 nM	NPASS
Prolyl endopeptidase	Homo sapiens	P48147		145000 nM\|142000 nM\|= 142000.0 nM\|= 145000.0 nM			BindingDB, NPASS
Lysine-specific histone demethylase 1A	Homo sapiens	O60341		6970 nM			BindingDB
Lysine-specific histone demethylase 1	Homo sapiens	O60341		= 6970.0 nM			NPASS
Neuraminidase	InflueA virus (strain A/Puerto Rico/8/1934 H1N1)	P03468				14300 nM	BindingDB
Protein-tyrosine phosphatase 1B	Homo sapiens	P18031		= 67000.0 nM			NPASS
Reverse transcriptase	Human immunodeficiency virus 1			297000 nM			BindingDB
Retinoic acid receptor RXR-alpha	Homo sapiens	P19793			24800 nM		BindingDB
LNCaP C4-2B	Homo sapiens			= 11200.0 nM			NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2			> 20000.0 nM\|> 19952.62 nM			NPASS
SK-HEP1	Homo sapiens			> 50000.0 nM			NPASS
SMMC-7721	Homo sapiens			= 18340.0 nM			NPASS
SW1990	Homo sapiens			= 18340.0 nM			NPASS
Sentrin-specific protease 8	Homo sapiens	Q96LD8		7660 nM			BindingDB
Serine/threonine-protein kinase Nek7	Homo sapiens	Q8TDX7		4200 nM	15600 nM		BindingDB
Sortase family protein	Staphylococcus aureus			25800 nM\|8.7 nM\|12 nM\|121000 nM\|120000 nM\|102000 nM			BindingDB
Telomerase reverse transcriptase	Homo sapiens	O14746		37000 nM\|= 37000.0 nM			BindingDB, NPASS
Zika virus	Zika virus			= 39100.0 nM			NPASS
RAW264.7	Mus musculus			> 30000.0 nM\|= 6900.0 nM			NPASS
LNCaP	Homo sapiens			= 3400.0 nM			NPASS
Vero	Chlorocebus aethiops			= 71.14 ug.mL-1			NPASS
Huh-7	Homo sapiens			> 50000.0 nM			NPASS
3T3-L1	Mus musculus			= 21840.0 nM			NPASS
Acetylcholinesterase	Electrophorus electricus	O42275		374 nM\|1600 nM\|2740 nM\|= 374.0 nM\|= 1600.0 nM		289 nM	BindingDB, NPASS
Interleukin-8	Homo sapiens	P10145		50000 nM\|= 50000.0 nM			BindingDB, NPASS
Acetylcholinesterase	Homo sapiens	P22303		770 nM\|100 nM\|40 nM\|610 nM\|700 nM\|17400 nM\|= 100.0 nM\|= 700.0 nM\|= 1330.0 nM			BindingDB, NPASS
Aldo-keto reductase family 1 member C2	Homo sapiens	P52895		= 6710.0 nM			NPASS
Aldo-keto reductase family 1 member C3	Homo sapiens	P42330		4080 nM			BindingDB
Aldo-keto-reductase family 1 member C3	Homo sapiens	P42330		= 5900.0 nM\|= 4080.0 nM			NPASS
Bile salt-activated lipase	Bos taurus	P30122		315000 nM			BindingDB
Butyrylcholinesterase	Homo sapiens	P06276		= 1090.0 nM\|= 30700.0 nM			NPASS
CWR22R	Homo sapiens			= 12700.0 nM			NPASS
Cell division protein FtsZ	Escherichia coli (strain K12)	P0A9A6		10000 nM\|16000 nM	23 nM		BindingDB
Cell division protein ftsZ	Staphylococcus aureus	P0A031		= 10000.0 nM			NPASS
Carboxylic ester hydrolase	Equus caballus			18200 nM			BindingDB
Cholesterol esterase	Bos taurus	P30122		= 106.0 ug.mL-1			NPASS
Hepatitis C virus	Hepacivirus hominis		= 7870.0 nM				NPASS
HepG2	Homo sapiens			= 46.9 ug.mL-1\|> 50000.0 nM			NPASS
Hep 3B2	Homo sapiens			> 50000.0 nM			NPASS
Chikungunya virus	Chikunguvirus		= 1900.0 nM\|= 1800.0 nM				NPASS
HeLa	Homo sapiens			= 12.08 ug.mL-1			NPASS
HUVEC	Homo sapiens			= 18340.0 nM			NPASS
HeLa 229	Homo sapiens			= 42930.0 nM			NPASS
Entamoeba histolytica	Eoeba histolytica			= 1.0 ug.mL-1			NPASS
Cytochrome P450 1B1	Homo sapiens	Q16678		330 nM\|2500 nM\|94 nM\|= 330.0 nM\|= 2500.0 nM\|= 94.0 nM		44 nM\|= 44.0 nM	BindingDB, NPASS
Cholinesterase	Homo sapiens	P06276		1090 nM\|18970 nM\|30700 nM\|47200 nM			BindingDB
Cholinesterase	Equus caballus	P81908		18200 nM\|9400 nM\|18210 nM\|= 18200.0 nM\|= 9400.0 nM		9200 nM	BindingDB, NPASS
HERG	Homo sapiens	Q12809		= 66069.34 nM			NPASS

a curated database

IMPPAT Phytochemical information:
Berberine

Bioactivity information

IMPPAT Phytochemical information: Berberine

Bioactivity information

IMPPAT Phytochemical information:
Berberine