IMPPAT Phytochemical information: 
Berberine

Berberine
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
the effects of berberine combined with metformin on metabolic abnormalities and ovulation in patients with polycystic ovary syndrome: a randomized controlled studythe effects of berberine combined with metformin on metabolic abnormalities and ovulation in patients with polycystic ovary syndrome: a randomized controlled studyChiCTR2200062984
Berberine Hyperglycemic ClampEffect of Berberine on Insulin Release at a High Blood Glucose Level in Normal ManNCT03972215
Effect of Berberine on Metabolic Syndrome, Efficacy and Safety in Combination With Antiretroviral Therapy in PLWH.Effect of Berberine on Metabolic Syndrome, Efficacy and Safety in Combination With Antiretroviral Therapy in People Living With HIV.NCT04860063
A double-blind randomized controlled clinical study of intervention treatment of berberine on clinical symptoms and intestinal flora in patients with depressionA double-blind randomized controlled clinical study of intervention treatment of berberine on clinical symptoms and intestinal flora in patients with depressionChiCTR2200057169
Impact of OCT1 and CYP2D6 Genotypes on Pharmacokinetics of Berberine in Healthy VolunteersImpact of OCT1 and CYP2D6 Genotypes on Pharmacokinetics of Berberine in Healthy VolunteersNCT05463003
Effect of Berberine Hydrochloride on Blood Pressure and Vascular Endothelial Function in Patients With HypertensionEffect of Berberine Hydrochloride on Blood Pressure and Vascular Endothelial Function in Patients With HypertensionNCT04790942
Study on the effect of berberine on the prevention of anastomotic scar formation after dacryocystorhinostomyStudy on the effect of berberine on the prevention of anastomotic scar formation after dacryocystorhinostomyChiCTR2100042026
Helicobacter Pylori Eradication With Berberine Plus Amoxicillin Triple Therapy Versus Bismuth-containing Quadruple TherapyEfficacy and Safety of Berberine Hydrochloride, Amoxicillin and Rabeprazole Triple Therapy in the First Eradication of Helicobacter PyloriNCT04697186
Effects Of Berberine Plus Inulin On Diabetes Care in Elder Patients With LADAEffects of Berberine Plus Inulin on Diabetes Care in Elder Patients With Latent Autoimmune Diabetes in Adults: A Randomized Controlled TrialNCT04698330
Effect of berberine on blood glucose and lipid regulation in type 2 diabetes mellitus patientsEffect of berberine on blood glucose and lipid regulation in type 2 diabetes mellitus patientsChiCTR1900023238
The effect of berberine on the symptoms of patients with schizophreniaThe effect of berberine alkaloid on positive and negative symptoms in patients with schizophrenia: a randomized placebo-controlled double-blind clinical trialIRCT20190726044339N1
Endoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in CirrhosisEndoscopic and Microbiological Assessment of the Effect of Carvedilol Combined With Berberine on GOV in Cirrhosis: a Prospective Cohort StudyNCT04543643
The Effect of Berberine on Intestinal Function and Inflammatory Mediators in Severe Patients With Covid-19The Effect of Berberine on Intestinal Function and Inflammatory Mediators in Severe Patients With Covid-19NCT04479202
Effect of berberine on COVID-19Clinical trial of berberine against COVID-19IRCT20081019001369N2
The effect of berberine hydrochloride on apolipoprotein A1, serum inflammatory factors, carotid atherosclerosis and clinical prognosis of patients with strokeThe effect of berberine hydrochloride on carotid atherosclerosis, middle cerebral artery stenosis and homocysteine in patients with strokeChiCTR2000029838
The effect of herbal toothpaste containing berberine and saponin on oral and dental healthClinical trial comparing the effect of standard toothpaste and herbal toothpaste containing berberine and saponin on dental plaque, gingival inflammation, and salivary bacterial countIRCT20170316033099N13
Effect of Gamma-cyclodextrin on the Bioavailability of BerberineA Phase I, Randomized, Crossover, Double-blind, Pharmacokinetic Study of Berberine Released From Cyclodextrin in Healthy VolunteersNCT04918667
The Effect of Combined Supplementation of Berberine and Fenugreek Seed Powder on Inflammatory Factors and Lipid and Glucose Profile in Patients with Type 2 DiabetesComparison of the combined efficacy of berberine and fenugreek in controlling blood glucose and lipid profile and inflammatory factors in type 2 diabetic patientsIRCT20191229045937N1
Berberine and Non-Alcoholic Fatty Liver Disease (NAFLD)The Effect of Berberine on Lipid Profile, Liver Enzymes and Fasting Blood Glucose in Patients With Non-Alcoholic Fatty Liver Disease (NAFLD): A Randomized Controlled TrialNCT04049396
Effect of Berberine for Endothelial Function and Intestinal Microflora in Patients With Coronary Artery DiseaseThe Study of Berberine Affecting Metabolism, Inflammation Status, Endothelial Function and Thrombotic Events in Patients With Coronary Artery Disease by Remodeling Gut MicrobiotaNCT04434365
Evaluating the Tolerability and Effects of Berberine on Major Metabolic Biomarkers: A Pilot StudyEvaluating the Tolerability and Effects of Berberine on Major Metabolic Biomarkers: A Pilot StudyNCT03976336
Effects of Berberine on Intestinal Microflora, Metabolites and Cardiovascular Function in People After High Choline DietEffects of Berberine on Intestinal Microflora, Metabolites and Cardiovascular Function in People After High Choline DietChiCTR2100046956
A single-center, prospective, randomized controlled clinical study of the short-term efficacy and safety of berberine combined with XELOX chemotherapy for advanced gastric cancerA single-center, prospective, randomized controlled clinical study of the short-term efficacy and safety of berberine combined with XELOX chemotherapy for advanced gastric cancerChiCTR2200061347
Pharmacological Profile of Different Berberine Formulations, and Effects on Blood Sugar LevelsComparing the Pharmacological Profile of Different Berberine Formulations, and Their Effects on Blood Sugar LevelsNCT05370261
Effect of Probiotics or Berberine in Hepatic Steatosis Markers, Cardiometabolic and Microbiotic Profile in NAFL.Effect of Probiotics or Berberine Supplementation on Hepatic Steatosis Markers, Cardiometabolic and Microbiotic Profile in NAFL - A Randomized Double- Blind Clinical Study.NCT05523024
Comparing the effects of Berberine, Curcumine and gonadotropin-releasing hormone agonist (GnRH) on uterine leiomyoma volumeComparing the effects of Berberine, Curcumine and gonadotropin-releasing hormone agonist (GnRH) on uterine leiomyoma volume , a controlled, randomized clinical trialsIRCT20220201053908N1
Efficacy and safety of berberine hydrochloride gargle in the treatment of oral candidiasis: a randomized controlled trialA randomized controlled study of berberine hydrochloride gargle in the treatment of oral candidiasis: a randomized controlled trialChiCTR2100053862
"""The effect of herbal supplements on neurotransmitters in the formation of dementia""""""Evaluation of the possible effect of berberine supplementation on changes in serum levels of glutamate-dopamin-serotonin and GABA neurotransmitters in dementia patients"""IRCT20211012052739N1
Treatment Benefits of Berberine Supplementation for Women With PCOSEffect of Berberine Supplementation on Metabolic and Hormonal Features in Women With Polycystic Ovary Syndrome (PCOS)NCT05480670
Treatment of minimal hepatic encephalopathy with berberine and caffeic acidBerberine and caffeic acid in the treatment of mild hepatic encephalopathy: a randomized open-labled parallel controlled prospective studyChiCTR2100052806
Berberine for the intestinal metaplasia after endoscopic therapy for early-stage gastric cancerExploratory randomized controlled trial to evaluate intestinal metaplasia improvement of gastric mucosa with berberine in patients after endoscopic therapy for early-stage gastric cancerJPRN-jRCTs031210319
Berberine and Altered Fasting GlucoseEffectiveness of the Assumption of a Berberine Phytosoma-based Supplement on the Hematic Values of Glucose in a Group of Patients With Altered Fasting GlucoseNCT05031715
Evaluation of the curative effect of berberine on patients with irritable bowel syndrome complicated with depressionA multicenter randomized controlled single-blind clinical study of berberine on the clinical symptoms and intestinal flora of patients with irritable bowel syndrome complicated with depressionChiCTR2100049397
Study on The Efficacy and Safety of Berberine-containing Triple Therapy in Helicobacter Pylori First-Line EradicationStudy on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line EradicationNCT05014334
Bioavailability of Berberine and Dihydroberberine and Their Impact on GlycemiaBioavailability of Berberine and Dihydroberberine and Their Impact on GlycemiaNCT05021341
Berberine and Polycystic Ovary SyndromeBerberine is an Effective Insulin Sensitizer and Improves Homeostasis of Metabolic and Hormonal Disorders in Women With Polycystic Ovary Syndrome: a Novel Treatment Strategy for PCOSNCT04932070
Cardiovascular Diseases and Diabetes Prevention Programme in Metabolic Syndrome (CDPP)Efficacy and Safety of Berberine on Primary Prevention of Cardiovascular Diseases and Diabetes in Metabolic Syndrome: a Randomized, Controlled TrialNCT05105321
Berberine acts on the Molecular Mechanism of Insulin Resistance in the treatment of Polycystic Ovary Syndrome by Gut microbiotaBerberine acts on the Molecular Mechanism of Insulin Resistance in the treatment of Polycystic Ovary Syndrome by Gut microbiotaChiCTR1900022444
Anti-platelet Effect of Berberine in Patients After Percutaneous Coronary InterventionA Single-center, Randomized, Open-label, Controlled, Dose-escalating, Parallel-group Study to Assess the Anti-platelet Effect of Berberine in Patients Receiving Aspirin and Clopidogrel After Percutaneous Coronary InterventionNCT03378934
A Mechanistic Randomized Controlled Trial on the Cardiovascular Effect of BerberineEffect of Berberine on Cardiovascular Disease Risk Factors: a Mechanistic Randomized Controlled TrialNCT03770325
Effect of Administration of the Combination Bezafibrate More Berberine on Lipid Profile in Patients With DyslipidemiaEffect of Administration of the Combination Bezafibrate More Berberine on Lipid Profile in Patients With Mixed DyslipidemiaNCT02548832
Berberine Chloride in Preventing Colorectal Cancer in Patients With Ulcerative Colitis in RemissionPhase I Trial of Berberine in Subjects With Ulcerative ColitisNCT02365480
Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Bismuth-containing Quadruple TherapyHelicobacter Pylori Eradication With Berberine Hydrochloride,Esomeprazole,Amoxicillin and Clarithromycin Versus Bismuth,Esomeprazole,Amoxicillin,and Clarithromycin: a Randomized,Open-label, Non-inferiority, Phase ? TrailNCT02296021
Study of Berberine Hydrochloride in Prevention of Colorectal Adenomas RecurrenceA Randomized, Placebo-controlled, Multicenter, Prospective Clinical Study of Berberine Hydrochloride in Preventing Recurrence and Carcinogenesis After Endoscopic Removal of Colorectal AdenomasNCT02226185
Effects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and TreatmentEffects of Berberine Hydrochloride and Bifidobacterium in Prediabetes Prevention and Treatment:an Open-label, Multicenter,Randomized, Prospective,Controlled StudyNCT02082756
Long Term Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols and Berberine) in Low-moderate Risk Hypercholesterolemic Patients: a Double-blind, Placebo Controlled StudyLong Term Efficacy and Tolerability of a Nutraceutical Combination (Red Yeast Rice, Policosanols and Berberine) in Low-moderate Risk Hypercholesterolemic Patients: a Double-blind, Placebo Controlled StudyNCT02078167
Effects of Berberine Hydrochloride and Bifidobacterium in Diabetes Mellitus Prevention and TreatmentEffects of Berberine Hydrochloride and Bifidobacterium in Diabetes Mellitus Prevention and Treatment:an Open-label, Multicenter,Randomized, Prospective,Controlled StudyNCT02084004
Berberine Chloride Stabilizes Coronary Atherosclerotic Plaques in Clinical ResearchBerberine Chloride Stabilizes Coronary Atherosclerotic Plaques in Clinical ResearchChiCTR-TRC-13003691
Effect of Berberis root active component (Berberine) in patients with Type2 Diabetes.The effect of Berberis root active component (Berberine) on blood sugar control in patients with Type2 Diabetes.IRCT2013040712933N1
Effect of berberine on diabetic retinopathyEffect of berberine on diabetic retinopathyChiCTR-TRC-12002898
The Therapeutic Effects of Statins and Berberine on the HyperlipemiaThe Therapeutic Effects of Combination of Statins With Berberine on the Patients With Hyperlipemia:a Single-center, Open Clinical TrialNCT01697735
The Efficacy of Berberine on Patients with PsoriasisThe Comparison of Efficacy of Berberine and Placebo on Skin Lesions of Psoriasis PatientsIRCT201201305069N6
Effect of Berberine on Hormonal and Metabolic Features in Obese Women With Polycystic Ovary Syndrome (PCOS)Effect of Berberine on Hormonal and Metabolic Features in Obese Women With PCOSNCT01138930
Polycystic Ovary Syndrome (PCOS): Effect Of Letrozole and BerberineLetrozole and Berberine in Infertile PCOS PatientsNCT01116167
Clinical evaluation of berberine therapy of acute coronary syndromeCEBTACSChiCTR-TRC-10000868
Letrozole, berberine, or their combination for anovulatory infertility in women with polycystic ovary syndrome: study design of a double blind randomised controlled trialLetrozole, berberine, or their combination for anovulatory infertility in women with polycystic ovary syndrome: study design of a double blind randomised controlled trialChiCTR-TRC-09000376
Role of Pioglitazone and Berberine in Treatment of Non-Alcoholic Fatty Liver DiseaseRole of Pioglitazone and Berberine in Treatment of Non-alcoholic Fatty Liver Disease(NAFLD) Patients With Impaired Glucose Regulation or Type 2 Diabetes MellitusNCT00633282
Efficacy and Safety of Berberine in the Treatment of Diabetes With DyslipidemiaThe Efficacy and Safety of Berberine in the Treatment of Type 2 Diabetes With DyslipidemiaNCT00462046
Therapeutic Effects of Berberine in Patients With Type 2 DiabetesEffects of Berberine on Improvement of Glucose and Lipid Metabolism in Patients With Type 2 DiabetesNCT00425009
Comparative BE Study of BioSNEDS in healthy subjectsAN OPEN LABEL,BALANCED, SINGLE-DOSE,MULTI-TREATMENT, TWO PERIOD,TWO-WAY CROSSOVER, COMPARATIVE ORAL BIOAVAILABILITY STUDY OF THYMOPRO 50 MG BIOSNEDS (0.001004 G THYMOQUINONE/ML), BERBERISOL 500 MG BIOSNEDS (0.010046 G BERBERINE HCL/ML),RESVERASOL 1000 MG BIOSNEDS (0.020048 G RESVERATROL/ML),BIOQUERCETIN 475 MG BIOSNEDS (0.010045 G QUERCETIN/ML) ANDBIOBUTYRIN 500 MG BIOSNEDS (0.010096 G TRIBUTYRIN/ML) MANUFACTURED BY VERDANT NATURE SP Z.O.O., WITH CONVENTIONAL RESVERATROL EXTRACT 1000 MG (2 X 500 MG CAPSULE) DISTRIBUTED BY BIOLAB, CONVENTIONAL QUERCETIN 475 MG CAPSULE DISTRIBUTED BY SWANSON HEALTH PRODUCTS, CONVENTIONAL TRIBUTYRIN 500 MG CAPSULE DISTRIBUTED BY DEVA NUTRITION, CONVENTIONAL THYMOQUINONE 50 MG CAPSULE DISTRIBUTED BY TRIQUETRA HEALTH AND CONVENTIONAL BERBERINE 500 MG CAPSULE DISTRIBUTED BY MEDFUTURE IN HEALTHY ADULT HUMAN SUBJECTS UNDER FASTING CONDITIONS - NilCTRI/2024/10/074604
Combination of Curcumin and Berberine Therapy in the Treatment of Post Acute Diverticulitis (SUDD)Combination of Curcumin and Berberine Therapy in the Treatment of Post Acute Diverticulitis (AD) Symptomatic Uncomplicated Diverticular Disease (SUDD)NCT05596214
Study on the effect of berberine hydrochloride in the treatment of familial patients with familial adenomatous polyposisRandomized, double blind, placebo-controlled study of berberine hydrochloride in the treatment of familial adenomatous polyposisChiCTR-IOR-15007227
Combination of Danazole With Berberine in the Treatment of ITPCombination of Danazole With Berberine in the Treatment of ITPNCT03909763
Helicobacter Pylori Eradication With Berberine Quadruple Therapy Versus Clarithromycin Quadruple TherapyHelicobacter Pylori Eradication With Berberine Hydrochloride, Lansoprazole, Amoxicillin and Bismuth Versus Clarithromycin Bismuth, Lansoprazole and Amoxicillin: A Randomized, Open-label, Non-inferiority, Phase ? TrialNCT02633930
Berberine Prevent Contrast-induced Nephropathy in Patients With DiabetesMulticenter Randomized Controlled Study of Berberine for Prevention of Contrast-Induced Acute Kidney Injury in Patients With Diabetes and Renal InsufficientNCT02808351
Berberine containing therapy for Helicobacter Pylori treatment among patients with previous failed eradicationBerberine containing therapy for Helicobacter Pylori treatment among patients with previous failed eradication - Berberine containing therapy for patients with previous failed helicobacter pylori eradicationJPRN-UMIN000034555
Berberine containing therapy for initial Helicobacter Pylori eradicationBerberine containing therapy for initial Helicobacter Pylori eradication - Berberine containing therapy for Helicobacter PyloriJPRN-UMIN000034554
Comparison of Berberine and Metformin for the Treatment for MS in Schizophrenia PatientsComparison of the Efficacy and Safety of Berberine and Metformin for Schizophrenia Patients With Metabolic SyndromeNCT03708549
A Randomized Controlled Trial for Efficacy and Safety of berberine on vasculopathy in patients with NSTE-ACS after stentingA Randomized Controlled Trial for Efficacy and Safety of berberine on vasculopathy in patients with NSTE-ACS after stentingChiCTR1800018742
Berberine containing quadruple therapy for initial Helicobacter Pylori eradicationBerberine containing quadruple therapy for initial Helicobacter Pylori eradication - Berberine containing therapy for Helicobacter PyloriJPRN-UMIN000033829
Helicobacter Rescue Therapy With Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple TherapyRescue Therapy for Helicobacter Pylori Eradication: A Randomized and Non-inferiority Trail of Berberine Plus Amoxicillin Quadruple Therapy Versus Tetracycline Plus Furazolidone Quadruple TherapyNCT03609892
Berberine Effects on Clinical Symptoms and Metabolic Disturbance in Patients With SchizophreniaBerberine Effects on Clinical Symptoms and Metabolic Disturbance as an Adjunctive Therapy in Patients With Schizophrenia: a Randomized Double-blind Placebo-controlled StudyNCT03548155
The mechanism of berberine to regulate the PI3K-AKT signal pathway in PCOS-IRThe mechanism of berberine to regulate the PI3K-AKT signal pathway in PCOS-IRChiCTR1800015605
Gefitinib and Berberine in the First-line Treatment of Lung Adenocarcinoma With EGFR MutationAn Open-label Phase II Trial of Gefitinib and Berberine in Patients With Advanced Non-small Cell Lung Cancer and Activating EGFR MutationsNCT03486496
The Absorption of Bioactive Berberine in HumanTo Test the Efficacy of Novel Berberine Emulsification by TPGS or Quillaja Extract on the Absorption of Berberine Compared to Berberine Powder in HumansNCT03438292
Evaluation of the efficacy of Berberine instead of clarithromycin against Helicobacter pylori in children, in vitro and in vivoEvaluation of the efficacy of Berberine instead of clarithromycin against Helicobacter pylori in children, in vitro and in vivoChiCTR-IOR-17013319
Effectiveness and Safety of Berberine Hydrochloride and Bifidobacterium in People With Abnormal Glucose LevelEffectiveness and Safety of Berberine Hydrochloride and Bifidobacterium in People With Abnormal Glucose Level: an Multicenter, Randomized, Double-blinded, Placebo-controlled Study.NCT03330184
The effect of berberine hydrochloride on the treatment of dyslipidemia with atherosclerosisThe effect of berberine hydrochloride on the treatment of dyslipidemia with atherosclerosisChiCTR-OPN-17012942
Berberine Treat Metabolic Syndrome in SchizophreniaBerberine in the Treatment of Metabolic Syndrome : an Open Label Clinical Study in Female Schizophrenia PatientsNCT03251716
Efficacy and Safety of Berberine in Non-alcoholic SteatohepatitisEfficacy and Safety of Berberine in Non-alcoholic Steatohepatitis: a Multicentre, Randomised, Placebo-controlled TrialNCT03198572
Berberine treat different curative effect observation of TCM syndrome type 2 diabetesBerberine treat different curative effect observation of TCM syndrome type 2 diabetesChiCTR-INR-16009989
Effect of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in PrediabetesEffect of Administration of Berberine Versus Metformin on Glycemic Control, Insulin Sensitivity and Insulin Secretion in Patients With PrediabetesNCT03029390
Berberine as Adjuvant Treatment for Schizophrenia PatientsA Double-blind, Randomized, Placebo-controlled Trial of Berberine as an Adjuvant to Treat Antipsychotic-induced Metabolic Syndrome in Patients With Schizophrenia Spectrum DisordersNCT02983188
Efficacy of Treatment With Berberine to Maintain Remission in Ulcerative ColitisEfficacy of Treatment With Berberine to Maintain Remission in Ulcerative Colitis: An Open-label,Randomized,Phase IV Clinical TrialNCT02962245
Berberine Effect on Cytokine, CRP, Metabolic Disturbance as an Adjunctive Therapy in Schizophrenia PatientsNCT02936414
A Study on the Efficacy and Gut Microbiota of Berberine and Probiotics in Patients With Newly Diagnosed Type 2 DiabetesProbiotics and BeRberine on the Efficacy and Change of Gut MicrObiota in paTients With Newly Diagnosed Type 2 diabEtes(PREMOTE Study)NCT02861261
The Therapeutic Effects of Insulin and Berberine on Stress HyperglycemiaThe Therapeutic Effects of Combination of Insulin With Berberine on the Patients With Stess Hyperlipemia:a Prospective, Double Blind, Randomized, Placebo-controlled, Single-center Clinical TrialNCT02806999
Berberine and Cinnamon in Management of DiabetesThe Effects of Berberine and Cinnamon Supplementation on Diabetes MangementNCT05570357
Effect of Berberine mouthwash on pain caused by orthodontic treatmentsEffect of Berberine mouthwash on pain caused by elastomeric Seprator placementIRCT20181115041667N1
A prospective, single-center, randomized controlled study of the efficacy of oral berberine hydrochloride in the treatment of diabetic nephropathyCurative effect of berberine hydrochloride on diabetic nephropathyChiCTR2400083889
Study on the Sex-specific, Lipid- and Lipoprotein-lowering Effects of BerberineAssessing the Sex-specific, Lipid- and Lipoprotein-lowering Effects of Berberine Using Randomized, Placebo-controlled, Double-masked TrialNCT06782646
Comparison of Metformin and Berberine in PCOD patientsEffects of Lifestyle Modification with Myoinositol and Berberine versus Myoinositol and Metformin in Women with Polycystic Ovary Syndrome: A Prospective Randomized Study: A case report - NILCTRI/2025/04/085859
Clinical study of Berberine extract in type 2 diabetes mellitus.A randomized, double-blind, parallel-arm clinical trial to assess the efficacy and safety of Berberine extract in participants with type 2 diabetes mellitus. - NILCTRI/2024/12/078418
Safety Profile of a New Berberine Formulation with Improved BioavailabilityEvaluating the Safety and Tolerability of LipoMicel BerberineNCT06732908
Effects of an herbal mixture plus D-mannose on the prevention of recurrent uncomplicated cystitisStudy on the effectiveness of an innovative combination of plant extracts (Berberine, Arbutin, Birch) that administered in conjunction with the D-mannose, for the prevention of recurrent urinary tract infectionsISRCTN13017713
Gene Modulation of NLRP3, IL-1ß and TNF-a in Peripheral Blood of Patients With Exogenous Obesity Treated With BerberineGene Modulation of NLRP3, IL-1ß and TNF-a in Peripheral Blood of Patients With Exogenous Obesity Treated With BerberineNCT06703086
Bioavailability study on Healthy SubjectsA Randomized, double-blind, two arm, crossover design to assess the bioavailability of Liposomal berberine and berberine formulations in otherwise healthy volunteers - NILCTRI/2024/11/076293
6-year Follow-up Data After the Berberine Intervention TrialA Multicenter, Placebo-controlled Clinical Study of Berberine Hydrochloride in Preventing Recurrence and Carcinogenesis After Endoscopic Removal of Colorectal Adenomas:6-year Retrospective Follow-up DataNCT06629051
Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.Study on the Efficacy and Safety of Berberine, Minocycline, Esomeprazole, and Colloidal Bismuth Quadruple Therapy in the Initial Treatment of Helicobacter Pylori.NCT06603688
A Single Dose Two-Way Crossover Oral Bioavailability Study Of The Study Product (BerbiQ) Which Contains Berberine, In Healthy, Adult, Human Subjects Under Fasting Conditions.A Double-Blind, Randomized, Single Dose, Two-Treatment, Two-Way Crossover,Oral Bioavailability Study of Investigational Product (Berbiq) Containing Berberine, In Healthy,Adult, Human Subjects Under Fasting Conditions. - NILCTRI/2024/07/070781
Study on The Efficacy and Safety of Vonoprazan-containing Berberine Triple Therapy in Helicobacter Pylori First-Line EradicationStudy on The Efficacy and Safety of Berberine,Amoxicillin and Vonoprazan Containing Triple Therapy in Helicobacter Pylori First-Line EradicationNCT06514274
A bioavailability study to compare two Berberine formulations with two Berberine + Turmeric formulations in healthy adult human subjects.Single dose, crossover bioavailability study to compare the Formulation A Berberine 95 percent with Formulation B Berberine 95 percent plus Turmeric and Formulation C Berberine 70 percent with Formulation D Berberine 70 percent plus Turmeric in healthy adult human subjects. - NILCTRI/2024/06/069426
Gymnema Sylvestre vs Berberine in Obesity Gene Expression of AdipokinesComparative Efficacy of Gymnema Sylvestre vs Berberine in the Clinical Outcomes and Gene Expression of Adipokines in Patients With Exogenous ObesityNCT06426966
A Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 PolymorphismsA Pilot Study of Berberine (Soloways ™) in Patients with Type 2 Diabetes Mellitus Carrying TCF7L2 PolymorphismsNCT06863922
Comparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 DiabetesComparative Efficacy of Metformin and Berberine Among TCF7L2 (rs7903146) TT vs. CC Genotype Carriers With Type 2 Diabetes: A Pilot Randomized Clinical StudyNCT06911983
Berberine extract in the management of type 2 diabetes mellitusA randomized, double-blind, placebo-controlled clinical trial to assess the safety and efficacy of standardized extract of berberine in patients with type 2 diabetes mellitus (T2DM). - NILCTRI/2024/04/065936
Clinical study of berberine in the treatment of sepsis with acute gastrointestinal injuryClinical study of berberine in the treatment of sepsis with acute gastrointestinal injuryChiCTR2400082935
Clinical Study With Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiCholClinical Study With Berberine-based Food Supplement, Artichoke Extract, Phytosterols, Fenugreek and SelectSIEVE® OptiCholNCT06340308
Effect of Oral Combined Berberine and Curcumin Pharmacological Therapy on IBSThe Adjuvant Synergistic Therapeutic Effect of Oral Berberine and Curcumin Alleviates Symptoms of Irritable Bowel Syndrome: Results From a Real-life Setting Clinical Intervention StudyNCT06187298
Prevention and treatment of chemotherapy-induced diarrhea with berberine in colorectal cancer patients: a randomized, double-blind controlled studyPrevention and treatment of chemotherapy-induced diarrhea with berberine in colorectal cancer patients: a randomized, double-blind controlled studyChiCTR2300078353
Evaluation of the efficacy of berberine combined with Vonoprazan and amoxicillin for eradication of Helicobacter pyloriEvaluation of the efficacy of berberine combined with Vonoprazan and amoxicillin for eradication of Helicobacter pyloriChiCTR2300077074
Berberine on the Secretion of IncretinThe Effect of Berberine on the Secretion of Incretin in Normal ManNCT05947370
A Clinical Study to Evaluate the Effects of Akkermansia Muciniphila and Berberine on Prediabetes Among Obese Subjects.A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate the Effects of Akkermansia Muciniphila and Berberine on Prediabetes Among Obese Subjects.NCT05720299
Sex Differences in Berberine PharmacokineticsSex Differences in Berberine Pharmacokinetics in Healthy Volunteers - BERKI-2NCT05845931
The effect of quercetin and berberine on pulmonary arterial hypertensionInvestigation of the effect of quercetin and berberine on laboratory and functional indices of the heart and pulmonary vessels in patients with pulmonary arterial hypertensionIRCT20230220057462N1
Clinical study of combined application of Berberine hydrochloride tablets in the treatment of cholestatic liver diseaseClinical study of combined application of Berberine hydrochloride tablets in the treatment of cholestatic liver diseaseChiCTR2300068536
Effects of Berberine on Preventing Cardiovascular Disease and Diabetes MellitusAssess the Effects of Berberine on Preventing Cardiovascular Disease and Diabetes Mellitus Among Individuals With High Cardiometabolic RiskNCT05749874
Effects of Berberine in Reducing Abdominal Visceral Adipose Tissue Among Individuals with Obesity and NAFLDAssess the Effects of Berberine in Reducing Abdominal Visceral Adipose Tissue Among Individuals with Obesity and Non-alcoholic Fatty Liver DiseaseNCT05647915