IMPPAT Phytochemical information: 
Caffeine
Caffeine
Bioactivity information
Target nameTarget organismUniProt identifierEC50IC50KdKiSource
Monoamine oxidase BHomo sapiensP27338> 50000.0 nM= 3600000.0 nM|= 3800000.0 nMNPASS
Monoamine oxidase AHomo sapiensP21397> 50000.0 nMNPASS
Liver microsomesRattus norvegicus= 520000.0 nMNPASS
Liver glycogen phosphorylaseRattus norvegicusP09811= 648000.0 nMNPASS
HERGHomo sapiensQ12809> 100000.0 nMNPASS
Guanine deaminaseHomo sapiensQ9Y2T310200 nM|= 10200.0 nM|= 10000.0 nMBindingDB, NPASS
Glycogen phosphorylase, muscle formRattus norvegicusP09812182000 nM|= 182000.0 nMBindingDB, NPASS
Glycogen phosphorylase, muscle formOryctolagus cuniculusP00489114000 nM|1.44e+5 nM|229000 nM|75300 nM|83100 nM|74900 nM|100000 nM|648000 nM|= 114000.0 nM|= 283000.0 nM|= 83100.0 nM|= 74900.0 nM|= 75300.0 nM|= 100000.0 nM|= 648000.0 nM|= 229000.0 nMBindingDB, NPASS
Glycogen phosphorylase, muscle formHomo sapiensP11217114000 nMBindingDB
Carbonic anhydrase 2Homo sapiensP009182.000e+6 nMBindingDB
GABA-A receptor; anion channelHomo sapiensP14867|P47870|P18507|P28472|P48169|Q99928|Q9UN88|P34903|O00591|O14764|Q8N1C3|P18505|P78334|P47869|P31644|Q16445> 100000.0 nMNPASS
Endochitinase B1Aspergillus fumigatusQ873X9469000 nMBindingDB
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B/Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C/PhosphodiesteraseRattus norvegicusQ01066|Q6342170000 nMBindingDB
DNA-dependent protein kinase catalytic subunitHomo sapiensP7852710000000 nMBindingDB
DNA-dependent protein kinaseHomo sapiensP78527= 10000000.0 nMNPASS
CholinesteraseHomo sapiensP06276>50000 nMBindingDB
Chitotriosidase-1Homo sapiensQ13231257000 nMBindingDB
Cavia porcellusCavia porcellus= 150000.0 nMNPASS
Multidrug resistance-associated protein 4Homo sapiensO15439> 133000.0 nMNPASS
Glycogen phosphorylase, liver formRattus norvegicusP09811648000 nMBindingDB
Nuclear receptor subfamily 2 group E member 1Homo sapiensQ9Y466= 7943.28 nMNPASS
PI3-kinase p110-alpha subunitHomo sapiensP42336= 400000.0 nMNPASS
cAMP-specific 3',5'-cyclic phosphodiesterase 4AHomo sapiensP27815747000 nMBindingDB
Toxoplasma gondiiToxoplasma gondii= 370000.0 nMNPASS
Sodium channel protein type 1/2/3 subunit alphaHomo sapiensP35498|Q99250|Q9NY46660000 nMBindingDB
Sodium channel alpha subunits; brain (Types I, II, III)Homo sapiensQ9NY46= 660000.0 nMNPASS
Serine/threonine-protein kinase mTORHomo sapiensP42345400000 nM|= 400000.0 nMBindingDB, NPASS
Serine/threonine-protein kinase ATRHomo sapiensQ135351100000 nMBindingDB
Serine-protein kinase ATRHomo sapiensQ13535= 1100000.0 nMNPASS
Serine-protein kinase ATMHomo sapiensQ13315200000 nM|= 200000.0 nMBindingDB, NPASS
Muscle glycogen phosphorylaseHomo sapiensP11217= 114000.0 nMNPASS
Replicase polyprotein 1abHuman SARS coronavirusP0C6X7100000 nMBindingDB
Radical scavenging activity> 100000.0 nMNPASS
Potassium voltage-gated channel subfamily H member 2Homo sapiensQ128094897.79 nMBindingDB
Phosphodiesterase 1Rattus norvegicusQ01066= 70000.0 nMNPASS
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoformHomo sapiensP487363630000 nMBindingDB
Palmitoleoyl-protein carboxylesterase NOTUMHomo sapiensQ6P98846000 nM|= 45800.0 nM|= 46000.0 nM19000 nM|= 18600.0 nM|= 19000.0 nM|= 100000.0 nM= 85000.0 nMBindingDB, NPASS
PI3-kinase p110-gamma subunitHomo sapiensP48736= 1000000.0 nM|= 3630000.0 nMNPASS
PI3-kinase p110-delta subunitHomo sapiensO00329= 75000.0 nMNPASS
PI3-kinase p110-beta subunitHomo sapiensP42338= 400000.0 nMNPASS
Rattus norvegicusRattus norvegicus= 170000.0 nMNPASS
Carbonic anhydrase 1Homo sapiensP009155.5000e+7 nMBindingDB
Potassium channel subfamily K member 2Homo sapiensO95069377000 nMBindingDB
Canalicular multispecific organic anion transporter 1Homo sapiensQ92887> 133000.0 nMNPASS
Adenosine A3 receptorHomo sapiensP0DMS8= 13300.0 nM= 13300.0 nM|> 100000.0 nM|> 13300.0 nM|= 12589.25 nMNPASS
Adenosine A2b receptorRattus norvegicusP29276= 30000.0 nMNPASS
Adenosine A2b receptorMus musculusQ60614= 23000.0 nMNPASS
Adenosine A2b receptorHomo sapiensP29275= 10400.0 nM= 10400.0 nM|= 33800.0 nM|= 20500.0 nM|= 10000.0 nM|= 31622.78 nMNPASS
Adenosine A2a receptorRattus norvegicusP30543= 16000.0 nM|= 22000.0 nM|= 43000.0 nM|= 48000.0 nM|= 23000.0 nM|= 32500.0 nM|= 9400.0 nM|= 32800.0 nM|= 50000.0 nM|= 47200.0 nM|= 28700.0 nM|= 45000.0 nMNPASS
Adenosine A2a receptorHomo sapiensP29274= 20472.0 nM|= 9600.0 nM= 25118.86 nM|= 5510.0 nM= 48000.0 nM|= 18100.0 nM|= 5011.87 nM|= 11493.0 nM|= 23400.0 nM|= 9560.0 nM|= 2480.0 nM|= 50118.72 nMNPASS
Canalicular multispecific organic anion transporter 2Homo sapiensO15438> 133000.0 nMNPASS
Adenosine A2a receptorCavia porcellusP46616= 80000.0 nM|= 50000.0 nMNPASS
Adenosine A3 receptorRattus norvegicusP28647> 100000.0 nMNPASS
Adenosine A2 receptorHomo sapiensP29274= 30000.0 nMNPASS
Adenosine A1 receptorHomo sapiensP30542= 10700.0 nM= 45000.0 nM= 49000.0 nM|= 29000.0 nM|= 44900.0 nM|= 44000.0 nM|> 10000.0 nM|= 10700.0 nM|= 50118.72 nMNPASS
Adenosine A1 receptorCavia porcellusP47745= 100000.0 nM|> 100000.0 nMNPASS
Adenosine A1 receptorBos taurusP28190= 130000.0 nM|= 29000.0 nMNPASS
AcetylcholinesteraseHomo sapiensP223037250 nM|= 7250.0 nM|= 7943.28 nMBindingDB, NPASS
ATP-binding cassette sub-family G member 2Homo sapiensQ9UNQ0= 14000000.0 nMNPASS
ATP-binding cassette sub-family C member 4Homo sapiensO15439>133000 nMBindingDB
ATP-binding cassette sub-family C member 3Homo sapiensO15438>133000 nMBindingDB
ATP-binding cassette sub-family C member 2Homo sapiensQ92887>133000 nMBindingDB
Adenosine A1 receptorRattus norvegicusP25099= 110000.0 nM|= 117000.0 nM= 41000.0 nM|= 26000.0 nM|= 29000.0 nM|= 55000.0 nM|= 44000.0 nM|= 59000.0 nM|= 29100.0 nM|= 18800.0 nM|= 23500.0 nM|= 17000.0 nM|= 43900.0 nM|> 10000.0 nM|= 32500.0 nMNPASS
Adenosine receptorRattus norvegicusP28647= 40000.0 nM|= 60000.0 nM|= 25000.0 nM|= 15000.0 nMNPASS
Adenosine A2 receptorRattus norvegicusP30543= 63000.0 nM= 27000.0 nM|= 48000.0 nM|= 37000.0 nM|= 43000.0 nM|= 48100.0 nMNPASS
Adenosine receptor A1Cavia porcellusP47745100000 nM|>100000 nMBindingDB
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiensQ9UNQ014000000 nMBindingDB
Bile salt export pumpHomo sapiensO95342>135000 nM|>1000000 nM|>133000 nM|> 135000.0 nM|> 1000000.0 nM|> 133000.0 nMBindingDB, NPASS
Amine oxidase [flavin-containing] BHomo sapiensP27338>50000 nM3800000 nM|3600000 nMBindingDB
Amine oxidase [flavin-containing] AHomo sapiensP21397>50000 nMBindingDB
Adenosine receptor A3Rattus norvegicusP28647>100000 nMBindingDB
Adenosine receptor A3Homo sapiensP0DMS813300 nM13300 nM|>100000 nM|>13300 nMBindingDB
Adenosine receptor A2bRattus norvegicusP2927630000 nMBindingDB
Adenosine receptor A2bMus musculusQ6061423000 nMBindingDB
ButyrylcholinesteraseHomo sapiensP06276> 50000.0 nM|> 100000.0 nMNPASS
Adenosine receptor A2bHomo sapiensP2927510400 nM20500 nM|10400 nM|33800 nM|10000 nMBindingDB
Adenosine receptor A2a/A2bRattus norvegicusP29276|P3054363000 nM37000 nM|48000 nM|27000 nM|48100 nMBindingDB
Adenosine receptor A2a/A2bHomo sapiensP29274|P2927530000 nMBindingDB
Adenosine receptor A2aRattus norvegicusP3054322000 nM|48000 nM|23000 nM|16000 nM|9400 nM|32500 nM|50000 nM|43000 nM|47200 nM|32800 nM|28700 nM|45000 nMBindingDB
Adenosine receptor A2aHomo sapiensP292749600 nM5510 nM>10000 nM|48000 nM|23400 nM|18100 nM|5011.87 nMBindingDB
Adenosine receptor A2aCavia porcellusP4661650000 nM|80000 nMBindingDB
Adenosine receptor A1/A2a/A2b/A3Rattus norvegicusP25099|P28647|P29276|P3054360000 nM|25000 nM|15000 nM|40000 nMBindingDB
Adenosine receptor A1Rattus norvegicusP25099110000 nM|117000 nM>10000 nM|29100 nM|55000 nM|59000 nM|41000 nM|29000 nM|26000 nM|17000 nM|23500 nM|18800 nM|44000 nM|43900 nM|32500 nMBindingDB
Adenosine receptor A1Homo sapiensP3054210700 nM45000 nM>10000 nM|44900 nM|49000 nM|29000 nM|44000 nM|10700 nMBindingDB
Adenosine receptor A1Bos taurusP28190>10000 nM|29000 nM|130000 nMBindingDB