IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	IC50	Ki	Source
Phosphodiesterase 4D	Homo sapiens	Q08499	= 2800.0 nM		NPASS
Phosphodiesterase 4A	Sus scrofa	O77823	= 5270.0 nM\|= 6400.0 nM		NPASS
Phosphodiesterase 4	Homo sapiens	P27815\|Q08499\|Q07343\|Q08493	= 500.0 nM		NPASS
Phosphodiesterase 3A	Sus scrofa	Q9XSW7	> 100000.0 nM\|= 44000.0 nM		NPASS
Phosphodiesterase 3	Homo sapiens	Q14432\|Q13370	= 43000.0 nM		NPASS
Phosphodiesterase	Trypanosoma cruzi		6.9e+3 nM		BindingDB
Phosphodiesterase 11A	Homo sapiens	Q9HCR9		= 400.0 nM	NPASS
Phosphodiesterase 10A	Homo sapiens	Q9Y233		= 1000.0 nM	NPASS
Phosphodiesterase 1	Homo sapiens	P54750\|Q01064\|Q14123	> 100000.0 nM\|= 45000.0 nM		NPASS
Phosphodiesterase	Sus scrofa		>100000 nM\|44000 nM		BindingDB
Phosphodiesterase 5A	Homo sapiens	O76074	= 574.0 nM\|= 520.0 nM\|= 2831.0 nM		NPASS
Phosphodiesterase 2A	Homo sapiens	O00408	= 4000.0 nM\|= 3240.0 nM\|= 3600.0 nM		NPASS
Phosphodiesterase 6	Homo sapiens	Q13956\|P18545\|P35913\|O43924\|P16499\|P51160		= 125.0 nM	NPASS
cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens	O76074	5e+2 nM\|520 nM\|574 nM		BindingDB
Phosphodiesterase 8A	Homo sapiens	O60658	= 4000.0 nM		NPASS
Plasmodium falciparum	Plasmodium falciparum		= 3162.28 nM\|= 1995.26 nM\|= 1300.0 nM\|= 64000.0 nM\|= 3981.07 nM\|= 7943.28 nM\|= 2511.89 nM		NPASS
Protein prune homolog	Homo sapiens	Q86TP1	= 780.0 nM		NPASS
SARS-CoV-2	Severe acute respiratory syndrome coronavirus 2		> 20000.0 nM\|> 19952.62 nM		NPASS
Solute carrier family 22 member 1	Homo sapiens	O15245	81000 nM\|= 81000.0 nM		BindingDB, NPASS
Solute carrier family 22 member 2	Homo sapiens	O15244	2600 nM\|= 2600.0 nM		BindingDB, NPASS
Trypanosoma brucei rhodesiense	Trypanosoma brucei rhodesiense		= 7450.0 nM		NPASS
Trypanosoma cruzi	Trypanosoma cruzi		= 29330.0 nM		NPASS
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	Homo sapiens	Q9Y233		1000 nM	BindingDB
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D	Homo sapiens	P27815\|Q07343\|Q08493\|Q08499	500 nM		BindingDB
cGMP-dependent 3',5'-cyclic phosphodiesterase	Homo sapiens	O00408	4000 nM\|3600 nM\|3240 nM		BindingDB
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B	Homo sapiens	Q13370\|Q14432	43000 nM		BindingDB
P-glycoprotein 1	Homo sapiens	P08183	= 34300.0 nM\|= 22700.0 nM\|= 23700.0 nM		NPASS
Phosphodiesterase 7	Homo sapiens	Q13946\|Q9NP56		= 600.0 nM	NPASS
O43924/P16499/P18545/P35913/P51160/Q13956	Homo sapiens	O43924\|P16499\|P18545\|P35913\|P51160\|Q13956		125 nM	BindingDB
L1210	Mus musculus		= 340.0 nM		NPASS
Multidrug resistance-associated protein 5	Homo sapiens	O15440	= 30000.0 nM		NPASS
3',5'-cyclic-AMP phosphodiesterase	Sus scrofa		6400 nM\|5270 nM		BindingDB
ATP-binding cassette sub-family C member 2	Homo sapiens	Q92887	>133000 nM		BindingDB
ATP-binding cassette sub-family C member 3	Homo sapiens	O15438	>133000 nM		BindingDB
ATP-binding cassette sub-family C member 4	Homo sapiens	O15439	8300 nM\|2000 nM		BindingDB
ATP-binding cassette sub-family C member 5	Homo sapiens	O15440	30000 nM		BindingDB
ATP-binding cassette sub-family G member 2	Homo sapiens	Q9UNQ0	= 6400.0 nM		NPASS
NON-PROTEIN TARGET			> 59450.0 nM\|= 38640.0 nM		NPASS
Arachidonate 15-lipoxygenase	Oryctolagus cuniculus	P12530	= 6956.0 nM		NPASS
Bile salt export pump	Homo sapiens	O95342	4000 nM\|= 4000.0 nM		BindingDB, NPASS
Broad substrate specificity ATP-binding cassette transporter ABCG2	Homo sapiens	Q9UNQ0	6400 nM		BindingDB
Canalicular multispecific organic anion transporter 1	Homo sapiens	Q92887	> 133000.0 nM		NPASS
Canalicular multispecific organic anion transporter 2	Homo sapiens	O15438	> 133000.0 nM		NPASS
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A	Homo sapiens	Q9HCR9		400 nM	BindingDB
ATP-dependent translocase ABCB1	Homo sapiens	P08183	34300 nM\|22700 nM\|23700 nM		BindingDB
Equilibrative nucleoside transporter 1	Homo sapiens	Q99808	144.8 nM\|= 144.8 nM\|= 8.1 nM	8.18 nM\|8.8 nM\|= 8.18 nM\|= 8.79 nM	BindingDB, NPASS
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C	Homo sapiens	P54750\|Q01064\|Q14123	45000 nM\|>100000 nM		BindingDB
Multidrug resistance-associated protein 4	Homo sapiens	O15439	= 2000.0 nM\|= 8300.0 nM		NPASS
Multidrug and toxin extrusion protein 2	Homo sapiens	Q86VL8	74000 nM\|= 74000.0 nM		BindingDB, NPASS
Multidrug and toxin extrusion protein 1	Homo sapiens	Q96FL8	26000 nM\|= 26000.0 nM		BindingDB, NPASS
Homo sapiens	Homo sapiens		> 500000000000.0 nM		NPASS
Leishmania donovani	Leishmadonovani		= 62020.0 nM\|> 59450.0 nM		NPASS
High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A/cAMP-specific 3',5'-cyclic phosphodiesterase 7B	Homo sapiens	Q13946\|Q9NP56		600 nM	BindingDB
Heat shock protein HSP90	Homo sapiens	P07900\|P08238	= 21068.2 nM		NPASS
Heat shock protein HSP 90-alpha	Homo sapiens	P07900	21068.2 nM		BindingDB
Gamma-aminobutyric acid receptor subunit alpha-1	Rattus norvegicus	P62813		87.9 nM\|162 nM	BindingDB
Exopolyphosphatase PRUNE1	Homo sapiens	Q86TP1	780 nM		BindingDB
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	Homo sapiens	O60658	5e+2 nM\|4000 nM		BindingDB

a curated database

IMPPAT Phytochemical information:
Dipyridamole

Bioactivity information

IMPPAT Phytochemical information: Dipyridamole

Bioactivity information

IMPPAT Phytochemical information:
Dipyridamole