IMPPAT | IMPPAT: Indian Medicinal Plants, Phytochemistry And Therapeutics

Bioactivity information

Target name	Target organism	UniProt identifier	EC50	IC50	Kd	Ki	Source
MAP kinase p38 alpha	Homo sapiens	Q16539		= 2210.0 nM			NPASS
MAP kinase-activated protein kinase 5	Homo sapiens	Q8IW41		1000 nM\|= 1000.0 nM			BindingDB, NPASS
MCF7	Homo sapiens			= 74000.0 nM\|= 4000.0 nM			NPASS
MDA-MB-231	Homo sapiens			= 76100.0 nM\|= 83000.0 nM\|= 149000.0 nM			NPASS
Matrilysin	Homo sapiens	P09237		8300 nM\|21500 nM			BindingDB
Matrix metalloproteinase 14	Homo sapiens	P50281		= 6800.0 nM			NPASS
Zinc finger protein mex-5	Caenorhabditis elegans	Q9XUB2	727 nM\|= 727.0 nM				BindingDB, NPASS
Matrix metalloproteinase-14	Homo sapiens	P50281		6800 nM			BindingDB
Microtubule-associated protein tau	Homo sapiens	P10636		1800 nM\|= 1800.0 nM			BindingDB, NPASS
Mitogen-activated protein kinase 14	Homo sapiens	Q16539		2210 nM			BindingDB
NAD kinase	Homo sapiens	O95544		960 nM\|= 960.0 nM	1780 nM\|= 1780.0 nM	3280 nM\|= 3280.0 nM	BindingDB, NPASS
NCI-H1299	Homo sapiens			> 80000.0 nM\|= 20600.0 nM			NPASS
NCI-H1650	Homo sapiens			= 24800.0 nM			NPASS
NCI-H1703	Homo sapiens			= 17100.0 nM			NPASS
NCI-H460	Homo sapiens			= 18000.0 nM			NPASS
NON-PROTEIN TARGET			= 100000.0 nM\|= 195000.0 nM	= 9900.0 nM\|= 26.1 ug.mL-1\|= 29800.0 nM\|= 69100.0 nM\|= 56000.0 nM			NPASS
Leukocyte elastase	Homo sapiens	P08246		= 12800.0 nM			NPASS
Matrix metalloproteinase-2	Homo sapiens	P08253		= 9600.0 nM			NPASS
Leishmania infantum	Leishmaitum		= 2600.0 nM				NPASS
Human herpesvirus 1	Human herpesvirus 1			= 48410.0 nM\|= 45360.0 nM\|= 16000.0 nM\|= 48180.0 nM\|= 49090.0 nM\|= 18300.0 nM\|= 72300.0 nM			NPASS
Latent membrane protein 1	Human herpesvirus 4 (strain B95-8)	P03230			= 360.0 nM		NPASS
HT-29	Homo sapiens			= 60000.0 nM			NPASS
Heat shock protein HSP 90-beta	Homo sapiens	P08238		155000 nM\|= 155000.0 nM			BindingDB, NPASS
Hepatitis B virus	Hepatitis B virus			= 10000.0 nM			NPASS
Hepatocyte growth factor receptor	Homo sapiens	P08581		10000 nM\|= 10000.0 nM		3300 nM\|= 3300.0 nM	BindingDB, NPASS
Histone acetyltransferase KAT2B	Homo sapiens	Q92831		60000 nM			BindingDB
Histone acetyltransferase KAT5	Homo sapiens	Q92993		70000 nM\|= 70000.0 nM			BindingDB, NPASS
Histone acetyltransferase PCAF	Homo sapiens	Q92831		= 60000.0 nM			NPASS
Histone acetyltransferase p300	Homo sapiens	Q09472		30000 nM\|= 30000.0 nM			BindingDB, NPASS
Leishmania amazonensis	Leishmaamazonensis			= 1600.0 nM			NPASS
Neutrophil elastase	Homo sapiens	P08246		12800 nM			BindingDB
Human immunodeficiency virus 1	Human immunodeficiency virus 1		= 7.0 ug.mL-1	= 19910.0 nM			NPASS
Human immunodeficiency virus type 1 reverse transcriptase	Human immunodeficiency virus 1	Q72547		= 730.0 nM			NPASS
Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist	Homo sapiens			= 920.0 nM			NPASS
Influenza A virus	InflueA virus		= 28930.0 nM\|= 30380.0 nM	= 41250.0 nM			NPASS
Influenza A virus (A/PR/8/34(H1N1))	InflueA virus (A/Puerto Rico/8/1934(H1N1))		= 94600.0 nM\|= 391.0 nM				NPASS
L1210	Mus musculus			= 690000.0 nM			NPASS
L929	Mus musculus			= 82300.0 nM			NPASS
LN-229	Homo sapiens			= 15000.0 nM			NPASS
Human herpesvirus 2	Human herpesvirus 2			= 12270.0 nM\|= 12480.0 nM\|= 12500.0 nM\|= 12470.0 nM\|= 12050.0 nM			NPASS
Nonstructural protein 3	Zika virus			87000 nM			BindingDB
Polycomb protein EED	Homo sapiens	O75530			15100 nM\|= 15100.0 nM		BindingDB, NPASS
P-glycoprotein 1	Homo sapiens	P08183		= 124.1 nM\|= 122.6 nM			NPASS
SK-BR-3	Homo sapiens			= 149000.0 nM\|= 150000.0 nM\|= 4000.0 nM			NPASS
SK-MEL-2	Homo sapiens			= 31000.0 nM			NPASS
SW480	Homo sapiens			= 195000.0 nM			NPASS
Salivary alpha-amylase	Homo sapiens	P04745		= 1400000.0 nM			NPASS
Sarcoplasmic/endoplasmic reticulum calcium ATP-ase	Oryctolagus cuniculus	P04191		= 12000.0 nM			NPASS
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	Oryctolagus cuniculus	P04191		12000 nM			BindingDB
Serine/threonine-protein kinase mTOR	Homo sapiens	P42345				= 320.0 nM	NPASS
Signal transducer and activator of transcription 1-alpha/beta	Homo sapiens	P42224			700 nM\|= 700.0 nM		BindingDB, NPASS
SH-SY5Y	Homo sapiens		= 39.87 nM				NPASS
Solute carrier organic anion transporter family member 2B1	Homo sapiens	O94956		= 79600.0 nM\|= 79432.82 nM			NPASS
T47D	Homo sapiens			= 57000.0 nM			NPASS
T98G	Homo sapiens			= 166000.0 nM			NPASS
Telomerase reverse transcriptase	Homo sapiens	O14746		1000 nM\|1080 nM\|1180 nM\|= 1000.0 nM\|= 1080.0 nM\|= 1180.0 nM			BindingDB, NPASS
Thiosulfate sulfurtransferase	Homo sapiens	Q16762		7300 nM\|= 7300.0 nM			BindingDB, NPASS
Transthyretin	Homo sapiens	P02766			400 nM\|= 400.0 nM		BindingDB, NPASS
Tyrosine-protein kinase FYN	Homo sapiens	P06241			= 367.0 nM		NPASS
U-266	Homo sapiens			= 23200.0 nM			NPASS
U-87 MG	Homo sapiens			= 18000.0 nM			NPASS
Squalene monooxygenase	Rattus norvegicus	P52020		690 nM\|= 690.0 nM			BindingDB, NPASS
Orphan methyltransferase M.SssI	Spiroplasma monobiae (strain ATCC 33825 / MQ-1)	P15840				28 nM	BindingDB
Reverse transcriptase/RNaseH	Human immunodeficiency virus 1			730 nM			BindingDB
Replicase polyprotein 1ab	Middle East respiratory syndrome-related coronavirus (isolate UnitedKingdom/H123990006/2012) (Betacoronavirus England 1) (Humancoronavirus EMC)	K9N7C7		> 10000.0 nM			NPASS
PANC-1	Homo sapiens			= 62000.0 nM			NPASS
PC-9				= 77400.0 nM			NPASS
PI3-kinase p110-alpha subunit	Homo sapiens	P42336				= 380.0 nM	NPASS
POsterior Segregation	Caenorhabditis elegans		5892 nM				BindingDB
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Homo sapiens	Q13526		20000 nM\|= 20000.0 nM			BindingDB, NPASS
Phosphoglycerate mutase 1	Homo sapiens	P18669		490 nM\|= 490.0 nM			BindingDB, NPASS
Plasminogen activator inhibitor 1	Homo sapiens	P05121		91 nM			BindingDB
Plasmodium falciparum	Plasmodium falciparum			= 25500.0 nM\|= 9900.0 nM\|= 610.0 nM\|= 1400.0 nM			NPASS
Replicase polyprotein 1ab	Severe acute respiratory syndrome coronavirus 2	P0DTD1		= 1580.0 nM\|= 720.0 nM			NPASS
Plasmodium falciparum D6	Plasmodium falciparum D6			= 73.0 nM			NPASS
Polymerase acidic protein	InflueA virus (A/Puerto Rico/8/1934(H1N1))	P03433		= 5860.0 nM\|= 6450.0 nM			NPASS
Polymerase acidic protein	InflueA virus (strain A/Puerto Rico/8/1934 H1N1)	P03433		6450 nM			BindingDB
Potassium voltage-gated channel subfamily H member 2	Homo sapiens	Q12809		6025.6 nM			BindingDB
Prostaglandin E synthase	Homo sapiens	O14684		1800 nM\|= 1800.0 nM			BindingDB, NPASS
Proteasome Macropain subunit MB1	Homo sapiens	P28074		= 86.0 nM\|= 1000.0 nM\|= 18000.0 nM			NPASS
Proteasome subunit beta type-5	Homo sapiens	P28074		86.0 nM\|18000 nM\|1000 nM			BindingDB
RAW264.7	Mus musculus			= 29800.0 nM			NPASS
Radical scavenging activity				= 3760000.0 nM\|= 5.6 ug.mL-1\|= 2.7 ug.mL-1\|= 8300.0 nM			NPASS
HT-22	Mus musculus			= 23800.0 nM			NPASS
HSP60/HSP10	Homo sapiens			= 2300.0 nM			NPASS
Matrix metalloproteinase 7	Homo sapiens	P09237		= 21500.0 nM			NPASS
HCT-116	Homo sapiens			= 161000.0 nM\|= 5000.0 nM			NPASS
Alpha-glucosidase MAL62	Saccharomyces cerevisiae	P07265		2000 nM			BindingDB
Amyloid-beta A4 protein	Homo sapiens	P05067		= 140.0 nM\|= 180.0 nM			NPASS
Amyloid-beta precursor protein	Homo sapiens	P05067		4600 nM\|500 nM			BindingDB
Anthrax lethal factor	Bacillus anthracis	P15917		= 97.0 nM			NPASS
Apoptosis regulator Bcl-2	Homo sapiens	P10415				335 nM\|= 234.42 nM\|= 335.0 nM	BindingDB, NPASS
BCL2/BAD	Homo sapiens	Q92934\|P10415				= 490.0 nM	NPASS
BCL2/BID	Homo sapiens	P10415\|P55957		= 450.0 nM			NPASS
BCL2A1/BID	Homo sapiens	Q16548\|P55957		= 1790.0 nM			NPASS
Alpha-amylase 1A	Homo sapiens	P0DUB6		1400000 nM			BindingDB
BCL2L10/BID	Homo sapiens	Q9HD36\|P55957		= 360.0 nM			NPASS
BXPC-3	Homo sapiens			= 33000.0 nM			NPASS
Bcl-xL/BH3-interacting domain death agonist	Homo sapiens			= 590.0 nM			NPASS
Beta amyloid A4 protein	Homo sapiens	P05067		= 100000.0 nM\|= 4600.0 nM\|= 3000.0 nM\|= 500.0 nM			NPASS
Beta-secretase 1	Homo sapiens	P56817		757 nM\|1600 nM\|= 757.0 nM\|= 1600.0 nM			BindingDB, NPASS
Bile salt export pump	Homo sapiens	O95342		214000 nM\|= 214000.0 nM			BindingDB, NPASS
CHO	Cricetulus griseus			= 3200.0 nM\|= 7700.0 nM\|= 271000.0 nM			NPASS
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1	Homo sapiens	Q11201		27000 nM			BindingDB
COLO 201	Homo sapiens			= 38000.0 nM			NPASS
BCL2L2/BID	Homo sapiens	Q92843\|P55957		= 2330.0 nM			NPASS
CREB-binding protein	Homo sapiens	Q92793		50000 nM\|= 50000.0 nM			BindingDB, NPASS
Alpha-(1,3)-fucosyltransferase 7	Homo sapiens	Q11130		700 nM\|2200 nM			BindingDB
ADAMTS5	Homo sapiens	Q9UNA0		= 100.0 nM			NPASS
HL-60	Homo sapiens			= 9400.0 nM			NPASS
11-beta-hydroxysteroid dehydrogenase 1	Homo sapiens	P28845		= 57990.0 nM			NPASS
11-beta-hydroxysteroid dehydrogenase 2	Homo sapiens	P80365		= 20930.0 nM			NPASS
3-hydroxyacyl-[acyl-carrier-protein] dehydratase	Plasmodium falciparum			400 nM\|30 nM			BindingDB
3-oxoacyl-(Acyl-carrier protein) reductase	Plasmodium falciparum (isolate 3D7)	Q8I2S7		= 320.0 nM			NPASS
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum			300 nM			BindingDB
3-oxoacyl-acyl-carrier protein reductase	Plasmodium falciparum	Q965D6		= 300.0 nM\|= 0.32 ug.mL-1			NPASS
3T3-L1	Mus musculus			= 112000.0 nM			NPASS
ATP-dependent translocase ABCB1	Homo sapiens	P08183		123 nM\|124 nM			BindingDB
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6	Homo sapiens	P51993		1800 nM			BindingDB
6-phosphogluconate dehydrogenase	Homo sapiens	P52209		= 720.0 nM			NPASS
6-phosphogluconate dehydrogenase, decarboxylating	Homo sapiens	P52209		720 nM			BindingDB
60 kDa chaperonin	Escherichia coli (strain K12)	P0A6F5		> 250000.0 nM			NPASS
60 kDa heat shock protein, mitochondrial	Homo sapiens	P10809		2300 nM			BindingDB
72 kDa type IV collagenase	Homo sapiens	P08253		3700 nM\|9600 nM			BindingDB
A-431	Homo sapiens		= 38000.0 nM\|= 266000.0 nM				NPASS
A549	Homo sapiens			= 29000.0 nM\|= 185000.0 nM			NPASS
ADAMTS4	Homo sapiens	O75173		= 100.0 nM			NPASS
40S ribosomal protein SA	Homo sapiens	P08865			= 39.9 nM		NPASS
Cannabinoid CB1 receptor	Homo sapiens	P21554				= 33600.0 nM	NPASS
3-oxoacyl-[acyl-carrier-protein] reductase	Plasmodium falciparum (isolate 3D7)			320 nM			BindingDB
Cannabinoid receptor 1	Homo sapiens	P21554				33600 nM	BindingDB
Dual specificity tyrosine-phosphorylation-regulated kinase 1B	Homo sapiens	Q9Y463		>100 nM\|> 10000.0 nM\|= 713.6 nM			BindingDB, NPASS
Dual specificity tyrosine-phosphorylation-regulated kinase 4	Homo sapiens	Q9NR20		= 5200.0 nM			NPASS
Dual-specificity tyrosine-phosphorylation regulated kinase 1A	Homo sapiens	Q13627		= 13440.0 nM\|= 330.0 nM\|= 490.7 nM\|= 765.6 nM\|= 232.0 nM			NPASS
Dual-specificity tyrosine-phosphorylation regulated kinase 2	Homo sapiens	Q92630		= 2004.0 nM			NPASS
Dual-specificity tyrosine-phosphorylation regulated kinase 3	Homo sapiens	O43781		= 1625.0 nM			NPASS
Enoyl-[acyl-carrier-protein] reductase	Escherichia coli K-12	P0AEK4		= 15000.0 nM\|= 5000.0 nM			NPASS
Enoyl-[acyl-carrier-protein] reductase [NADH] FabI	Escherichia coli (strain K12)	P0AEK4		15000 nM\|5000 nM			BindingDB
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum	Q965D5		= 200.0 nM\|= 250.0 nM		= 186.0 nM\|= 79.0 nM\|= 8.0 nM	NPASS
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Rattus norvegicus	Q63470		330 nM\|= 330.0 nM		330 nM	BindingDB, NPASS
Fatty acid synthase	Gallus gallus	P12276		100000 nM\|52000 nM\|= 100000.0 nM\|= 52000.0 nM			BindingDB, NPASS
Fatty acid synthase	Plasmodium falciparum	Q965D7		= 400.0 nM\|= 0.03 ug.mL-1\|= 30.0 nM			NPASS
Genome polyprotein	Zika virus	A0A024AXB9		= 87000.0 nM			NPASS
H9	Homo sapiens			= 8.0 ug.mL-1			NPASS
Glucose-6-phosphate 1-dehydrogenase	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P11412		250 nM			BindingDB
Glucose-6-phosphate 1-dehydrogenase	Saccharomyces cerevisiae S288c	P11412		= 250.0 nM			NPASS
Glycogen synthase kinase-3 beta	Homo sapiens	P49841		= 6269.0 nM			NPASS
GroEL/GroES	Escherichia coli			= 580.0 nM\|= 360.0 nM			NPASS
Cannabinoid CB2 receptor	Homo sapiens	P34972				= 42800.0 nM	NPASS
Fatty acid synthase	Homo sapiens	P49327		51970 nM\|= 51970.0 nM			BindingDB, NPASS
Dual specificity tyrosine-phosphorylation-regulated kinase 1A	Homo sapiens	Q13627		>100 nM\|13440 nM\|330 nM			BindingDB
Enoyl-acyl-carrier protein reductase	Plasmodium falciparum			200 nM\|250 nM		186 nM\|8 nM\|79 nM	BindingDB
Dual specificity protein kinase CLK3	Homo sapiens	P49761		= 2577.0 nM			NPASS
Dual specificity protein kinase CLK4	Homo sapiens	Q9HAZ1		= 367.7 nM			NPASS
Casein kinase I epsilon	Homo sapiens	P49674		= 365.0 nM			NPASS
Chaperonin GroEL	Escherichia coli			>250000 nM			BindingDB
Chikungunya virus	Chikunguvirus		= 6.54 ug.mL-1				NPASS
Co-chaperonin GroES	Escherichia coli			580 nM\|360 nM			BindingDB
CpG DNA methylase	Spiroplasma monobiae	P15840				= 28.0 nM	NPASS
Cytoplasmic zinc-finger protein	Caenorhabditis elegans	G5EF15	= 5892.0 nM				NPASS
DNA (cytosine-5)-methyltransferase 1	Homo sapiens	P26358		500 nM\|= 500.0 nM			BindingDB, NPASS
DNA repair protein RAD52 homolog	Homo sapiens	P43351		277 nM\|= 277.0 nM			BindingDB, NPASS
Cyclin-dependent kinase 5/CDK5 activator 1	Homo sapiens	Q00535\|Q15078		= 431.0 nM			NPASS
Cannabinoid receptor 2	Homo sapiens	P34972				42800 nM	BindingDB
DNA topoisomerase 2	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	P06786		3000000 nM			BindingDB
Dual specificity protein kinase CLK1	Homo sapiens	P49759		> 10000.0 nM\|= 71.6 nM			NPASS
Disintegrin and metalloproteinase domain-containing protein 17	Homo sapiens	P78536		21000 nM			BindingDB
Dipeptidyl peptidase IV	Homo sapiens	P27487		= 10210.0 nM			NPASS
Dual specificity protein kinase CLK2	Homo sapiens	P49760		= 1317.0 nM			NPASS
Dihydrofolate reductase	Mycobacterium tuberculosis	P9WNX1		= 10910.0 nM			NPASS
DNA topoisomerase 2	Saccharomyces cerevisiae S288c	P06786		= 3000000.0 nM			NPASS
Dipeptidyl peptidase 4	Homo sapiens	P27487		10210 nM			BindingDB

a curated database

IMPPAT Phytochemical information:
Epigallocatechin gallate

Bioactivity information

IMPPAT Phytochemical information: Epigallocatechin gallate

Bioactivity information

IMPPAT Phytochemical information:
Epigallocatechin gallate