| Comparison of the effectiveness of proteolytic enzymes and diclofenac in patients with impacted third molars in the mandible. | Comparison of efficacy of combinations of proteolytic enzymes (trypsin, bromelain, and rutoside) and diclofenac versus serratiopeptidase and diclofenac versus diclofenac alone in patients with similar Pederson’s difficulty index impacted mandibular third molars in a randomised control double blind trial - NIL | CTRI/2023/08/056907 |
| Effectiveness of a Gel with Glucosamine and Other Ingredients in Reducing Pain from Jaw Muscle and Disc Problems A Clinical Study | Evaluation of the Effectiveness of Glucosamine and Bromelain-Trypsin-Rutoside Combination Gel in the Management of Myogenous and Disc Disorders of Temporomandibular Joint- A Randomised Clinical Trial - NIL | CTRI/2025/04/085392 |
| The effects of rutin supplement on the brain of type 2 diabetes mellitus patients | The effects of rutin flavonoid supplement on brain white matter neural tracts volume in type 2 diabetes mellitus patients by MRI | IRCT20151128025274N6 |
| The Effect of Three Different Medications on Anesthetic Success and Postoperative Pain | The Effect of Premedication With Trypsin, Bromelain and Rutoside Combination on the Success of IAN Block and Post Endodontic Pain in Patients With Symptomatic Irreversible Pulpitis: A Randomized Clinical Trial | NCT06298383 |
| Impact of Rutin and Vitamin C Combination on Oxidative Stress, Insulin Sensitivity and Lipid Profile in Type 2 Diabetic Patients | Evaluation of the Impact of Rutin and Vitamin C Combination on Oxidative Stress, Insulin Sensitivity and Lipid Profile in Type 2 Diabetic Patients | NCT03437902 |
| Identifying the efficacy of the plant-origin flavonoid rutin in 2 doses (250mg and 500mg) and 2 delivery forms (yoghurt and capsules) | Comparison the pharmocokinetics properties of 2 doses of rutin (250mg and 500mg) in 2 delivery forms (yoghurt and capsules) in 6 healthy participants | ACTRN12618000630213 |
| Effect of rutin on insulin secretion in prediabetes | Identifying the efficacy of the plant-origin flavonoid rutin and targeting amylin to restore insulin secretion and prevent progression to diabetes in prediabetic participants | ACTRN12618000656235 |
| Pilot Study on Rutin Combined With Tislelizumab and GC (Gemcitabine and Cisplatin) as Neoadjuvant Therapy for Platinum-refractory Muscle-invasive Bladder Cancer | A Single-Arm, Open-Label, Multicenter Pilot Study:Rutin Combined With Tislelizumab and GC (Gemcitabine and Cisplatin) for Platinum-refractory Muscle-Invasive Bladder Cancer | NCT06916494 |
| Evaluating the use of Rutin gel after scaling and root planing in the treatment of periodontal disease | Evaluating the clinical efficacy and GCF Superoxide Dismutase(SOD) Activity of Locally Delivered Rutin gel Adjunct to scaling and root planing in Stage II Grade A Periodontitis-A Randomised Control Trial. - nil | CTRI/2025/04/084505 |
| The effects of rutin flavonoid on type 2 diabetes mellitus | The effects of rutin flavonoid supplement consumption on blood pressure, heart rate, quality of life and some serum antioxidant enzymes in type 2 diabetic patients | IRCT20170116031993N5 |
| Study to evaluate the safety and efficacy of Fixed Dose Combination of Trypsin-Chymotrypsin, Bromelain and Rutoside Trihydrate Tablets. | ââ?¬Å?An Open Label, Prospective, Non-comparative, Multicentre, Phase IV Clinical Study to Evaluate the Safety, Tolerability and Efficacy of FDC of Trypsin - Chymotrypsin 50000 AU plus Bromelain 90 mg plus Rutoside Trihydrate 100 mg Tablets in Subjects for the treatment of conditions associated with Inflammation and edema of traumatic origin.ââ?¬? | CTRI/2021/10/037277 |
| The effects of rutin flavonoid on type 2 diabetes mellitus | The effects of rutin flavonoid supplement on glycemic status, lipid profile, plasma atherogenic index, brain derived neurotropic factor (BDNF), some serum inflammatory biomarkers and oxidative stress in patients with type 2 diabetes mellitus | IRCT20151128025274N5 |
| Study of the mechanism of action of a medicinal product based on Bromelain, Trypsin and Rutoside, compared to the same medicinal product without active ingredient called Placebo in subjects suffering from osteoarthritis. | A Randomized, Double-blind, Placebo-controlled, Crossover Study to Investigate the Mechanism of Action of an Oral Enzyme Treatment with Bromelain, Trypsin and Rutoside versus Placebo in Subjects with OsTeoarthritis (WOBE-SMART) - WOBE-SMART study | EUCTR2020-003154-80-BE |
| Study to compare efficacy and safety of trypsion plus bromelain plus rutoside tablet along with cefuroxime axetil tablet versus cefuroxime axetil tablet given alone in patients with surgical wound after minor surgery | A Prospective, Single-center, Open label, Randomized, Parallel-group, Active-controlled Clinical Study to Evaluate the Efficacy and Safety of FDC of Trypsin plus Bromelain plus Rutoside trihydrate given along with Cefuroxime axetil versus Cefuroxime axetil for Healing in Patients with Surgical Wound after Minor Surgery | CTRI/2020/08/027070 |
| A study to evaluate the Safety and Effectiveness of Fixed Dose Combination of Trypsin 96 mg plus Bromelain 180 mg plus Rutoside Trihydrate 200 mg versus Trypsin - chymotrypsin (1,00,000 AU) in patients with surgical wounds after minor surgery | A Multicentric, Open label, Randomized, Comparative, Clinical Study evaluating Safety and Efficacy of Fixed Dose Combination of Trypsin 96 mg plus Bromelain 180 mg plus Rutoside Trihydrate 200 mg enteric coated tablet versus Chymoral Forte (Trypsin - chymotrypsin (1,00,000 AU)) enteric coated Tablet in patients for healing potential in surgical wounds after minor surgery | CTRI/2017/10/010004 |
| A study to evaluate the Safety and Effectiveness of Fixed Dose Combination of Trypsin 48 mg plus Bromelain 90 mg plus Rutoside Trihydrate 100 mg enteric coated tablet versus Serratiopeptidase 10 mg enteric coated tablet in patients with surgical wounds after minor surgery | A Multicentric, Open label, Randomized, Comparative, Clinical Study evaluating Safety and Efficacy of Fixed Dose Combination of Trypsin 48 mg plus Bromelain 90 mg plus Rutoside Trihydrate 100 mg enteric coated tablet versus Serratiopeptidase 10 mg enteric coated tablet in patients for healing potential in surgical wounds after minor surgery | CTRI/2018/04/013151 |
| Study to evaluate the therapy of pigmented purpura progressiva with rutin and vitamin c - a retrospective study | Study to evaluate the therapy of pigmented purpura progressiva with rutin and vitamin c - a retrospective study - CiPPP | DRKS00003561 |
| Double-blind, placebo-controlled study for the effect of rutin-rich processed buckwheat (Manten-kirari) on dyslipidemia | Double-blind, placebo-controlled study for the effect of rutin-rich processed buckwheat (Manten-kirari) on dyslipidemia - Effect of rutin-rich buckwheat on dyslipidemia | JPRN-UMIN000012507 |
| Phlogam and Disperzyme use for reducing pain and swelling after small surgery | A multicentre, randomized, assessor blind, active controlled, comparative, phase IV study to assess the safety and efficacy of two fixed dose combinations (FDC) formulations of trypsin BP 48/96mg plus bromelain 90/180 plus Rutoside trihydrate BP 100/200 mg viz Phlogam and Disperzyme in post-operative inflammation in subjects undergoing minor surgery and dental procedures | CTRI/2017/12/010804 |
| A clinical study of Trypsin, Bromelain and Rutoside combination in wound management. | An open label, prospective, multicentric, randomized, controlled, comparative clinical trial to evaluate the safety and efficacy of fixed dose combination of Trypsin 48mg, Bromelain 90mg and Rutoside 100mg tablets in comparison to Trypsin: Chymotrypsin tablets with 1,00,000 armour units of enzymatic activity in wound management. | CTRI/2021/07/035082 |
| A Study to evaluate the Safety and Efficacy of FDC of Trypsin 48 mg plus Bromelain 90 mg plus Rutoside Trihydrate 100 mg plus Diclofenac Sodium 50 mg enteric coated tablet versus Diclofenac Sodium 50 mg enteric coated tablet in patients with surgical wounds after minor surgery. | A Multicentric, Open label, Randomized, Comparative, Clinical Study evaluating Safety and Efficacy of Fixed Dose Combination of Trypsin 48 mg plus Bromelain 90 mg plus Rutoside Trihydrate 100 mg plus Diclofenac Sodium 50 mg enteric coated tablet versus Diclofenac Sodium 50 mg enteric coated tablet in patients for healing potential in surgical wounds after minor surgery. | CTRI/2017/11/010384 |
| Double-Blind, Placebo-Controlled Study for the Effect of Daily Ingestion of the Tea Containing Enzymatically Modified Rutin on Lipid Metabolism Improvement | Double-Blind, Placebo-Controlled Study for the Effect of Daily Ingestion of the Tea Containing Enzymatically Modified Rutin on Lipid Metabolism Improvement - The Effect of Daily Ingestion of the Tea Containing Enzymatically Modified Rutin on Lipid Metabolism Improvement | JPRN-UMIN000017204 |
| To Assess Efficacy and Safety of Enzomac in patients with Osteoarthritis | A Prospective Single center Open label Randomized Parallel group Comparative Clinical Study to Evaluate the Efficacy and Safety of FDC of Trypsin Bromelain Rutoside trihydrate versus FDC of Glucosamine sulphate Chondroitin sulfate and Collagen peptide in the Treatment of Patients with Osteoarthritis | CTRI/2020/10/028616 |
| Effectiveness of proteolytic enzymes in controlling the post operative sequelae of surgical third molar disimpactions | Prospective, Observer Blinded, Randomized Clinical Study to Evaluate the Effectiveness of Trypsin, Bromelain, Rutoside Fixed Dose Combination and Trypsin, Chymotrypsin Fixed Dose Combination on Post-Operative Pain, Swelling and Trismus following the Surgical Removal of an Impacted Mandibular Third Molar. | CTRI/2017/10/010076 |
| A study of Trypsin, Bromelain, Rutoside and Diclofenac combination in comparison with Diclofenac to observe rapid healing of the wound and reducing pain intensity in surgery patients. | An open label, multicentric, randomized, comparative clinical trial to evaluate safety and efficacy of fixed-dose combination of Trypsin 48 mg, Bromelain 90 mg, Rutoside 100 mg and Diclofenac 50 mg tablet in comparison to Diclofenac 50 mg tablet in wound management. | CTRI/2021/03/032053 |
| Double-blind, placebo-controlled study for the effect of rutin-rich processed buckwheat (Manten-kirari) on dyslipidemia and antioxidant | Double-blind, placebo-controlled study for the effect of rutin-rich processed buckwheat (Manten-kirari) on dyslipidemia and antioxidant - Effect of rutin-rich buckwheat on dyslipidemia and antioxidant | JPRN-UMIN000015682 |
| To Assess Efficacy and Safety of Enzomac in patients with Osteoarthritis | A Prospective, Single-center, Open label, Randomized, Parallel-group, Comparative Clinical Study to Evaluate the Efficacy and Safety of FDC of Trypsin + Bromelain + Rutoside trihydrate versus FDC of Glucosamine sulphate + Chondroitin sulfate and Collagen peptide in the Treatment of Patients with Osteoarthritis | CTRI/2020/03/024039 |
