IMPPAT Phytochemical information: 
Quinine

Quinine
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
Treatment of Malaria With Quinine Plus Sulfadoxine-PyrimethamineShort Course of Quinine Plus a Single Dose of Sulphadoxine-Pyrimethamine for Plasmodium Falciparum MalariaNCT00167739
Quinine and Food IntakeThe Effect of Quinine on Food Intake: Oral Sham Feeding Versus Intragastric DeliveryNCT03565133
Effects of intragastric administration of quinine (bitter agonist), on appetite and gut hormone release in healthy, lean volunteers.Effects of intragastric administration of quinine (bitter agonist), on appetite and energy intake, and gut hormone release, in healthy, lean volunteers.ACTRN12618000814279
The effect of quinine on food intake: oral sham feeding versus intragastric deliveryThe effect of quinine on food intake: oral sham feeding versus intragastric delivery - Quinine and food intakeNL-OMON48861
Effects of intraduodenal versus intragastric administration of quinine on gut function in healthy, lean volunteers.Effects of intraduodenal versus intragastric administration of quinine on gut and gluco-regulatory hormone release, antropyloroduodenal motility, blood glucose concentrations and appetite perceptions, in healthy, lean volunteers.ACTRN12619000707167
Effects of intraduodenal versus intragastric administration of quinine on blood glucose and gut function in healthy, lean volunteers.Effects of intraduodenal versus intragastric administration of quinine on blood glucose concentrations, gastric emptying, gut and gluco-regulatory hormone release, and gastrointestinal symptoms in healthy, lean volunteers.ACTRN12619001269123
Effects of intraduodenal administration of quinine on blood glucose concentrations, gastric emptying, gut and gluco-regulatory hormone release, and gastrointestinal symptoms in humans with type 2 diabetes.Effects of intraduodenal administration of quinine on blood glucose concentrations, gastric emptying, gut and gluco-regulatory hormone release, and gastrointestinal symptoms in humans with type 2 diabetes.ACTRN12620000972921
Efficacy and safety of injectable quinine for the treatment of malaria in JapanEfficacy and safety of injectable quinine for the treatment of malaria in Japan - Efficacy and safety of injectable quinine for the treatment of malaria in JapanJPRN-UMIN000027485
Effects of intraduodenal administration of quinine on appetite, energy intake and gut hormone release, in response to a standardized buffet-style meal, in humans with type 2 diabetes.Effects of intraduodenal administration of quinine on appetite, energy intake and gut hormone release, in response to a standardized buffet-style meal, in humans with type 2 diabetes.ACTRN12621000218897
Effect of Quinine Hydrochloride in Overweight Population on Food Intake, Hunger and Gut Peptide ReleaseThe Effect of Quinine Hydrochloride on Hedonic Food Intake, Appetite-related Sensations and Gastrointestinal Hormone Release in Overweight Female SubjectsNCT04873011
The effects of the bitter agonist, quinine, on gastric emptying in healthy normal-weight volunteers.The effects of the bitter agonist, quinine, on gastric emptying in healthy normal-weight volunteers.ACTRN12622000735752
Effects of quinine, alone and combined with dietary nutrients before a highly palatable milkshake, on gut function and blood glucose in healthy volunteersEffects of quinine, alone and combined with dietary nutrients before a highly palatable milkshake, on gut function and blood glucose in healthy volunteersACTRN12623000029695
The Effect of Quinine Hydrochloride on Pain after HemorrhoidectomyThe Effect of Quinine Hydrochloride on Pain after Hemorrhoidectomy - The Effect of Quinine Hydrochloride on Pain after HemorrhoidectomyJPRN-UMIN000024128
Effects of quinine, alone and combined with dietary nutrients, on gut function and blood glucose in healthy volunteersEffects of quinine, alone and combined with dietary nutrients, on gut function and blood glucose in healthy volunteersACTRN12623000048684
Effects of Intragastric Quinine, Alone or Combined With L-leucine, on Postprandial Glycaemic ControlEffects of Intragastric Quinine, Alone or Combined With L-leucine, on Postprandial Glycaemic ControlNCT05720390
Effectiveness and Safety of Quinine Sulfate as add-on Therapy for COVID-19 in Hospitalized Adults in Indonesia ( DEAL-COVID19 )An aDaptive, multicEnter, rAndomized, Open-Label, Controlled Trial to Assess Effectiveness and Safety of Quinine Sulfate for COVID-19 in Hospitalized AdultsNCT05808231
Efficacy of Only IV Artesunate Versus IV Artesunate Plus IV Quinine in the Treatment of Severe Malaria in Children: A Comparative StudyEfficacy of Only IV Artesunate Versus IV Artesunate Plus IV Quinine in the Treatment of Severe Malaria in Children: A Comparative StudyNCT06472258
The Africa Quinine versus Artesunate in Severe Malaria TrialThe AQUAMAT trial: An open label randomised comparison of injectable artesunate and quinine in children with severe falciparum malaria in AfricaISRCTN50258054
Influence of Probenecid and Quinine on the Pharmacokinetics of AzidothymidineInfluence of Probenecid and Quinine on the Pharmacokinetics of AzidothymidineNCT00000706
Interactions Between Intravenous Cocaine and Acetazolamide or QuininePharmacodynamic and Pharmacokinetic Interactions Between Intravenous Cocaine and Acetazolamide or QuinineNCT01851473
Efficacy of Intrarectal Versus Intravenous Quinine for the Treatment of Childhood Cerebral MalariaEfficacy of Intrarectal Versus Intravenous Quinine for the Treatment of Childhood Cerebral Malaria: a Randomized Clinical TrialNCT00124267
Effects of intragastric administration of quinine on gastric emptying, gut hormone release, blood glucose and appetite sensations, in healthy, lean volunteers.Effects of intragastric administration of quinine on gastric emptying, gut hormone release, blood glucose and appetite sensations, in healthy, lean volunteers.ACTRN12618000813280
Effects of Intragastric Quinine, Alone or Combined With L-isoleucine, on Postprandial Glycaemic ControlEffects of Intragastric Quinine, Alone or Combined With L-isoleucine, on Postprandial Glycaemic ControlNCT05682339
Single blinded study for the evaluation of bitterness of quinine hydrochloride and loperamide hydrochloride in healthy adult female and male volunteersSingle blinded study for the evaluation of bitterness of quinine hydrochloride and loperamide hydrochloride in healthy adult female and male volunteers - Study of the evaluation of bitter tasteJPRN-UMIN000021789
Effects of intraduodenal administration of quinine on blood glucose concentrations, gastric emptying, gut and gluco-regulatory hormone release, and gastrointestinal symptoms in healthy females.Effects of intraduodenal administration of quinine on blood glucose concentrations, gastric emptying, gut and gluco-regulatory hormone release, and gastrointestinal symptoms in healthy females.ACTRN12620001139965
A Trial of the Efficacy of Artesunate and Three Quinine Regimens in the Treatment of Severe Malaria in Children at the Ebolowa Regional Hospital - CameroonA Randomized Trial of the Efficacy of Artesunate and Three Quinine Regimens in the Treatment of Severe Malaria in Children at the Ebolowa Regional Hospital - CameroonNCT02563704
Cotrifazid Safety and Efficacy Against MalariaA Randomised Safety and Efficacy Trial of Rifampicin/Cotrimoxazole/Isoniazid Versus Mefloquine or Quinine+SP Against Resistant Malaria in Papua New GuineaNCT00322907
Investigation of the Efficacy of Quinine Sulphate Administered Via Taste-Masked Pellets to Children With Falciparum MalariaInvestigation of the Efficacy of Quinine Sulphate Administered Via Taste-Masked Pellets to Children With Falciparum MalariaNCT00329134
Quinine vs. Artemether/Lumefantrine in Uncomplicated Malaria During PregnancyA Randomised, Open-label Non-inferiority Trial of Artemether-lumefantrine Versus Quinine for the Treatment of Uncomplicated Falciparum Malaria During Pregnancy, Mbarara, Uganda (2006-2007)NCT00495508
Effectiveness of Oral Quinine and Artemether-Lumefantrine in the Treatment of Uncomplicated Malaria in Ugandan ChildrenEffectiveness of Oral Quinine and Artemether-Lumefantrine in the Treatment of Uncomplicated Malaria in Ugandan ChildrenNCT00540202
Comparative effect of quinine with with lidocaine on pain of venipuncture.Comparative effects of quinine plant and lidocaine on pain of acquiring vessels (venipuncture)IRCT2015031614229N3
Evaluation of the best approach to retreating recurrent malaria in Ugandan childrenComparison of quinine, artemether lumefantrine and dihydroartemisinin piperaquine for retreatment of recurrent malaria in Ugandan childrenISRCTN99046537
A Dose Proportionality Study of Quinine Sulfate Capsules Under Fasting ConditionsA Randomized, Two-way Crossover Design Used to Compare the Dose Proportionality of Quinine Sulfate Capsules, 324 mg Following a Single Oral Dose of 1 x 324 mg Capsule Versus 2 x 324 mg Capsules in Healthy Adult VolunteersNCT00726895
A Relative Bioavailability Study of Quinine Sulfate Capsules 324mgA Relative Bioavailability Study of Quinine Sulfate Capsules 324mg Under Fasting and Fed ConditionsNCT00726414
A Relative Bioavailability Study of Quinine Sulfate Capsules Under Fasting and Fed ConditionsA Relative Bioavailability Study of Quinine Sulfate Capsules Under Fasting and Fed ConditionsNCT00727272
Drug - Drug Interaction Study Between Quinine Sulfate and TheophyllineA Pharmacokinetic Drug-Drug Interaction Study to Evaluate the Effect of Steady-State Quinine Sulfate on the Pharmacokinetics of Single-Dose Theophylline in Healthy Adult MalesNCT00779259
Drug-Drug Interaction Study Between Quinine Sulfate and RosiglitazoneAn Open-Label Drug-Drug Interaction Study to Investigate the Effects of Steady State Quinine on the Single-Dose Pharmacokinetics of Rosiglitazone Maleate in Healthy VolunteersNCT00785213
Drug - Drug Interaction Study of Quinine Sulfate and CiprofloxacinA One-Directional, Open-Label Drug Interaction Study to Investigate the Effects of Multiple-Dose Ciprofloxacin HCl on the Single-Dose Pharmacokinetics of Quinine in Healthy VolunteersNCT00785980
Effects of small intestinal quinine (bitter agonist) on gut function and blood glucose in healthy, lean volunteers.Effects of intraduodenal quinine (bitter agonist), on upper gastrointestinal (GI) functions, energy intake and blood glucose, in healthy, lean volunteers.ACTRN12617000719336
Drug-Drug Interaction Study of Qualaquin and MidazolamA Pharmacokinetic Interaction Study Evaluating the Effect of Qualaquin (Quinine Sulfate) Capsules on MidazolamNCT00785486
Comparison Bioavailability Study of Quinine Sulfate in Chocolate PuddingA Comparison of the Bioavailability of Quinine Sulfate Capsules Following a 648 mg Dose When Mixed in Chocolate Pudding Relative to That With Intact Capsules in Healthy Adults Under Fasting ConditionsNCT00806078
Efficacy of ArTiMistâ„¢ in ChildrenAn Open Label Randomised Comparative Trial to Establish the Efficacy of 3 mg/kg ArTiMistâ„¢ When Compared to Intravenous Quinine in Children With Severe or Complicated Falciparum Malaria, or Uncomplicated Falciparum Malaria With Gastrointestinal ComplicationsNCT01047436
Superiority of ArTiMist Versus Quinine in Children With Severe MalariaA Phase III, Randomised, Open Labelled, Active Controlled, Multi Centre, Superiority Trial of ArTiMistâ„¢ Versus Intravenous Quinine in Children With Severe or Complicated Falciparum Malaria, or Uncomplicated Falciparum Malaria With Gastrointestinal Complications.NCT01258049
Impact of Artemisinin-based Combination Therapy and Quinine on Treatment Failure and Resistance in Uncomplicated MalariaA Randomized Clinical Trial to Measure the Impact of Retreatment With an Artemisinin-based Combination on Malaria Incidence and Its Potential Selection of Resistant StrainsNCT01374581
IV ARTESUNATE PLUS ACT Vs IV QUININE PLUS ACT AND EVALUATION OF PHARMACOKINETICS OF ARTEMETHER-LUMEFANTRINE AND DIHYDROARTEMISININ-PIPERAQUINEINTRAVENOUS ARTESUNATE PLUS ACT Vs INTRAVENOUS QUININE PLUS ACT FOR SEVERE MALARIA TREATMENT IN UGANDAN PATIENTSPACTR201110000321348
Parenteral Artesunate Compared to Quinine as a Cause of Late Anaemia in African Children With MalariaParenteral Artesunate Compared to Quinine as a Cause of Late Post-treatment Anaemia in African Children With Hyperparasitaemic P. Falciparum MalariaNCT02092766
EFFECT OF QUININE ON PLATELET COUNT IN CHILDREN WITH SEVERE MALARIAEFFECT OF QUININE AND ARTESUNATE COMBINATION THERAPY ON PLATELET COUNT OF CHILDREN WITH SEVERE MALARIA:A RANDOMIZED CONTROLLED TRIAL - ACTCTRI/2014/02/004440
Radical cure for vivax malaria in IndonesiaEfficacy of primaquine against Plasmodium vivax relapses when combined with dihydroartemisinin-piperaquine or quinine in Indonesian soldiersISRCTN38290380
Intravenous Artesunate and MalariaIntravenous Artesunate Versus Quinine in Severe Malaria at Kassla, SudanNCT01805232
A study comparing the efficacy of clindamycin plus quinine with coartem for treating Kenyan children with uncomplicated falciparum malariaAn open-label randomized controlled trial of the efficacy and safety of clindamycin plus quinine compared with artemether-lumefantrine for the treatment of children with uncomplicated falciparum malaria in western KenyaPACTR201209000419241
Comparative Study of Quinine Sulfate in Healthy Patients and in Patients With Renal ImpairmentA Single-Dose, Open-Label Comparative Study of the Pharmacokinetics, Safety,and Tolerability of Oral Quinine Sulfate in Healthy Volunteers and Adults With Mild and Moderate Renal ImpairmentNCT00785551