| Public title (as per ICTRP) | Scientific title (as per ICTRP) | Trial identifier |
|---|---|---|
| Comparing effects of melatonin and duloxetine in the treatment of osteoarthritis | Comparing effects of melatonin and duloxetine in the treatment of osteoarthritis | IRCT20200516047468N2 |
| Analgesic Effect of Melatonin and Vitamin C Administration, Alone or In Combination in Major Abdominal Surgery. | Analgesic Effect of Melatonin and Vitamin C Administration, Alone or In Combination in Major Abdominal Surgery. A Randomized Double-blind Study | NCT06374771 |
| Melatonin's Effect on Nighttime Blood Pressure and Sleep in OSA Patients (MEBP-OSA) | Impact of Melatonin Treatment on Blood Pressure Circadian Rhythm, Sleep and Metabolic Variables. | NCT06380491 |
| The survival and quality of life benefits of melatonin when administered to cancer patients at the optimal time of day | A Multi-Center Randomized, Double-Blind, Trial Evaluating the Chronotherapeutic Role of Melatonin in the Treatment of Stage IIIB and IV Non-Small Cell Lung Carcinoma | ISRCTN16419921 |
| Comparison of Music and Melatonin for intraoperative anxiety reduction in patients undergoing surgery. | Intraoperative anxiety reduction: A comparison of Music and Melatonin interventions. - NIL | CTRI/2024/04/065216 |
| Effect of Melatonin on radiation induced fatigue | Comparison of the effectiveness of Melatonin with placebo on radiation induced fatigue in breast cancer patients | IRCT20220907055912N1 |
| Yoga can be an effective intervention for shift workers to cope with sleep-related problems. | Effect of Yoga on Melatonin Secretion and Associated Psycho-Physiological Parameters among Shift Workers: 3-Arm Randomized Control Trial - NIL | CTRI/2024/04/065119 |
| Does melatonin help children with Attention Deficit Hyperactivity Disorder (ADHD) sleep better? | Does melatonin reduce sleep onset latency compared to placebo in children with ADHD on stimulant medication? | ACTRN12614000542695 |
| Beneficial effects of concurrent training associated with melatonin on postmenopausal women. | Effect of concurrent training associated with melatonin on physical capacities, cognitives and biochimicals responses | PACTR202301527879754 |
| To see effects of oral melatonin and oral zolpidem on blood pressure, heart rate in patients undergoing surgery under general anaesthesia. | Comparative efficacy of oral melatonin versus oral zolpidem for attenuation of hemodynamic response to intubation in adult patients undergoing elective surgeries. | CTRI/2023/02/049527 |
| Melatonin in patients with sleep disorders in infants, children and adolescents. | Efficacy and safety of Melatonin for sleep problems in infants, children and adolescents with neurodevelopmental disorders - Mel-moe study | JPRN-jRCTs071220104 |
| Melatonin and Sleep Spindles in Autism | The Effects of Melatonin on Sleep Spindles in Children With Autism | NCT05716906 |
| which drug reduces preoperative anxiety | A comparative study of melatonin and gabapentin in reducing preoperative anxiety | CTRI/2023/01/049073 |
| Melatonin ischemic stroke | The effects of melatonin on oxidative pathways in patients with acute ischemic stroke: A randomized double-blind clinical trial | IRCT20190804044429N10 |
| Impact of a Melatonin Supplementation on the Quality of Life in Elderly Metastatic Cancer Patients | Impact of a Melatonin Supplementation on the Quality of Life in Elderly Metastatic Cancer Patients (> = 70 Years) - PHRC-K13-170 | NCT02454855 |
| Melatonin and Its Effect on the Perioperative Opioid Needs in Pediatric Patients Undergoing Laparoscopic Surgery. | Melatonin and Its Effect on the Perioperative Opioid Needs in Pediatric Patients Undergoing Laparoscopic Surgery. | NCT05728892 |
| Melatonin for Treatment of Delirium in Critically Ill Adult Patients | DELIRE-ICU: a Randomised Controlled Feasibility Trial of Melatonin Vs Placebo in the Treatment of Delirium in the Intensive Care Unit | NCT05713877 |
| Comparison of the Effect of Two Drugs Melatonin and Midazolam on Abnormal Behaviour in Chilren Coming Out of General Anaesthesia After Surgery. | Comparison of Melatonin Versus Midazolam as Premedicants on Emergence Delirium in Paediatric Surgical Patients. | CTRI/2023/01/049166 |
| Melatonin and how the body uses and transforms energy from food in Autism Spectrum Disorder | Melatonin and energy metabolism in Autism Spectrum Disorder | RBR-6wjfmm7 |
| The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome | The Effect of MElatonin on Depression, Anxiety, CIrcadian and Sleep Disturbances in Patients After Acute Myocardial Syndrome | NCT02451293 |
| Evaluation of the effect of sildenafil and melatonin on fertility outcomes in women with poor ovarian response | Evaluation of the effect of sildenafil plus melatonin on fertility outcomes in infertile women with poor ovarian response undergoing assisted reproductive treatment. | IRCT20160524028038N15 |
| The PRECISE trial – Pain RElief Combination Intervention StratEgies | Clinical trial of a melatonin-pregabalin combination for fibromyalgia | ISRCTN18278231 |
| Does melatonin after tonsillectomy enhance sleep and recovery in children (MATES)? | A multicentre, double blinded randomised controlled trial investigating the efficacy of postoperative Melatonin in improving children’s sleep quality and recovery post-tonsillectomy. | ACTRN12624000252516 |
| Role of Melatonin Receptors MT1 and MT2 in the evaluation of Esophageal Cancer | Expression patterns of melatonin receptors MTI and MT2 in oesophageal cancer - nil | CTRI/2024/03/064478 |
| he effect of pregabalin and melatonin on diabetic neuropathy | Comparison of the effect of pregabalin and melatonin on the Severity of Pain caused by painful diabetic polyneuropathy, a double-blind clinical trial study | IRCT20191030045277N3 |
| The effect of Melatonin and QT on complications during and after open heart surgery | Comparison of the effect of Melatonin and Q10 on clinical outcomes following coronary artery bypass surgery | IRCT20130311012782N58 |
| Oral melatonin effect on pain after percutaneous lumbar disc decompression: a double-blind randomized clinical trial | Oral melatonin Effect on pain after percutaneous lumbar disc decompression | IRCT20220514054846N1 |
| evaluation and comparison the effectiveness of oral melatonin and midazolam as premedication on sedation and post operative complications of candidate children for dental treatment under general anesthesia with contral group | evaluation and Comparison the effectiveness of oral melatonin versus midazolam as premedication in children undergoing general anesthesia for dental treatment with contral group | IRCT201602074224N36 |
| The beneficial effect on sleep function of a food supplement based on melatonin, Withania somnifera (L.) Dunal, L-ornithine, magnesium and Crocus sativus L. | Efficacy study on a food supplement based on melatonin, Withania somnifera (L.) Dunal, L-ornithine, magnesium and Crocus sativus L. for sleep management: single-centre, placebo-controlled, randomized, double-blind cross-over, clinical study with a period of run-in | ISRCTN17704876 |
| Management of cancer related insomnia: A comparative study between melatonin and zolpidem | Comparison of effectivity and adverse effects of two different doses of melatonin with zolpidem on insomnia in cancer patients: A prospective, comparative, interventional study - NIL | CTRI/2024/03/063740 |
| Melatonin in Youth: N-of-1 Trials in a Stimulant-treated Attention Deficit Hyperactivity Disorder (ADHD) Population | Melatonin in Youth: N-of-1 Trials in a Stimulant-treated Attention Deficit Hyperactivity Disorder (ADHD) Population | NCT02333149 |
| Bringing Relief to Adolescents Naturally Using Melatonin for Migraine | "Melatonin for Migraine Prevention in Adolescents: A Pilot Remote Trial: ""The BRAiN-M Study""" | NCT02344316 |
| Procedural pain and anxiety in children | Comparison of the effectiveness of intranasal Midazolam, oral Melatonin and distraction method in reducing stress and pain caused by intravenous cannulation in children 3 to 10 years old | IRCT20220128053852N2 |
| The effect of adding melatonin to tamsulosin to cure BPH | The effect of adding or avoiding melatonin to tamsulosin to cure BPH | IRCT2015011314333N27 |
| Melatonin for Nocturia in Parkinson's Disease | Single-centre Open Label Exploratory Phase IIb Pilot Study of Exogenous Oral Melatonin for the Treatment of Nocturia in Adults With Parkinson's Disease | NCT02359448 |
| Effect of Melatonin supplementation on obesity | Effect of Melatonin supplementation on Body Weight, Body Fat Mass percentage and Body Mass Index changes in overweight or class-1 obese people | IRCT2015020120891N1 |
| Melatonin and Epilepsy | The Effect of Melatonin in patients with intractable epilepsy | IRCT2015013117811N7 |
| Melatonin and Stroke | The effect of melatonin in clinical improvement of patients with ischemic stroke | IRCT2015012917811N6 |
| Comparative assessment of the absorption of a generic formulation of melatonin prolonged release tablet against the innovator melatonin prolonged release tablet conducted under fasting conditions in healthy male and female volunteers | A single dose, randomized, blinded, bioequivalence study of a test formulation of melatonin prolonged release tablet in a 2 way crossover comparison against the innovator melatonin prolonged release tablet conducted under fasting conditions in healthy male and female volunteers | ACTRN12615000141549 |
| Effect of melatonin on fertility in women with loss of ovarian reserve | Evaluation of the effect of melatonin on the success of invitro fertilization in women with decreased ovarian reserve. | IRCT2014041417264N1 |
| Effect of Melatonin on Oxidative Stress in Obese Adults (MELASTRESSOB) | Effect of Melatonin on Oxidative Stress in Obese Adults Undergoing an Acute Exercise Session | NCT05759429 |
| Effect of Resveratrol , Melatonin and Inositols in childless Women | Comparative Study to Evaluate the Effect of Resveratrol , Melatonin and Inositols on Hormonal Profile, Ovarian Morphology and Endometrial Receptivity in PCOS Infertile Women | CTRI/2023/02/049569 |
| Investigation of the effect of organic light-emitting diode illumination on melatonin secretion. | Investigation of the effect of organic light-emitting diode (OLED) illumination on melatonin secretion. - Investigation of the effect of organic light-emitting diode (OLED) illumination on melatonin secretion. | JPRN-UMIN000050321 |
| Nebulized Dexmedetomidine VS ODF Melatonin for Peri Operative Anxiety and Emergence Agitation in Pediatric Day Surgery | Nebulized Dexmedetomidine VS Oro-dispersible Film Melatonin for Peri Operative Anxiety and Emergence Agitation in Pediatric Outpatient Surgeries: A Randomized Controlled Double-blinded Study | NCT05766436 |
| Evaluation of the effect of sildenafil plus melatonin on oxidative stress markers in polycystic ovarian syndrome patients who treated with metformin | Evaluation of the effect of sildenafil plus melatonin on oxidative stress markers in polycystic ovarian syndrome patients who treated with metformin | IRCT20230427058010N1 |
| The Effect of Melatonin Upon Post-Acute Withdrawal Among Males in a Residential Treatment Program | The Effect of Melatonin Upon Post-Acute Withdrawal Among Males in a Residential Treatment Program: A Randomized, Double Blind, Placebo, Controlled Trial | NCT02431728 |
| Melatonin in Obese Patients in Laparoscopic Cholecystectomy | The Evaluation of Adding Melatonin to Opioid Free Anesthesia on Postoperative Pain in Obese Patients Undergoing Laparoscopic Cholecystectomy | NCT06355687 |
| Comparison between pregabalin, melatonin and clonidine as premedication to blunt vital signs during induction of general anaesthesia via laryngoscopy in laparoscopic surgeries. A prospective randomised double blinded study. | Comparison between oral Melatonin, Pregabalin & Clonidine as premedication for attenuation of hemodynamic responses to laryngoscopy & intubation in laparoscopic surgeries; A prospective randomised double blinded study. - Cbompc | CTRI/2024/03/064816 |
| The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery | The Effect of Premedication With Melatonin on Postoperative Recovery From Bariatric Surgery: a Prospective Randomised Controlled Cohort Study | NCT02424071 |
| Effect of oral melatonin premedication with gabapentin on pain and anxiety of patients in the phaco cataract surgery under local anesthesia with topical block | Comparison of oral melatonin premedication with gabapentin on pain and anxiety of patients in the phaco cataract surgery under local anesthesia with topical block | IRCT2015031121436N1 |
| Comparison of melatonin and acetaminophen in cataract surgery | Comparison of melatonin and acetaminophen on pain and hemodynamic alterations associated with retrobulbar eye block in cataract surgery | IRCT2015012315963N4 |
| Therapeutic Effects of Maternal Melatonin Administration on Brain Injury and White Matter Disease | Therapeutic Effects of Maternal Melatonin Administration on Brain Injury and White Matter Disease in Very Preterm Infants | NCT02395783 |
| Anxiolytic and Analgesic Effects of Melatonin | Anxiolytic and Analgesic Effects of Melatonin: A Randomized, Double-blinded, Placebo-controlled Clinical Study | NCT02386319 |
| Comparative assessment of the absorption of a generic formulation of melatonin prolonged release tablet against the innovator melatonin prolonged release tablet conducted under fasting conditions and at steady state in healthy male and female volunteers | A multiple dose, randomized, blinded, bioequivalence study of a test formulation of melatonin prolonged release tablet in a 2 way crossover comparison against the innovator melatonin prolonged release tablet conducted under fasting conditions and at steady state in healthy male and female volunteers | ACTRN12615000143527 |
| Effects of melatonin alone and with vitamin C in the treatment of periodontitis | The effects of antioxidant supplements melatonin alone and in combination with vitamin C on the clinical characteristics of periodontal treatment phase | IRCT2014112410155N2 |
| Premedication With Melatonin in Lumbar Medial Branch Block Procedure | Premedication With Melatonin vs. Placebo in Patients Undergoing Interventional Pain Procedure | NCT02415309 |
| Melatonin vs Gabapentin for Post Trauma Surgery | A Comparative Study of Melatonin and Gabapentin as Premedication for Patients Undergoing Surgery Following Trauma | NCT05699876 |
| Effect of systemic melatonin in periodontal therapy | Evaluation of the effect of systemically administered melatonin in patients undergoing regenerative surgical periodontal therapy- a double blind placebo controlled clinical trial | CTRI/2022/12/048262 |
| Efficacy of melatonin on postoperative outcomes after hysterectomy: a randomised, doubl-blinded, placebo-controlled trial | Efficacy of melatonin on postoperative outcomes after hysterectomy: a randomised, doubl-blinded, placebo-controlled trial | TCTR20140516001 |
| Effects of melatonin and zolpidem compared with placebo on sleep disorders in premenopause and menopause women | Effects of melatonin and zolpidem compared with placebo on sleep disorders in premenopause and menopause women | IRCT2014010216035N1 |
| Effect of melatonin ( a hormone for sleep induction) supplement on the quality of sleep and control of blood pressure in hemodialysis patients | Study of Oral Melatonin on Sleep quality and Blood pressure in Maintenance Hemodialysis patients - NIL | CTRI/2024/07/069863 |
| Melatonin for Neuroprotection Following Perinatal Asphyxia | Melatonin for Neuroprotection Following Perinatal Asphyxia | NCT02071160 |
| Dentin bridge formation and resolution of pain comparing two different medicated agents for dental filling | Cone Beam Computed Tomographic evaluation of dentin bridge formation using Mineral Trioxide Aggregate with Melatonin and Freeze Dried Amniotic Membrane for Direct Pulp Capping in permanent Molars A Randomized Controlled Trial - NIL | CTRI/2024/06/069664 |
| Neuroplasticity:Melatonin and Transcranial Current Stimulation in Healthy Subjects. | Effect of Melatonin and Transcranial Direct Current Stimulation (tDCS) on Neuroplasticity and the Heat-pain Detection Threshold in Healthy Subjects:Randomized, Double-blind,Crossover Trial | NCT02195271 |
| Cardiac Surgery and the Risk of Atrial Fibrillation: an Intervention Trial Evaluating Melatonin | Cardiac Surgery and the Risk of Atrial Fibrillation: an Intervention Trial Evaluating Melatonin | NCT02099331 |
| Topical/Oral Melatonin for Preventing Concurrent Radiochemotherapy Induced Oral Mucositis/Xerostomia Cancer Patients | Topical and Oral Melatonin for Preventing Concurrent Radiochemotherapy Induced Oral Mucositis and Xerostomia in Head and Neck Cancer Patients | NCT02430298 |
| The effect of melatonin on delirium prophylaxis | The effects of melatonin versus placebo on delirium prophylaxis in patients hospitalized in intensive care unit of Alzahra hospital, Isfahan, 2014-2015 | IRCT2015022421159N1 |
| The Effect of Melatonin on Gene Expression and Activity of the Sirt1 and Its Target Genes Catalase and MnSOD in Multiple Sclerosis Patients and Healthy Subjects | NCT02463318 | |
| Comparing hemodynamic responses for Endotracheal Intubation and Laparoscopic gas inflation with dexmedetomidine and melatonin | Attenuation of haemodynamic effects to intubation and pneumoperitoneum in patients receiving two different doses of dexmedetomidine with addition of melatonin to the lower dosage group during laparoscopic cholecystectomy A prospective randomized double blind trial - NIL | CTRI/2024/06/069624 |
| Evaluation of the melatonin tablet efficacy as an adjuvant therapy for patients with mild to moderate COVID-19 | Evaluation of melatonin tablet efficacy as an adjuvant treatment for patients with mild to moderate COVID-19 in Qaem and Imam Reza Hospital, Mashhad: A triple-blind randomized placebo controlled clinical trial | IRCT20200408046990N12 |
| Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery | Comparing Two Doses of Oral Melatonin as Premedication in Children Undergoing Surgery: A Double-Blind Randomized Trial | NCT06489327 |
| Effect of Melatonin onImproving Fertility in Women with Diminished Ovarian Reserve | Evaluation of the Effect of Melatonin on the Follicular Oxidative Stress and Quality of Oocyte and Embryo in Women with Diminished Ovarian Reserve | IRCT20170529034209N2 |
| effect of a new medicine on how the mother feels after the Caesarean operation | Effect of Melatonin on the Quality of Recovery after elective caesarean section: A randomised controlled trial | CTRI/2022/11/047355 |
| oral melatonin in the treatment of acute respiratory distress syndrome | The effect of oral melatonin in the treatment of acute respiratory distress syndrome in neonates | IRCT20130308012743N3 |
| The effects of melatonin on the consumption of opioids | The effects of melatonin on the amount of opioids in orthopedic surgery patients | IRCT20221222056890N2 |
| How melatonin helps manage Blood pressure and Heart Rate during laryngoscopy and endotracheal intubation | Effects of melatonin premedication on the hemodynamic responses and perfusion index during laryngoscopy and endotracheal intubation-A Randomized control study - NIL | CTRI/2024/07/070106 |
| To compare effectiveness of 3mg versus 5mg Melatonin in patients of insomnia | To study comparative efficacy and safety of melatonin 3mg vs 5mg in patients of insomnia: A randomized controlled trial - NIL | CTRI/2024/07/070440 |
| Does Melatonin Restore Sleep Architecture in Autistic Children | Does Melatonin Restore Sleep Architecture in Autistic Children? | NCT01993251 |
| Comparison effect of melatonin and zinc in optimization of sleep disorder in cirrhotic patients | Comparison effect of melatonin and zinc in optimization of sleep disorder in cirrhotic patients | IRCT20121021011192N18 |
| Effect of melatonin in situ gel in the treatment of periodontitis. | Evaluation of regenerative potential of melatonin in-situ gel in the treatment of periodontal intrabony defects- A randomised clinical trial. | CTRI/2022/11/047171 |
| MIART: Can melatonin improve the live birth rate in infertile couples undergoing assisted reproductive technologies? | A double-blind randomised placebo-controlled dose-response trial assessing the effects of melatonin on infertility treatment (MIART) | ACTRN12613001317785 |
| The clinical research of melatonin combined with oligosaccharide on improving insomnia | The clinical research of melatonin combined with oligosaccharide on improving insomnia | ChiCTR-TRC-13003997 |
| To compare the efficacy of escitalopram versus escitalopram and melatonin combination therapy in treating major depressive disorder. | Comparative Efficacy of Escitalopram Monotherapy and Escitalopram-Melatonin Combination Therapy in Treating Major Depressive Disorder-A Randomized Interventional Study. - NIL | CTRI/2024/07/070641 |
| Melatonin supplementation and midazolam reduction | Investigating the effect of oral melatonin compared to placeto in the required dose of venous midazolam in children under mechanical ventilation | IRCT20240518061831N1 |
| Evaluating the Effects of Melatonin Supplementation on Anxiety and Depression in Patients with Breast Cancer | Evaluating the Effects of Melatonin Supplementation on Anxiety and Depression in Patients with Breast Cancer, a Randomized Clinical Trial Study | IRCT20240304061165N1 |
| Efficacy of Melatonin in Burning Mouth Syndrome (BMS) | Melatonin to Treat Burning Mouth Syndrome (BMS): A Randomized, Cross-over, Placebo-controlled, Triple-blind Clinical Trial | NCT02580734 |
| Melatonin in the treatment of the ICU sleep deprivation: a single-center, prospective, randomized, double-blind, placebo-controlled, parallel study | Melatonin in the treatment of the ICU sleep deprivation: a single-center, prospective, randomized, double-blind, placebo-controlled, parallel study | ChiCTR-TRC-14004319 |
| To assess the effect of oral melatonin administration on clinical outcomes in women undergoing in-vitro fertilisation (IVF) | To assess the effect of oral melatonin administration on clinical outcomes in women undergoing in-vitro fertilisation (IVF) | IRCT2015042912307N4 |
| Melatonin vs. placebo for the symptoms of delirium in elderly medical inpatients | A double blinded, randomised, placebo controlled pilot trial of moderate dose melatonin for the abatement andtreatment of delirium in elderly general medical inpatients. | ACTRN12614000101684 |
| Melatonin in melasma | Clinical trial of the effectiveness of melatonin as an add-on treatment to the common treatment of melasma | IRCT20090808002306N10 |
| Oral Melatonin premedication for decreasing preoperative anxiety in neurosurgery | Efficacy of oral melatonin premedication in reducing preoperative anxiety in patients undergoing supratentorial craniotomy - NIL | CTRI/2024/07/070448 |
| Intratympanic dexamethasone plus melatonin versus melatonin in the treatment of acute idiopathic tinnitus | Intratympanic dexamethasone plus melatonin versus melatonin in the treatment of acute idiopathic tinnitus ? a randomized clinical trial | ISRCTN39221710 |
| Evaluating the effects of melatonin on weight and depression | Effects of melatonin supplementation on weight and depression among overweight women with depression compared with the control group | IRCT2014020316465N1 |
| Effect of administration of tablet melatonin and tablet clonidine before surgery in reduction of blood pressure and heart rate in response to breathing tube placement in wind pipe for pediatric patients undergoing surgery under general anaesthesia. | Comparison of Oral Melatonin and Oral Clonidine, premedication for attenuation of intubation response in pediatric patients, undergoing surgical procedures under general anaesthesia: A double blinded randomized controlled trial | CTRI/2022/11/047564 |
| Whole body hypothermia + melatonin vs whole body hypothermia + placebo in asphyctic newborns. A multicentric, ramdomized, controlled and double blind clinical trial | Whole body hypothermia + melatonin vs whole body hypothermia + placebo in asphyctic newborns. A multicentric, ramdomized, controlled and double blind clinical trial - hypothermia + melatonin in asphyctic newborns | EUCTR2012-000184-24-ES |
| Efficacy of melatonin reducing weight gain in patients with schizophrenia using second generation antipsychotic drugs | Efficacy of melatonin reducing weight gain in patients with schizophrenia using second generation antipsychotic drugs | TCTR20160907002 |
| Melatonin for Post Operative Delirium Prevention in Elderly Patients | The Impact of Melatonin on the Postoperative Delirium in Geriatric Patients After Colorectal Surgeries. A Randomised Placebo-controlled Trial | NCT05640934 |
| Evaluation of melatonin supplementation on infertile couples | Comparison of the effectiveness of melatonin supplementation with placebo on oxidative and inflammatory stress markers in infertile couples with unknown cause. | IRCT20240415061493N1 |
| Investigating the effect of melatonin and tizanidine on pain and anxiety after cataract surgery | Investigating the effect of melatonin and tizanidine on pain and anxiety after cataract surgery | IRCT20190528043737N3 |
| The effect of sildenafil and melatonin on sexual function | Evaluation of the effect of sildenafil along with melatonin on the sexual function of patients with polycystic ovary syndrome treated with metformin. | IRCT20160524028038N13 |
| The effect of using Oral Melatonin and oral pregabalin before surgery on vitals of the patient during intubation and general anaesthesia. | Oral Melatonin versus oral pregabalin as premedication for attenuation of hemodynamic response during laryngoscopy and intubation: Randomised Control Trial | CTRI/2022/12/048021 |
| Pain management with three oral drugs in patients undergoing robotic surgeries | """A comparison of analgesic efficacy between oral pregabalin, gabapentin and melatonin as non-opioid anaesthesia for robotic assisted laparoscopic surgeries: A prospective randomised double blinded clinical study.""" | CTRI/2022/11/047740 |
| Evaluation of additive efficacy of filler material hyaluronic acid combined with melatonin to close black triangle formed in between the teeth after gum surgery. | Evaluation of Additive Efficacy of Hyaluronic acid with Melatonin gel in papilla reconstruction post flap surgery. - Nil | CTRI/2024/04/066082 |
| Comparison Between Oral Melatonin and Hydroxyzine in Pediatric Patients Undergoing Adenotonsillectomy | Comparison Between the Effect of Oral Melatonin and Hydroxyzine for Preventing Preoperative Anxiety in Pediatric Patients Undergoing Adenotonsillectomy | NCT05680584 |
| Effectiveness of melatonin prophylaxis on the post-operative pain and sensory recovery following lower jaw fractures. | Effectiveness of melatonin prophylaxis on the post-operative pain and sensory recovery following mandibular fractures - A Randomized controlled clinical trail - NIL | CTRI/2024/02/062277 |
| The Relative Bio-availability of Oral and Oromucosal Melatonin in Different Formulations in Healthy Human Volunteers. | The Relative Bio-availability of Oral and Oromucosal Melatonin in Different Formulations in Healthy Human Volunteers. A Three-phased Cross-over Study. | NCT02107079 |
| Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift | Effect of Melatonin on Sleep Patterns of Resident Trainees During Night Float Shift | NCT05701969 |
| Efficacy of melatonin with ibuprofen chronotherapy after periodontal surgery | A randomized controlled, double blind cross over trial to compare the efficacy of melatonin with ibuprofen chronotherapy to ibuprofen chronotherapy alone in reducing the pain perception after periodontal surgery | CTRI/2023/01/048820 |
| Efficacy of melatonin on nocturnal irritability | Efficacy of an oral suspension of melatonin on idiopathic nocturnal irritability in infants over 6 months | IRCT20090808002306N8 |
| Pharmacokinetics of Melatonin Administered in Oral, Lotion, and Bubble Bath Formulations | Pharmacokinetics of Melatonin Administered in Oral, Lotion, and Bubble Bath Formulations | NCT06382610 |
| comparision of melatonin and olanzapine in prevention and treatment of delirium in elderly male undergoing arthroplasty of hip or knee under neuraxial block | â??Assessment and comparison of efficacy of oral melatonin versus oral olanzapineversus oral placebo for prevention and treatment of post operative delirium in elderlypatient after arthroplasty of hip or knee under neuraxial block: A three arm, doubleblinded, randomised control trial.â?? | CTRI/2022/11/047545 |
| of Myo-inositol, Melatonin and Co-enzyme q10 on Ovarian Reserve | The Effect of Myo-inositol, Melatonin and Co-enzyme q10 on Ovarian Reserve Parameters and Intra-cytoplasmic Sperm Injection Outcomes in Patient With Poor Ovarian Reserve: an Open Label Randomized Clinical Trial | NCT06405204 |
| Protocol for a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of sleep disorders in patient with cirrhosis | Protocol for a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of sleep disorders in patients with cirrhosis | SLCTR/2019/008 |
| Effects of Melatonin Supplementation on Sleep Quality in Breast Cancer Patients | Effects of Melatonin Supplementation on Sleep Quality in Breast Cancer Patients, a Randomized Clinical Trial Study | IRCT20240304061164N1 |
| Melatonin vs Sleep Deprivation for Nap EEG | Efficacy of Melatony Versus Sleep Deprivation for EEG Recordings in Sleep: a Randomized Crossed-over Study in Pediatric Patients With Epilepsy | NCT05654415 |
| Effect of Tablet Melatonin on pain in patients undergoing Lower limb surgery | Effect of Melatonin On Pain In Patients Undergoing Lower Limb Surgery: A Randomized Open Label study- PG Dissertation - NIL | CTRI/2024/06/068288 |
| Effect of acute use of Melatonin on Hemodynamic, Metabolic and Physical Variables during and after Running exercise in different conditions | Effect of acute Melatonin administration on Physiological and Physical Performance Parameters during and after Running in different conditions | RBR-5y5pbpr |
| Melatonin Therapy in Methamphetamine use individuals | Efficacy of melatonin to normalize the cytokines network and balance the oxidative stress in methamphetamine-induced psychosis patients: a double-blinded randomized controlled trial. | TCTR20240529005 |
| Comparison of the effect of dexmedetomidine and melatonin on unconsciousness in patients after coronary artery bypass surgery. | Comparison of the effect of Dexmedetomidine and Melatonin on delirium in patients after coronary artery bypass graft surgery | IRCT20120214009011N3 |
| Evaluation of the effect of Melatonin on prevention of postpartum bleeding | Comparison of the effect of using and not using of melatonin on prevention of patients' postpartum uterus bleeding after normal vaginal delivery | IRCT2015050919037N9 |
| Combine effect of tab melatonin and pectointercostal fascial block on postoperative pain management in patients undergoing open heart surgeries. | To study the effect of combination, oral melatonin and pectointercostal fascial block for postoperative pain management in patients undergoing open cardiac surgery- Prospective randomized study. - NIL | CTRI/2024/05/067707 |
| Evaluation of the effects of melatonin supplementation in patients with type 2 diabetes | Evaluation of the effects of melatonin supplementation in patients with type 2 diabetes: a randomized: double-blind clinical trial | IRCT20230212057393N3 |
| Investigating the effect of melatonin use versus placebo on delirium in patients admitted to the intensive care unit | Investigating the effect of melatonin use versus placebo on delirium in patients admitted to the intensive care unit | IRCT20240429061595N1 |
| The effect of oral melatonin in reduction pain during venipuncture _a double blind clinical trial | The effect of oral melatonin in reduction pain during venipuncture _a double blind clinical trial | IRCT20220812055665N1 |
| To compare the effect of two doses of tablet melatonin on occurrence of ICU delirium | Comparison of the effect of two prophylactic doses of tablet melatonin on incidence of delirium in patients admitted in intensive care unit - NIL | CTRI/2024/05/067172 |
| Evaluation of therapeutic effect of melatonin to improve nerve injury due to oxaliplatin | Evaluation of melatonin efficacy in prophylaxis of Oxaliplatin induced acute peripheral neuropathy in FOLFOX regimen in patients with colon cancer | IRCT20150726023349N5 |
| A Clinical study to find the effect of melatonin in reducing stress to intubation in patients undergoing surgeries. | To Study The Effect Of Preoperative Sublingual Melatonin In Attenuation Of Haemodynamic Stress Response To Laryngoscopy And Endotracheal Intubation In Patients Undergoing Elective Surgeries Under General Anaesthesia. - Nil | CTRI/2024/05/066842 |
| The effect of oral melatonin before percutaneous nephrolithotomy surgery | The effect of oral melatonin before percutaneous nephrolithotomy (PCNL) on the incidence of SIRS and sepsis and postoperative outcomes and complications: a double-blind randomized clinical trial study | IRCT20190624043991N26 |
| Melatonin Supplementation for Cancer-related Fatigue in Patients Receiving Radiotherapy | Melatonin Supplementation for Cancer-related Fatigue in Patients Receiving Radiotherapy: A Double Blind Placebo-Controlled Trial | NCT02332928 |
| To study effect of melatonin in patients who are undergoing nose surgery the effect of preventing agitation. | Effect of oral melatonin premedication on emergence agitation after nasal surgery | CTRI/2023/05/052989 |
| a Chronobiological Treatment Combining Evening Melatonin and Morning Light Therapy in Idiopathic Hypersomnia: a Prospective, Double Bind, Randomized, Placebo-controlled -Trial | a Chronobiological Treatment Combining Evening Melatonin and Morning Light Therapy in Idiopathic Hypersomnia: a Prospective, Double Bind, Randomized, Placebo-controlled -Trial | NCT06252571 |
| Comparison of effect of melatonin on sleep with control groups in cancer patients | Comparison of effect of oral melatonin on sleep and fatigue with control groups in cancer patients of head and neck region | CTRI/2023/07/055598 |
| Efficacy of melatonin, low-dose quetiapine, or placebo in patients with psychiatric disorders and comorbid insomnia: a randomized clinical trial | Efficacy of melatonin, low-dose quetiapine, or placebo in patients with psychiatric disorders and comorbid insomnia: a randomized clinical trial | CTIS2023-504728-24-00 |
| Melatonin As an Analgesic in Preterm Neonate | Efficacy of Melatonin As an Analgesic in Preterm Neonate | NCT05971485 |
| Dose assessment of melatonin in sepsis trial | Dose Assessment of Melatonin in SEpsis triaL: a pilot phase I/II study | ISRCTN70688534 |
| Comparison Efficacy of platelet-rich fibrin membrane and melatonin on sensory recovery following mandibular fracture | Comparison Efficacy of platelet-rich fibrin membrane and melatonin on sensory recovery following mandibular fracture: a double-blind randomized trial | IRCT20230517058216N1 |
| Improving Sleep of Children With Neurodevelopmental Disorders: Pulsed Current Stimulation Versus Melatonin | Improving Sleep of Children With Neurodevelopmental Disorders: A Prospective, Randomised Controlled Trial Using Pulsed Current Stimulation Versus Melatonin | NCT06236191 |
| Effects of melatonin on patients after coronary artery bypass surgery | Evaluation of effects of melatonin on heart function and inflammatory and oxidant biomarkers in patients after coronary artery bypass grafting surgery | IRCT20111119008129N14 |
| Assessing the role of oral melatonin agonist ramelteon in prevention of ICU delirium | Evaluation of effect of oral melatonin agonist ramelteon for prevention of delirium in adult patients admitted in intensive care unit - Nil | CTRI/2023/08/056002 |
| "A Study to know the effect of drug ""Melatonin"" on Sleep in patients with Idiopathic Parkinsonâ??sdisease" | Effect of Melatonin on Sleep in Idiopathic Parkinsonâ??sdisease: A Randomized Double blind Placebo controlledtrial | CTRI/2023/08/056190 |
| Comparative evaluation of sedative, anxiolytic and post-operative effects of oral melatonin andnitrous oxide inhalation sedation in 5 to 8 year old children - an ELISA based study | Comparative evaluation of sedative, anxiolytic and post-operative effects of oral melatonin andnitrous oxide inhalation sedation in 5 to 8 year old children - an ELISA based study. - NIL | CTRI/2023/08/056173 |
| Melatonin for Knee Osteoarthritis Patients | Efficacy and Safety of Melatonin for Pain Relief in Knee Osteoarthritis Patients: A Randomized, Double-Blind, Placebo-Controlled Trial | NCT06012175 |
| Clinical Outcomes of Melatonin Supplementation As Adjuvant Therapy of In-Vitro Fertilization | Clinical Outcomes of Melatonin Supplementation as Adjuvant Therapy: A Randomized Controlled Trial Amongst Women Undergoing In-Vitro Fertilization at Jos University Teaching Hospital, Plateau State, North-Central, Nigeria | PACTR202308477172970 |
| The effects of melatonin supplementation on oxidative stress, inflammatory biomarkers and lipid profile in diabetic patients with chronic kidney disease- a randomized trial | The effects of melatonin supplementation on oxidative stress, inflammatory biomarkers and lipid profile in diabetic patients with chronic kidney disease- a randomized trial | IRCT20170202032367N9 |
| Evaluation of the Effect of Melatonin and Valerian in Treatment of Tinitus | Evaluation of the Effect of Melatonin and Valerian versus Placebo in Treatment of Tinitus | IRCT2016011825083N3 |
| Clinical evidence for melatonin-rich milk to improve sleep | Clinical evidence for melatonin-rich milk to improve sleep | ChiCTR2300070906 |
| investigation of melatonin in sleep quality in patients with cancer | investigation of effectiveness and non effectiveness of melatonin in sleep quality in patients with | IRCT2016051027840N1 |
| Investigating the effect of melatonin and zolpidem on postoperative sleep disturbance | comparison of the effect of melatonin and zolpidem on the onset and number of sleep hours after laparoscopic abdominal surgery | IRCT20221015056176N1 |
| The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children | The Role of Melatonin in the Effective Attainment of Sleep Electroencephalograms (EEG) in Children | NCT02195661 |
| Comparison Effectiveness of Melatonin and Clonidine in Treatment of Insomnia in Children with Attention Deficit Hyperactivity Disorder: Randomized Controlled Trial | Comparison Effectiveness of Melatonin and Clonidine in Treatment of Insomnia in Children with Attention Deficit Hyperactivity Disorder: Randomized Controlled Trial | TCTR20230821001 |
| The Effect of Dexmedetomidine, Melatonin and Pregabalin | Comparison Between the Effect of Dexmedetomidine, Melatonin and Pregabalin on Hypotensive Anesthesia in Patients Undergoing Functional Endoscopic Sinus Surgery | NCT05829148 |
| The effect of melatonin in the prevention of bronchopulmonary dysplasia in neonates admitted to Neonatal intensive care unit of Mahdieh Hospital | The effect of melatonin in the prevention of bronchopulmonary dysplasia in neonates admitted to Neonatal intensive care unit | IRCT20230526058294N1 |
| Melatonin Supplementation and Performance | Nocturnal Melatonin Ingestion Ameliorates Short Term Maximal Performances on the Following Day | NCT02876770 |
| The effect of melatonin on perioperative myocardial protection and oxidative stress in patients undergoing cardiac valve replacement under cardiopulmonary bypass | The effect of melatonin on perioperative myocardial protection and oxidative stress in patients undergoing cardiac valve replacement under cardiopulmonary bypass | ChiCTR2300074823 |
| Studies on the effects of light on human neuroendocrine physiology and cognition | Within-subjects comparison of the effect of evening light exposure of different spatial and temporal properties on melatonin production in healthy adults | ISRCTN88955347 |
| Efficacy of melatonin in fetal pulmonary artery doppler index and a role of this parameters in prevention of neonatal respiratory distress syndrome in preterm neonates with maternal abnormal implantation placenta | Efficacy of melatonin in fetal pulmonary artery doppler index and a role of this parameters in prevention of neonatal respiratory distress syndrome in preterm neonates with maternal abnormal implantation placenta | IRCT20230801059003N1 |
| Oral Bioavailability of Two Melatonin Supplements | Interventional Study for the Comparison of the Oral Bioavailability of Two Melatonin Supplements | NCT05835258 |
| Effect of Melatonin on the incidence of agitation and delirium | Effect of Melatonin on agitation and delirium in hospitalized patients with head trauma | IRCT2014071016917N2 |
| Effect of melatonin on semen parameters and reproductive hormones in men with idiopathic infertility | The effect of melatonin on semen parameters and reproductive hormones in men with idiopathic infertility | IRCT20230418057949N1 |
| Radioprotective effect of melatonin for hyperthyroidism treatment with iodine-131 | Radioprotective effect of melatonin in hyperthyroid patients treated by iodine-131 | IRCT2014090419045N1 |
| Pharmacokinetics of Melatonin Niosomes Oral Gel in Healthy Volunteers | Pharmacokinetics of Melatonin Niosomes Oral Gel in Healthy Volunteers | NCT02845778 |
| Control of chronic nonbacterial prostatitis symptoms | A clinical trial to comparison the effectiveness of melatonin and capsules containing starch (placebo) as an adjuvant therapy to control symptoms of chronic nonbacterial prostatitis patients | IRCT2016071025507N4 |
| The efficacy of melatonin for the prevention of taxane-induced peripheral neuropathy | Evaluating the effectiveness of melatonin for the prevention of taxane-induced peripheral neuropathy in patients with breast cancer: A double-blinded randomized clinical trial | IRCT20160310026998N14 |
| effects of melatonin as premedication agent in caesarean section | A double-blind randomized placebo - controlled trial of melatonin as premedication agent in Caesarean section | IRCT20230809059105N1 |
| The effect of Melatonin for sleep and function of shift workers | Effects of Melatonin on Sleep Quality and Cognitive Function of Shift Workers with Sleep Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial | IRCT20090117001556N153 |
| Effects of Melatonin in Patients with Pulmonary Sarcoidosis | Evaluation of the Effects of Melatonin in Improvement of Chronic Fatigue Syndrome and Quality of life in Patients with Pulmonary Sarcoidosis | IRCT20151227025726N32 |
| Effect of Melatonin on Cognitive Performance Impairment | The Effect of Melatonin on Cognitive Performance Impairment During Electro Convulsive Therapy in Patients with Bipolar Disorder | IRCT20220516054879N5 |
| SLUMBER: A Study on the impact of Late-night Use of Melatonin in the Burden of Endometriosis-Related Sleep Disturbance | SLUMBER: A Study on the impact of Late-night Use of Melatonin in the Burden of Endometriosis-Related Sleep Disturbance | ACTRN12625000681459 |
| To evaluate the analgesic effect of melatonin in patients with Post Herpetic Neuralgia and to assess the improvement in pain score | Evaluate the effect of Melatonin in amelioration of pain as Add-on therapy in Post Herpetic Neuralgia | CTRI/2023/05/052771 |
| Effect of Melatonin in Patients With Diabetic Peripheral Neuropathy | Effect of Melatonin on the Clinical Outcomes in Type 2 Diabetic Patients With Peripheral Neuropathy | NCT07036796 |
| The effect of melatonin on night sleep quality in Emergency Medicine Residents | comparison between oral melatonin effect versus placebo on night sleep quqlity in Emergency Medicine residents of Tehran University of Medical Sciences after night shifts | IRCT2015112925286N1 |
| Efficacy and Safety of Melatonin PR and Clonazepam in Patients With REM Sleep Behavior Disorder in Parkinson Disease | A Randomized Double-Blind, Double-Dummy, Crossover Study to Evaluate the Efficacy and Safety of Prolonged-Release Melatonin and Clonazepam in Patients With Rapid Eye Movement (REM) Sleep Behavior Disorder in Parkinson Disease | NCT02789592 |
| The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study | The Preventative Role of Exogenous Melatonin Administration in Patients With Advanced Cancer Who Are at Risk of Delirium: a Feasibility Study Prior to a Larger Randomized Controlled Trial | NCT02200172 |
| Efficacy and Safety of Sublingual Melatonin in alleviation of irratable Bowel | Efficacy and Safety of Sublingual Melatonin in alleviation of IBS Symptoms | IRCT20121021011192N14 |
| Melatonin 3mg and 5mg Compared to Cognitive Behavioral Therapy for Insomnia (CBT-I) in the Treatment of Insomnia | National, Phase II/III, Multicenter, Randomized, Double-blind, Controlled, Parallel,Effect of Melatonin 3mg and 5mg Plus Cognitive Behavioral Therapy for Insomnia (CBT-I) Compared to the CBT-I Alone in the Treatment of Insomnia Disorder | NCT02798367 |
| Carryover effects in melatonin suppression | Carryover effects in melatonin suppression during repeated light exposure in healthy adults: a within-subject controlled trial | ISRCTN38107747 |
| To evaluate the Effectiveness and Safety of Tugain F plus solution in Male baldness | A Single Centre, Open Label Study to Evaluate Effectiveness and Safety of Minoxidil 5 percentage + Finasteride 0.1 percentage Solution Fortified with 0.0033 percentage Melatonin (Tugain F plus) in Males with Pattern Hair Loss - NIL | CTRI/2025/06/088918 |
| A randomised trial of the pro-phylactic use of melatonin in critically ill patients to evaluate if this leads to a reduction in incidence of delirium (Pro-MEDIC study) | Pro-phylactic administration of Melatonin for the prevention of Delirium in Intensive Care units – a randomized placebo controlled trial (Pro-MEDIC study) | ACTRN12616000436471 |
| The study of the effects of melatonin on nocturnal blood pressure fluctuation in patients with obstructive sleep apnea | The study of the effects of melatonin on nocturnal blood pressure fluctuation in patients with obstructive sleep apnea | IRCT20221023056278N1 |
| Melatonin and Triclofos Sodium comparison to produce sleep in children during CT | Oral Melatonin vs Oral Triclofos sodium for sedation during computerised tomography in children: A single Blinded Randomised Controlled Trial. - Nil | CTRI/2023/06/053793 |
| To evaluate the effect Of Scaling and Root planing with the use of 1% Melatonin Gel in stage III Periodontitis using cone beam computed tomography(CBCT) | Comparative Evaluation of 1% melatonin gel as an Adjunct to Non-Surgical Periodontal Therapy in Stage III Periodontitis: A CBCT study | CTRI/2019/03/018066 |
| Evaluation the effects of different doses of Melatonin on pain control after surgery and their effects on the need for opioid and non-opioid analgesics in patients who are candidates for spinal anesthesia | Evaluation the effects of different doses of Melatonin on pain control after surgery and their effects on the need for opioid and non-opioid analgesics in patients who are candidates for spinal anesthesia: a double-blind clinical trial | IRCT20230516058207N1 |
| Comparing the Effects of Melatonin and Chlorhexidine mouthwash in People with Gingivitis | Comparison of Anti-inflammatory Effect of Melatonin and Chlorhexidine mouthwashes in People with Gingivitis | IRCT20230606058391N1 |
| Study to compare the effect of melatonin gel in combination with artificial bone material in treating bony defects caused by gum diseases. | Clinical and Radiological evaluation of periodontal intrabony defects using 1% Melatonin gel with Demineralized freeze-Dried Bone Allograft (DFDBA) and its effect on Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL) and Osteoprotegerin (OPG) levels in Gingival Crevicular Fluid - A Randomized Controlled Trial - NIL | CTRI/2023/07/055039 |
| Pain relief with oral melatonin vs 24% sucrose during venipuncture in neonates | Oral Melatonin vs 24% sucrose for pain relief during venipuncture in neonates- a non-inferiority randomised controlled trial - NIL | CTRI/2023/07/055046 |
| The effect of melatonin on endometrial histology in patients with disordered simple hyperplasia. | The effect of melatonin and megestrol acetate compared to megestrol acetate alone on endometrial histology in patients with endometrial proliferative disorders: a double blind randomized clinical trial | IRCT20120922010901N10 |
| Evaluation of melatonin effects on oxidative stress in hemodialysied patiant | Evaluation of melatonin effects on oxidative stress in hemodialysied patiant, A prospective,randomizized, double-blind, controlled trial | IRCT20190120042430N1 |
| Application and mechanism research of Melatonin on improving fertility in patients with endometriosis by acting on lipid metabolism of granulosa cell | Application and mechanism research of Melatonin on improving fertility in patients with endometriosis by acting on lipid metabolism of granulosa cell | ChiCTR2300073405 |
| The effects of melatonin treatment on risk for diabetes and heart disease | Chronotherapeutic lifestyle intervention for diabetes and obesity to reset the circadian rhythm and improve cardiometabolic risk in the European population - Chronotherapeutic Lifestyle Intervention for Diabetes (Eurhythdia) | EUCTR2012-005255-17-GB |
| Comparing the effectiveness of melatonin with placebo in reducing the level of interleukin-6 in operated infants. | Comparing the effectiveness of melatonin with placebo in reducing the level of interleukin-6 in operated infants. | IRCT20200109046061N2 |
| Melatonin supplementation effect on the Induction of labour rates in first-time MothErs:The MyTIME Trial | A double-blind, randomised, placebo-controlled trial to evaluate the effect of oral Melatonin administered to nulliparous women at 39 weeks' gestation, on the rate of induction of labour. | ACTRN12623000502639 |
| melatonin and sleep quality | The effect of melatonin on the sleep quality of patients with chronic pelvic pain caused by endometriosis, a triple-blind randomized controlled trial study in the provider unit | IRCT20171209037794N4 |
| The Effect of Resistance Training and Melatonin in Primary Dysmenhorrea Girls | The Effect of Resistance Training and Melatonin on Sexual Hormone Levels, Pgf2a, LH, FSH, Pain Intensity and Sleep Quality in Primary Dysmenhorrea Girls | IRCT20230703058653N1 |
| Investigating The Effect Of Melatonin On Infantile Colic | Investigating The Effect Of Melatonin On Infantile Colic | IRCT20080930001285N2 |
| The efficacy and safety of exogenous melatonin in the treatment of acute central serous chorioretinopathy | The efficacy and safety of exogenous melatonin in the treatment of acute central serous chorioretinopathy | ChiCTR2300073143 |
| Investigating the effect of melatonin supplementation in obesity | Investigating the effect of melatonin supplementation on plasma levels of ghrelin, 2-arachidonoylglycerol and hedonic eating intensity | IRCT20080904001197N22 |
| Effects of melatonin administration and physical exercise during Ramadan diurnal intermittent Fasting on overweight/obesity management | Concomittant effects of melatonin supplementation combined with concurrent training during Ramadan diurnal intermittent fasting on sleep quality, quality of life, postural balance and biological responses in Women With Overweight/Obesity | PACTR202306614083752 |
| The effect of Melatonin in Schizophrenia treatment | Investigating the effect of Melatonin on the cognitive symptoms of patients with Schizophrenia treated with Risperidone: a randomized double-blind clinical trial | IRCT20230619058537N1 |
| Effects of Melatonin on Non-alcoholic fatty liver disease | Evaluation of the effects of Melatonin Supplementation on Hepatic Enzymes, Inflammatory Factors, Lipid profile, blood glucose, Insulin Sensitivity, and Hepatic Steatosis grade in patients with Non-alcoholic fatty liver disease | IRCT2016061516123N8 |
| The effect of melatonin on endometrial thickness | Investigation of the effect of oral melatonin on the thickness of the endometrium of infertile women in the IUI cycle | IRCT20221127056633N1 |
| Melatonin Supports Non Surgical Periodontal Treatment in Patients With Type 2 Diabetes and Periodontitis | Melatonin Supports Non Surgical Periodontal Treatment in Patients With Type 2 Diabetes and Periodontitis | NCT05870358 |
| A study to compare effectiveness of oral Triclofos versus Melatonin for inducing sedation in children for recording EEG in a Tertiary care centre: A Randomised Control Trial | Effectiveness of oral Triclofos versus Melatonin for inducing sedation in children for recording EEG in a Tertiary care centre: A Randomised Control Trial - Nil | CTRI/2023/10/059031 |
| Investigation of the effects of organic light-emitting diode illumination on melatonin secretion and sleep. | Investigation of the effects of organic light-emitting diode (OLED) illumination on melatonin secretion and sleep. - Investigation of the effects of organic light-emitting diode (OLED) illumination on melatonin secretion and sleep. | JPRN-UMIN000052648 |
| Evaliuation of the effect of Melatonin and Agomelatin on sleep problem in children and adolescent with Autism spactrum disorder | Evaliuation of the effect of Melatonin and Agomelatin on sleep problem in children and adolescent with Autism spactrum disorder | IRCT20230607058407N1 |
| Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study | Comparative Evaluation of Melatonin Versus Mineral Trioxide Aggregate on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study | NCT06372561 |
| To compare the ease of inducing sleep in children posted for EEG between Intranasal Dexmedetomidine, oral Triclofos and oral Melatonin | To compare the efficacy of Intranasal Dexmedetomidine vs oral Melatonin vs oral Triclofos as procedural sedative for drug induced sleep EEG in children: A double-blind, parallel design, randomized clinical trial - NIL | CTRI/2023/11/059517 |
| The effect of melatonin on sleep quality in patients with mild traumatic brain injury | The effect of melatonin on sleep quality in patients with mild traumatic brain injury | IRCT20220504054738N1 |
| CAN MELATONIN IN HELP JAW PAIN ,SLEEP RELATED ISSUE,DEPRESSION & ANXIETY? | TOTAL BLIND RANDOMIZED CONTROLLED TRIAL TO EVALUATE THE EFFICACY OF MELATONIN IN TREATMENT OF TEMPOROMANDIBULAR DISORDER - NIL | CTRI/2023/11/059552 |
| A randomized, double-blind, placebo-controlled, multicenter study evaluating the effect of a 12-week DHEA combination of 20 mg and 2 mg prolonged-release melatonin on sleep quality and mood in postmenopausal women. | A randomized, double-blind, placebo-controlled, multicenter study evaluating the effect of a 12-week DHEA combination of 20 mg and 2 mg prolonged-release melatonin on sleep quality and mood in postmenopausal women. - DHM/EPH/01/2022 | EUCTR2022-004160-16-PL |
| Effects of Melatonin and Ranolazine on Trastuzumab-Induced Cardiac Dysfunction in HER2-Positive Breast Cancer Patients | Effects of Melatonin and Ranolazine on Trastuzumab-Induced Cardiac Dysfunction in HER2-Positive Breast Cancer Patients | TCTR20231110007 |
| Effectiveness of adding melatonin and sleep hygiene education to the usual treatment of attention deficit hyperactivity disorder with sleep phase delay syndrome. | A comparative study of the effectiveness of adding melatonin and sleep hygiene education to the usual treatment (pharmacological and non-pharmacological treatment) in reducing the symptoms of attention deficit hyperactivity disorder in adolescents with attention deficit hyperactivity disorder and sleep phase delay syndrome. | IRCT20211004052670N5 |
| Effect of Melatonin in relieving pain and Quality of Recovery following spine surgery when given preoperatively | Effect of Preoperative Melatonin on Postoperative pain relief and Quality of Recovery in patients undergoing spinal fusion surgery: A randomised, triple-blinded, placebo-controlled trial - NIL | CTRI/2023/11/059763 |
| Oral Bedtime Melatonin in Critically Ill Patients | Oral Bedtime Melatonin in Critically Ill Patients | NCT06156059 |
| Melatonin in medium brain trauma | Investigation of Melatonin Therapeutic Effect in Patients with Moderate Brain Trauma | IRCT20221108056446N5 |
| Melatonin Use in Patients With Climacterious Symptoms in the Perimenopause | Benefits of Melatonin Use in Patients With Climacterious Symptoms in the Perimenopause: Randomized, Double-blind, Placebo-controlled Clinical Trial | NCT06192641 |
| Melatonin for Chronic back pain | Melatonin for Chronic back pain (The MOCHA trial) - 23.002 | CTIS2023-503530-41-00 |
| Investigating the effect of melatonin combined with betamethasone mouthwash compared to betamethasone mouthwash alone in the treatment of ulcerative oral lichen planus | Investigating the effect of melatonin combined with betamethasone mouthwash compared to betamethasone mouthwash alone in the treatment of ulcerative oral lichen planus | IRCT20230823059238N2 |
| Melatonin Administration as an Adjuvant Therapy in Preterm Infants with Neonatal Jaundice | Melatonin Administration as an Adjuvant Therapy in Preterm Infants with Neonatal Jaundice | IRCT20231210060317N1 |
| Effect of oral melatonin versus oral ketamine on the incidence of emergence delirium in children undergoing squint surgery: A prospective randomized controlled trial | Effect of oral melatonin versus oral ketamine on the incidence of emergence delirium in children undergoing squint surgery: A prospective randomized controlled trial | PACTR202402880294495 |
| The effect of melatonin, clonidine, and gabapentin on reducing the preoperative anxiety and postoperative pain in patients undergoing laparoscopic cholecystectomy | A comparative study of the effect of melatonin, clonidine or gabapentin on reducing the preoperative anxiety and postoperative pain in patients undergoing laparoscopic cholecystectomy in Shariati Hospital in 1393 | IRCT2014041217231N1 |
| Role of oral melatonin in prevention of catheter related bladder discomfort (CRBD) in patients undergoing surgery for benign prostate hypertrophy | Pre-emptive role of oral melatonin in prevention of catheter related bladder discomfort (CRBD) in patients undergoing transurethral resection of prostate (TURP) surgery: A prospective randomized controlled study - NIL | CTRI/2024/01/062153 |
| The effect of melatonin pre-treatment on the consumption of inhaled anaesthetic in children undergoing planned surgery. | To evaluate the effect of melatonin premedication on Bispectral Index guided sevoflurane consumption in pediatric surgery: A randomized controlled trial - NIL | CTRI/2024/01/062064 |
| Melatonin on Anxiety and Sleep Quality in Adults Undergoing Coronary Artery Bypass Graft Surgery | The Effect of Melatonin on Anxiety and Sleep Quality in the Peri-Operative Course of Adults Undergoing Coronary Artery Bypass Graft Surgery: Prospective Randomized Controlled Study | NCT06237556 |
| The comparison of melatonin and chloral hydrate on sleep induction for electroencephalography recording | Comparison of melatonin and chloral hydrate on sleep induction for recording Electroencephalography in children aged six months to five years old | IRCT20221227056944N1 |
| Anxiolytic effects of melatonin. A study on surgical patients. | The anxiolytic effects of melatonin: A randomized, placebo-controlled, double-blinded clinical study. - The anxiolytic effects of melatonin. | EUCTR2014-003789-25-DK |
| postoperative delirium in patients with colorectal cancer | Investigating the incidence of postoperative delirium in patients with colorectal cancer undergoing elective surgery after intervention with ketamine and/or melatonin compared to the control group | IRCT20120527009886N2 |
| The effect of 12 weeks Melatonin administration on depressive symptoms in youth with major depressive disorders - A Randomised, Placebo-controlled, Double-blinded Trial. | The effect of 12 weeks Melatonin administration on depressive symptoms in youth with major depressive disorders - A Randomised, Placebo-controlled, Double-blinded Trial. | ACTRN12624000017527 |
| Effect of use of combination of ear plugs, eye mask and a drug called melatonin in icu patients to prevent sleep disturbances and mental disturbances. | Effect of combination of melatonin with non pharmacological strategies on delirium prevention in ICU- a randomised controlled trial - N/A | CTRI/2024/01/061285 |
| Comparative evaluation of premedication with oral Melatonin versus Pregabalin for attenuation of hemodynamic stress response to laryngoscopy and endotracheal intubation. | Comparative evaluation of premedication with oral Melatonin versus Pregabalin for attenuation of hemodynamic stress response to laryngoscopy and endotracheal intubation. - NIL | CTRI/2024/01/061064 |
| Melatonin and Reduction of the Radiation Dermatitis in Breast Cancer Patients | Investigation of the Effect of Melatonin on Reduction of the Grade Three Radiation Dermatitis in Breast Cancer Patients: A Randomized Controlled Trial | IRCT20231218060453N1 |
| The effect of melatonin in the prevention of preeclampsia | Investigating of the adjuvant effect of melatonin in the prevention of preeclampsia in moderate and high risk women | IRCT20230930059563N1 |
| Protective effect of Melatonin on clinical outcomes in patients with acute ischemic stroke | Evaluation of the Effect of Melatonin on Clinical Outcomes in Patients with Acute Ischemic Stroke: a Randomized Double-Blind Placebo-Controlled Clinical Trial | IRCT20231220060484N1 |
| Effect of a Novel Melatonin Supplement on Sleep Quality | Effect of a Novel Melatonin Supplement on Sleep Quality | NCT06215573 |
| Comparing the Effect of Melatonin, Diazepam, and Placebo on Decreasing the Level of Anxiety Preoperatively | Comparing Melatonin to Diazepam as a Premedication: a Triple-blind, Randomized, Placebo Controlled Clinical Trial | NCT06103188 |
| Dose Assessment of Melatonin in Sepsis Trial | Dose Assessment of Melatonin in Sepsis Trial | NCT02319265 |
| Using melatonin pill to reduce the risk of cancer due to exposure to radiation doses from CT imaging . | The investigation radioprotective effect against DNA double-stranded breaks induced in Peripheral blood lymphocytes of patients undergoing CT examinations of the abdomenpelvic of melatonin by immunofluorescence assay | IRCT20171122037593N1 |
| Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies | Effects of Oral Melatonin on Neurosensory Recovery Following Facial Osteotomies - A Randomised, Controlled Clinical Trial | NCT02889432 |
| role of melatonin as premedication | Efficacy of Melatonin as a Premedication in Children Undergoing Elective Surgery, a double-blinded randomized trial | ITMCTR2023000044 |
| Cerebroprotective Effect of Melatonin in Stroke | Cerebroprotective Effect of Melatonin in Acute Ischemic Stroke | NCT05857046 |
| Evaluation of the effect of melatonin on executive function of ADHD child with sleep problems | Evaluation of the effect of melatonin on executive function of ADHD child with sleep problems | IRCT20230524058282N1 |
| melatonin in neonates with hypoxic encephalopathy | Investigating the effect of melatonin in pro-oxidant antioxidant balance of neonates with hypoxic ischemic encephalopathy: A Randomized Parallel Clinical Trial | IRCT20230605058385N1 |
| The effect of oral melatonin on the quality of life, sleep and blood pressure of renal failure patients | Assessment of the effect of oral melatonin on the quality of life and sleep and blood pressure of kidney failure patients in the hemodialysis departments of Yasouj city: a randomized clinical trial. | IRCT20230205057333N1 |
| Comparison of Melatonin or Metformin and Dacarbazine Combination Versus Dacarbazine Alone in Disseminated Melanoma | Phase II Multicenter Randomized Study to Compare Dacarbazine With Melatonin or Metformin Versus Dacarbazine in the First Line Therapy of Disseminated Melanoma | NCT02190838 |
| Melatonin for Delirium Prophylaxis | A Randomized Double-Blind Placebo-Controlled Study on the Use of Melatonin for the Prevention of Delirium | NCT02282241 |
| follow up of Effects of Melatonin on Health-Related Quality of Life | The Effect of Melatonin on Increasing The Health-Related Quality of Life in Female Patients with Non-metastatic Breast Cancer: Three-year Follow up a Clinical Trial | IRCT20221205056712N1 |
| Therapeutic effect of physical and cognitive training combined with melatonin supplementation in subjects with mild to moderate Parkinson's disease. | The effect of physical activity and simultaneous cognitive enrichment coupled with melatonin supplementation on cognitive-motor performance and biochemical adaptations in subjects with mild to moderate Parkinson's disease. | PACTR202309885617364 |
| Investigation of melatonin effect on outcome of moderate and severe diffuse axonal injury(DAI) in men admitted in Kerman Educational And Traputical Center Of Shahid Bahonar: changes in inflammatory, oxidant activity and injury factors | Investigation of melatonin effect on the outcome of moderate and severe diffuse axonal injury(DAI) in men admitted in Kerman Educational And Traputical Center Of Shahid Bahonar: changes in inflammatory, oxidant activity and injury factors | IRCT20190717044248N6 |
| Investigating the effect of Melatonin supplement on the incidence of Delirium After Coronary Artery Bypass Graft surgery | Investigating the Effect of Melatonin Supplement on the Incidence of Delirium in Patients Undergoing Coronary Artery Bypass Graft Surgery in a Three-blind, Placebo-controlled Clinical Trial. | IRCT20230820059193N1 |
| Melatonin Premedication in Children Undergoing Surgery | Assessment of the Effects of Melatonin on Preoperative Anxiety and Postoperative Analgesia in Children Undergoing Surgery: a Prospective, Randomized Clinical Trial | NCT02265822 |
| Comparing the effectiveness of melatonin and clobazam in the prophylaxis of febrile seizures | Comparing the effectiveness of melatonin and clobazam in the prophylaxis of febrile seizures | IRCT20221102056380N1 |
| The Premedication Properties of Oral Melatonin in Pediatrics Undergoing Therapeutic Cardiac Catheterization | A Double-blind Randomized Placebo - Controlled Trial of Oral Melatonin as Premedication Agent in Pediatrics Undergoing Therapeutic Cardiac Catheterization | NCT06031961 |
| Evaluation of the effect of melatonin on inflammatory factors and clinical outcomes in sepsis | Evaluation of the effect of melatonin on inflammatory factors and clinical outcomes in sepsis patients hospitalized in the Intensive Care Unit | IRCT20181104041551N4 |
| Melatonin and Vitamin D in Breast Cancer | Anti-proliferative Effects of Melatonin and Vitamin D in Breast Cancer | NCT02288806 |
| Dexmedetomidine Infusion Versus Oral Melatonin for Prevention of Intensive Care Delirium | Dexmedetomidine Infusion Versus Oral Melatonin for Prevention of Intensive Care Unit (ICU) Delirium; A Prospective Randomized Controlled Study | NCT06076668 |
| Role of music therapy in preventing delirium | The effect ofmusic therapy as an adjuvant to melatonin for preventing delirium in patients on mechanical ventilation in ICU- a randomised double blind study - nil | CTRI/2023/10/058672 |
| The investigation of the effects of melatonin on the rate of postoperative artrial fibrillation after coronary artery bypass grafting sutgery | The investigation of the effects of melatonin supplement on the rate of postoperative artrial fibrillation after coronary artery bypass grafting sutgery | IRCT20230902059320N1 |
| Comparative assessment of the absorption of a generic formulation of melatonin prolonged release tablet against the innovator melatonin prolonged release tablet conducted under fed conditions in healthy male and female volunteers | A single dose, randomized, blinded, bioequivalence study of a test formulation of melatonin prolonged release tablet in a 2 way crossover comparison against the innovator melatonin prolonged release tablet conducted under fed conditions in healthy male and female volunteers | ACTRN12614001249640 |
| The Effects of Melatonin on Cardiovascular and Bone Metabolism Markers in Peritoneal Dialysis Patients | Effects of Melatonin, as a Dietary Supplement, on Glycemic Parameters, Cardiovascular Disease Risk Factors, Bone Metabolism Markers and Quality of Life in Peritoneal Dialysis Patients | NCT06096558 |
| The Effect of Melatonin Supplementation on Fatigue Symptoms During Chemotherapy Treatment of Breast Cancer Patients | The Effect of Melatonin Supplementation on Fatigue Symptoms During Chemotherapy Treatment of Breast Cancer Patients | NCT06125353 |
| Comparative study between Oral melatonin and Oral Clonidine in controlling blood pressure, Heart rate in General Anaesthesia. | A comparative study between oral melatonin and oral clonidine in the attenuation of hemodynamic response to laryngoscopy and tracheal intubation—A prospective double blinded randomized controlled trial. - NIL | CTRI/2023/10/058433 |
| Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment | Effect of oral melatonin and wearing earplugs and eye masks on nocturnal sleep in healthy subjects in a simulated intensive care unit environment | ChiCTR-IPR-14005458 |
| Studying Melatonin and Recovery in Teens | SurgerySMART: Studying Melatonin and Recovery in Teens | NCT06093477 |
| Effect of oral melatonin in controlling pruritus in patients with atopic dermatitis | Evaluation of the effect of oral melatonin versus placebo in controlling pruritus in patients with atopic dermatitis: a double-blind randomized clinical trial | IRCT20120215009014N483 |
| Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects | Clinical and Radiographic Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects: A Randomized Controlled Clinical Trial | NCT05906563 |
| The effect of melatonin in the treatment of delirium in critically ill patients admitted to the intensive care unit | The effect of melatonin in the treatment of delirium in critically ill patients admitted to the intensive care unit | IRCT20141209020258N189 |
| Does clonidine or melatonin reduce pain after brain tumour surgeries ? | Comparison of effect of preoperative melatonin and clonidine on postoperative pain in patients undergoing craniotomy for supratentorial tumours - a randomized controlled study - NIL | CTRI/2023/09/057874 |
| "Impact of Commercial ""Sleep Lotion"" on Salivary Melatonin Levels and Sleep Quality in Undergraduates" | "Impact of Commercial ""Sleep Lotion"" on Salivary Melatonin Levels and Sleep Quality in Undergraduates" | NCT06053385 |
| Comparison of effect of two drugs on nervousness before operation in adult patients | Impact of oral melatonin versus alprazolam on preoperative anxiety in adult patients posted for elective surgery under general anaesthesia - NIL | CTRI/2023/09/057795 |
| The effect of oral melatonin supplementation on the number and quality of oocytes and embryos in infertile women with endometriosis | The effect of oral melatonin supplementation on the number and quality of oocytes and embryos in infertile women with endometriosis and undergoing intracytoplasmic sperm insemination | IRCT20171209037794N5 |
| Comparison of Melatonin and Triclofos for Inducing Sedation for Sleep EEG in Children: An open labeled Randomized Controlled Trial | Comparison of Melatonin and Triclofos for Inducing Sedation for Sleep EEG in Children: An open labeled Randomized Controlled Trial - NIL | CTRI/2024/01/061446 |
| Melatonin in catamenial migraine headache compare with naproxen | evaluation of melatonin efficacy on frequency and intensity of catamenial migraine headache comparing to naproxen | IRCT20121110011424N4 |
| Effectiveness of drugs in hemodynamic changes during laryngoscopy and intubation in patients undergoing surgey under General Anaesthesia. | To compare the efficacy of oral Melatonin, Gabapentine, Clonidine and Placebo in attenuating hemodynamic response during laryngoscopy and intubation in patients undergoing surgery under General Anaesthesia , A four armed Randomized Double blinded clinical trial. | CTRI/2024/07/070958 |
| Efficacy of premedication with melatonin versus oral midazolam in pediartic patients | Efficacy of premedication with melatonin versus oral midazolam in pediartic patients | IRCT2016101616106N2 |
| Melatonin in Pregnancy | Investigation of Melatonin Production in Pregnancy: a Pilot Study to Define the Contribution of the Placenta | NCT03609086 |
| Evaluating the possible effect of melatonin on oxaliplatin-induced peripheral neuropathy | A randomized, placebo controlled, double-blind study of melatonin to prevent oxaliplatin-induced neuropathy in patients receiving FOLFOX and XELOX chemotherapy regimens for stage II- IV colorectal cancer | IRCT20170326033139N1 |
| MELADERM-trial: Melatonin cream against acute radiation dermatitis in patients with breast cancer | MELADERM-trial: Melatonin cream against acute radiation dermatitis in patients with early breast cancer: a pivotal phase 2, double-blind, randomized, placebo-controlled trial | EUCTR2018-001705-91-DK |
| Comparasion of oral melatonin and clonidine for attenuation of increase BP and Pulse rate due to tube placement in trachea for anaesthesia posted for surgery. | Comparative evaluation of oral melatonin and clonidine for attenuation of haemodynamic response to tracheal intubation-A Prospective Randomized Double Blind Comparative Study. | CTRI/2018/07/015112 |
| Comparing the effect of single dose of rectal Indomethacin and oral Melatonin on prevention of post ERCP pancreatitis | Comparing the effect of single dose of rectal Indomethacin and oral Melatonin on prevention of post ERCP pancreatitis | IRCT20121021011192N6 |
| """Evaluation of melatonin effect on uremic pruritus""" | Evaluation of Anti-pruritus Effect of melatonin on hemodialysis patients with uremic pruritus: A Randomized Clinical Trial | IRCT20180714040462N1 |
| Comparison Between Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures | Comparison Between Melatonin and Diazepam for Prevention of Recurrent Simple Febrile Seizures: Randomized Clinical Trial | NCT03631901 |
| Evaluation of anti-pruritus effect of melatonin in liver disease | Evaluation of anti-pruritus effect of melatonin on patient with liver disease: a randomized clinical Trial | IRCT20180519039718N1 |
| New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin | Innovative Technology for Assessing the Periodontal Disease and New Periodontitis Treatment Based on Hyaluronic Acid and Melatonin | NCT03656484 |
| Melatonin to improve induction of labour: a double blind, randomised, placebo controlled trial. | A double blind, randomised, placebo controlled trial to evaluate the effect of Melatonin as an adjuvant agent at Induction of labour on the rate of induction of labour failure in healthy, pregnant women undergoing cervical ripening prior to induction of labour for prolonged pregnancy | ACTRN12616000311459 |
| Effect of melatonin premedication on propofol consumption in GA | To assess the effect of oral melatonin premedication on propofol requirement for induction in entropy guided general anaesthesia- a randomised double blind study | CTRI/2018/08/015537 |
| Radioprotective effect of melatonin in patient with rectal cancer | Radioprotective effect of melatonin on preventing of cancer-related thrombocytopenia in patient with rectal cancer | IRCT2016021626586N1 |
| Melatonin's Effects on Treatment Of Diabetes Mellitus | The Effects of Melatonin on Serum Glucose Levels of Patients With Type 2 Diabetes Mellitus | NCT02691897 |
| Evaluation of nephroprotective effects of Melatonin | Evaluation of nephroprotective effects of Melatonin in cancer patients treated with Cisplatin | IRCT20171225038073N1 |
| Melatonin in doctors and nurses working nightshifts | Melatonin In Doctors and nurses working NIGHTshifts (MIDNIGHT): a randomised double-blind placebo-controlled crossover pilot study | ISRCTN15529655 |
| Oral Melatonin as Premedication During MAC for Patients Undergoing Loco-regional Chronic Subdural Hematoma Evacuation | Oral Melatonin as Premedication During Monitored Anaesthesia Care for Patients Undergoing Loco-regional Chronic Subdural Hematoma Evacuation, a Randomized Controlled Trial | NCT03732963 |
| Melatonin Degradation Rate in Human Milk | Melatonin Degradation Rate in Human Milk | NCT03591341 |
| Effect of melatonin on diabetes | Effect of melatonin on serum glucose level in patiets with type 2 diabetes | IRCT2016010520219N2 |
| Transdermal Fentanyl and Melatonin Patches for Postoperative Pain Relief | Comparative Study Between Transdermal Fentanyl and Melatonin Patches on Postoperative Pain Relief After Lumber Laminectomy, a Double-blind, Placebo-controlled Trial | NCT02726126 |
| Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy | Effect of Melatonin on Seizure Outcome, Neuronal Damage and Quality of Life in Patients With Generalized Epilepsy: A Randomized, add-on Placebo-controlled Clinical Trial | NCT03590197 |
| Effect of Melatonin on the Daytime Sleepiness side-effect of Gabapentin in Patients With Neuropathic Pain | Effect of Melatonin on the Daytime Sleepiness side-effect of Gabapentin in Adult Patients With Neuropathic Pain | ACTRN12618000522213 |
| Evaluation of the Preventive Effect of Pain by the Use of Melatonin During Female Sterilization Surgery | Evaluation of Melatonin Analgesic Effects Used in the Perioperative Period of Bilateral Tubal Ligation: Randomized Clinical Trial | RBR-2685h6 |
| Melatonin on sleep architecture in COPD patients | A Pilot study to assess the effect of melatonin on sleep and daily activity in patients with Stable COPD | CTRI/2018/04/013444 |
| Prevention of Delirium in Intensive Care by Melatonin | Prevention of Delirium in Intensive Care by Melatonin: a Prospective, Multicentre, Randomized, Double Blind, Placebo, Multi-arm, Multi-stage Study | NCT03524937 |
| Effects of Melatonin on incidence of delirium in the critically ill patients in ICU Maharaj Nakorn Chiang Mai hospital, A randomized control trial | Effects of Melatonin on incidence of delirium in the critically ill patients in ICU Maharaj Nakorn Chiang Mai hospital, A randomized control trial | TCTR20180504002 |
| Safety and Efficacy of Melatonin in Patients with Multiple Progressive Primary Sclerosis | Randomized, Double-blind, Placebo-controlled Clinical Trial to Evaluate the Safety and Efficacy of Melatonin Administration in Patients with Multiple Progressive Primary Sclerosis | NCT03540485 |
| use of melatonin to decrease the hemodynamic responses to laryngoscopy and intubation | A prospective, randomized, double blinded study to assess the efficacy of melatonin in attenuation of hemodynamic responses to laryngoscopy and intubation | CTRI/2018/05/013835 |
| To study the role of oxygen byproducts in the blood in the causation of facial pigmentation or melasma | Role of melatonin and oxidative stress in melasma and correlation with melasma area and severity index | CTRI/2018/05/013910 |
| Clinical trial evaluation the effect of melatonin on analgesia and intraocular pressure in patient with cataract surgery under topical anesthesia. | The effect of melatonin on analgesia and intraocular pressure in cataract surgery with topical anesthesia. | IRCT20160430027677N8 |
| Melatonin in women with endometriosis | Effect of Melatonin on pelvic pain relief in women with endometriosis | IRCT20170612034489N2 |
| Effect of Melatonin Drug in Decreasing Fatigue Caused by Radiotherapy and Chemotherapy | Evaluation of the Effect of Melatonin Drug in Decreasing Fatigue Caused by Adjuvant Radiotherapy and Chemotherapy in Women with Breast Cancer: A Clinical Trial | IRCT20180426039421N1 |
| The Effect of Melatonin on Aerobic Capacity and Time of Exhaustion in Girls | The Effect of Melatonin on Aerobic Capacity and Time of Exhaustion during a Sub-Maximum Activity in Girls student in Physical Education | IRCT20180325039147N1 |
| Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury | Exploratory Study of Melatonin Induced Sleep Regularization in Severe Brain Injury | NCT02732288 |
| Long term effects on sleep quality and adverse effects related to (continued) melatonin use since early childhood. | Long term effects on sleep quality and adverse effects related to (continued) melatonin use since early childhood. | NL-OMON25842 |
| Melatonin Effects on Genital Herpes in Brazilian Women | Effects of Melatonin in the Treatment of Genital Herpes | NCT03831165 |
| The effect of melatonin in patients with gum disease | Comparative evaluation of melatonin with PRF and PRF alone in periodontal intrabony defects among patients with chronic periodontitis-A Split Mouth Randomised Controlled Trial - PRF- Platelet Rich Fibrin | CTRI/2018/07/014725 |
| A clinical study to evaluate the safety and blood concentration of Melatonin sublingual in healthy male research participants | A randomized, double-blind, monocentric, phase I clinical trial to assess the tolerability, safety, and pharmacokinetics of Melatonin Sublingual Suspension, after a single dose in healthy male participants | RBR-8hc3zf |
| Transdermal Nicotine and Melatonin Patches for Postoperative Pain Relief | Comparative Study Between Transdermal Nicotine and Melatonin Patches on Postoperative Pain Relief After Laparoscopic Cholecystectomy, a Double-blind, Placebo-controlled Trial | NCT02747628 |
| The effect of Environmental Light on Sleep and Level of Urinary Melatonin in women who gave birth | The effect of Environmental Light on Sleep and Level of Urinary Melatonin in Postpartum Women | RBR-6vg875 |
| Use of melatonin and sleep deprvation in Children for EEG recordings. | Melatonin compared to sleep deprivation for sleep EEG recordings in children: impact on epileptiform discharges and sleep, contributing factors on the results and the influence on children's and parents' experiences of the investigation. | EUCTR2016-000606-11-SE |
| Examination of day-night cycle and the effect of medication with the neurohormone melatonin on visual functions in patients with diabetic retinopathy | Diabetic retinopathy: Effects of melatonin treatment on visual functions and circadian rhythm. | EUCTR2015-003955-23-DK |
| Effect of Ritalin with and without Melatonin on the quality of sleep and the severity of clinical symptoms in children with attention deficit hyperactivity disorder | Effect of Ritalin with and without Melatonin on the quality of sleep and the severity of clinical symptoms in children with attention deficit hyperactivity disorder: a randomized clinical trial | IRCT20120215009014N235 |
| The effect of melatonin in patients with diabetic nephropathy | Evaluation of the effect of melatonin supplementation on Insulin metabolism markers, parameters of oxidative stress and gene expression of PPAR-? & ox-LDL in patients with diabetic nephropathy | IRCT20150606022562N5 |
| A Randomized Study with the use of Melatonin as Complementary Therapy to the Regimen of Analgesia and Sedation in Intensive Care: Analysis of Serum Levels | A Randomized Study with the use of Melatonin as Adjuvant to the Analgesic Regimen in Intensive Care: Analysis of Serum Levels | RBR-4d9cv7 |
| Melatonin Plus Aminoacids for Sarcopenic Elderly | Is a Combination of Melatonin and Aminoacids Useful to Sarcopenic Elderly Patients? A Randomized Trial | NCT03784495 |
| Treatment for Sleep Disturbance in Orthopaedic Trauma Patients | Melatonin Treatment for Sleep Disturbance in Orthopaedic Trauma Patients | NCT03779243 |
| MIND After Surgery | Melatonin for Preventing Postoperative Delirium in Elderly Patients; a Multi-centre Randomized Placebo Controlled Pilot Study | NCT03785158 |
| The Efficacy of Melatonin in the Burning Mouth Syndrome | Study of the Efficacy of Melatonin in the Burning Mouth Syndrome | NCT03788733 |
| Melatonin in patients with chronic pain | Double blind randomised controlled trial of exogenous administration of melatonin in chronic pain (DREAM-CP) - Melatonin and chronic pain (DREAM-CP) V1 | EUCTR2018-004048-50-GB |
| The effect of Melatonin on remission in patients with pulmonary contusion | Evaluation of the effect of melatonin on remission in patients with pulmonary contusion due to trauma | IRCT20170206032419N5 |
| Effects of systemic melatonin and non surgical periodontal therapy on serum ferritin inpatients with periodontitis disease | Effects of systemic melatonin and non surgical periodontal therapy on serum ferritin inpatients with periodontitis disease | IRCT20100412003690N9 |
| Evaluation the effect of melatonin on tourniquet pain | The effect of melatonin on sedation and tourniquet pain tolerance in intravenous regional anesthesia | IRCT20160430027677N9 |
| Melatonin in elevated blood pressure | A triple blinded randomized controlled trial of oral Melatonin in elevated blood pressure individuals | IRCT20181003041218N2 |
| Melatonin for Anxiety prior to General anaesthesia In Children (MAGIC) | The MAGIC trial (Melatonin for Anxiety prior to General anaesthesia In Children): A Multicentre, Parallel Randomised Controlled Trial of Melatonin Versus Midazolam in the Premedication of Anxious Children Attending for Elective Dental, Ophthalmologic or ENT Surgery Under General Anaesthesia | ISRCTN18296119 |
| Comparison oral caffeine and oral Melatonin on prevention of headache caused by spinal anesthesia in lower limb surgery | Comparison between oral caffeine and oral Melatonin on prevention of headache caused by spinal anesthesia in lower limb surgery | IRCT20141209020258N94 |
| Melatonin for Delirium Reduction, Resolution And Mitigation of Abnormal Arousal (MelaDRRAMAA) | Melatonin for Delirium Reduction, Resolution And Mitigation of Abnormal Arousal (MelaDRRAMAA): a double blinded placebo-controlled randomised trial of Melatonin 5mg nightly for 5 nights for the reduction of severity of delirium in older adult medical inpatients | ACTRN12619000034134 |
| The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant in Anterior Region | The Effect Of Hyaluronic Acid And Melatonin With Systemic Administration of Vitamin C On Implant Stability After Immediate Implant Placement in Anterior and Premolar Region in Systemically Healthy Patients | NCT03804177 |
| Use of Melatonin for Neuroprotection in Asphyxiated Newborns | Use of Melatonin for Neuroprotection in Term Infants With Hypoxic-ischaemic Encephalopathy | NCT03806816 |
| Melatonin Effects on Sleep and Circadian Rhythm in Youth and Young Adults With At-risk Symptoms | Melatonin Effects on Sleep and Circadian Rhythm in Youth and Young Adults With At-risk Symptoms | NCT03826563 |
| Melatonin for Prevention of Radiation Induced Oral Mucositis | The Effectiveness of Melatonin in Prevention of Radiation-induced Oral Mucositis | NCT03833570 |
| comparison of 2 medicines: Melatonin and Triclofos to achieve sleep for EEG | Randomized controlled trial to compare the efficacy and tolerability of melatonin with triclofos in inducing sleep for pediatric electroencephalograms | CTRI/2019/01/016917 |
| Melatonin in Patients With Multiple Sclerosis (MS). | Evaluating the Potential Role of Melatonin in Subjects With Relapsing Multiple Sclerosis (MS) | NCT03498131 |
| Decrease of haemodynamic response to intubation by Melatonin | Role of melatonin in attenuation of haemodynamic response to laryngoscopy and intubation: a randomised controlled double blind study | CTRI/2018/12/016498 |
| The effect of melatonin on Cardiac Enzymes after Cardiac surgery | The effect of melatonin on cardiac biomarkers after coronary artery bypass graft (CABG) surger: ?a pilot clinical trial | IRCT20141006019417N2 |
| Effect of Melatonin on Cardiometabolic Risk- FULL | Effect of Melatonin on Cardiometabolic Risk- FULL | NCT02681887 |
| Relationship between IL6 and fatigue induced by radiotherapy and chemotherapy in patients treated with Melatonin drug | The evaluation of relationship between IL6( Interleukin-6) serum level and fatigue induced by adjuvant radiotherapy and chemotherapy in women with breast cancer treated with Melatonin drug: A clinical trial | IRCT20180426039421N2 |
| Reduction of agitation associated with ketamine | Comparing the effect of intravenous midazolam and oral melatonin on controlling agitation caused by ketamine in emergency department | IRCT20180129038549N8 |
| Treatment of Nighttime Pruritus in Atopic Dermatitis | Efficacy of Melatonin and Diphenhydramine Versus Placebo in Treatment of Nighttime Pruritus in Atopic Dermatitis | NCT03688464 |
| Exogenous Melatonin in Intensive Care Unit Chronodisruption | Exogenous Melatonin in Intensive Care Unit Chronodisruption: Randomized Controled Trial | NCT03708341 |
| Evaluation of Melatonin Application of Immediate Dental Implant | Clinical Evaluation of Topical Melatonin Application on Implant Stability of Immediate Dental Implant in Anterior & Premolar Region in Systemically Healthy Patients (Randomized Clinical Trial) | NCT03689998 |
| The effect of melatonin in children insomnia | The effect of Melatonin treatment for chronic insomnia one to three years old children | IRCT20180719040526N1 |
| Assessment of Immediate Implant Stability When Adding Mixture of Hyaluronic Acid and Melatonin | Assessment of Implant Stability in Immediate Post-extraction Implants With and Without the Application of Hyaluronic Acid and Melatonin Mixture: Randomized Clinical Trial | NCT03692026 |
| Evaluating the effect of melatonin on the prevention of postoperative atrial fibrillation and acute kidney and injury following open heart surgery | Evaluating the effect of melatonin on the prevention of postoperative atrial fibrillation and acute kidney and injury (AKI) following coronary artery bypass grafting (CABG) surgery | IRCT20151227025726N11 |
| The effects of melatonin, administered prior to sleep at an irregular time, on Rapid Eye Movement (REM) sleep and fear inhibition in healthy young adults | Placebo-controlled analysis of the effects of melatonin, administered prior to circadian misalignment, on REM sleep and fear inhibition in healthy adults aged 18-39 years | ACTRN12618001624279 |
| Effects of Melatonin on the incidence of Delirium | The effect of Melatonin on the incidence of Delirium in hospitalized patients in the Intensive Care Unit | IRCT20150928024236N5 |
| Melatonin for Renal Protection in Patients Receiving Polymyxin B | Melatonin for Renal Protection in Patients Receiving Polymyxin B:a Randomized Clinical Trial | NCT03725267 |
| Effects of Melatonin in PCOS Women | Effects of 6 Months of Melatonin Treatment on Clinical, Endocrine ed Metabolic Features in Women Affected by PCOS | NCT02663570 |
| Effect of propolis and melatonin on clinical factors of patients in intensive care units | Evaluation of propolis supplementation and high doses of melatonin effects on oxidative stress indices, inflammatory factors, clinical status in patients with Systemic Inflammatory Response Syndrome (SIRS) in Intensive Care Unit | IRCT20181025041460N1 |
| Effect of Melatonin on Reduction of Pelvic Pain | Effect of Melatonin on Reduction of Pelvic Pain | NCT03782740 |
| The effect of melatonin and atorvastatin on diabetic nephropathy | Evaluating the effect of co-administration of melatonin and atorvastatin in type II diabetic patients with microalbuminuria | IRCT20181118041689N1 |
| Oral Melatonin Plus Zinc Supplementation in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) | An Unicentric, Double-blind, Placebo Controlled, Phase IV Clinical Trial of Oral Melatonin Plus Zinc to Evaluate Relieving Self-reported Fatigue in CFS/ME | NCT03000777 |
| Trial of Oral Melatonin in Elevated Blood Pressure | A Triple Blinded Randomized Controlled Trial of Oral Melatonin in Elevated Blood Pressure Individual (MRCTEBP) | NCT03764020 |
| Comparison of two separate dose of Melatonin as a drug used before anesthesia in cancer patient. | A Comparative Study of Two dose of Melatonin as Oral Premedication in Oncoanaesthesia; A Randomized Single Blind Control Study. | CTRI/2018/10/015917 |
| Melatonin in Acute Stroke | Role of Melatonin in the Acute Phase of Stroke as Measured by Interleukin 6 Biomarker | NCT03843008 |
| Effect of melatonin on anxiety and pain in patient undergoing eye surgery | Effect of preoperative melatonin on anxiety and pain in patient undergoing Phacoemulsification cataract surgery | CTRI/2018/04/012960 |
| The Influence of Melatonin Supplementation in the Group of Persons Performing Competitive Sport. | NCT03505411 | |
| Effect of supplementation in treatment of Coronary Heart Disease | Clinical trial of the effect of melatonin supplementation compared with the placebo on metabolic profiles in patients with coronary heart disease and type 2 diabetes mellitus | IRCT2017051333941N1 |
| Acute Metabolic Effects of Melatonin Treatment | Acute Metabolic Effects of Melatonin Treatment | NCT03204877 |
| Melatonin Against Temazepam in Comparing adverse events in vulnerable elderly Hospitalized patients with sleeping problems | Melatonin Against Temazepam in Comparing adverse events in vulnerable elderly Hospitalized patients with sleeping problems - MATCH | NL-OMON46069 |
| CHOCOlate MeLatonin for AdolescenT MigrainE | CHOCOlate MeLatonin for AdolescenT MigrainE: The CHOCOLATE Study | NCT03597529 |
| Melatonin as a Circadian Clock Regulator, Neuromodulator and Myelo-protector in Adjuvant Breast Cancer Chemotherapy | Melatonin as a Circadian Clock Regulator, Neuromodulator and Myelo-protector in Adjuvant Breast Cancer Chemotherapy: a Randomized, Double-blind, Placebo-controlled Trial. | NCT03205033 |
| A trial for melatonin effect on postprandial glucose elevation | A trial for melatonin effect on postprandial glucose elevation - Melatonin intake study on glucose metabolism | JPRN-UMIN000027950 |
| Effect of supplementation with melatonin (a hormone secreted by the gland in the human body that regulates the sleep cycle) in obese patients on a diet with reduced caloric intake | Effect of melatonin on weight loss and on selected parameters of oxidative stress and inflammation state in subjects with class I and class II obesity on a calorie-restricted diet | CTRI/2017/07/009093 |
| The intervention and follow-up study of the combined intervention strategy including MI, integrated desensitization therapy (IDT) and Melatonin supplies on improving abstinence for methamphetamine dependence patients | Effectiveness of a combined strategy for methamphetamine dependence: A randomized controlled pilot trial | ChiCTR-IOR-17012091 |
| Plasma Melatonin AND Mortality After Acute Myocardial Infarction | Early-morning Plasma Melatonin Levels Predict Cardiovascular Mortality After Acute Myocardial Infarction | NCT03230630 |
| Effects of Melatonin on? radiological changes of multiple sclerosis patient ? | Effects of Melatonin on? radiological changes of multiple sclerosis patient ? | IRCT2017072520258N56 |
| Melatonin Effect on Fertility | Comparison of treatment outcomes from IUI cycles in PCO patients with and without melatonin | IRCT2017021132489N1 |
| Using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson’s Disease | Using N-of-1 tests to identify responders to melatonin for sleep disturbance in Parkinson's Disease | ACTRN12617001103358 |
| The effects of melatonin supplementation during resistance training on antioxidant, inflammatory and as a predictor of cardiovascular disease factors | The effects of progressive resistance training with melatonin ingestion on antioxidant, inflammatory markers, and cardiovascular risk factors in overweight males | IRCT2017031333064N1 |
| study of possible beneficial effects of melatonin and gabapentin on patients blood pressure during anesthesia | Comparative efficacy of oral Melatonin vs Gabapentin for attenuation of haemodynamic response to direct laryngoscopy and endotracheal intubation | CTRI/2017/08/009245 |
| The effect of Melatonin on the disability of multiple sclerosis patients | The effect of Melatonin on the disability of multiple sclerosis patients | IRCT2017072520258N55 |
| Effect of melatonin supplementation in treatment of maintenance methadone treatment patients | A Clinical trial to assess the effect of melatonin supplementation compared with the placebo on mental health parameters, metabolic profiles and genetic response in methadone maintenance treatment patients | IRCT2017072933551N3 |
| Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease | Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease: Double Blind, Randomized, Placebo Controlled Trial | NCT03258294 |
| The effect of melatonin supplementation in the treatment of type 2 diabetic patients | Effect of Melatonin supplement with Non surgical periodontal therapy on periodontal status, some inflammatory markers and serum antioxidant status in type 2 diabetic patients with chronic periodontitis. | IRCT2017030831993N4 |
| Efficacy and Safety of Melatonin and Clonazepam for IRBD | Efficacy and Safety of Melatonin and Rivotril Treatment for Idiopathic Rapid Eye Movement Sleep Disorder: Prospective Randomized Study. | NCT03255642 |
| Effects and Mechanisms of Melatonin on Blood Pressure, Insulin Resistance, and Platelets | Effects and Mechanisms of Melatonin on Blood Pressure, Insulin Resistance, and Platelets | NCT03178396 |
| Effects of trazodone and melatonin on sleep in depressed patients receiving sertraline | Comparing effects of 8-week treatment with melatonin versus trazodone on sleep quality in patients with major depressive disorder who are on sertraline | IRCT201411297202N9 |
| Effects of Melatonin on Metabolic Syndrome disease | Evaluation of the effects of Melatonin Supplementation on metabolic Syndrome components and plasma Leptin and Adiponectin levels in patients with metabolic Syndrome | IRCT2016111016123N11 |
| Melatonin as Adjuvant Treatment for ADHD in Adults | Melatonin as Adjuvant Treatment for ADHD in Adults | NCT03062839 |
| The effect of melatonin on patients with hemorrhagic stroke | The benefit of Melatonin on damage associated molecular pattern following hemorrhagic strokepatients under mechanical ventilation | IRCT2016100530164N1 |
| the effect of Melatonin on sphincter disorder in multiple sclerosis | the effect of Melatonin on sphincter disorder(urinary symptoms) in multiple sclerosis | IRCT2017022620258N34 |
| The effect of melatonin supplementation in the treatment of type 2 diabetic patients with chronic periodontitis disorder. | The effect of melatonin supplement along with non surgical periodontal therapy on periodontal status, salivary melatonin, glycemic control, inflammatory markers and blood lipid profile in type 2 diabetic patients with chronic periodontitis | IRCT2017011631993N1 |
| Melatonin in Patients Under Carotid Endarterectomy | The Protective Effect of Melatonin in Patients Under Carotid Endarterectomy | NCT03115034 |
| Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients. | Relationship Between Melatonin Level and Postoperative Analgesia Consumption in Bariatric Surgery Patients. | NCT03107702 |
| Effect of sertraline and melatonin on tinnitus | A clinical trial to compare the effect of sertraline and melatonin on the treatment of tinnitus | IRCT2017011412782N13 |
| effect of melatonin on prevention of delirium in admitted patients | A study of the effect of melatonin on prevention of delirium in Intensive Care Unite (ICU) inpatients | IRCT2017061234482N1 |
| Melatonin Study Between Diminished and Normal Responder in IVF | Comparison of IVF Outcome and Endometrium Effect in Infertility Patients Between Diminished and Normal Ovarian Reserve After Melatonin Administration. | NCT03117725 |
| The effect of melatonin on the eradication of Helicobacter pylori | Effect of melatonin addition to quadruple therapy (Bismuth, Amoxicillin, Metronidazole, Proton pump inhibitors) for the eradication of Helicobacter pylori (H.pylori) in people who have proven H.pylori infection | IRCT2016082111192N5 |
| The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment | The Effects of Melatonin on Elevated Liver Enzymes During Statins Treatment | NCT03121521 |
| Biological Rhythms Impact of 12 Hours Shift Work | Wake-sleep Cycle and Melatonin Secretion Dynamics Associated With 12 Hours Shift Work in French Nurses | NCT03153917 |
| Effect of melatonin and vitamin E on working shift nurses’ sleep in ValiAsr Hospital located in Arak | Investigation Effect of melatonin, vitamin E administration on EEG and sleep quality in shift worker Nurses | IRCT2015040621626N1 |
| The effect of Melatonin on Fatigue in Multiple sclerosis patients | The effect of Melatonin on Fatigue in Multiple sclerosis patients | IRCT2017030120258N35 |
| The therapeutic effect of Melatonin, Metformin and Vitamin E in patients with non-alcoholic fatty liver disease | Compare the therapeutic effect of Melatonin, Metformin and Vitamin E on liver function, sugar and lipid factors in patients with non-alcoholic fatty liver disease (NAFLD) dietary regimen | IRCT2016040318124N3 |
| Melatonin for Adolescent Migraine Prevention Study | Melatonin for Adolescent Migraine Prevention Study (The MAP Study). | NCT03150797 |
| Efficacy of melatonin as an adjunct in the treatment of acute mania | Efficacy of melatonin as an adjunct in the treatment of acute mania :A double blind and placebo controlled trial | IRCT201705181556N98 |
| Melatonin Use for Sleep Problems in Alcohol Dependent Patients | Melatonin for Alcohol Use Disorder Patients With Sleeping Problems | NCT03043443 |
| The effect of melatonin on the quality of sleep | Comparison the effect of melatonin and placebo on the quality of sleep in patients admitted in Post Coronary Care Unit | IRCT2017081010340N18 |
| Comparison Between Melatonin and Zolpidem in Improving Sleep quality, Anxiety and Depression | comparison of the effect of melatonin and zolpidem in improving quality of sleep, anxiety and depression in colorectal cancer patients receiving chemotherapy | IRCT201602147202N10 |
| Effect of melatonin supplementation in treatment of women with polycystic ovary syndrome | Clinical trial of the effect of melatonin supplementation compared with the placebo on hormonal profiles, inflammatory factors, oxidative stress biomarkers and gene expression related to inflammation in women with polycystic ovary syndrome | IRCT2017082733941N9 |
| Melatonin in type 2 diabetes | Comparison of the effect of oral melatonin administration with placebo on biochemical parameters associated with diabetes in diabetes mellitus Type 2 patients | IRCT20121021011192N4 |
| Evaluation of effect of melatonin on the duration of mechanical ventilation in patients requiring hospitalization in the intensive care unit | Clinical trial of the effect of melatonin administration on duration of mechanical ventilation in patients requiring hospitalization in the intensive care unit | IRCT20170729035360N1 |
| Evaluation of the effect of Melatonin in Sepsis | Effect of Melatonin Supplement on Damage Associated Indicators in Patients with Sepsis Admitted to General Intensive Care Unit of Sina Hospital | IRCT20171104037228N1 |
| Effect of melatonin supplementation in treatment of patients with Parkinson's disease | Clinical trial of the effect of melatonin supplementation compared with the placebo on clinical status, metabolic profiles and gene expression related to inflammation, insulin and lipid in patients with Parkinson's disease | IRCT20170513033941N29 |
| The Basel BOMP-AID Randomized Trial | Better Outcome With Melatonin Compared to Placebo Administered to Normalize Sleep-wake Cycle and Treat Hypoactive ICU Delirium The Basel BOMP-AID Randomized Trial | NCT03438526 |
| The effects of melatonin and branched-chain amino acids supplementation in cardiac cachexia | The effects of melatonin and branched-chain amino acids (BCAA) supplementation, separately and together on inflammatory factors, muscle wasting, nutritional status and quality of life in cachectic heart failure patients | IRCT20121028011288N14 |
| Melatonin Receptor Agonist and Peripheral Biological Markers | Effects of a Melatonin Receptor Agonist on Clinical Manifestations and Peripheral Biological Markers of Circadian Rhythm | NCT03432091 |
| Effect of melatonin on cortisol and sleep quality of Hemodialysis Patients | Study of the effects of short-term melatonin on salivary cortisol and sleep quality of hemodialysis patients | IRCT20180117038418N1 |
| Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude | Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude | NCT03588676 |
| Can music and a drug (melatonin)help in decreasing nervousness before operation? | To assess the effect of preoperative melatonin and music on anxiety and recovery profile in patients undergoing day care surgery: A randomized control trial. | CTRI/2018/02/011895 |
| Effect of melatonin on sleep quality in breast cancer patients during chemotherapy | Comparison evaluation of sleep disorders incidence in patients with primary breast cancer admitted to Imam Khomeini hospital in Tehran received melatonin during adjuvant chemotherapy | IRCT20150726023349N4 |
| comparing oral melatonin with oral clonidine as a drug given before anaesthesia, on anaesthetic usage and post operative pain in patients undergoing general anaesthesia | Comparison of oral melatonin and clonidine as premedication on isoflurane consumption and postoperative analgesia in patients undergoing general anaesthesiaâ?? A randomised controlled trial | CTRI/2018/02/012032 |
| Effects of Melatonin on clinical manifestations, inflammation and sleep quality in patients with Rheumatoid Arthritis | A randomized prospective study on the effects of chronic administration of Melatonin on clinical manifestations, oxidative stress, inflammation, and sleep-wake rhythm in patients with Rheumatoid Arthritis | RBR-8pjqh2 |
| The Effect of Melatonin on interleukin in patients undergoing Coronary Artery Bypass Graft Surgery | The Effect of Melatonin on interleukin 13 and interleukin 22 in patients undergoing Coronary Artery Bypass Graft Surgery | IRCT20141009019470N71 |
| Manipulating alertness using (exogenous) melatonin and light | Manipulating alertness using (exogenous) melatonin and light - Manipulating alertness | NL-OMON47885 |
| Melatonin in Adults With SMS | Characterization of Behavioral Disorders and 24 H-melatonin Level in Adults With Smith Magenis Syndrome | NCT03492970 |
| The effect of melatonin on interleukin 6 & interleukin 9 in coronary artery bypass grafting surgery | The effect of melatonin on interleukin 6 & interleukin 9 in coronary artery bypass grafting surgery | IRCT20141009019470N72 |
| Effect of a drug on blood pressure and heart rate on placement of a tube in trachea and dose requirement of propofol during induction of anaesthesia | Effect of oral melatonin on haemodynamic response to laryngoscopy and intubation and dose requirement of propofol during induction of general anaesthesia a randomized double blind study | CTRI/2018/03/012416 |
| Effect of melatonin supplementation in treatment of diabetic hemodialysis patients | Clinical trial of the effect of melatonin supplementation compared with the placebo on metabolic status and gene expression related to inflammation, insulin and lipid in diabetic hemodialysis patients | IRCT20170513033941N31 |
| Effects of Melatonin in Untreated Obstructive Sleep Apnea | Does Melatonin Improve Neurocognitive Function, Cardiovascular Outcomes and Control of Breathing in Untreated Obstructive Sleep Apnea? | NCT03492736 |
| The study of efficacy of melatonin, and zolpidem on the sleep quality, and severity of pain in the patients with chronic non-specific low back pain | The study of efficacy of melatonin, and zolpidem on the sleep quality, and severity of pain in the patients with chronic non-specific low back pain | IRCT20111109008035N4 |
| Melatonin treatment for sleep disturbance in eye disorders: Sandman Trial | A randomised placebo-controlled trial to assess the effect of melatonin on circadian sleep-wake disturbances in ocular disease. - Melatonin treatment for sleep disturbance in ocular disorders:Sandman | EUCTR2017-002189-39-GB |
| Effect of blue light from electronic devices on melatonin and sleep/wake rhythms in high school children | Effect of blue light from electronic devices on melatonin and sleep/wake rhythms in high school children | NL-OMON27272 |
| The effect of melatonin treatment in patients with Irritable Bowel Syndrome | The effect of melatonin treatment in patients with Irritable Bowel Syndrome (IBS) | IRCT2017012532186N1 |
| Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis | Effects of Melatonin as a Novel Antioxidant and Free Radicals Scavenger in Neonatal Sepsis | NCT03295162 |
| Effect of blue light from electronic devices on melatonin and sleep/wake rhythms in high school children | Effect of blue light from electronic devices on melatonin and sleep/wake rhythms in high school children | NL-OMON23034 |
| Effects of Melatonin on Reperfusion Injury | Effects of Melatonin on Reperfusion Injury in Patients With ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention | NCT03303378 |
| Effect of melatonin supplementation in treatment of atopic dermatitis | Clinical trial of the effect of melatonin supplementation on disease severity and sleep quality in children with atopic dermatitis | IRCT2017082733941N12 |
| A feasibility trial comparing a behavioural intervention, melatonin and usual care for people with dementia and sleep disturbance | A feasibility trial comparing a behavioural intervention, melatonin and usual care for people with dementia and sleep disturbance | ACTRN12617000056392 |
| Melatonin Use in the Intensive Care Elderly Population | Melatonin Use in the Intensive Care Elderly Population | NCT03013790 |
| Comparison of melatonin, temazepam and placebo for the treatment of sleep problems in hospitalized older patients. | MelAtonin, Temazepam and plaCebo in Hospitalized older patients with sleeping problems. | NL-OMON21870 |
| A randomised controlled trial of antenatal melatonin supplementation in fetal growth restriction for fetal neuroprotection. | A triple-blind, randomized, parallel-group, placebo controlled trial to assess the impact of maternal antenatal melatonin supplementation on early childhood neurodevelopmental outcomes in the setting of severe preterm fetal growth restriction. | ACTRN12617001515381 |
| analgesic role of premative Oral Melatonin before thoracic epidural in bilateral multiple fracture ribs | Role of addition of Oral Melatonin in thoracic epidural analgesia in pain control for patients with bilateral multiple fracture ribs | PACTR201711002741378 |
| Melatonin to treat Delirium in Older People | Melatonin to reduce sedative use in older general medical inpatients with delirium | ACTRN12617001537347 |
| Effect of melatonin supplementation in treatment of patients with polycystic ovary syndrome | Clinical trial of the effect of melatonin supplementation compared with the placebo on metabolic profiles and gene expression related to insulin and lipid in women with polycystic ovary syndrome | IRCT2017090533941N23 |
| Absorption and excretion of melatonin when applied intravenously, rectally, in the bladder, vaginally and dermally in healthy female volunteers | Pharmacokinetics of intravenous, rectal, intravesical, vaginal, and transdermal administration of exogenous melatonin in healthy female volunteers: a crossover study | EUCTR2017-000997-13-DK |
| Comparison of Effects of melatonin and gabapentin on pain and anxiety following lumbar spine surgery | Comparison of Effects of melatonin and gabapentin on pain and anxiety following lumbar spine surgery | IRCT2017100436566N1 |
| Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude. | Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude. | NCT03368352 |
| Effect of blue light from electronic devices on melatonin and sleep/wake rhythms in high school children | Effect of blue light from electronic devices on melatonin and sleep/wake rhythms in high school children - Blue light and sleep in children | NL-OMON45569 |
| Melatonin as an Adjunctive Therapy for Chronic Periodontitis. | Is Dietary Melatonin Supplementation a Viable Adjunctive Therapy for Chronic Periodontitis? A Preliminary Randomized Clinical Trial. | NCT03368430 |
| A clinical study to evaluate the safety and blood concentration of melatonin nasal suspension in healthy male research participants. | A randomized, double-blind, monocentric, phase I clinical trial to assess the tolerability, safety, and pharmacokinetics of melatonin nasal suspension, after a single dose in healthy male participants. | RBR-3t7fcy |
| Effect of Melatonin and Metformin on Glycemic Control Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes | Effect of the Administration of Melatonin and Metformin on Glycemic Control, Genotoxicity and Cytotoxicity Markers in Patients With Prediabetes: Pilot Study | NCT03848533 |
| A Study on the Effect of Melatonin in Helping Bone Growth After dental implant Placement in Adults | Effect of melatonin on bone formation when placed in the jumping gap in immediate dental implant placement - a case control study - nil | CTRI/2025/06/088681 |
| Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma | Effectiveness of Oral Melatonin vs Oral Tranexamic Acid in the Treatment and Recurrence of Melasma : A Comparative, Randomized, Controlled Study | NCT07034560 |
| Effect of melatonin on shivering after cesarean section done under anesthesia of the lower part of the body | Effect of Melatonin on post spinal shivering during cesarean section under intrathecal anesthesia : A randomized controlled trial. - NIL | CTRI/2024/10/075175 |
| Effect of melatonin on sleep in sulfur mustard exposed patients | Effect of melatonin administration on sleep quality in sulfur mustard exposed patients with sleep disorders | IRCT2015092924267N1 |
| The effect of combination therapy with buspirone and melatonin in the treatment of adults with Major Depressive Disorder (MDD) with Treatment-Resistant Depression (TRD) | Double-Blind, Placebo-Controlled, Proof-of-Concept Trial of Fixed-Dose, Bedtime, Oral Buspirone and Sustained-release Melatonin 15mg/3mg Combination (BMC-15/3) added to ongoing, stable, and adequate antidepressant therapy (ADT) in the treatment of adults with treatment-resistant Major Depressive Disorder (MDD) | IRCT201505271743N13 |
| Investigating the effect of melatonin on polycystic ovary syndrome | The effect of melatonin supplementation on the improvement of menstrual parameters in women with polycystic ovary syndrome: a randomized, double-blind trial | IRCT20220704055367N5 |
| Melatonin for Prevention of Delirium in Critically Ill Patients | Feasibility of Melatonin for Prevention of Delirium in Critically Ill Patients: a Multi-centre, Randomized, Placebo-controlled Study. | NCT02615340 |
| Effects of Melatonin Supplementation on Renal Physiology in a Habitual Sleep Restricted Population. | Effects of Melatonin Supplementation on Renal Physiology in a Habitual Sleep Restricted Population. | NCT02631148 |
| Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia | Comparison Of The Effects Of Preoperative Melatonin Or Vitamin C Administration On Postoperative Analgesia | NCT02639741 |
| Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism | Effect of Melatonin on Body Composition, Glucose Metabolism and Lipid Metabolism | NCT02604095 |
| Melatonin in Smoke-induced Vascular Injury | The Protective Effect of Melatonin on Smoke-induced Vascular Injury in Human | NCT02591238 |
| The Effect of Melatonin on Postoperative Delirium in Elderly ICU Patients | The Effect of Melatonin on Postoperative Delirium in Elderly ICU Patients : Randomized, Placebo-controlled, Double Blind Study | NCT02588742 |
| Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia | Melatonin as a Neuroprotective Therapy in Neonates With HIE Undergoing Hypothermia | NCT02621944 |
| Investigating the effect of melatonin in patients with chronic renal failure | Investigating the effect of melatonin on glomerular filtration rate, proteinuria and appetite in adult patients with chronic renal failure: a double-blind randomized clinical trial study | IRCT20241008063295N1 |
| Melatonin and Sleep in Preventing Delirium in the Hospital | Melatonin and Sleep in Preventing Delirium in the Hospital: A Randomized Placebo-controlled Trial | NCT02597231 |
| Comparison of therapeutic effect of Melatonin, Metformin and Ursodeoxycholic acid with placebo in treatment of patients with Nonalcoholic Fatty Liver Disease (NAFLD) | Health impact of Melatonin, Metformin and Ursodeoxycholic acid in treatment of patients with Nonalcoholic Fatty Liver Disease (NAFLD) | IRCT201407201155N21 |
| Preoperative effect of 15 mg Melatonin on Anxiety, Pain, difficulty in mouth opening, Swelling, and Psychomotor Function in lower wisdom tooth Extraction: a randomized, double-blind, placebo-controlled clinical trial | Effect of preoperative use of 15mg Melatonin on Anxiety, Pain, Trismus, Edema and Psychomotor Function in lower third molar Extraction: a randomized double-blind, placebo-controlled clinical trial | RBR-7h4zchf |
| Effect of melatonin on sleep quality in patients with chronic obstructive pulmonary disease | Effect of melatonin on sleep quality in patients with chronic obstructive pulmonary disease: a before-after clinical trial | IRCT20120215009014N533 |
| Efficacy of Melatonin in Decreasing the Incidence of Delirium in End of Life Patients | Efficacy of Melatonin in Decreasing the Incidence of Delirium in End of Life Patients: A Randomized Double-blinded Placebo Controlled Pilot Study | NCT02536417 |
| Effect of Melatonin in Osteoarthritis | Investigating the effect of Melatonin on NFKb signaling pathway in patients with osteoarthritis: Role of the inflammatory markers | IRCT20150202020908N3 |
| To see role of melatonin in decreasing frequency of micturition at night time | The role of melatonin in the management of nocturnal- randomised phase 2 trial - Nil | CTRI/2024/10/075466 |
| Application of melatonin (sleep hormone) gel in close proximity to the tooth with gum disease | Evaluation of melatonin gel as local drug delivery system for the treatment of periodontitis: a randomised controlled trial | ISRCTN40460432 |
| Effect of Melatonin on anxiety before dentist appointment in children | Effect of Melatonin on pre-consultation anxiety in pediatric dental care: randomized clinical trial | RBR-4c37bch |
| The survey effect of Melatonin pill to relieve the pain of endometriosis in patients with endometriosis. | The survey effect of Melatonin pill to relieve the pain of endometriosis in patients with endometriosis: Randomization Clinical Trial | IRCT2016052523684N1 |
| efficacy of different doses of preoperative Melatonin on intraoprative blood loss and postoperative pain in patients undergoing cesarean section | Efficacy of different doses of preoperative melatonin on intraoperative blood loss and postoperative pain in patients undergoing cesarean section : clinical academic trial - NIL | CTRI/2024/12/078540 |
| Effect of oral melatonin as premedication on haemodynamic changes during laparoscopic cholecystectomy | Effect of oral melatonin as premedication on haemodynamic changes during laparoscopic cholecystectomy - A randomized double blinded controlled trial - Nil | CTRI/2024/12/078503 |
| A study to compare how well two different dosages of oral melatonin (6mg and 9mg) attenuate rise in blood pressure and heart rate in response to laryngoscopy and intubation when given 1 hour before administration of general anaesthesia. | A study to compare the effects of two different dosages of oral melatonin 1 hour before induction for attenuation of haemodynamic response to endotracheal intubation under general anaesthesia. - NIL | CTRI/2024/12/078260 |
| Evaluation of the oral Melatonin effects on the incidence, severity and results of Retinopathy of Prematurity in preterm infants, a randomized clinical trial-Imam Khomeini Hospital complex-Valiasr,Tehran | Evaluation of the oral Melatonin effects on the incidence, severity and results of Retinopathy of Prematurity in preterm infants, a randomized clinical trial-Imam Khomeini Hospital complex-Valiasr,Tehran | IRCT20240703062313N1 |
| Maxillary Sinus Augmentation by Xenograft Mixed With Melatonin | Clinical, Radiographic and Histomorphometric Assessment of the Effect of Melatonin Gel Mixed With Xenograft in Augmentation of the Maxillary Sinus: A Randomized Controlled Clinical Trial | NCT06736821 |
| The effect of melatonin on aphthous ulcers | Investigating the effectiveness of melatonin-containing mucoadhesive on minor recurrent aphthous stomatitis | IRCT20240712062408N1 |
| Melatonin for Prevention of Post- Operative Delirium Pilot Study Protocol | Melatonin for Prevention of Post- Operative Delirium Pilot Study Protocol | NCT02903901 |
| The Healthy Heart-Mind Trial: Efficacy of melatonin for decreasing the incidence and severity of delirium following cardiac surgery | The Healthy Heart-Mind Trial: Efficacy of melatonin versus placebo for decreasing the incidence and severity of delirium following cardiac surgery in adults | ACTRN12615000819527 |
| Analgesic and Antioxidant Effects of Melatonin in Pediatric Surgery | Evaluation of Effects of Melatonin in Reducing Postoperative Pain and Oxidative Stress in Children Undergoing Surgery,. Trought Circulating miR-34 and miR-124a, 4-Hydroxynonenal and Sirtuin 1 (SIRT1) Plasma Concentrations. | NCT06724432 |
| A Clinical Study to Evaluate the Efficacy and Safety of ThymoDream(TM) in Comparison with Melatonin in healthy volunteers with poor sleep quality. | A Randomized, Double-Blind, Active-Controlled, Cross-over, Clinical Study to Evaluate the Efficacy and Safety of ThymoDream(TM) in healthy volunteers with poor sleep quality. - NIL | CTRI/2024/11/077454 |
| The effect of melatonin in addiction to opium patients, candidates for elective lumbar spine surgery | The effect of melatonin on drug consumption and hemodynamic responses after laryngoscopy in addiction to opium patients, candidates for elective lumbar spine surgery | IRCT20210415050983N9 |
| Effect of Melatonin in depressed patients with diabetes | Investing the effect of melatonin on Nrf2 signaling pathway in depressed patients with diabetes: A randomized controlled clinical trial study | IRCT20150202020908N4 |
| The effect of melatonin in the prevention of retinopathy | The effect of melatonin in preventing retinopathy of prematurity | IRCT20240923063125N1 |
| Effect of melatonin versus placebo on the prevention of contrast medium-induced nephropathy in patients undergoing primary angioplasty | Effect of melatonin versus placebo on the prevention of contrast medium-induced nephropathy in patients undergoing primary angioplasty: a double-blind randomized clinical trial | IRCT20120215009014N539 |
| Melatonin for Pulmonary Hypertension in Full Term Neonates | Melatonin As an Adjunct Therapy to Milrinone for Pulmonary Hypertension in Full Term Neonates | NCT06685679 |
| Examining the effect of adding melatonin to chemotherapy in patients with ovarian cancer. | Assessment the effect of adding melatonin to chemotherapy compared to placebo on the rate of relapse or metastasis in ovarian cancer patients undergoing adjuvant chemotherapy. | IRCT20110523006563N5 |
| Examining the effect of Melatonin on quality of sleep in Heart failure patients | Examining the effect of Melatonin on quality of sleep in patients with Heart Failure in cardiology clinic of Kosar hospital, Semnan, 2024, a clinical trial | IRCT20241027063510N1 |
| Effects of 3-Month Melatonin Treatment on Regional Cerebellar Structure and Blood Biomarkers in Alzheimer's Disease Spectrum | Study on Regional Structural Changes in the Cerebellum Associated with Blood Biomarkers, Cognitive Decline, and Physical Performance in Alzheimer's Spectrum Patients Following a 3-Month Melatonin Treatment Using Digital Health Technology | NCT06756828 |
| Does melatonin help ADHD kids sleep better and think clearer | To study the effectiveness of melatonin supplementation on sleep and cognition in children with ADHD experiencing sleep disturbances - NIL | CTRI/2024/10/074931 |
| Evaluate the Safety and efficacy of melatonin in Men with Benign Prostatic Hyperplasia (Nocturia). | An Open-Label Randomized Controlled Trial to Compare the Clinical Efficacy and Safety of Alpha Blocker Versus Alpha Blocker + Melatonin 3 mg in the Treatment of Men Having Nocturia Associated with Benign Prostatic Hyperplasia - NIL | CTRI/2024/10/074889 |
| Effect of melatonin in irritable bowel syndrome | A Comparative Study on Efficacy and Safety of Melatonin as an Add on Therapy with Standard Treatment in Patients with Irritable Bowel Syndrome: A Randomised Open Labelled Prospective Study - NIL | CTRI/2024/10/074953 |
| A clinical trial to study the effect of oral melatonin versus pregabalin in decreasing hemodynamic response (heart rate, blood pressure) to laryngoscopy and endotracheal intubation. | A comparative study of oral melatonin versus pregabalin for attenuation of hemodynamic response to laryngoscopy and endotracheal intubation: A prospective randomized open label study. - NIL | CTRI/2024/08/073110 |
| The effect of melatonin on the severity of sleep symptoms in patients with restless leg syndrome | Investigating the effect of melatonin on the severity of signs and sleep quality of patients with restless leg syndrome | IRCT20191104045328N26 |
| The effect of adding oral melatonin in In Vitro Fertilization in infertile women. | The effect of adding oral melatonin in In Vitro Fertilization (IVF) cycles on the quality and quantity of eggs and embryos and the rate of clinical and chemical pregnancy in infertile women. | IRCT20110301005942N9 |
| Melatonin for Sleep Disturbances in Children | Melatonin for Sleep Disturbances in Children with Autism Spectrum Disorder: A fixed-dose, Open-label, Randomised, Pilot Intervention trial - NIL | CTRI/2024/08/072970 |
| Melatonin Supplementation and Exercise Program in Breast Cancer Women | Impact of Melatonin Supplementation Plus Exercise Program in Women Who Have Suffered from Breast Cancer in the Province of Soria, Spain | NCT06696378 |
| a clinical trial to study efficacy of two different doses of melatonin for anxiety alleviation in pre-operative patients | Comparison of two doses of melatonin for preoperative anxiolysis - NIL | CTRI/2024/08/072706 |
| Evaluation of the effect of melatonin in reducing migraine attacks in comparison with standard treatment in patients treated in Shahid Sadoughi Hospital in Yazd | Evaluation of the effect of melatonin in reducing migraine attacks in comparison with standard treatment in patients treated in Shahid Sadoughi Hospital in Yazd, a double-blind randomized clinical trial | IRCT20240220061059N2 |
| Effect of tablet melatonin on heart enzymes in coronary artery bypass graft surgery | A prospective randomized double blind study to assess the cardioprotective role of melatonin in patients undergoing coronary artery bypass graft surgery - Nil | CTRI/2024/08/072225 |
| The Effect of Melatonin on Sleep and Ventilatory Control in Obstructive Sleep Apnea | The Effect of Melatonin on Sleep and Ventilatory Control in Obstructive Sleep Apnea | NCT02484300 |
| A prospective study on Oral melatonin for MRI sedation in neonates and infants | Swaddle Vs Swaddle with oral melatonin for MRI in neonates and infants- A prospective randomised control study - NIL | CTRI/2024/08/072135 |
| The anti-migraine activity of supplement formulation PEATONIDE® combining palmitoylethanolamide and melatonin | Anti-migraine activity of supplement formulation (PEATONIDE®) based on the synergic combination of palmitoylethanolamide and melatonin | ISRCTN52370199 |
| Evaluating the effect of melatonin compared to duloxetine in the treatment of chemotherapy-induced neuropathy (CINP): a clinical trial | Evaluating the effect of melatonin compared to duloxetine on improvement of neuropathy symptoms of chemotherapy-induced neuropathy (CINP): a Randomized Clinical Trial | IRCT20211028052893N1 |
| The Effect of Melatonin Supplementation on Cumulus Cells and IVF Outcomes | The Effect of Melatonin Supplementation on Cumulus Cells and Reproductive Outcomes in Older Women Undergoing IVF Cycles | NCT06546774 |
| Effect of Melatonin in smoking cessation in COPD patients | Investigating the efficacy of Melatonin in smoking cessation in patients with COPD: A triple-blind randomized clinical trial | IRCT20190810044500N25 |
| To see whether advice about sleeping practices along with medicines can reduce sleeplessness in patients with cancer receiving treatment | Modified Cognitive Behavioural Therapy -I (MCBT-I) with melatonin for acute insomnia in patients undergoing chemotherapy: A Double Blind Randomised Controlled Trial (COMET) - COMET | CTRI/2024/07/071467 |
| Observational study to evaluate safety and effectiveness of approved combination of medicines in participants with Insomnia & Sleep Disorder. | A Prospective, Multicenter, Open labeled, Randomized, phase IV clinical study to evaluate safety and efficacy of 2 FDCs of Zolpidem Tartrate IP 5 mg / 10 mg plus Melatonin 3 mg film coated tablets in subjects with Primary Insomnia and Sleep Disorder. - NIL | CTRI/2024/07/071200 |
| To study the effects of two drugs , melatonin under the tongue and tranexamic acid in the vein for reducing blood loss during operation for delivery of baby. | Comparison of Sublingual Melatonin and Intravenous Tranexamic Acid for reducing intraoperative blood loss during Caesarean Section under Spinal Anaesthesia : A Double Blind Randomized Clinical Trial - NIL | CTRI/2024/07/071167 |
| A clinical trial to study the effect of melatonin in prevention of postoperative delirium in patients undergoing bypass surgeries for chronic limb ischaemia. | A placebo controlled double-blind randomized clinical trial to study the effect of melatonin in prevention of post-operative delirium in patients undergoing reperfusion surgery for chronic limb ischaemia. - nil | CTRI/2024/07/071135 |
| Melatonin in Epilepsy: Trial of Melatonin as add on anti-seizure medication in Epilepsy patients | Efficacy of add on Melatonin on seizure outcome in Focal drug resistant epilepsy patients : A Randomized controlled trial. - NIL | CTRI/2024/08/072001 |
| The effect of Melatonin treatment on primary school aged children suffering from insomnia | The effect of Melatonin treatment on primary school aged children with difficulty in initiation and maintenance of sleep | IRCT2015111225008N1 |
| Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers | Multicenter, Randomized, Double-blind, Placebo Controlled Trial of 2 mg Melatonin for Circadian Phase Adjustment and Improvement of Metabolic Control in Night Shift Workers | NCT02108353 |
| Evaluation of melatonin efficacy in prevention of colistin induced nephrotoxicity | Evaluation of melatonin tablet efficacy in prevention of colistin induced nephrotoxicity in hospitalized patients in ICU | IRCT20200408046990N16 |
| Evaluating the Safety and Efficacy of Tugain Eva verses Tugain in Treating Female Pattern Hair Loss | Compare the safety and efficacy of Tugain Eva (minoxidil 5 percent solution fortified with 0.0033 percent melatonin) with Tugain solution (minoxidil 5 percent solution) in female pattern hair loss - NIL | CTRI/2024/10/074861 |
| effect of melatonin on unexplained infertility | Investigating the effect of melatonin supplement on the success rate of intrauterine sperm insemination (IUI) in couples with unexplained infertility | IRCT20240916063068N1 |
| Treatment of periodontitis non-surgically by topical melatonin and vitamin C | Evaluation of the effect of topically applied melatonin and vitamin C in non-surgical treatment of chronic periodontitis | ISRCTN68604984 |
| Investigating the Effect of Melatonin on Mortality and Morbidity of Sepsis Patients in ICU | Investigating the Effect of Melatonin on Mortality and Morbidity of Sepsis Patients in ICU | IRCT20150706023084N22 |
| "Salivary Melatonin and Cortisol Levels in Individuals with Bruxism" | The Investigation of Melatonin and Cortisol Levels in the Saliva of Individuals with Bruxism | NCT06623643 |
| Effect of 8-hour time-restricted feeding diet and melatonin supplementation on metabolic and hormonal factors in PCOS patients | Investigating the effect of 8-hour time-restricted feeding diet and melatonin supplementation on insulin resistance, glycemic indices, lipid profile, hormonal indices, hirsutism, acne, and menstrual cycle in women with polycystic ovarian syndrome | IRCT20240912063018N1 |
| A study comparing Oral Melatonin and Pregabalin for Reducing Anxiety and Postoperative Pain in Daycare Surgeries | Comparative Evaluation of oral Melatonin and Pregabalin as premedicants for perioperative anxiety and post operative pain in daycare surgeries-A Randomized control trial - nil | CTRI/2024/09/074438 |
| The effect of melatonin in treatment of acute ischemic stroke | The Study of the Efficacy and side effects of adding oral Melatonin to intravenous Thrombolysis in Acute Ischemic Stroke | IRCT20240824062857N1 |
| """Comparison of the effect of melatonin and pregabaline on reduction of pain and anxiety in Orthopedic surgery""" | Comparison of the effect of melatonin and pregabaline on reduction of postoperative pain and perioperative anxiety in Orthopedic surgery | IRCT20240716062443N1 |
| to assess the effect of Melatonin in patients undergoing awake craniotomy | Effect of Melatonin Premedication in Patients Undergoing Awake Craniotomies: A Randomized Controlled Trial - NIL | CTRI/2024/09/074211 |
| Effects of sleep enhancing methods in ICU patients | Effectiveness of Combination of Oral Melatonin with Non-Pharmacological Measures vs Non-Pharmacological measures alone on Quality of Sleep in critically ill Adult patients- Randomised Controlled Trial - NIL | CTRI/2024/09/074154 |
| A Comparison Between Oral Melatonin With Nasal Sevoflurane Versus Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Children Undergoing Brain MRI | A Comparative Study Between Efficacy of Combined Oral Melatonin With Nasal Sevoflurane Versus Combined Oral Chloral Hydrate With Nasal Sevoflurane in Sedation of Pre-school Children Undergoing Brain Magnetic Resonance Imaging | NCT06606899 |
| An Open Label Balanced Randomized Single Dose Two Treatment Three Sequence Three Period Crossover Partial Replicate Reference Scaled Average Oral Bioequivalence Study Comparing Melatonin 2 Mg Prolonged Release Tablets | An Open Label Balanced Randomized Single Dose Two Treatment Three Sequence Three Period Crossover Partial Replicate Reference Scaled Average Oral Bioequivalence Study Comparing Melatonin 2 Mg Prolonged Release Tablets Manufactured By Vs International Pvt Ltd India With Circadin Melatonin 2 Mg Prolonged Release Tablets Marketing Authorization Holder Rad Neurim Pharmaceuticals Eec Sarl 4 Rue De Marivaux 75002 Paris France In Healthy Adult Human Subjects Under Fasting Conditions - NIL | CTRI/2024/09/073804 |
| Neoadjuvant FDC With Melatonin or Metformin for Locally Advanced Breast Cancer. | Phase II Multicenter Randomized Study to Compare Neoadjuvant FDC With Melatonin or Metformin Versus FDC Alone in The Therapy of Locally Advanced Breast Cancer. | NCT02506777 |
| Neoadjuvant Toremifene With Melatonin or Metformin in Locally Advanced Breast Cancer | Phase II Multicenter Randomized Study to Compare Neoadjuvant Toremifene With Melatonin or Metformin Versus Toremifene in the Therapy of Locally Advanced Breast | NCT02506790 |
| Melatonin Treatment for Night-Eating Syndrome | Melatonin Treatment for Night-Eating Syndrome | NCT02500017 |
| Phase IB-II clinical trial of melatonin oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing chemoradiation. | Phase IB-II clinical trial of melatonin oral gel for the prevention and treatment of oral mucositis in patients with head and neck cancer undergoing chemoradiation. | EUCTR2015-001534-13-ES |
| Primary Dysmenorreh pain severity | The study of the effects of Melatonin and Meloxicam on sleep quality and pain severity in patients with primary dysmenorreh | IRCT2015031521475N1 |
| This Repeated Measures Parallel-group Investigation Will Examine the Influence of Short-term Melatonin Supplementation (5mg, 3 x Day for 72 Hours) on Cellular Responses, Functional Performance and Recovery Following an Acute Bout of Dynamic Resistance Exercise in Resistance Trained Men and Women | The Effect of Melatonin Supplementation on Immune Cell Responses and Functional Recovery Following Acute Resistance Exercise | NCT06617351 |
| Effect of Melatonin in side effects of second-generation antipsychotic medications | Melatonin attenuates antipsychotic metaboliceffects: | IRCT2016051027832N1 |
| Comparative study of the effects of trazodone, melatonin, and trazodone/melatonin in the treatment of sleep disorders after traumatic brain injury: A randomized clinical trial | A comparative study of the effect of trazodone, melatonin and trazodone/melatonine in the treatment of sleep disorders following traumatic brain injury | IRCT20241121063793N1 |
| Sublingual Melatonin for Anxiety and Pain in Elective Gynecologic Surgery | Comparison Between Two Different Doses of Sublingual Melatonin to Alleviate Anxiety and Pain Associated With Elective Gynecological Surgeries Under General Anesthesia: A Randomized Controlled Trial | NCT06997263 |
| Effect of Melatonin Patches on Sleep in Urological Surgery | Effect of Melatonin Patches on Sleep Quality in Patients Undergoing Urological Surgery | NCT06910345 |
| Melatonin for patients with chronic low back pain - a randomized placebo-controlled trial | Melatonin for patients with chronic low back pain (MELBACK) - a randomized placebo-controlled trial | CTIS2024-514769-20-00 |
| Comparing the effects of Melatonin and Alprazolam as pre-medication for anaesthesia | To compare the effects of oral melatonin with oral alprazolam when used as premedication in adult patients undergoing general anaesthesia or spinal anaesthesia. - Nil | CTRI/2025/03/082817 |
| The Effectiveness of a Proprietary of a Botanical Extract on Sleep Quality | The Effectiveness of a Proprietary of a Botanical Extract on Sleep Quality As Compared to a Melatonin Control: a Randomized, Double-Blinded, Controlled Clinical Trial | NCT06894108 |
| The effectiveness of sleep-wake cycle regulating agents in mitigating altered sensorium and promoting recovery in acutely ill patients receiving intensive care | Navigating sensorium: Lemborexant vs. melatonin vs. placebo for management of delirium a hospital-based, single-center, parallel, double blinded, randomized controlled trial - SENTINEL-D | CTRI/2025/03/082347 |
| the interaction between nocturnal intense exercice effect, optimal dose of melatonin to recuperate. | Nocturnal exercise and MLT supplementation : Effect on physical, cognitives and physiological and psychologicals responces, | PACTR202503918121742 |
| Oral Melatonin vs Midazolam for Emergence Delirium in Pediatric Anesthesia: A Randomized Study | A prospective randomized study to know the effect of premedication with oral melatonin vs oral midazolam on emergence delirium in children undergoing general anesthesia - NIL | CTRI/2025/03/082307 |
| Comparison Of The Effects Of Melatonin Premedication And Ketamine On Postoperative Sleep Quality In Rhinoplasty | Comparison Of The Effects Of Melatonin Premedication And Ketamine On Postoperative Sleep Quality In Rhinoplasty: A Prospective Randomized Controlled Study | NCT06898463 |
| Preventing post-surgery confusion by comparing two approaches using dexmedetomidine and melatonin | To compare the effectiveness of Dexmedetomidine with Melatonin vs Dexmedetomidine alone in preventing postoperative delirium in elderly patients undergoing cardiac surgery -A prospective randomised interventional study. - nil | CTRI/2025/03/083309 |
| Effect of Melatonin on Postoperative Pain After Simple Nephrectomy | Effect of Melatonin on Postoperative Pain After Simple Nephrectomy: A Randomized Double-Blinded Controlled Study | NCT06872944 |
| Effects of melatonin on depression and cognition function in hemodialyzed patients, A randomized, double-blind, controlled trial | Effects of melatonin on depression and cognition function in hemodialyzed patients, A randomized, double-blind, controlled trial | IRCT20110226005914N3 |
| Comparison effects of Melatonin premedication on Propofol and induction ?dose in abdominal surgery | Comparison effects of Melatonin premedication on Propofol and induction ?dose in abdominal surgery | IRCT20141209020258N98 |
| Effect of Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation | Effect of Oral Melatonin, Oral Clonidine and Oral Pregabalin Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation - nil | CTRI/2025/02/081425 |
| Efficacy of melatonin to increase cognitive function in depressed patients(Pilot study) | Efficacy of Melatonin to increase cognitive function in depressed patients (pilot study) | TCTR20161219004 |
| Study on preoperative sedation in pediatric surgery. | Comparison Of Oral Premedication In Children With Midazolam, Dexmedetomidine And Melatonin For Ease Of Separation From Parents Before Anesthesia : A Randomized Controlled Study - nil | CTRI/2025/02/081317 |
| THE EFFECT OF MELATONIN ADJUVANT ON COGNITIVE FUNCTION AND MELATONIN LEVELS OF SCHIZOPHRENIA PATIENTS RECEIVING RISPERIDONE THERAPY | THE EFFECT OF MELATONIN ADJUVANT ON COGNITIVE FUNCTION AND MELATONIN LEVELS OF SCHIZOPHRENIA PATIENTS RECEIVING RISPERIDONE THERAPY | TCTR20250222001 |
| comparing the effectiveness of oral Melatonin and Pregabalin in reducing blood pressure , heart rate while inserting tube during anaesthesia in patients undergoing Laparoscopic Cholecystectomy | Comparative study of Melatonin versus Pregabalin in attenuation of Hemodynamic stress response to Laryngoscopy and Endotracheal intubation in Patients undergoing Laparoscopic Cholecystectomy - A Randomised Control Trial - Nil | CTRI/2025/02/081076 |
| Assessment of combination of Melatonin and Hyaluronic acid when used for wound healing following extraction of molars and premolars | Combination of Melatonin with Hyaluronic Acid for socket preservation following extraction of posterior teeth - A randomized controlled trial - NIL | CTRI/2025/02/080776 |
| Melatonin Versus Tizanidine with Cervical Plexus Block for Thyroidectomy | A Randomized Comparative Study of Effect of Preanesthetic Melatonin Versus Tizanidine Combined with Superficial Cervical Plexus Block on Anesthetic Outcome of Thyroidectomy Surgeries | PACTR202503835746796 |
| Postoperative pain control by oral melatonin in manbibular fracture surgery | Effect of oral melatonin on postoperative analgesia in mandibular fracture fixation surgery-A randomized controlled study - Nil | CTRI/2025/02/080784 |
| The Role of Melatonin as an Adjuvant Therapy in Childhood Pneumonia | The Role of Melatonin as an Adjuvant Therapy in Childhood Pneumonia | NCT06949904 |
| A study to test the safety of a new melatonin treatment for babies with brain injury receiving cooling therapy | Phase I dose escalation and cohort expansion study to affirm the safety of pharmacological doses of a novel formulation of intravenous melatonin in babies with hypoxic-ischaemic encephalopathy (HIE) to augment therapeutic hypothermia (HT) treatment; to reduce the incidence and severity of disability in babies with moderate-severe HIE | ISRCTN61218504 |
| Metabolic Effects of Melatonin Treatment | Metabolic Effects of Melatonin Treatment | NCT03859934 |
| The effect of melatonin on iTBS induced LTP plasticity | The effect of melatonin on iTBS induced LTP plasticity | ChiCTR2500103964 |
| The treatment of polycystic ovary syndrome with melatonin | The Mechanism of Melatonin Activation of MT1/SIRT1/PGC-1a in Alleviating Polycystic Ovary Syndrome | ChiCTR2500103517 |
| To compare Melatonin given orally and Midazolam given intranasally to check anxiety of pediatric patients during extraction of teeth. | Effect of Intranasal Midazolam and Oral Melatonin in anxious children during dental procedure - NIL | CTRI/2025/05/087870 |
| Influence of melatonin on physiological responses and physical performance during and after running | Effect of acute melatonin administration on physiological parameters and physical performance during and after running under different conditions | RBR-8phx8f5 |
| Comparative Efficacy of Magnesium Supplement and Melatonin Congener in Young Adults With Primary Insomnia | Comparative Efficacy of Magnesium Supplement and Melatonin Congener in Young Adults With Primary Insomnia | NCT06996171 |
| comparison of two different doses of tablet melatonin as a medication before surgery in altering the blood pressure and heart rate during inserting endotracheal tube in general anaesthesia - a randomised controlled trial | Comparison of Two Different Doses of Melatonin as a Premedication Agent in Attenuation of Haemodynamic Stress Response during Intubation in General Anaesthesia - A Randomized Controlled Trial - nil | CTRI/2025/05/087022 |
| To know the effect of two oral drugs clonidine and melatonin in patients posted for surgeries in the nasal cavity. | Effect of Oral Melatonin and Oral Clonidine Premedication on Hemodynamic Response To Laryngoscopy and Intubation and Intraoperative Period in Patients Posted For FESS - A double blinded randomised prospective comparative study - Nil | CTRI/2025/04/085921 |
| Giving melatonin 2 hours before surgery to see its effects on blood pressure and heart rate in older patients. | Effects of Oral Melatonin Premedication on Attenuation of Haemodynamic Response to Intubation and Anaesthetic Requirements in Geriatric Patients: A Randomized Clinical Trial - nil | CTRI/2025/04/084520 |
| A clinical trial to study the effect of melatonin on pain following caesarean section at the Federal Medical Centre, Yenagoa Bayelsa State | Effect of preoperative melatonin on post-caesarean section pain at the Federal Medical Centre, Yenagoa Bayelsa State: A double-blind randomized study | PACTR202504516804183 |
| Comparison of Low-Dose and High-Dose Melatonin for Prevention of Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery: A Randomized Controlled Trial | Comparison of Low-Dose and High-Dose Melatonin for Prevention of Postoperative Delirium in Elderly Patients Undergoing Orthopedic Surgery: A Randomized Controlled Trial | TCTR20250424001 |
| Exploring use of melatonin in patients with inability to sleep after knee surgery | A Phase 4 open, single-arm, pilot study to evaluate the effectiveness and tolerability of a 4-week flexible dose regimen of Melatonin (5-10mg/day) and cognitive behavioural therapy for insomnia (CBT-I) for improving sleep quality and quantity and patient-reported outcomes in Post-Total Knee Arthroplasty/Replacement Adult Patients - NIL | CTRI/2025/04/085471 |
| Protective effect of melatonin on optic nerve in glaucoma | Neuroprotective Efficacy and Safety of Exogenous Melatonin in Primary Open-Angle Glaucoma: A Single-Arm, Prospective Clinical Study | ChiCTR2500101268 |
| Changes at the micronuclear level in the mucosal cells around the implant with and without Melatonin gel. | Comparative evaluation of micro nuclear changes in mucosal epithelial cells, crestal bone levels and implant stability with and without melatonin gel- A randomized controlled clinical study. - NIL | CTRI/2025/04/085336 |
| A comparative study of effect of two tablets melatonin and alprazolam given by mouth on anxiety in adult patients posted for surgery | A comparative study of impact of oral melatonin versus alprazolam on anxiety in adult patients undergoing elective surgery - NIL | CTRI/2025/04/085231 |
| To check the effect and safety of Melatonin capsule (2 mg) in improving sleep in healthy adults with poor sleep quality. | A Randomized, double-blind, placebo controlled, parallel group clinical study to evaluate the efficacy and safety of Melatonin Sustained Release (SR) Capsules (2 mg) in improving Sleep Parameters in healthy adults with poor sleep quality. - Nil | CTRI/2025/04/085087 |
| Prevention of Delirium in Inpatients Utilizing Melatonin | Prevention of Delirium in Inpatients Utilizing Melatonin | NCT02654314 |
| The Effect of Melatonin on Early Signs of Hypertension in Teenagers With Diabetes Mellitus Type 1 | The Effect of Melatonin on Early Signs of Hypertension in Teenagers With Diabetes Mellitus Type 1 | NCT02644590 |
| Effects of Melatonin Supplementation on Sleep Quality in Patients with Advanced Glaucoma | Randomized Clinical Trial: Effects of Melatonin Supplementation on Sleep Quality in Patients with Advanced Glaucoma | RBR-8nqsfsn |
| A study comparing a gel containing 5 percent melatonin with platelet rich fibrin versus just platelet rich fibrin for treating bony defects a study using clinical and radiographic exam. | Comparative evaluation of 5 percent Melatonin gel in combination with Platelet rich Fibrin and Platelet Rich Fibrin alone in the treatment of Intrabony defects: A Clinico-Radiographic Study. - Nil | CTRI/2024/07/070947 |
| Effect of Melatonin on Schizophrenic Symptoms: a Randomized Placebo-Controlled Trial | Effect of Melatonin on Positive and Negative Symptoms of Schizophrenic Patients: a Randomized Placebo-Controlled Study | NCT06838104 |
| The impact and protective effect of melatonin on the prognosis of patients with inflammatory bowel disease | Exploring the impact of sleep disorders on the prognosis of patients with inflammatory bowel disease and the protective effect of melatonin | ChiCTR2500097177 |
| Impact of Melatonin on IVF/ICSI Outcomes in Prospective Poor Responders | Impact of Melatonin Adjuvant Therapy on IVF/ICSI Outcomes in Prospective Poor Responders: A Double-blind, Randomized, Placebo-controlled Trial | NCT02993588 |
| Melatonin effect in Stroke patients | Evaluation of melatonin effect on coagulation factors in hemorrhagic stroke | IRCT201610225073N2 |
| Melatonin Gel As an Adjuvant in the Surgical Management of Intrabony Defects | Melatonin Gel As an Adjunct to Xenograft in the Surgical Management of Intrabony Periodontal Defects (A Randomized Controlled Clinical Study) | NCT06821425 |
| Effects of Melatonin on injury caused by transplant process in renal transplant patients | Effects of Melatonin on ischemia-reperfusion injury and the klotho protein expression in renal transplant patients | IRCT201610203812N5 |
| Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty | Effect of Oral Melatonin Versus Intraoperative Lidocaine Infusion on Incidence of Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty: Prospective Randomized Controlled Blinded Study | NCT06768580 |
| Melatonin vs. placebo for prevention of delirium in hospital in people with advanced cancer | Randomised, double-blind, placebo-controlled phase III trial of oral melatonin for the prevention of delirium in hospital in people with advanced cancer | ACTRN12616001618448 |
| Effects of Melatonin to Reduce Nocturnal Hypertension in Patients With Neurogenic Orthostatic Hypotension | Identifying the Pathophysiology of Neurogenic Orthostatic Hypotension and the Effects of Melatonin on Reducing Supine Hypertension in Peripherally Intact Versus Denervated Post-ganglionic Sympathetic Nerves | NCT02963181 |
| The effect of melatonin tablet on sleep disorders in patients in cardiac surgery intensive care unit | Effect of melatonin tablets compared to lorazepam tablets on circadian rhythm of sleep and serum level of leptin and cortisole and melatonin in CABG patients admited in heart ICU ward of Mousavi hospital, Zanjan | IRCT2015082523760N1 |
| Investigating the effect of oral melatonin on urinary tract infection in children and adolescents | Investigating the effect of oral melatonin on urinary tract infection in children and adolescents | IRCT20241125063843N1 |
| The Impact of Melatonin Lotion on Sleep and Mental Health | The Impact of Melatonin Lotion on Actigraphy, Sleep Quality, Autonomic Nervous System Indicators, Mood, Anxiety Symptoms, and Side Effects | NCT06768749 |
| Melatonin versus quetiapine in adolescents (MEL-QUE-A) | Efficacy of melatonin, low-dose quetiapine, or placebo in adolescents with psychiatric disorders and comorbid insomnia: a randomized clinical trial | CTIS2024-519597-39-00 |
| Effect of Melatonin in Prevention of Vancomycin-Induced Nephrotoxicity | Comparison of the Effectiveness of Melatonin Versus Placebo in Prevention of Vancomycin-Induced Nephrotoxicity in Hospitalized Patients: A Randomized Clinical Trial | IRCT20241126063867N1 |
| The effect of melatonin on pediateric drug resistant epilepcy | The effect of melatonin on pediateric drug resistant epilepcy | IRCT2016100730187N1 |
| Evaluation the effect of melatonin on oxidative stress factors and blood sugar control in kidney transplantation patients | Evaluation the effect of melatonin on oxidative stress factors and blood sugar control in kidney transplantation patients, a randomized, double-blind, placebo-controlled clinical trial | IRCT20160412027346N10 |
| The Use of Sublingual Melatonin Premedication in Geriatric Cataract Surgery | The Use of Sublingual Melatonin Premedication in Geriatric Cataract Surgery | NCT07036367 |
| The clinical trial of combined treatment of melatonin plus DHEA in Diminished Ovarian Reserve (DOR) patients on oocyte/embryo quality and pregnancy outcome in IVF cycles | The clinical trial of combined treatment of melatonin plus DHEA in Diminished Ovarian Reserve (DOR) patients on oocyte/embryo quality and pregnancy outcome in IVF cycles | ChiCTR-INC-16009306 |
| The effect of melatonin on cognitive function, after coronary artery bypass grafting surgery. | The effect of melatonin on cognitive function, after coronary artery bypass grafting surgery. | IRCT20141009019470N77 |
| Effect of oral melatonin in critically ill sepsis patients | Effect of enteral melatonin on invasive fungal infection and antifungal susceptibility profile in critically ill sepsis patients: A prospective randomized control trial | CTRI/2024/12/078819 |
| Effect of Melatonin on diabetic retinopathy | The Effect of Daily Melatonin Supplement on Diabetic Macular Edema | IRCT20241130063903N1 |
| Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy | A Clinical Study to Assess the Cardioprotective Effects of Melatonin in Patients With Cardiomyopathy | NCT06846086 |
| Investigating the effect of melatonin on memory impairment and oxidative stress biomarkers after ischemic stroke in patients admitted to the neurology department of Imam Khomeini Hospital in Urmia. | Investigating the effect of melatonin on memory impairment and oxidative stress biomarkers after ischemic stroke | IRCT20241229064208N1 |
| A Novel Inhaled Formulation of Melatonin to Treat Adults with Insomnia: Efficacy Study | A Novel Inhaled Formulation of Melatonin to Treat Adults with Insomnia Disorder: a Randomised Open-Label Crossover Trial | NCT06802913 |
| MELATONIN IN PREVENTION OF DELIRIUM | ROLE OF MELATONIN IN PREVENTION AND MANAGEMENT OF DELIRIUM IN CRITICALLY ILL PATIENTS: A PROSPECTIVE, PLACEBO CONTROLLED STUDY - nil | CTRI/2025/02/080199 |
| Melatonin Effects on Cardiovascular Disease Mechanisms in the Menopause Transition: A Randomized Clinical Trial | Melatonin Effects on Cardiovascular Disease Mechanisms in the Menopause Transition: A Randomized Clinical Trial | NCT06826755 |
| Effect of Preoperative Oral Melatonin Versus Gabapentin on Rebound Pain and Perioperative Anxiety with a Single-Shot Inferior Alveolar Nerve Block for Unilateral Mandibulectomy Cancer Surgery | Effect of Preoperative Oral Melatonin Versus Gabapentin on Rebound Pain and Perioperative Anxiety with a Single-Shot Inferior Alveolar Nerve Block for Unilateral Mandibulectomy Cancer Surgery | PACTR202502833693256 |
| Combined effects of physical training and melatonin supplementation on biological adaptations, cardiorespiratory fitness, sleep status and functional capacity in patients with type 2 diabetes. | Effect of interval functional training combined with melatonin supplementation on cardiometabolic health in diabetic patients | PACTR202502545946977 |
| Combined effects of melatonin supplementation and physical training on glycemic variability, cardiorespiratory fitness, sleep status and functional capacity in patients with type 1 diabetes. | Effect of interval functional training combined with melatonin supplementation on cardiometabolic health in diabetic patients. | PACTR202502850476916 |
| Assessment on the effect of Melatonin on Pain control after Abdominal Hystrectomy | Assessment on the effect of Melatonin on Pain control after Abdominal Hystrectomy | IRCT2015090816325N3 |
| Exploring the Effects of Melatonin on Orthodontic Mini-Implant Stability: A Clinical Study | Assessing the Effect of Exogenous Melatonin on The Stability of Orthodontic Mini-Implants: A Randomized Controlled Clinical Trial - NIL | CTRI/2025/02/079934 |
| A clinical trial of comparing the effect of melatonin and placebo on improving the neurological complications, infarct size and sleep and cognitive impairments in patients with ischemic stroke. | Evaluation of melatonin as a potential drug for the improvement of clinical outcome, reduction of infarct size, sleep parameters and cognitive functions in post-stroke patients: A randomized, double blind, placebo-controlled study | IRCT201609059566N2 |
| Use of melatonin, oral and cream, to counteract skin ageing: a controlled trial | Skin anti-aging effect of a melatonin-based in&out strategy in comparison with topical treatment alone: a randomized, assessor-blinded, prospective trial with VISIA evaluation | ISRCTN58661770 |
| Melatonin Oral Gel for Oral Mucositis in Patients With Head and Neck Cancer Undergoing Chemoradiation | Phase IB-II Clinical Trial of Melatonin Oral Gel for the Prevention and Treatment of Oral Mucositis in Patients With Head and Neck Cancer Undergoing Chemoradiation. | NCT02630004 |
| An Open Label Single Dose Two Treatment Two Period Two Way Crossover Oral Pharmacokinetic Study Healthy Adult Human Male And Female Subjects Under Fed Conditions | An Open Label Balanced Randomized Single Dose Two Treatment Two Sequence Two Period Two Way Crossover Oral Pharmacokinetic Study Comparing Microactive Melatonin 3mg SR Capsules Manufactured by Kalpatharu Naturals Pvt Ltd U 76 Hootagalli Industrial Area Mysore 570018 Karnataka With Melatonin 3mg IR Capsules Manufactured by Kalpatharu Naturals Pvt Ltd U 76 Hootagalli Industrial Area Mysore 570018 Karnataka In Healthy Adult Human Male And Female Subjects Under Fed Conditions - NIL | CTRI/2025/01/079823 |
| Melatonin for Patients with Chronic Low Back Pain | Melatonin for Patients with Chronic Low Back Pain - a Randomized Placebo-controlled Trial | NCT06859957 |
| Evaluating Efficacy and Safety of Oral Melatonin in Acute Central Serous Chorioretinopathy | Evaluating Efficacy and Safety of Oral Melatonin in Acute Central Serous Chorioretinopathy (CSCR): a Double-blind Randomized Clinical Trial | NCT06809751 |
| Melatonin on the outcome of patients with Polycystic ovarian syndrome | Studying the effect of melatonin on the outcome of patients with Polycystic ovarian syndrome treated with intrauterine insemination | IRCT20250126064525N1 |
| To See The Effect of Oral Antihypertensive for The Attenuation of Haemodynamic Response to Laryngoscopy and Tracheal Intubation | Clinical Evaluation of Oral Melatonin and Oral Clonidine for The attenuation of Haemodynamic Response to Laryngoscopy and Tracheal Intubation - NIL | CTRI/2025/01/079672 |
| Effects of Melatonin and Massage After Third Molar Surgery | Comparison of the Effects of Melatonin and Lymphatic Drainage Massage on Pain, Edema, and Mouth Opening Following Impacted Third Molar Extraction | NCT06812026 |
| Effects of Melatonin Supplementation on Sleep Quality in Patients with Advanced Glaucoma | Randomized Clinical Trial: Effects of Melatonin Supplementation on Sleep Quality in Patients with Advanced Glaucoma | NCT06868745 |
| A Novel Inhaled Formulation of Melatonin to Treat Adults with Insomnia: Pharmacokinetic Study | A Novel Inhaled Formulation of Melatonin to Treat Adults with Insomnia Disorder: a Randomised Open-Label Crossover Trial | NCT06801379 |
| A Comparison of Zopiclone, Melatonin, and Alprazolam as a pre-medication on preoperative anxiety, psychomotor functions, and soporific effect | Premedication before surgeries: A Comparison of Zopiclone, Melatonin, and Alprazolam on preoperative anxiety, psychomotor functions, and soporific effect. - NIL | CTRI/2025/01/079825 |
| Studying the effect of melatonin on migraine | The effect of melatonin on reducing the frequency and intensity of migraine attacks | IRCT20190107042264N5 |
| Impact of Melatonin in the Pretreatment of Organ Donor and the Influence in the Evolution of Liver Transplant. | Impact of Melatonin in the Pretreatment of Organ Donor and the Influence in the Evolution of Liver Transplant: a Prospective, Randomised Double-blind Study. | NCT01860716 |
| MELATOX: Pharmacodynamic evaluation of topical use of melatonin as sun protection: a study on healthy volunteers. | MELATOX: Pharmacodynamic evaluation of topical use of melatonin as sun protection: a randomized, double blinded, placebo controlled crossover study on healthy volunteers. | EUCTR2013-003023-10-DK |
| The effect of melatonin on endometriosis | The effects of melatonin on endometriosis-associated chronic pelvic pain and regression of endometrioma; a triple blind randomized controlled trial | IRCT20171209037794N3 |
| melatonin in dialysis patients | The effect of melatonin on CRP and lipid profiles of dialysis patients | IRCT20200308046724N1 |
| Acute Concussion and Melatonin | The Effectiveness of Melatonin for the Treatment of Acute Pediatric Concussion | NCT04731974 |
| Circadian Melatonin Rhythms in Critically Ill Patients With Delirium | Circadian Melatonin Rhythms in Critically Ill Patients With Delirium - A Prospective Single-centre Observational Proof-of-concept Study | NCT04721613 |
| Protective effects of melatonin on kidney function against contrast media-induced kidney damage in patients with chronic kidney disease: A prospective, randomized, double-blinded, placebo-controlled trial | Effect of melatonin on the reduction of oxidative stress and the prevention of contrast-induced acute kidney injury | TCTR20210123004 |
| The effect of melatonin on sleep quality, mental health and performance in patients with drug abuse in methadone-treated patients | The effect of melatonin on sleep quality, mental health and performance in patients with drug abuse in methadone-treated patients | IRCT20201214049718N1 |
| The effect of melatonin on anxiety before hysterectomy | Investigating the effect of melatonin on reducing preoperative anxiety in abdominal hysterectomy; a double blinded clinical trial study | IRCT20100707004345N6 |
| Prospective clinical study of melatonin combined with radiofrequency ablation in the treatment of early lung cancer | Efficacy and safety of melatonin combined with radiofrequency ablation in the treatment of early lung cancer | ChiCTR2100042695 |
| A comparation of lidocaine, lidocaine and melatonin and Valsalva maneuver, lidocaine and Valsalva maneuver to reduce the pain associated with administration of ethomidate | A comparative study of lidocaine, lidocaine and melatonin and Valsalva maneuver, lidocaine and Valsalva maneuver to reduce the pain associated with administration of ethomidate | IRCT20160307026950N31 |
| Effect of melatonin versus placebo on clinical outcomes in patients with ischemic stroke | Effect of melatonin versus placebo on clinical outcomes in patients with ischemic stroke: a double-blind randomized clinical trial | IRCT20120215009014N378 |
| To compare the efficacy of 1% Melatonin gel in and Platelet Rich fibrin in the treatment of Grade II furcation defects | Comparative Evaluation of 1% Melatonin gel in combination with Platelet Rich Fibrin and Platelet Rich Fibrin (PRF) alone in Treatment of Grade II Furcation Defects: A Randomized Controlled Trial | CTRI/2021/02/030916 |
| Comparison of melatonin versus gabapentin on post operative pain and anxiety in breast cancer surgery | Comparative study of melatonin versus gabapentin on post operative pain and anxiety in breast cancer surgery: A prospective comparative study | CTRI/2021/02/031072 |
| Evaluation of the role of melatonin as a potential drug for prevention of delirium in patients who have been operated and are admitted in the intensive care unit. | Evaluation of role of exogenous melatonin in prevention of delirium in postoperative patients admitted in the intensive care unit | CTRI/2021/02/031183 |
| Bioavailability and Bioactivity of Red Wine Melatonin in Humans | Serum and Salivary Melatonin Levels and Antioxidant Power of Melatonin-rich Red Wine | NCT02767102 |
| To reduce the Pre operative anxiety before various surgical procedures under General Anaesthesia, buy using various drugs like Oral Melatonin, Oral Alprazolam, Combination of both and Placebo | Comparision of Oral Melatonin, Oral alprazolam, combination of both and placebo, premedication for preoperative anxiety in adult patients undergoing surgical procedures under General anaesthesia: A prospective blinded randomized study. | CTRI/2021/02/031184 |
| Antioxidant Effects of Melatonin in Preterm | Early Supplementation of Melatonin in Preterm Newborns: the Effects on Oxidative Stress | NCT04785183 |
| melatonin in patients with COVID-19 | Evaluation of the effect of melatonin in patients with COVID-19-induced pneumonia admitted to the Intensive Care Unit | IRCT20200506047323N7 |
| The effect of melatonin in the improvement of the symptoms in irritable bowel syndrome patients with sleep disturbance | The effect of melatonin in the improvement of the symptoms in irritable bowel syndrome patients with sleep disturbance | TCTR20210218002 |
| Melatonin add on anti epileptic drug | Evaluation of efficacy of Melatonin add on routine anti-epileptic drug regimen versus placebo in adult epileptic patients | IRCT20101209005352N4 |
| Variation in Sleep Time and Glucose Variation in Patients with Type 2 Diabetes Mellitus | Sleep Duration Variability: a Therapeutic Target of Melatonin for Glycemic Control in patients with Type 2 Diabetes Mellitus | RBR-6wg54rb |
| Effect of Melatonin on Cardiovascular and Muscle Mass and Function in Patients With Heart Failure | Effect of Melatonin on Cardiovascular and Muscle Function in Patients With Heart Failure: a Double Blinded Prospective Randomized Clinical Trial. | NCT03894683 |
| RANDOMISED CONTROLLED TRIAL TO COMPARE BETWEEN MELATONIN AND 24% SUCROSE FOR PAIN MANAGEMENT DURING ROP SCREENING | COMPARISION BETWEEN MELATONIN AND 24% SUCROSE FOR PAIN MANAGEMENT DURING ROP SCREENING-A RANDOMISED CONTROL TRIAL | CTRI/2021/02/031458 |
| This study is to see the effect of premedication with melatonin and pregabalin Perioperatively in total hip arthroplasty case under spinal anaesthesia | COMPARATIVE STUDY OF PERIOPERATIVE EFFECT OF PREMEDICATION WITH MELATONIN VERSUS PREGABALIN IN TOTAL HIP ARTHROPLASTY UNDER SPINAL ANAESTHESIA | CTRI/2021/02/031574 |
| The Adjunctive Use of Melatonin Therapy in the Treatment of Obese Periodontitis Patients (Clinical and Immunological Study). | The Adjunctive Use of Systemic Melatonin Therapy in the Treatment of Periodontitis Associated With Obesity (Clinical and Immunological Study). | NCT04788979 |
| Evaluation of the effect of melatonin on colistin nephrotoxicity | Evaluating the effect of oral melatonin in colistin induced nephrotoxicity in the intensive care unit | IRCT20210110049990N1 |
| Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery | Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery | NCT04791943 |
| Melatonin Use After Primary Total Joint Arthroplasty | Melatonin Use After Primary Total Joint Arthroplasty: A Randomized, Double Blind Placebo-Controlled Trial | NCT04795336 |
| Effect of melatonin on incidence of post-operative delirium. | To study the effect of premedication with oral melatonin on incidence of post-operative delirium in patients undergoing elective surgery under general anaesthesia | CTRI/2021/03/031804 |
| The effect of topical betamethasone and oral melatonin in the treatment of atopic dermatitis | Comparison of the effect of topical betamethasone with oral melatonin in the treatment of atopic dermatitis | IRCT20200825048515N23 |
| To assess the effect of different doses of tablet melatonin (used as sedative, anxiolytic, antihypertensive drug) in reducing blood pressure and heart rate response while inserting a tube in trachea for providing general anaesthesia | Effect of different doses of oral melatonin as a premedication for attenuation of intubation response | CTRI/2021/03/032123 |
| The effectiveness of melatonin on migraine headaches | Comparison of the efficacy of propranolol alone and propranolol plus melatonin on the severity, duration, and number of migraine attacks in patients with migraine headaches | IRCT20170316033099N12 |
| The effects of premedication on postoperative behavioral disturbances in pediatric patients undergoing sevoflurane general anesthesia | The effects of oral melatonin or midazolam on postoperative behavioral disturbances in pediatric patients undergoing sevoflurane general anesthesia | ChiCTR1900022440 |
| Colostral Milk and Blood IL-6 Levels in Types of Labour | The Comparison of Serum and Colostral Melatonin, and IL-6 Levels Between Women With Vaginal Delivery, Emergency Cesarean Section and Elective Cesarean Section | NCT03953066 |
| Evaluation of the effect of melatonin in the treatment of problems caused by androgen deprivation therapy in prostate cancer patients | Evaluation of the effect of Melatonin in treatment of menopausal like problems, mood and sleep chaging caused by androgen deprivation therapy in prostate cancer patients | IRCT20180722040556N5 |
| Selective Estrogen Modulation and Melatonin in Early COVID-19 | Selective Estrogen Modulation and Melatonin in Early COVID-19 | NCT04531748 |
| The effects of melatonin treatment on bone, marrow, sleep and arterial stiffness in postmenopausal women | The effects of melatonin treatment on bone, marrow, sleep and arterial stiffness in postmenopausal women | EUCTR2020-002934-34-DK |
| EFFECT OF TABLET MELATONIN FOR SLEEP PROBLEMS IN CHILDREN WITH CEREBRAL PALSY | ROLE OF ORAL MELATONIN SUPPLEMENTATION IN CHILDREN WITH CEREBRAL PALSY FOR SLEEP DISTURBANCES;A RANDOMISED CONTROLLED TRIAL - MESCP | CTRI/2020/09/027813 |
| Efficacy of Intravenous Melatonin on Mortality in Adult Patients Admitted to the Intensive Care Unit With COVID-19 | A Phase II, Single-center, Double-blind, Randomized Placebo-controlled Trial to Explore the Efficacy and Safety of Intravenous Melatonin in Patients With COVID-19 Admitted to the Intensive Care Unit (MelCOVID Study) | NCT04568863 |
| The effect of Melatonin in patients with Low Anterior Resection Syndrome | The effect of Melatonin in patients with Low Anterior Resection Syndrome - MELLARS trial | EUCTR2020-004442-11-DK |
| Melatonin in COVID-19 | Inflammation control in patients with COVID-19 using melatonin supplement compare to controls referred to Imam Khomani Hospital | IRCT20200922048804N1 |
| Melatonin Adolescent Research Study | Understanding the Impact of Melatonin Use on Adolescent Functioning: A Pilot and Feasibility Trial of the Melatonin Adolescent Research Study (MARS) | NCT04588233 |
| Randomized Trial Investigating Melatonin Supplementation vs Placebo on Sleep Disturbance Following Total Joint Arthroplasty | Randomized Trial Investigating Melatonin Supplementation vs Placebo on Sleep Disturbance Following Total Joint Arthroplasty | NCT04590742 |
| The effect of nortriptyline and melatonin on diabetic neuropathy | Comparison of the effect of nortriptyline and melatonin on the severity of diabetic polyneuropathy | IRCT20191030045277N2 |
| Study of two drugs melatonin and gabapentin for control of anxiety and stress response to anaesthesia. | Melatonin Vs Gabapentin as Premedication for Anxiolysis and Attenuation of Haemodynamic Response to Laryngoscopy and Intubation in General Anaesthesia | CTRI/2020/10/028421 |
| Evaluation of melatonin effect on breast cancer | The effect of melatonin supplementation on tumor grading, pathologic findings, serum levels of biomarkers related to inflammation and oxidative stress in patient with breast cancer | IRCT20171105037262N5 |
| Efficacy and safety of a hair growth promoting product containing topical 1% melatonin for treatment of androgenetic alopecia in women: A randomized double-blind trial | Efficacy and safety of a hair growth promoting product containing topical 1% melatonin for treatment of androgenetic alopecia in women: A randomized double-blind trial | TCTR20201227001 |
| A Study on Effect of Oral Melatonin and Oral Clonidine on stability of Heart rate and blood pressure during administration of general anesthesia | A Study on Effect of Oral Melatonin and Oral Clonidine Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Endotracheal Intubation | CTRI/2020/10/028682 |
| Effect of Melatonin in treatment of COVID-19 | Evaluating the effect of Melatonin in prognosis and clinical improvement in patients with COVID-19: A Randomized Clinical Trial | IRCT20200426047206N4 |
| Melatonin and Hyaluronic Acid in Maxillary Sinus Augmentation | Evaluation of Melatonin and Hyaluronic Acid in Maxillary Sinus Augmentation (a Randomized Controlled Clinical Trial) | NCT04625179 |
| QUALITY OF RECOVERY AFTER SPINE SURGERY AND MELATONIN | EFFECT OF MELATONIN PREMEDICATION ON QUALITY OF RECOVERY IN PATIENTS UNDERGOING COMPLEX SPINE SURGERIES UNDER NEUROMONITORING:AN EXPLORATORY STUDY | CTRI/2020/11/029002 |
| Prospective Evaluation of Treatment Success in Patients with REM Sleep Behavior Disorder Using Melatonin | Prospective Evaluation of Treatment Success in Patients with REM Sleep Behavior Disorder Using Melatonin - PEBMPR | DRKS00023534 |
| Melatonin supplementation in treatment of obese children and adolescents with nonalcoholic fatty liver disease | The effects of melatonin supplementation compared with placebo on ultrasound findings and metabolic profiles in obese children and adolescents with nonalcoholic fatty liver disease | IRCT20200531047614N2 |
| Effect of preoperative oral elatonin on pain intensity | Effect of preoperative oral Melatonin on pain intensity after cesarean section | IRCT20170220032676N3 |
| A clinical study to see efficacy of melatonin as an addon drug in the treatment of drug resistant epilepsy | Melatonin as an add on therapy in treatment of children with drug resistant epilepsy: An open label randomized controlled trial. - No specific acronym | CTRI/2020/11/029330 |
| To compare the effectiveness of Midazolam and Melatonin to decrease anxiety | A RANDOMIZED CLINICAL TRIAL: COMPARATIVE EVALUATION OF MELATONIN AND MIDAZOLAM AS ANXIOLYTIC DRUG FOR DENTAL PROCEDURES AMONG 5-12 YEAR OLD CHILDREN. | CTRI/2020/11/029397 |
| Dexmedetomidine and Melatonin for Sleep Induction for EEG in Children | Comparison of Efficacy of Dexmedetomidine and Melatonin for Sleep Induction for Electroencephalography in Children | NCT04665453 |
| The effect of melatonin on the lipid levels | Investigation of the effect of melatonin on the lipid levels in menopausal woman attending in selected Gynecology Clinics of Shiraz University of medical sciences, 1391 | IRCT2012090810774N1 |
| To compare syrup Melatonin with syrup Triclofos for putting children to sleep while undergoing undergoing Auditory Brainstem Evoked Response Audiometry | Comparison of efficacy and safety of syrup Melatonin with syrup Triclofos for procedural sedation of children undergoing Auditory Brainstem evoked Response Audiometry ââ?¬â?? a Randomized, Parallel, Triple blinded, Non inferiority trial. | CTRI/2020/12/029616 |
| Effects of Melatonin on Bone Metabolism in Thalassemia Patients with Low Bone Mineral Density (Randomized Controlled Study) | Effects of Melatonin on Bone Metabolism in Thalassemia Patients with Low Bone Mineral Density (Randomized Controlled Study) | TCTR20201223008 |
| Comparison the effect of Melatonin and Dexmedetomidine on dose requirements of propofol in induction and maintenance of anesthesia by guidance of BIS in femur fracture surgeryon | Comparison the effect of Melatonin and Dexmedetomidine on dose requirements of propofol in induction and maintenance of anesthesia by guidance of BIS in femur fracture surgery | IRCT20141009019470N103 |
| Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease | Effect of Melatonin on Sleep Disturbances in Patients With Parkinson's Disease: Double Blind, Randomized, Placebo Controlled Trial | NCT02768077 |
| study to assess the efficacy of oral melatonin plus rectal indomethacin versus rectal indomethacin for the prevention of post-ercp pancreatitis | Randomized comparative study to assess the efficacy of Oral Melatonin plus Rectal Indomethacin versus Rectal Indomethacin for the Prophylaxis of Post-Ercp Pancreatitis - PEP | CTRI/2021/03/032127 |
| A randomized, double-blind, placebo-controlled clinical trial of melatonin combined with acitretin in the treatment of children with generalized pustular psoriasis | A randomized, double-blind, placebo-controlled clinical trial of melatonin combined with acitretin in the treatment of children with generalized pustular psoriasis | ChiCTR2100044690 |
| Comparison of two drugs ,dexmedetomidine and melatonin for agitation after surgery in children | Comparison of efficacy of pre-medication with intranasal dexmedetomidine versus oral melatonin in prevention of emergence agitation due to sevoflurane in pediatric patients undergoing elective ocular surgery- randomized controlled trial | CTRI/2021/03/032388 |
| Melatonin for Prevention of Kidney Injury | Melatonin for the Prevention of Antibiotic Associated Acute Kidney Injury | NCT05084196 |
| Evaluation of the effect of melatonin in the treatment of sepsis | The effect of melatonin on the course of treatment and complications of sepsis in infants | IRCT20210825052289N1 |
| Metabolism and safety of different melatonin doses for healthy children and adolescents | A parallel group, double-blinded randomised multi dose pharmacokinetic and safety study of melatonin in children and adolescents - MORPHEUS | EUCTR2020-002187-31-DK |
| Does melatonin improve the organ donation process? | Role of melatonin as a therapeutic strategy against tissue ischemia in the cadaveric donor and its assessment using oxidative stress biomarkers and microRNAs | ISRCTN66157570 |
| Evaluating the Effect of melatonin on mechanically ventilated COVID 19 patients | Evaluating the Effect of melatonin on mechanically ventilated COVID 19 patients in Intensive care unit | IRCT20210225050495N1 |
| Study MIPAE - Melatonin and Essential Arterial Hypertension | Melatonin and Essential Arterial Hypertension | NCT05257291 |
| Can Melatonin prevent delirium in ICU patients or not ? | Prophylactic Melatonin for Delirium in Intensive Care Unit- an open labelled randomized control study - PROMEDIC | CTRI/2021/10/037315 |
| Evaluation of melatonin tablets in patients with beta thalassemia major | Evaluation of melatonin tablets in oxidative stress in patients with beta thalassemia major: A double blind placebo controlled, cross over clinical trial | IRCT20201212049684N1 |
| Efficacy and Safety of Sublingual Melatonin in alleviation of reflux disease | Efficacy and Safety of Sublingual Melatonin in alleviation of GERD Symptoms | IRCT20121021011192N12 |
| Melatonin in Depression or Anxiety | Evaluating the effects of melatonin in improving sleep quality in patients with generalized anxiety disorder or major depressive disorder | IRCT20210921052540N1 |
| Melatonin niosome gel vs Chloral hydrate for sedation in children undergoing auditory brainstem response: a randomized controlled trial | Melatonin niosome gel vs Chloral hydrate for sedation in children undergoing auditory brainstem response: a randomized controlled trial | TCTR20211121003 |
| DeCaf-Me: Can delirium be prevented with caffeine and melatonin? A randomised, placebo-controlled trial | DeCaf-Me: Can delirium be prevented with caffeine and melatonin? A randomised, placebo-controlled trial | ACTRN12621001633875 |
| The efficacy of amitriptyline and melatonin in the treatment of tinnitus | Comparative study of the efficacy of amitriptyline and melatonin in the treatment of tinnitus | IRCT20200825048515N48 |
| Comparing effect of drug Melatonin in reducing stress response to anesthesia interventions during bypass heart surgery in smokers and non smokers | Effect of MELATONIN premedication on hemodynamic changes during tracheal intubation in cigarette smokers compared with non-smokers in patients undergoing elective off-pump CABG surgery | CTRI/2021/09/036367 |
| The effect of concurrent administration of melatonin and neoadjuvant Chemotherapy on the pathological response in breast cancer patients | The effect of concurrent administration of melatonin and neoadjuvant Chemotherapy on the pathological response in breast cancer patients | IRCT20200409047007N3 |
| evaluation of Melatonin effect on short outcome in newborns with hypoxic ischemic encephalopathy | The evaluation of Melatonin effect on short outcome in newborns with hypoxic ischemic encephalopathy | IRCT20160523028008N19 |
| the effect of melatonin for the management of delirium and agitation | Evaluation of the effect of melatonin for the management of delirium and agitation in patients with delirium receiving quetiapine in intensive care unit: a randomized-controlled clinical trial | IRCT20150221021159N8 |
| The Effect of Melatonin on sleep quality and cognitive function of hemodialysis patients | The Effect of Melatonin on Sleep Quality and Cognitive Function of Hemodialysis Patients | IRCT20211030052917N1 |
| Effect of tablet Melatonin on prevention of Confusion in severe COVID 19 patients admitted in ICU | Effect of Melatonin on prevention of delirium in severe COVID-19 patients admitted in ICU. A double blind randomised control trial. | CTRI/2021/12/038630 |
| OXYTOCIN VERSUS OXYTOCIN AND MELATONIN IN THE REDUCTION OF BLOOD LOSS AT CAESAREAN SECTION AT THE ALEX EKWUEME FEDERAL UNIVERSITY HOSPITAL, ABAKALIKI | OXYTOCIN VERSUS OXYTOCIN AND MELATONIN IN THE REDUCTION OF BLOOD LOSS AT CAESAREAN SECTION AT THE ALEX EKWUEME FEDERAL UNIVERSITY HOSPITAL, ABAKALIKI | PACTR202201838645377 |
| The Efficacy of Oral Melatonin in Preventing Postoperative Delirium for Patients Undergoing Orthopedic Surgery Under General Anesthesia | The Efficacy of Oral Melatonin in Preventing Postoperative Delirium for Patients Undergoing Orthopedic Surgery Under General Anesthesia | NCT05236907 |
| Melatonin for Pediatric Emergence Agitation | Evaluation of Preoperative Melatonin on Emergence Agitation After Herniorrhaphy Surgeries in Pediatrics | NCT05223010 |
| Melatonin vs Pregabalin for Anxiolysis and Sedation | Efficacy of Preoperative Melatonin Versus Pregabalin on Intraoperative Anxiolysis and Sedation During Hip Arthroplasty Under Regional Anesthesia | NCT05221151 |
| Evaluation of Melatonin efficacy in prophylaxis of Doxorubicin induced cardiotoxicity in patients with breast cancer and receiving the Doxorubicin-Cyclophosphamide regimen | Evaluation of Melatonin efficacy in prophylaxis of Doxorubicin induced cardiotoxicity in patients with breast cancer and receiving the Doxorubicin-Cyclophosphamide regimen : Double-blind randomized clinical trial | IRCT20211109053025N1 |
| The effect of melatonin on SSRIs-induced sexual dysfunction in depressed patients | Effectiveness of melatonin on sexual dysfunction caused by SSRIs in patients with depression | IRCT20211202053250N1 |
| Evaluation of the effect of melatonin on COVID 19 | Evaluation of the effect of melatonin in the treatment of patients with COVID19 compared ?with placebo. | IRCT20210411050925N1 |
| Evaluation of the effect of melatonin in preventing delirium in patients after neurosurgery | Evaluation of the effect of oral melatonin administration in preventing delirium in patients after neurosurgery | IRCT20211211053353N1 |
| Effects of a Novel Supplement on Sleep, Metabolism, Body Composition and Performance | Effects of a Novel Melatonin and Magnesium-Containing Pod on Sleep, Metabolism, Body Composition and Performance | NCT05236504 |
| Clinical Trial for the Evaluation of Melatonin in the Treatment of Pressure Ulcers | Clinical Trial for the Evaluation of Melatonin in the Treatment of Pressure Ulcers | NCT06421454 |
| Evaluation of the effect of melatonin(sleep-wake regulating hormone) premedication on preoperative anxiety, propofol(general anaesthetic) induction dosage, perioperative haemodynamics(blood pressure,heart rate) and quality of recovery : An exploratory study | Evaluation of the effect of melatonin premedication on preoperative anxiety, propofol induction dosage, perioperative haemodynamics and quality of recovery : An exploratory study | CTRI/2021/09/036209 |
| A bioavailability study of Melatonin oral solution in healthy adults | An open label one-treatment, one-period, one-sequence, single oral dose bioavailability study for Melatonin in healthy, adult, human subjects under fasting conditions. | EUCTR2020-005895-37-HR |
| Effectiveness Of High Dose Melatonin As Adjunctive Therapy For Dengue Fever With Warning Signs | Effectiveness Of High Dose Melatonin As Adjunctive Therapy For Pediatric Patients Diagnosed With Dengue Fever With Warning Signs: A Randomized Control Trial | NCT05034809 |
| The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation | The Effects of Acute Melatonin Supplementation on Cardiovascular Responses to Sympathetic Activation | NCT04831398 |
| Evaluation of The efficacy of topical Melatonin on healing of diabetic foot | Evaluation of The efficacy of topical Melatonin on healing of diabetic foot ulcers in a double blind placebo-controlled clinical trial | IRCT20200220046560N1 |
| COMPARISON OF ORAL MELATONIN AND CLONIDINE AS PREMEDICATION ON PERIOPERATIVE ANALGESIC REQUIREMENT IN LAPAROSCOPIC CHOLECYSTECTOMY. | COMPARATIVE EVALUATION OF ORAL MELATONIN AND ORAL CLONIDINE AS PREMEDICATION ON PERIOPERATIVE ANALGESIC REQUIREMENT IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY: PROSPECTIVE RANDOMISED DOUBLE BLIND STUDY | CTRI/2021/04/032786 |
| Clinical application of melatonin | Effect of melatonin on clinical outcome of patients with repeated cycles after failed cycles of in vitro fertilization and intracytoplasmic sperm injection | ChiCTR2100045552 |
| Effect of gum treatment on sleep disturbed patients | The Effect of Non Surgical Periodontal Therapy on the levels of Salivary Melatonin and NLRP3 in Chronic Periodontitis Patients with Altered Quality of Sleep | CTRI/2021/05/033330 |
| Treatment of Sleep Disturbance in Children With ASD | Comparing the Effectiveness of Physical Exercise and Melatonin Supplement in Treating Sleep Disturbance in Children With ASD: A RCT Study | NCT04878198 |
| Anti-proliferative Effects of Vitamin D and Melatonin in Breast Cancer | Anti-proliferative Effects of Vitamin D and Melatonin in Breast Cancer | NCT01965522 |
| Investigating the effect of melatonin on myocardial tissue when administered before cardiac surgery in adults. | A randomized controlled trial investigating the effect of pre-operative melatonin on the extend of ischemic-reperfusion injury in adult patients undergoing coronary artery bypass grafting (CABG) surgery. | ACTRN12621000543886 |
| Effects of oral melatonin on heart rate and blood pressure responses and sedation in patients undergoing surgeries under general anaesthesia | Effects of oral melatonin premedication on haemodynamic responses to intubation, intraoperative anaesthetic requirements and level of sedation in patients undergoing surgeries under general anaesthesia | CTRI/2021/05/033532 |
| Effect of sour cherry juice concentrate and Melatonin tablet on improving sleep disorders in children with ADHD | Comparative investigation of the effect of sour cherry juice (tart cherry) concentrate and Melatonin tablet on improving sleep disorders in children with Attention Deficit Hyperactivity Disorder | IRCT20101130005280N38 |
| The Effects of Melatonin in Sleep Disorders of Sarcoidosis Patients | Evaluating the Efficacy of Melatonin in Sleep Disorders of Sarcoidosis Patients | IRCT20151227025726N25 |
| The effect of melatonin on the side effects of methamphetamine | The Effect of Melatonin Supplementation on Mental Health, Stem Cells Mobilization and central nervous system function among Methamphetamine Users: Behavioral, Biochemical | IRCT20200521047533N1 |
| Emergence Agitation After Nasal Surgery: a Randomized Controlled Comparison Between Melatonin and Mirtazapine | Emergence Agitation After Nasal Surgery: a Randomized Controlled Comparison Between Melatonin and Mirtazapine | NCT04908605 |
| Comparison of effectiveness of Oleanzepine versus Melaton in for treatment of delirium in critically Ill patients | Comparison of melatonin vs olanzapine for treating delirium in critically ill patient | CTRI/2021/05/033908 |
| Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin | Sleep Management And Recovery After Traumatic Brain Injury in Kids (SMARTKids): Evidence for Targeting Sleep to Improve Outcomes | NCT04932096 |
| Comparison Of Pre Emptive Medication In Attenuation Of Pressor Changes To Laryngoscopy And Intubation In Abdominal Laproscopic Surgeries | Comparison of pre emptive medication of pregabalin, clonidine and melatonin in attenuation of pressor responses to laryngoscopy and intubation in abdominal laproscopic surgeries | CTRI/2021/06/033968 |
| Melatonin and Vaccine Response, Immunity, and Chronobiology Study | Melatonin and Vaccine Response, Immunity, and Chronobiology Study (MAVRICS): The Impact of Sleep, Circadian Health, and Melatonin on Vaccine Immunogenicity and Outcomes | NCT04953754 |
| Preparation & evaluation of Topical Rosuvastatin & Melatonin vs placebo in Patients with Mild to Moderate Plaque Psoriasis | Preparation & evaluation of Topical Rosuvastatin & Melatonin vs placebo in Patients with Mild to Moderate Plaque Psoriasis? A Randomized Double-blinded Clinical Trial | IRCT20190810044500N16 |
| Effect of melatonin in treatment of schizophrenia | Evaluating the effect of melatonin on positive and negative symptoms of schizophrenic patients admitted to psychiatry ward of Golestan hospital in 2021-2022 | IRCT20210528051416N1 |
| Comparison of Zolpidem and melatonin in postoperative pain control in intervertebral disc herniation surgery under general anesthesia | Comparison of Zolpidem and melatonin in postoperative pain control in intervertebral disc herniation surgery under general anesthesia | IRCT20141209020258N161 |
| Effectiveness Of Melatonin In Preventing Delirium In Critically Ill Patients | Effectiveness Of Melatonin In Preventing Delirium In Critically Ill Patients: A Comparison Between Two Different Doses. | CTRI/2021/06/034425 |
| The effect of melatonin on sleep disorders in children with cerebral palsy | The study of effectiveness of melatonin on sleep disorders in children with cerebral palsy (CP) | IRCT20191017045142N1 |
| Melatonin and Covid-19 | Study of therapeutic effect of melatonin in patients with COVID-19 : a double-blind randomized clinical trial | IRCT20210505051197N1 |
| Evaluation of the effect of melatonin in the treatment of patients with COVID-19 | Evaluation of the effect of melatonin on improving the symptoms of patients with COVID-19-double-blind randomized clinical trial | IRCT20150724023315N2 |
| A study of two drugs melatonin and diazepam given orally to compare anxiety and sedation experienced by the patients in preoperative period before undergoing general anesthesia. | Oral Melatonin and Oral Diazepam - A comparative study for anxiety and sedation in patients under general anaesthesia | CTRI/2021/07/035156 |
| A study on the effects of commonly used pre operative anxiety reducing medicines midazolam and melatonin on cognition and psychomotor function | A triple blinded randomised controlled trial on neurocognitive and psychomotor effects of melatonin versus midazolam when administered as preanaesthetic medication before surgery | CTRI/2021/07/035284 |
| To study the effect of two different doses of oral melatonin on post-operative cognitive dysfunction in elderly patients after surgery under regional anesthesia | A comparison of the effect of two different doses of oral melatonin on post-operative cognitive dysfunction in elderly patients after surgery under regional anaesthesia : A randomized controlled double blinded study | CTRI/2021/08/035467 |
| TKA Melatonin and Sleep Quality | Association Between Melatonin Use and Improved Sleep Quality After Total Knee Arthroplasty: A Randomized Control Trial | NCT05332717 |
| Efficacy Of Oral Melatonin To Prevent Necrotizing Enterocolitis | Efficacy Of Oral Melatonin To Prevent Necrotizing Enterocolitis Among Preterm Infants In A Tertiary Level Hospital In The Philippines: A Randomized Control Trial | NCT05033639 |
| Sleep Inducing for EEG Recording in Children: A Comparison between Triclofos, Melatonin, Promethazine and Hydroxyzine for sedation during EEG in Children | Efficacy and safety of Triclofos, Melatonin, Promethazine and Hydroxyzine for sedation during EEG in Children: A Comparative triple blind randomized control trial | CTRI/2019/04/018713 |
| Study the effect of Melatonin on physical recovery and sleep quality in elderly with ischemic stroke. | STUDY THE EFFECT OF MELATONIN ON PSYCHOLOGICAL AND PHYSICAL OUTCOME IN OLDER ADULTS WITH ACUTE ISCHEMIC STROKE | CTRI/2022/01/039619 |
| Effects of oral melatonin and gabapentin on tube placement in trachea for anaesthesia in patient posted for surgery | Effects of oral Melatonin and Gabapentin on Attenuation of Haemodynamic response to Tracheal intubation - A Prospective Randomized Double Blind Comparative Study. | CTRI/2019/04/018717 |
| Melatonin and DNA Damage Study | Melatonin Supplementation and Oxidative DNA Damage Repair Capacity Among Night Shift Workers: a Randomized Placebo-controlled Trial | NCT03945955 |
| Effect of melatonin supplement versus placebo on the severity of pain, sleep disorder, and quality of life in patients with painful diabetic neuropathy | Effect of melatonin supplement versus placebo on the severity of pain, sleep disorder, and quality of life in patients with painful diabetic neuropathy: a double-blind randomized clinical trial | IRCT20120215009014N299 |
| Effects of pulmonary rehabilitation-associated melatonin hormone on sensation of difficulty breathing, respiratory muscle strength, ability to perform daily living activities and sleep quality in individuals with chronic lung disease | Effects of pulmonary rehabilitation-associated melatonin on dyspnea, respiratory muscle strength, functional capacity, and sleep quality in individuals with chronic obstructive pulmonary disease - : | RBR-99gyq8 |
| Effect of dexmedetomidine combined with melatonin on postoperative sleep disturbance in patients undergoing laparoscopic hysterectomy | Effect of dexmedetomidine combined with melatonin on postoperative sleep disturbance in patients undergoing laparoscopic hysterectomy | ChiCTR1900026205 |
| Effect and mechanism of postoperative melatonin administration on postoperative sleep in patients undergoing laparoscopic total hysterectomy under general anesthesia | Effect and mechanism of postoperative melatonin administration on postoperative sleep in patients undergoing laparoscopic total hysterectomy under general anesthesia | ChiCTR1900026227 |
| Effect of Melatonin on arthralgia-myalgia of Paclitaxel | The effect of melatonin on incidence and severity of arthralgia-myalgia caused by weekly paclitaxel in patients with breast cancer | IRCT20190630044057N1 |
| The comparison of Memantine and Melatonin on memory | The comparison of memantine and melatonin in alleviation of cognitive impairment after ECT | IRCT20121021011192N8 |
| Does melatonin improve sleep and functioning in children with Fetal Alcohol Spectrum Disorder? A comparison with placebo. | Assessing the effect of melatonin on sleep behaviour and executive functioning in children with Fetal Alcohol Spectrum Disorder | ACTRN12619001360101 |
| Combined probiotic and melatonin supplementation in treatment of atopic dermatitis | The impact of combined probiotic and melatonin administration on disease severity and inflammatory markers in children with atopic dermatitis | IRCT20170513033941N64 |
| Endogenous Melatonin Levels on Anxiety in Living Liver Donors | The Role of Endogenous Melatonin Levels on Preoperative and Postoperative Anxiety in Living Liver Donors | NCT04230707 |
| Effect of sleep duration on performance-deficient, visually impaired athletes, physical performance, and hormones related to sleep, melatonin, and cortisol | Effect of sleep duration on high performance poor visually impaired athletes, on physical performance and hormonal responses | RBR-6rkz85 |
| Melatonin Effect in Combination With Neoadjuvant Chemotherapy to Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma | Effect of Melatonin in Combination With Neoadjuvant Chemotherapy to HIF-1?, CD44, CD133, and miR-210 Expression and Clinical Response in Locally Advanced Oral Squamous Cell Carcinoma (OSCC) | NCT04137627 |
| Evaluation the Effects of Melatonin on Amount of Opioids Intake | Evaluation the Effects of Melatonin versus Placebo on Amount of Opioids Intake in Patients Admitted to Intensive Care Unit | IRCT20190912044752N1 |
| Melatonin assessment on sleep and metabolism of overweight night workers | Effect of melatonin on sleep and metabolism of overweight night workers | RBR-6pncm9 |
| Melatonin for sleep disturbance in breast cancer patients | Phase II randomised control trial of melatonin versus placebo for the management of sleep disturbance in women with early stage breast cancer on adjuvant endocrine therapy | ACTRN12619001284156 |
| Effect of Melatonin in brain injury | Evaluation of the effect of melatonin on biomarkers of mitochondrial damage in patients with brain injury hospitalized in Alzahra hospital, Isfahan: A randomized placebo-controlled clinical trial | IRCT20081208001497N8 |
| Evaluation of The Effect of Melatonin in Thrombocytopenia | Evaluation of The Effect of Melatonin in Chemotherapy Induced Thrombocytopenia in Cancerous Patients | IRCT20080901001165N41 |
| Evaluation of the Cardio protective Effect of Melatonin in Acute Aluminum Phosphide Poisoning: A Randomized Clinical Trial | Evaluation of the Cardio protective Effect of Melatonin in Acute Aluminum Phosphide Poisoning: A Randomized Clinical Trial | PACTR201911790018554 |
| To know how many old people who are undergoing surgery for hip fracture have problem of awareness to surrounding and have confused thinking | Preoperative CSF Melatonin Concentrations and the Incidence of Delirium in Elderly Patients Undergoing Surgery for Hip Fracture; A Preliminary Study | CTRI/2019/11/021958 |
| A Randomised Controlled Trial of Treatment for Post-Concussion Clinical Insomnia in Children and Adolescents: The Effect of Melatonin Plus Sleep Hygiene Education Versus Education Alone | A Randomised Controlled Trial of Treatment for Post-Concussion Clinical Insomnia in Children and Adolescents: The Effect of Melatonin Plus Sleep Hygiene Education Versus Education Alone | ACTRN12619001585112 |
| Rivastigmine Patch Compared to Melatonin Patch in Prevention of Postoperative Delirium | Rivastigmine Patch (Exelon Patch) Compared to Melatonin Patch in Prevention of Postoperative Delirium in Elderly | NCT04189666 |
| The effects of melatonin supplementation in the treatment of rheumatoid arthritis | Study of the effects of melatonin supplementation on clinical status and metabolic profiles in patients with rheumatoid arthritis | IRCT20170513033941N67 |
| In this study we will see effects of melatonin tablets on S100B protein in delirium patients | """Effects of exogenous melatonin on inflammatory protein (S100B) of delirium and its clinical correlation- a case control study"" - DELSM" | CTRI/2019/12/022200 |
| Effect of melatonin on refractory seizure of children | Clinical trial of the effect of melatonin on children with refractory seizure | IRCT20090412001808N6 |
| The effect of melatonin in Ulcerative colitis | Evaluation of the effect of melatonin on clinical, biochemical parameters and quality of life in Ulcerative colitis patients | IRCT20121021011192N9 |
| Efficacy of the Administration of Melatonin 5mg in the Prevention of Delirium in Older Adults Hospitalized in the Emergency Department | Efficacy of the Administration of Melatonin 5mg in the Prevention of Delirium in Older Adults Hospitalized in the Emergency Department | NCT04187807 |
| Melatonin Supplementation as adjuvant Therapy for Prevention of Bronchopulmonary Dysplasia in Neonates | Melatonin Supplementation as adjuvant Therapy for Prevention of Bronchopulmonary Dysplasia in Neonates | TCTR20191211004 |
| Comparing the effects of Melatonin with Alprazolam to reduce anxiety before surgery and pain after surgery in adults undergoing laparoscopic removal of gall bladder under general anaesthesia | COMPARISON OF EFFECTS OF MELATONIN WITH ALPRAZOLAM ON PRE-OPERATIVE ANXIETY IN ADULT PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY UNDER GENERAL ANAESTHESIA | CTRI/2019/12/022358 |
| The effect of melatonin supplementation on migraine | The effect of melatonin supplementation on symptoms of headache and CGRP in women with migraine | IRCT20121216011763N40 |
| Effect of melatonin versus placebo on the sleep improvement and quality of life in patients with bipolar disorder in the manic phase | Effect of melatonin versus placebo on the sleep improvement and quality of life in patients with bipolar disorder in the manic phase: a double-blind randomized clinical trial | IRCT20120215009014N314 |
| Melatonin and magnesium in polycystic ovary syndrome | Investigating the Effect of melatonin and magnesium co-supplementation on metabolic, hormonal, inflammatory parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome | IRCT20191130045556N1 |
| Effect of melatonin versus placebo on serum levels of oxidative stress biomarkers and clinical outcomes in patients with septic shock | Effect of melatonin versus placebo on serum levels of oxidative stress biomarkers and clinical outcomes in patients with septic shock: a double-blind randomized clinical trial | IRCT20120215009014N296 |
| The Effect of Melatonin on Pneumatic Tourniquet Ischemia Reperfusion Injury in Lower Extremity Orthopedic Operation | Study of the Effect of Melatonin on Pneumatic Tourniquet Ischemia Reperfusion Injury in Lower Extremity Orthopedic Operation | IRCT20141009019470N87 |
| Use of Melatonin for Preventing POCD in Transurethral Prostate Resection Under Spinal Anesthesia | Use of Melatonin for Prevention of POCD After TURP Surgery Under Spinal Anesthesia for Elderly Patients | NCT03966950 |
| Disease Modifying Potential of 5mg of Melatonin on Cognition and Brain Health in Aging | Evaluating the Disease Modifying Potential of a Sleep Intervention on Alzheimer's Disease (AD) Biomarkers | NCT03954899 |
| The effects of melatonin supplementation on type 2 diabetes mellitus | The effects of melatonin supplementation on mean arterial pressure, pulse pressure, atherogenic index of plasma and new anthropometric index in type 2 diabetes mellitus patients | IRCT20190303042905N1 |
| The effect of Melatonin on Delirium Prevention | Comparing melatonin and placebo in prevention of postoprative delirium after orthopedic surgery under spinal anesthesia in the elderly. | IRCT20190419043320N1 |
| Oral Melatonin as Neuroprotectant in Preterm Infants | Oral Melatonin as Neuroprotectant in Preterm Infants .A Prospective, Double Blind vs Placebo, Parallel Arms Study | NCT04235673 |
| Total Joint Arthroplasty and Sleep | Postoperative Sleep Quality Following Total Joint Arthroplasty: A Prospective, Randomized, Controlled Trial of Diphenhydramine and Melatonin Versus Sleep Skills Training | NCT03968939 |
| Melatonin on Coronary Artery Calcification | Effects of Melatonin on Progression of Coronary Artery Calcification | NCT03966235 |
| Effects of melatonin supplementation in the treatment of fibrocystic breast disease | Effects of melatonin supplementation on clinical status and metabolic profiles in overweight or obese women with fibrocystic breast disease | IRCT20170513033941N59 |
| Melatonin for Prevention of Post Stroke Delirium | Melatonin for Prevention of Post Stroke Delirium | NCT04122599 |
| The effect of melatonin in patients with polycystic ovary syndrom | The effect of melatonin supplemention for ovarian stimulation cycles on sleep and mood and microinjection outcomes in patients with polycystic ovary syndrom | IRCT20160717028967N10 |
| Melatonin Supplementation in Mild Cognitive Impairment. | The effect of 3 months Melatonin supplementation on brain oxidative stress and sleep in mild cognitive impairment - A Randomised Placebo Controlled Pilot Study | ACTRN12619000876190 |
| Melatonin – production and release in children and adolescents with ADHD and chronic sleep problems | Melatonin – production and release in children and adolescents with ADHD and chronic sleep problems | EUCTR2019-000211-80-DK |
| The Effect of Melatonin on Postoperative Pain Reduction After Orthognathic Surgery | The Effect of Melatonin on Postoperative Pain Reduction After Orthognathic Surgery | NCT03995004 |
| The effect of melatonin on the severity of postoperative pain | Effect of preoperative sub-lingual melatonin on postoperative pain of patients undergoing colorectal surgery | IRCT20190811044506N1 |
| Effects of Selenium and Melatonin on Ocular Ischemic Syndrome | Determine the Effects of Selenium and Melatonin on Ocular Ischemic Syndrome | NCT04005222 |
| Comparative effect of Melatonin, Gabapentin and Dexmedetomidine on post-operative pain and anxiety in patients undergoing laminectomy | Comparative effect of Melatonin, Gabapentin and Dexmedetomidine on post-operative pain and anxiety in patients undergoing laminectomy | IRCT20141009019470N82 |
| calculation of anaesthesia dose required required for making patient unconscious following adinistration of tablet melatonin ninety minutes before surgery | Effect of Melatonin On Dose Response of Propofol Used During Induction Of General Anaesthesia Using Bispectral Index | CTRI/2019/07/019998 |
| Comparison of two oral precursors of melatonin and gabapentin in female candidates for cesarean section under spinal anesthesia | Comparison of two oral precursors of melatonin and gabapentin in female candidates for cesarean section under spinal anesthesia | IRCT20190120042432N1 |
| The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol | The Effect of Melatonin Administration on Sedation Level as Adjuvant to Propofol in Mechanically Ventilated Traumatic Brain Injury Patient: RCT | NCT04034771 |
| Melatonin for Sleep in MS | A Randomized, Crossover Pilot Trial of Melatonin for Sleep Disturbance in Adults With Multiple Sclerosis (MS) | NCT04035889 |
| Delirium after Cardiac Surgery | Effect of Melatonin on Delirium after Cardiac Surgery | IRCT20180909040979N3 |
| Perioperative melatonin level changes in postmenopausal women with general anesthesia and postoperative anxiety and the effect of melatonin on postoperative anxiety in perimenopausal women | Perioperative melatonin level changes in postmenopausal women with general anesthesia and postoperative anxiety and the effect of melatonin on postoperative anxiety in perimenopausal women | ChiCTR1900024906 |
| Melatonin in patients with Burning Mouth syndrome | Comparison of the Effectiveness Of Melatonin in patients with Burning Mouth syndrome | IRCT20141220020377N3 |
| Melatonin in patients with Atypical Facial Pain | Comparison of the Effectiveness Of Melatonin in patients with Atypical Facial Pain | IRCT20141220020377N4 |
| A Study to Investigate the Pharmacokinetics of Prolonged-release Melatonin Compared to Standard, Immediate-release Melatonin in Healthy Adults | A Randomized, Double-blind, Comparator-controlled, Cross-over Study to Investigate the Pharmacokinetics of Prolonged-release Melatonin Compared to Standard, Immediate-release Melatonin in Healthy Adults | NCT04067791 |
| The effect of oral melatonin on the clinical feature in patients with ischemic stroke | The effect of oral melatonin on the clinical feature in patients with ischemic stroke: a randomized clinical trial | IRCT20130424013110N7 |
| The effect of melatonin on pain after cesarean section | Evaluation of different doses of melatonin effect on post operation pain score in patients who underwent cesarean section with spinal anesthesia | IRCT20190627044040N1 |
| Use of Melatonin in the control of pain in face fractures | Use of melatonin as an analgesic adjuvant in face fractures | RBR-878g2j |
| A study to compare the effects of two drugs melatonin and midazolam given before surgery on behaviour after emerging from inhalation anaesthesia in children. | Comparison of effect of preoperative melatonin versus midazolam on emergence delirium in children: a double blind randomized placebo controlled study. | CTRI/2019/06/019850 |
| Melatonin and Osteogenic Loading on Osteopenia | Assessing the Efficacy of Melatonin and Osteogenic Loading on Bone Health in an Osteopenic Population: MelaOstrong Study | NCT04233112 |
| Effect of Melatonin on Coronary perfusion after primary percutaneous coronary intervention | Effect of Melatonin on Coronary perfusion after primary percutaneous coronary intervention | IRCT20191214045726N1 |
| A study to investigate if melatonin can improve sleep in hospital after abdominal surgery. | Melatonin to Improve Sleep in Patients Undergoing Major Abdominal Surgery:A Double-blind, Randomised Placebo-controlled Trial | ACTRN12620000031965 |
| Effect of Melatonin on prevention of delirium | Effect of Melatonin on the incidence of delirium in patients admitted to the intensive care unit: A randomized controlled clinical trial | IRCT20100816004578N8 |
| Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19 | A Pilot Placebo-controlled Randomized Double-blind Trial of Melatonin in Outpatients With COVID-19 Infection | NCT04474483 |
| Temazepam or Melatonin Versus Placebo for the Treatment of INsomnia in Advanced CAncer: A Three Arm, Double Blind, Phase III, Multicentre, Randomised Clinical Trial | Temazepam or Melatonin Versus Placebo for the Treatment of INsomnia in Advanced CAncer: A Three Arm, Double Blind, Phase III, Multicentre, Randomised Clinical Trial | ACTRN12620000581965 |
| Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID19 Patients | Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID19 Patients | NCT04409522 |
| To asses the role of drug therapy in disease of muscle dysfunction of children | The role of Metformin and Melatonin in Duchenne Muscular Dystrophy- A Randomized Control Trial | CTRI/2020/06/025541 |
| Melatonin for Huntington's Disease (HD) Gene Carriers With HD Related Sleep Disturbance - a Pilot Study | Melatonin for Huntington's Disease (HD) Gene Carriers With HD Related Sleep Disturbance - a Pilot Study | NCT04421339 |
| Melatonin Immune Boost COVID 19 Study | Melatonin For COVID 19 pre exposure prophylaxis in High Risk population . (MELATONIN IMMUNE BOOST COVID 19 STUDY ) | CTRI/2020/06/025613 |
| The Effect of Melatonin Application Following Removal of Impacted Third Molar | Local Melatonin Application Following Removal of an Impacted Mandibular Third Molar: A Randomized Controlled Clinical Trial | NCT04424875 |
| Clinical study to evaluate the effect of sublingual gel melatonin in healthy research participants | Monocentric phase I clinical study to assess the tolerability, safety and pharmacokinetics of sublingual melatonin gel in healthy research participants (PPES 003/19) | RBR-2vfqnz |
| A study comparing effects of two drugs ie., melatonin and midazolam which are given orally before surgery for relieving anxiety in children undergoing surgery | A comparitive study on effects of oral melatonin versus oral midazolam as premedicant in children undergoing surgery under general anesthesia | CTRI/2020/06/025698 |
| Improving sleep in Intensive Care | Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial. | ACTRN12620000661976 |
| Potential therapeutic effect induced by melatonin supplementation and combined physical activity on postural stability and biological responses in obese patients | Acute melatonin ingestion reduced muscle damage, inflammation and oxidative stress after an exhaustive exercise in obese patients. | PACTR202006677216503 |
| The effect of melatonin and N-acetyl cysteine on colistin-associated nephrotoxicity | Evaluation of the protective effect of melatonin and N-acetyl cysteine on colistin-induced nephrotoxicity in critically ill patients: A randomized, controlled clinical trial | IRCT20150221021159N3 |
| Melatonin for Cerebral Palsy Children's Sleep and Health | Effect of Melatonin Supplementation on Sleep and Health of Children With Cerebral Palsy | NCT04392063 |
| Sleep, Diabetic Retinopathy and Melatonin | Sleep and Circadian Regulation in Diabetic Retinopathy: the Role of Intrinsically Photosensitive Retinal Ganglion Cells and Melatonin Supplementation | NCT04547439 |
| In Vitro Fertilization | Evaluation of the Effect of Melatonin on In Vitro Fertilization (IVF) in Women with Poly Cystic Ovarian | IRCT20151123025202N11 |
| Sildenafil Citrate with melatonin and intrauterine growth restriction | Evaluation of the effect of Sildenafil Citrate with melatonin on intrauterine growth restriction | IRCT20160524028038N6 |
| PHASE II CLINICAL TRIAL, SINGLE-BLIND, RANDOMIZED, PLACEBO CONTROLLED TO EXPLORE THE EFFECTIVENESS AND SAFETY OF MELATONIN IN PATIENTS WITH COVID-19 ENTERED INTO THE INTENSIVE CARE UNIT | PHASE II CLINICAL TRIAL, SINGLE-BLIND, RANDOMIZED, PLACEBO CONTROLLED TO EXPLORE THE EFFECTIVENESS AND SAFETY OF MELATONIN I.V. IN PATIENTS WITH COVID-19 ENTERED INTO THE ICU (MELCOVID STUDY) - MELCOVID | EUCTR2020-001808-42-ES |
| Melatonin to Decrease the Incidence of Postoperative Delirium in Geriatric Patients | Efficacy of Prophylactic Melatonin to Decrease the Incidence of Postoperative Delirium in Geriatric Patients Undergoing Surgeries Under General Anesthesia. A Randomized Controlled Trial. | NCT04483596 |
| Evaluation of the effect of melatonin supplementation on vascular diseases in patients with diabetic nephropathy | Evaluation of the effect of melatonin supplementation on Carotid Intima-Media Thickness, pulse-wave velocity and serum levels of hs-CRP in patients with diabetic nephropathy | IRCT20200527047584N2 |
| Therapeutic effect of physical activity associated with melatonin or synbiotic consumption on biological, psycho-cognitive and physiological adaptations in multiple sclerosis patients | Effect of concurent training (strength and endurance) on biochemical and neurophysiological adaptations and physical and psycho-cognitive performance in people with multiple sclerosis: role of melatonin or synbiotics supplementation | PACTR202007465309582 |
| Kinetic of Melatonin Subsequent to the Consumption of Melatonin-rich Food Supplements | Randomized, Open-label Bioavailability Study of the Kinetics of Plasma, Urinary and Salivary Concentrations of Melatonin and 6-sulfatoxymelatonin Subsequent to the Consumption of Melatonin-rich Food Supplements With Different Galenic Forms | NCT04574141 |
| Effect of concurent training (strength and endurance) on biochemical and neurophysiological adaptations and physical and psycho-cognitive performance in people with multiple sclerosis: role of melatonin or synbiotics supplementation | Effect of Nocturnal Melatonin Ingestion on postural balance, risk of falling and functionnal mobility in patients with multiple sclerosis (MS) (1) and the effect of gender difference on postural stability and physical performances without the execution of a fatiguing task (study 2) and following performing a fatiguing task (study 3) in persons with MS | PACTR202007922243550 |
| The Effects of Melatonin Treatment on Bone, Marrow, Sleep and Blood Pressure | The Effects of Melatonin Treatment on Bone, Marrow, Sleep and Blood Pressure in Post Menopausal Women | NCT04864509 |
| Melatonin in COVID-19 | Evaluation of the efficacy and safety of Melatonin in patients with COVID-19: a randomized clinical trial | IRCT20200506047323N5 |
| Melatonin in rheumatoid arthritis | Survey the effect of melatonin supplementation on clinical symptoms and sleep quality in patients with rheumatoid arthritis | IRCT20191231045964N1 |
| Melatonin and Risk Of Cardiovascular Events And Malignant Tumors In The Elderly | The Intervention Effect Of Melatonin On The Risk Of Cardiovascular Events And Malignant Tumors In The Elderly: A Prospective, Randomized Parallel Controlled Study Based On Large Cohorts | NCT04631341 |
| Melatonin as add-on treatment for infantile spasms | Melatonin supplementation in the treatment of infantile spasms: a randomized placebo-controlled triple-blind trial | ChiCTR2000036208 |
| valuation the effect of melatonin in prevention of vancomycin induced nephrotoxicity | Evaluation the effect of melatonin in prevention of vancomycin induced nephrotoxicity in critically ill patients: A randomized controlled clinical trial | IRCT20150221021159N4 |
| Melatonin in prevention of cisplatin-induced acute nephrotoxicity | Melatonin in the prevention of cisplatin-induced acute nephrotoxicity in hospitalized cancer patients: a randomized ?clinical trial | IRCT20180722040556N4 |
| Evaluation of the efficacy of melatonin tablets as auxiliary medication in accelerating the improvement of the COVID-19 symptoms and clinical findings | Evaluation of the efficacy of melatonin tablets as auxiliary medication in accelerating the improvement of the COVID-19 symptoms and clinical findings: A double-blind randomized and placebo controlled trial | IRCT20200408046988N1 |
| Nocturnal Blood Pressure dipping re-establishment with Melatonin. | Role of Melatonin in re-establishment of nocturnal dip of blood pressure in patients with hypertension: a randomized controlled trial. - NBPD-M | CTRI/2020/04/024768 |
| The effect of melatonin on sleep quality of patients in the intensive care unit | The effect of oral melatonin on sleep quality of hospitalized patients in the intensive care unit | IRCT20191105045342N1 |
| Comparing safety and efficacy of melatonin, trazodone, and clonazepam on the sleep quality of patients with Parkinson's disease | Comparing safety and efficacy of melatonin, trazodone, and clonazepam on the sleep quality of patients with Parkinson's disease in patients referring to the Neurology Clinic of Roozbeh Hospital | IRCT20170821035819N2 |
| Melatonin for prevention of icu delirium | RANDOMISED CONTROLLED TRIAL OF MELATONIN AS PROPHYLAXIS FOR PREVENTION OF DELIRIUM IN ICU | CTRI/2020/01/023038 |
| Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia | Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia: A Randomized Placebo Controlled Study | NCT04251845 |
| Comparison of different methods to induce sleep in pediatric electroencephalogram recording | Comparison efficacy of melatonin versus combined melatonin and sleep deprivation versus combined chloral hydrate and sleep deprivation for sleep induction in pediatric patients’ EEG recording; A randomized controlled trial. | TCTR20200204002 |
| Effects of Melatonin supplementation and Physical Exercise practice on aged individuasl with Muscular Weakness | Effects of Melatonin supplementation on Sarcopenic aged individuals submitted to a Physical Exercise program | RBR-557ngk |
| A study to evaluate the effect of two doses of oral melatonin on anxiety and pain relief in patients undergoing lower limb surgeries. | A study to evaluate clinical impact of two doses of oral melatonin on preoperative anxiety and postoperative pain relief in patients undergoing orthopaedic surgeries | CTRI/2020/02/023330 |
| Melatonin in ADHD and Sleep Problems | Melatonin - Production and Release in Children and Adolescents With ADHD and Chronic Sleep Problems and Effects of Melatonin on Sleep | NCT04318067 |
| Comparison of the effect of Melatonin and Clonazepam on the REM sleep behavior disorder of patients with Parkinson's disease | Comparison of the effect of Melatonin and Clonazepam on the REM sleep behavior disorder of patients with Parkinson's disease, a double blind randomized trial | IRCT20170821035819N3 |
| Effect of Melatonin on autologous hematopoietic stem cells transplant success | Evaluation of the effect of Melatonin on the stem cells collection and engraftment in autologous hematopoietic stem cells transplant recipients | IRCT20100127003210N20 |
| Melatonin on Clock Genes in Parkinson's Disease | Effect of Melatonin Administration on the PER1 and BMAL1 Clock Genes in Patients With Parkinson's Disease | NCT04287543 |
| Comparison of Oral Melatonin and Oral Triclofos for use in sleep deprived sleep EEG in children | To compare the efficacy and safety of Melatonin and Triclofos as sedatives in children posted for sleep deprived drug induced sleep EEG: A double-blind, parallel design, randomized clinical trial | CTRI/2020/02/023592 |
| Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients | Melatonin for Prevention of Postoperative Delirium After Lower Limb Fracture Surgery in Elderly Patients: a Randomized Controlled Trial | NCT04335968 |
| Comparison the effect of melatonin plus propranolol and propranolol on the improvement of symptoms of migraine headache with sleep disorders in children | Comparison the effect of melatonin plus propranolol and propranolol on the improvement of symptoms of migraine headache with sleep disorders in children | IRCT20190619043946N1 |
| Melatonin Supplementation in Postmenopausal Women With H. Pylori-associated Dyspepsia | The Usefulness of Melatonin Supplementation in Postmenopausal Women With Helicobacter Pylori-associated Dyspepsia | NCT04352062 |
| Effect of Melatonin on Feeding Intolerance and Incidence of Necrotizing Enterocolitis in Preterm Infants | Effect of Melatonin on Feeding Intolerance and Incidence of Necrotizing Enterocolitis in Preterm Infants | NCT04304807 |
| The effects of Melatonin, Gabapentin and Dextromethorphan on post operative pain control in patients undergoing hip fracture surgery with general anesthesia | The effects of Melatonin, Gabapentin and Dextromethorphan on post operative pain control in patients undergoing hip fracture surgery with general anesthesia | IRCT20141209020258N136 |
| Effect of propranolol with melatonin on the clinical symptoms in children with migraine | Effect of propranolol with melatonin versus propranolol alone on the clinical symptoms in children with migraine without sleep disorder: a randomized clinical trial | IRCT20120215009014N345 |
| Renal Effects of Melatonin Trial in Chronic Kidney Disease | Renal Function in Chronic Kidney Disease and the Effect of Exogenous Melatonin Administration (REM TRIAL) | NCT04336566 |
| Efficacy of Melatonin Treatment of Nocturia : a randomized controlled study | Efficacy of Melatonin Treatment of Nocturia : a randomized controlled study | TCTR20200317007 |
| Melatonin and Salt on Blood Vessel Function | Melatonin and Salt on Blood Vessel Function | NCT04325191 |
| Melatonin supplementation as an adjuvant therapy in neonatal respiratory distress syndrome | Melatonin supplementation as an adjuvant therapy in neonatal respiratory distress syndrome | TCTR20200326001 |
| The effect of Melatonin on stress induced hyperglycemia | Evaluating the effect of Melatonin on stress induced hyperglycemia and insulin resistance in critically ill patients: a randomized double-blind clinical trial | IRCT20100107003014N23 |
| Evaluation of Melatonin Efficacy in Treatment of Respiratory Distress Syndrome and Prevention of Bronchopulmonary Dysplasia | Evaluation of Melatonin Efficacy in Treatment of Respiratory Distress Syndrome and Prevention of Bronchopulmonary Dysplasia | IRCT20190518043629N1 |
| A study on melatonin and Vitamin C and zinc efficacy in patients with COVID19 | A study on melatonin and Vitamin C and zinc efficacy in patients with COVID19 hospitalized in intensive care unit of Semnan Kowsar Hopsital | IRCT20151228025732N52 |
| Clinical trial to avoid infection by SARS-CoV-2 in high-risk population. COVID-19 | Randomized multicenter clinical trial to evaluate the efficacy of melatonin in the prophylaxis of SARS-CoV-2 infection in high-risk contacts. COVID-19 | EUCTR2020-001530-35-ES |
| Efficacy of Melatonin in the Prophylaxis of Coronavirus Disease 2019 (COVID-19) Among Healthcare Workers. | Multicenter Randomized Controlled Trial of the Efficacy of Melatonin in the Prophylaxis of SARS-coronavirus-2 Infection Among High Risk Contacts. | NCT04353128 |
| The effect of melatonin on the quality of sleep in COVID-19 patients | Evaluation of adding melatonin to routine treatment on outcomes and quality of sleep in COVID-19 patients | IRCT20200411047030N1 |
| Melatonin in the management of breast cancer patients | Melatonin in the management of menopausal complication, mood and sleep changes due to hormonal therapy in breast cancer patients | IRCT20180722040556N3 |
| Effect Evaluation of Melatonin in treatment of Polycystic Ovarian Syndrome | Comparing the Effect of Melatonin with Placebo in Combination with Medroxy Progesterone in Women with Polycystic Ovarian Syndrome | IRCT20200711048078N1 |
| Efficacy of the oral use of the drug melatonin in the treatment of facial melasma in women. | Efficacy of the use of oral melatonin in the treatment of facial melasma in women: a double-blind, randomized, placebo-controlled clinical trial. | RBR-10gx2qhj |
| Melatonin in PCOS | Investigating the effect of melatonin supplementation on plasma level of Visfatin and insulin sensitivity on women with polycystic ovarian syndrome | IRCT20210224050490N1 |
| Effect of Melatonin on Sleep Quality in Patients Dementia | A Randomized Placebo-controlled Trial Evaluating the Effect of Melatonin on Sleep Quality in Patients With Dementia | NCT03066518 |
| A randomised control study to know the efficacy of oral medications like melatonin, pregabalin and clonidine in controlling the blood pressure and heart rate during laryngoscopy and intubation in patients undergoing laparoscopic cholecystectomy. | A STUDY ON EFFICACY OF ORAL MELATONIN, PREGABALIN AND CLONIDINE IN ATTENUATING HEMODYNAMIC RESPONSE DURING LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION IN PATIENTS UNDERGOING LAPAROSCOPIC CHOLECYSTECTOMY UNDER GENERAL ANAESTHESIA, A RANDOMISED CONTROL TRIAL. | CTRI/2022/09/045635 |
| The effect of melatonin and cherry concentrate for preoperative anxiety in children | Evaluation of the effect of melatonin and cherry concentrate for preoperative anxiety in children : a randomized clinical trial | IRCT20220429054694N1 |
| MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children | MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children. The MELA-PAED Trial: a Randomized, Double-blind, Placebo-controlled Trial. | NCT05541276 |
| Investigating the sedative effect of Melatonin in Cataract surgery | Investigating the effect of oral Melatonin premedication on the quality of sedation and pain scale in Cataract surgery | IRCT20160307026950N45 |
| Effect of melatonin on opioids used in patients undergoing laparotomy | The effect of sublingual melatonin on the use of opioids used in patients undergoing laparotomy admitted to the ICU | IRCT20220807055631N1 |
| Comparison of effects of oral melatonin and alprazolam as preoperative medicine and their effects on post operative recovery in patients undergoing ear surgery | Comparative evaluation of effects of oral melatonin and oral alprazolam as premedication and their effects on post operative recovery characteristics in patients undergoing tympanoplasty | CTRI/2022/08/044912 |
| Oral comparative study of melatonin capsules | An Open Label Balanced Randomized Single Dose Two Treatment Two Sequence Two Period Two way Crossover Oral Comparative Pharmacokinetic Study Of Melotime Capsules (Melatonin SR Granules 11 Mg Equivalent To 5 Mg Melatonin) Manufactured By Nutriventia Limited, India With Melatonin Capsules 5 Mg Manufactured By Huanggang Saikang Pharmaceutical Co., Ltd, China In Healthy, Adult Human Subjects under Fasting Conditions. - Nil | CTRI/2022/08/044837 |
| The effect of melatonin on sleep disturbances of hemodialysis patients. | The effect of melatonin on sleep disturbances of hemodialysis patients. | IRCT201108077253N1 |
| Comparison of oral Midazolam, Clonidin and Melatonin with Chloral hydrate for recording sleep EEG in children | Comparison of oral Midazolam, Clonidin and Melatonin with Chloral hydrate for recording sleep EEG in children | IRCT201106286907N1 |
| Therapeutic effect of one session of physical activity combined with melatonin supplementation after myocardial infarction | Acute effect of one session of physical activity combined with nocturnal ingestion of melatonin on cardiovascular adaptations and sleep quality after myocardial infarction treated by primary percutaneous coronary intervention | PACTR202208826495102 |
| Evaluating the effectiveness of locally applied melatonin gel in the treatment of advanced gum disease. | Melatonin, as a locally delivered drug in the treatment of periodontal infra bony defects - A randomized controlled trial. | CTRI/2022/08/044750 |
| The effect of melatonin in the prevention of retinopathy of prematurity | The effect of melatonin in the prevention of retinopathy of prematurity in preterm neonates | IRCT20211226053528N2 |
| The Melatonin Adjunct in the Acute myocaRdial Infarction Treated With Angioplasty | Randomized, Double-blind, Parallel-group, Placebo-controlled Study of Melatonin as an Adjunct in Patients With Acute myocaRdial Infarction Undergoing Primary Angioplasty | NCT00640094 |
| Is melatonin useful in patients whom underwent coronary angiography. | Assessing the effects of melatonin on blood pressure and heart rate in patients undergoing elective coronary angiography? | IRCT201012105359N1 |
| The relative bio-availability of oral and oromucosal melatonin in different formulations in healthy human volunteers - a three-phased cross-over study. | The relative bio-availability of oral and oromucosal melatonin in different formulations in healthy human volunteers - a three-phased cross-over study. - MELAFORM | NL-OMON37529 |
| Melatonin and oral midazolam in sedation for electroencephalography of children | Comparison of efficacy of melatonin and oral midazolam in sedation for electroencephalography of children | IRCT201107182639N5 |
| Efficacy of Melatonin for Sleep Disturbance Following Acquired Brain Injury | Efficacy of Melatonin for Sleep Disturbance Following Acquired Brain Injury | ACTRN12611000734965 |
| The effect of melatonin on post-appendectomy pain | The effect of melatonin versus placebo on post-appendectomy pain | IRCT20220507054763N1 |
| Comparing Treatment With Melatonin to Treatment With Stimulants (Methylphenidate) in Children With Attention Deficit Hyperactivity Disorder and Sleep Difficulties | Comparing Treatment With Melatonin to Treatment With Stimulants (Methylphenidate) in Children With Attention Deficit Hyperactivity Disorder and Sleep Difficulties | NCT01393574 |
| Melatonin Treatment for Tardive Dyskinesia in Schizophrenia | The Effect of Melatonin Treatment on Tardive Dyskinesia and Oxidative Stress: A Double-Blind Placebo-Controlled Trial | NCT01391390 |
| The effect of melatonin or ramelteon for patients with circadian rhythm sleep disorder. | The effect of melatonin or ramelteon for patients with circadian rhythm sleep disorder. - The effect of melatonin or ramelteon for patients with circadian rhythm sleep disorder. | JPRN-UMIN000005744 |
| Melatonin As A Novel Neuroprotectant In Preterm Infants-Trial Study - MINT- Melatonin Neuroprotection Trial Study -Ver 1 | Melatonin As A Novel Neuroprotectant In Preterm Infants-Trial Study - MINT- Melatonin Neuroprotection Trial Study -Ver 1 | EUCTR2008-004740-36-GB |
| The effects of melatonin versus placebo on post-operative delirium (POD) in hip fracture patients – a randomized double-blind trial | The effects of melatonin versus placebo on post-operative delirium (POD) in hip fracture patients – a randomized double-blind trial | NL-OMON23033 |
| The effects of melatonin on anxiety and pain scores of patients, intraocular pressure and operating conditions during cataract surgery under topical anesthesia | The effects of melatonin on anxiety and pain scores of patients, intraocular pressure and operating conditions during cataract surgery under topical anesthesia | IRCT201102223051N3 |
| An assessment of effects of melatonin on metabolic effects of olanzapine in patients with schizophrenia | An assessment of effects of melatonin on metabolic effects of olanzapine in patients with schizophrenia | IRCT201107187049N1 |
| Melatonin Therapy in Heart Failure | Melatonin therapy may improve left ventricular function in heart failure patients: A clinical, double blind, placebo controlled trial | IRCT201109147560N1 |
| Melatonin Impact on the Outcomes of Myocardial Ischemia/Reperfusion Injury During Coronary Artery Bypass Grafting Surgery | The Effect of Melatonin on the Outcomes of Myocardial Ischemia/Reperfusion Injury During Coronary Artery Bypass Grafting Surgery | NCT05552586 |
| Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone | Premedication With Melatonin and Alprazolam Combination Versus Alprazolam or Melatonin Alone: a Randomized, Double Blind Placebo Controlled Study | NCT01486615 |
| MELatonin for children with idiopathic chronic sleep onset insomnia, with or without attention deficit hyperkinesia disorder - a DOSe finding trial: a randomised placebo-controlled double-blind parallel group trial | ISRCTN20033346 | |
| Melatonin Effects in Ritalin Treated Children with Attention Deficit Hyperactivity Disorder | Melatonin Effects on Sleep Patterns, Symptoms of Hyperactivity and Attention Deficiency in Ritalin Treated Children with Attention Deficit Hyperactivity Disorder: A Randomized Double Blind Clinical Trial | IRCT201203167462N4 |
| Melatonin as Adjuvant Therapy in Breast Cancer Patients | Melatonin in Improving the Quality of Life of Breast Cancer Patients and Reduction of Postoperative Pain and Chemotherapy Induced Toxicity | NCT01557478 |
| Comparison of melatonin and midazolam on preoperative anxiety and intraoperative hemodynamic disorders in cataract surgery patients | Comparison of melatonin and midazolam on preoperative anxiety and intraoperative hemodynamic disorders in patients candidates for cataract surgery | IRCT20190618043934N15 |
| Oral Melatonin in Critically Ill High-risk Patients | Randomized, Controlled, Double Blind Trial to Evaluate Sedation and Quality of Life in High-risk, Critically Ill Patients Treated With Oral Melatonin | NCT00470821 |
| Melatonin Postoperative Sleep Study in Breast Cancer Patients | Melatonin Postoperative Sleep Study in Breast Cancer Patients | NCT00506064 |
| Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine | Melatonin Metabolism Abnormality in Patients With Schizophrenia or Schizoaffective Disorder Treated With Olanzapine and Melatonin Dose Finding for the Correction of the Metabolic Abnormality | NCT00512070 |
| Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients | A Randomized Clinical Trial of Melatonin Versus Placebo and the Effect on Appetite in Advanced Cancer Patients | NCT00513357 |
| The Effect of Melatonin on Cognitive Function in Patients Diagnosed With Mild Cognitive Impairment | The Effect of Melatonin on Memory and Other Cognitive Function in Patients Diagnosed With Mild Cognitive Impairment (MCI): A Placebo- Controlled Study. | NCT00544791 |
| Melatonin Replacement Therapy in Pinealectomized Patients | Melatonin Replacement Therapy Effects on Cardiac Autonomic Activity in Pinealectomized Patients | NCT03885258 |
| SThe Effects of Melatonin on GERD Symptoms | The Effects of Melatonin on GERD Symptoms and Esophageal Acid Exposure | NCT00564590 |
| Comparison of clonidine and melatonin for treating insomnia in children 6 to12 years old with anxiety disorders | Comparison of clonidine and melatonin for treating insomnia in children 6 to12 years old with anxiety disorder | IRCT20220820055756N1 |
| The effect of Melatonin-fentanyl and Midazolam-fentanyl on pain and anxiety in cataract surgery | Comparing the effectiveness of preoperative injection of Melatonin-Fentanyl and Midazolam-Fentanyl on the amount of anxiety and pain in Cataract surgery under local anesthesia | IRCT20160307026950N41 |
| Melatonin As A Novel Neuroprotectant in Preterm Infants- Dosage study - MIND-Melatonin Neuroprotection Dosage Study | Melatonin As A Novel Neuroprotectant in Preterm Infants- Dosage study - MIND-Melatonin Neuroprotection Dosage Study | EUCTR2007-007156-33-GB |
| Role of Melatonin Supplementation in Follicular Fluid of in Vitro Fertilization (IVF) Patients With Polycystic Ovarian Syndrome | NCT01540747 | |
| Hererditary effects of melatonin treatmen on glucose toleranse | Does melatonin (CircadinR) worsen glucose tolerance in individuals with at (rs10830963) variant in the melatonin receptor 1B (MTNR1B) gene? | EUCTR2011-005360-22-FI |
| Efficacy of melatonin for postoperative pain relief and reduced blood loss after cesarean section | Evaluation of melatonin's effect on pain and blood loss after cesarean section | ACTRN12612000117819 |
| Platelet Rich Fibrin Versus Melatonin Around Dental Implants | Evaluation of Local Delivered Platelet Rich Fibrin Versus Melatonin Gel on the Osseointegration of Dental Implant. A Randomized Controlled Clinical Trial | NCT05593731 |
| Role of Ashwagandha and Melatonin on patients with Insomnia | Comparative Evaluation of Ashwagandha Standardized Extract and Melatonin on Sleep in Subjects Having Insomnia: A Prospective, Randomized, Double-Dummy, Double-Blind, Placebo-Controlled Study | CTRI/2022/10/046179 |
| Study of Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery | Effects of Perioperative Melatonin on Sleep, Pain, and Confusion After Joint Replacement Surgery | NCT01505465 |
| Effect of melatonin on subjective sleep quality in patients with chronic obstructive pulmonary disease | Effect of melatonin on subjective sleep quality in patients with chronic obstructive pulmonary disease | IRCT201110237872N1 |
| Effect of Melatonin in Pediatric Hemodialysis Patients | Effect Of Melatonin On The Clinical Outcome In Pediatric Hemodialysis Patients | NCT05570526 |
| Before prostate surgery give melatonin tablet to prevent loss in thinking and sensing ability in old patients | Exogenous Melatonin to prevent early postoperative Cognitive Dysfunctionin in elderly undergoing Transurethral Resection of Prostate Surgeries:A Randomised Controlled Trial. - RCT | CTRI/2022/09/045988 |
| The effect of melatonin on bedwetting | The effect of melatonin on nocturnal enuresis | EUCTR2011-004138-33-DK |
| Melatonin and gabapentin in pain of lumbar puncture in children | Comparison of efficacy of melatonin and gabapentin in reducing of pain and anxiety of lumbar puncture in children | IRCT201112032639N7 |
| Melatonin Levels in Preterm and Term Newborn Infants | Melatonin Levels in Preterm and Term Newborn Infants | NCT01340417 |
| Kan melatonin gøre det nemmere for patienter med skizofreni at trappe ud af langvarig benzodiazepinbehandling? | Melatonin vs. placebo til nedtrapning af benzodiazepiner hos patienter med skizofreni: et randomiseret klinisk forsøg (SMART) - SMART | EUCTR2010-024065-46-DK |
| The effect of melatonin on depression, anxiety, cogntive function and sleep disturbances in breast cancer patients - MELODY | The effect of melatonin on depression, anxiety, cogntive function and sleep disturbances in breast cancer patients - MELODY | EUCTR2010-022460-12-DK |
| Adjuvant Melatonin for Prevention of Lung Cancer Recurrence and Mortality | Adjuvant Melatonin for Prevention of Lung Cancer Recurrence and Mortality: A Randomized Placebo Controlled Clinical Trial | NCT00668707 |
| The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease | The Potential Therapeutic Effect of Melatonin in Gastro-Esophageal Reflux Disease | NCT00915616 |
| Melatonin for Circadian Sleep Disorders in the Blind | Melatonin for Circadian Sleep Disorders in the Blind | NCT00911053 |
| Melatonin Supplementation for Delirium Prevention in Acutely Hospitalized Elderly | Melatonin Supplementation for Delirium Prevention in Acutely Hospitalized Elderly: a Randomized, Double Blind, Placebo-Controlled Trial | NCT00873379 |
| Melatonin Supplementation to Improve Sleep in Patients With Heart Failure | Restoration of Sleep in Heart Failure Patients | NCT00869869 |
| Efficacy of prolonged-release melatonin versus placebo in a three-week treatment of diabetic patients suffering from insomnia | A randomised double-blind, crossover study comparing the efficacy of prolonged-release melatonin versus placebo in a three-week treatment of diabetic patients suffering from insomnia | ISRCTN55944464 |
| The Efficacy of Oral Melatonin Attenuating Renal Ischaemia-Reperfusion Injury in Abdominal Aortic Aneurysm Surgery: A Randomized Controlled Trial | The Efficacy of Oral Melatonin Attenuating Renal Ischaemia-Reperfusion Injury in Abdominal Aortic Aneurysm Surgery: A Randomized Controlled Trial | TCTR20220720006 |
| Melatonin for Migraine Prevention | Melatonin for Migraine Prevention (The MMP-study): A Randomized, Double-blind, Cross-over, Placebo-controlled Study of Melatonin in Prophylactic Treatment of Migraine | NCT00849511 |
| The effects of melatonin in the treatment of delirium-a double blind, randomized, placebo-controlled trial. | The effects of melatonin in the treatment of delirium-a double blind, randomized, placebo-controlled trial. | NL-OMON21861 |
| Melatonin for træthed og andre symptomer hos patienter med fremskreden kræft | Melatonin for træthed og andre symptomer hos patienter med fremskreden kræft | EUCTR2008-008377-56-DK |
| Randomized Controlled Trial on the Treatment Effects of Melatonin and Light Therapy on Delayed Sleep Phase Syndrome | Delayed Sleep Phase Syndrome in Adolescents and Young Adults. Sleep, Personality, Developmental History, Circadian Rhythm, Daytime Functioning and Treatment | NCT00834886 |
| MAPLE A(Melatonin Against PLacebo in Elderly patients). | The Effects of melatonin versus placebo on the occurence of delirium in hip fracture patients - a randomized, placebo controlled, double-blind trial. | NL-OMON22152 |
| Melatonin Studies of Totally Blind Children | Melatonin Studies in Young Blind Children and Adolescents | NCT00795236 |
| Melatonin and Ulcerative Colitis: A Pilot Clinical Trial | Melatonin and Ulcerative Colitis: A Pilot Clinical Trial | NCT00790478 |
| Controlled-release melatonin in fast withdrawal of temazepam, zopiclone or zolpidem in elderly persons with insomnia - Satauni | Controlled-release melatonin in fast withdrawal of temazepam, zopiclone or zolpidem in elderly persons with insomnia - Satauni | EUCTR2008-006795-30-FI |
| Randomised, double-blind, 3-way crossover, single dose, placebo-controlled study investigating the effect on postural instability of melatonin and zolpidem in healthy elderly subjects | Randomised, double-blind, 3-way crossover, single dose, placebo-controlled study investigating the effect on postural instability of melatonin and zolpidem in healthy elderly subjects | EUCTR2008-002164-34-DE |
| Melatonin In Acute Mania Investigation (MIAMI-uk) | Melatonin In Acute Mania Investigation (MIAMI-uk): a randomised controlled phase 2 trial | ISRCTN28988273 |
| Sleep disruption in quadriplegia – A pilot study exploring whether 3mg melatonin induces sleep | Pilot study examining whether daily administration of 3mg melatonin alters sleep architecture in complete quadriplegia | ACTRN12608000504314 |
| Blind Adult Melatonin Treatment Study | Melatonin for Circadian Sleep Disorders in the Blind | NCT00686907 |
| The effects of melatonin the occurence of on post-operative delirium in hip fracture patients a randomized, double-blind, placebo controlled trial | The effects of melatonin the occurence of on post-operative delirium in hip fracture patients a randomized, double-blind, placebo controlled trial - MAPLE A | NL-OMON31932 |
| Efficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD) | A Double-Blind, Placebo-Controlled Study of a Combination Product (BCI-024 and BCI-049) in Patients With Major Depressive Disorder (MDD) | NCT00705003 |
| Melatonin treatment for sleep problems in children with autism: a randomised controlled crossover trial | ISRCTN77884120 | |
| The efficacy and safety of a topical facial day serum containing L-ascorbic acid and ultraglycans in combination with a topical night serum formulated with melatonin to improve skin elasticity: a pilot study | The efficacy and safety of a topical facial day serum containing L-ascorbic acid and ultraglycans in combination with a topical night serum formulated with melatonin to improve skin elasticity: a pilot study | TCTR20220719004 |
| Blind Child Melatonin Treatment Study | Melatonin Studies of Blind Children | NCT00691444 |
| Blind Elderly Melatonin Treatment Study | Melatonin Entrainment of Elderly Blind Free-runners | NCT00692094 |
| Melatonin Versus Hydroxizin for Pre Operative Anxiety in Elderly Patients With Hip Fracture | Melatonin Versus Hydroxizin for Pre Operative Anxiety in Elderly Patients With Hip Fracture | NCT05224167 |
| Melatonin for Fatigue and Other Symptoms in Patients With Advanced Cancer | Melatonin for Fatigue and Other Symptoms in Patients With Advanced Cancer | NCT00925899 |
| Pilot study of the safety and tolerance of preoperative melatonin application in patients undergoing major liver resection. - PORTAL | Pilot study of the safety and tolerance of preoperative melatonin application in patients undergoing major liver resection. - PORTAL | EUCTR2006-005308-15-DE |
| Melatonin for Sleep in Children With Autism | Melatonin for Sleep in Children With Autism: Safety Tolerability and Dose | NCT00927030 |
| Melatonin Treatment for Induced Transient Insomnia | Efficacy of Melatonin Treatment in a Phase Advance Model of Transient Insomnia | NCT00950885 |
| Sleep and melatonin secretion in women with severe premenstrual disorder | Sleep and melatonin across the menstrual cycle in women with premenstrual dysphoric disorder (PMDD) | ISRCTN96702191 |
| Melatonin in Relapsing-Remitting Multiple Sclerosis Patients | Effects of Melatonin on Clinical and Neuroimaging Indices of Relapsing-Remitting Multiple Sclerosis Patients | NCT01279876 |
| Ovarian Stimulation: Inositol and Melatonin | Improving Oocyte Retrieval Using a Combined Therapy of Recombinant Follicle Stimulating Hormone (rFSH) and Inositol and Melatonin | NCT01267604 |
| Therapeutic effect of early cardiac rehabilitation combined with melatonin supplementation after acute myocardial infarction treated by primary percutaneous coronary intervention during hospitalization. | Effect of cardiac rehabilitation combined with melatonin supplementation on functional capacity and sleep quality in patients with acute myocardial infarction treated by primary percutaneous coronary intervention during hospitalization. | PACTR202208654400090 |
| Treatment with melatonin to patients with heart infarction. | Intracoronary administration of melatonin for patients with acute myocardial infarction: a placebo controlled randomized study. - IMPACT | EUCTR2010-022400-53-DK |
| Postoperative Melatonin Administration and Delirium Prevention in Patients Undergoing Vascular and Cardiac Surgery | Postoperative Melatonin Administration and Delirium Prevention in Patients Undergoing Vascular and Cardiac Surgery | NCT01198938 |
| Evaluation of Anxiolysis and Pain Associated with Retrobulbar Eye Block for Cataract Surgery : Melatonin versus Gabapentin ( A randomized, double-blind, placebo-controlled study) | Evaluation of Anxiolysis and Pain Associated with Retrobulbar Eye Block for Cataract Surgery : Melatonin versus Gabapentin (A randomized, double-blind, placebo-controlled study) | ACTRN12610000727044 |
| The Effect of Melatonin on Ischemia-reperfusion Injury Following Acute Myocardial Infarction | Intracoronary Injection of Melatonin for Patients With ST-elevation Myocardial Infarction: a Placebo Controlled Randomized Study | NCT01172171 |
| Trial of Melatonin to Improve Sleep in Children With Epilepsy and Neurodevelopmental Disabilities | A Randomized Controlled Trial Pilot Project to Evaluate the Efficacy of Melatonin in Children With Insomnia, Intractable Epilepsy and Neurodevelopmental Disabilities | NCT01161108 |
| Therapeutic effect of early cardiac rehabilitation combined with melatonin supplementation after acute myocardial infarction treated by primary percutaneous coronary intervention. | Chronic effect of early cardiac rehabilitation combined with melatonin supplementation on myocardial function, aerobic capacity, endothelial function, oxidative stress, autonomic cardiac function and sleep quality in patients with acute myocardial infarction treated by primary percutaneous coronary intervention. | PACTR202208834230748 |
| Melatonin Osteoporosis Prevention Study | Assessing the Efficacy of Melatonin on Bone Health in Peri-menopausal Women | NCT01152580 |
| Perioperative Melatonin in Lumbar Laminectomy | Perioperative Analgesic and Anxiolytic Effect of Melatonin in Patients Undergoing Lumbar Laminectomy | NCT01126294 |
| Study With Amitriptylin to Evaluate the Efficacy of Melatonin in Treatment of Migraine | Double Blind Randomized Study Controlled by Placebo and Amitriptylin to Evaluate the Efficacy of Melatonin in the Preventive Treatment of Migraine | NCT01357031 |
| Effects of Melatonin and Oxygen Consumption and Choroidal Blood Flow | Effects of Melatonin on Oxygen Consumption and Choroidal Blood Flow in Women With Vasospastic Syndrome in Comparison to Controls | NCT00675181 |
| Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study | Melatonin and Nighttime Blood Pressure in African Americans--24 mg Study | NCT01114373 |
| Melatonin and Nighttime Blood Pressure in African Americans-8 mg Study | Melatonin and Nighttime Blood Pressure in African Americans- 8 mg Study | NCT01114360 |
| Myo-inositol and Melatonin in Pre-menopausal Women | Myo-inositol and Melatonin in Menopausal Transition. A Prospective, Randomized Trial | NCT01115127 |
| follow up of Effects of Melatonin on Fatigue Associated associated with radiotherapy and chemotherapy | Two-year follow up of a Randomized, Controlled Trial: the Effects of Melatonin on Fatigue Associated with Breast Cancer and Its Adjuvant Treatments | IRCT20180426039421N3 |
| Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia | Antiinflammatoric and Antioxidative Effect of Melatonin in Human Endotoxaemia | NCT01087359 |
| Exogenous Melatonin to Improve Sleep in Critically Ill Patients | The effect of exogenous melatonin versus placebo on sleep improvement in tracheostomised Intensive Care Unit (ICU) patients. | ACTRN12610000008022 |
| Melatonin and the Metabolic Syndrome | Melatonin Supplementation and the Metabolic Syndrome: A Phase II Crossover Design Clinical Trial | NCT01038921 |
| Delayed sleep phase in adolescents - effects of melatonin treatment | Delayed sleep phase in adolescents - effects of melatonin treatment | EUCTR2009-017075-24-SE |
| Pilot Study of Melatonin and Epilepsy | Melatonin and Sleep in Patients With Epilepsy | NCT00965575 |
| Adjuvant Melatonin for Uveal Melanoma | Adjuvant Melatonin for Uveal Melanoma: A Randomized Open Phase III Study | NCT05502900 |
| Sleep disruption in quadriplegia, its hormonal basis and a randomized controlled trial (RCT) of melatonin supplementation | Study examining whether daily administration of 3mg melatonin alters subjective sleep experience and sleep architecture in people with complete quadriplegia | ACTRN12609000714280 |
| Study to Investigate the Effects of Melatonin, Temazepam & Zolpidem on Sleep EEG in Men and Women | A Randomised, Double-Blind, Placebo-Controlled Four-Way Cross-Over Trial to Study the Effects of Prolonged-Release Melatonin, Temazepam and Zolpidem on the Spectral Composition of the EEG During Nocturnal Sleep in Healthy Middle-Aged Men and Women | NCT00940550 |
| Impact of melatonin in the pretreatment of organ donor and the influence in the evolution of liver transplant: a prospective, randomised double-blind study. | Impact of melatonin in the pretreatment of organ donor and the influence in the evolution of liver transplant: a prospective, randomised double-blind study. | EUCTR2011-000991-33-ES |
| The use of melatonin in children with neuro-developmental disorders and impaired sleep; a randomised, double-blind, placebo-controlled, parallel study | The use of MElatonin in children with Neuro-developmental Disorders and impaired Sleep; a randomised, double-blind, placebo-controlled, parallel study | ISRCTN05534585 |
| The Efficacy of Melatonin in Sleep Problems of Hemodialysis and Peritoneal Dialysis Patients | The Efficacy of Melatonin in Sleep Problems of Hemodialysis and Peritoneal Dialysis Patients | NCT00404456 |
| Effect of Sedation on sleep EEG recording | Effect of Triclofos versus Melatonin on sleep EEG recording- A Prospective Randomised Controlled study | CTRI/2022/04/041952 |
| Effect of melatonin on pain intensity after lumbar disc surgery | Effect of preoperative melatonin on pain intensity after lumbar disc surgery | IRCT201701304365N20 |
| A clinical trial of melatonin for the study of abdominal surgery patients with sepsis may develop multiorgan failure. | Prevention MODS by modulating the inflammatory response throughmelatonin administration in surgical patients with severe sepsis. | EUCTR2008-006782-83-ES |
| The investigation of the Effect of Melatonin Supplement on Dermatitis | The investigation of the effect of Melatonin Supplement on Dermatitis Severity in Patients: a randomized, double-blinded, placebo-controlled clinical trial | IRCT20220331054378N1 |
| Testing Effects of Melatonin on Uterine Contractions in Women | Testing Effects of Melatonin on Uterine Contractions in Women | NCT05358834 |
| Clinical trial of melatonin for the treatment of neuropathic pain | Melatonin for neuropathic pain | ISRCTN16215617 |
| The effect of dexmedetomedine and melatonin on delirium | Comparison of dexmedetomidine injection alone or with the addition of oral melatonin on the incidence of delirium after coronary artery bypass graft surgery | IRCT20180909040979N7 |
| Phase I Dose Finding Study for Melatonin in Pediatric Oncology Patients With Relapsed Solid Tumors | Phase I Dose Finding Study for Melatonin in Pediatric Oncology Patients With Relapsed Solid Tumors | NCT01858155 |
| A pilot study of antenatal maternally administered melatonin to decrease the level of oxidative stress in human pregnancies affected by preeclampsia (PAMPR Trial). | A pilot study of antenatal maternally administered melatonin in human pregnancies affected by preterm preeclampsia to prolong pregnancy. | ACTRN12613000476730 |
| The sun protective effect of melatonin: a study on healthy volunteers. | The sun protective effect of melatonin: a randomized, placebo-controlled, double-blinded study on healthy volunteers. - The sun protective effect of melatonin | EUCTR2013-000629-30-DK |
| Effect of melatonin in post operative sleep disorder (POSD), and cardiac biomarckers after coronary artery bypass graft (CABG) | Effect of melatonin in post operative sleep disorder (POSD) acccording to their Pittsburg sleep quallity index , and cardiac enzymes after coronary artery bypass graft (CABG) | IRCT201303148698N11 |
| The analgesic effects of melatonin. A study on healthy volunteers | The analgesic effects of melatonin: A randomized, placebo-controlled, double-blinded study on healthy volunteers - The analgesic effects of melatonin | EUCTR2013-000205-23-DK |
| Comparison of sleep quality and anxiety after acute myocardial infarction | Comparing effects of oxazepam with melatonin on sleep quality and anxiety in hospitalized patients after acute myocardial infarction | IRCT201206277202N6 |
| Comparison of two different doses of oral Melatonin in patients undergoing lower limb Orthopaedic surgeries to check anxiety before and after surgery and pain after surgery | To compare two doses of oral melatonin as premedicant in patients undergoing orthopaedic surgeries. | CTRI/2022/05/042801 |
| Melatonin Versus Placebo in Breast Cancer | A Randomized Trial of Oral Melatonin Supplementation in Breast Cancer Survivors | NCT01805089 |
| Metabolic Effects of Melatonin in Patients Treated With Second Generation Antipsychotics | Metabolic Effects of Melatonin in Patients Treated With Second Generation Antipsychotics | NCT01811160 |
| Melatonin Dose-effect Relation in Childhood Autism | Melatonin Dose-effect Relation in Childhood Autism | NCT01780883 |
| The effect of melatonin receptor agonist on patients with atopic dermatitis | The effect of melatonin receptor agonist on patients with atopic dermatitis - The effect of melatonin receptor agonist on atopic dermatitis | JPRN-UMIN000009707 |
| Effectiveness of Melatonin in managing sleep impairment in Opioid withdrawal patients | Melatonin as an adjuvant in managing sleep impairment in Opioid withdrawal patients- A Randomised Controlled Trial | CTRI/2022/05/042865 |
| Melatonin for Nocturia in patients with Multiple Sclerosis | A randomized, double blind, placebo controlled, cross over trial of Melatonin for the treatment of nocturia in adults with progressive multiple sclerosis, with an open label, single-arm extension study - Melatonin for Nocturia in MS | EUCTR2012-004183-21-GB |
| The Role of Melatonin in the Regulation of Blood Coagulation | The Role of Melatonin in the Regulation of Blood Coagulation | NCT01741389 |
| Effect of Melatonin on Multiple Sclerosis Related Fatigue | Study of Melatonin in Treatment of Fatigue in Multiple Sclerosis | NCT01718678 |
| Melatonin effects on visual and sleep patterns anomalies in subjects diagnosed with Retinitis Pigmentosa | Melatonin effects on visual and sleep patterns anomalies in subjects diagnosed with Retinitis Pigmentosa | EUCTR2012-002436-82-ES |
| The evaluation of the effect of oral melatonin in the treatment of oral mucositis and oral pain reduction in patients with upper gastrointestinal tract tumors | The evaluation of the effect of oral melatonin in the treatment of oral mucositis and oral pain reduction in patients with upper gastrointestinal tract tumors | IRCT20220426054666N1 |
| Melatonin In Reduction of Chemotherapy-Induced Toxicity (MIRCIT) Trial | Melatonin In Cancer Patients Receiving Chemotherapy: A Randomized, Double Blind, Placebo, Controlled Trial | NCT01706627 |
| Evaluation of melatonin on insomnia and daytime sleepiness associated with comisa | Evaluation of effect of melatonin tablet administration or placebo on insomnia and daytime sleepiness in patients with obstructive sleep apnea and insomnia (COMISA) treated with continuous positive airway pressure: A randomized double-blind placebo-controlled trial | IRCT20220105053635N1 |
| Kinetic of Compounds of a Melatonin-based Formulation in Healthy Subjects | Kinetic of Plasmatic Compounds and Metabolites of a Melatonin-based Formulation in Healthy Subjects | NCT05419466 |
| Investigation of the effect of Melatonin mouthwash on prevention of chemotherapy-induced oral mucositis | Investigation of the effect of Melatonin mouthwash on prevention of chemotherapy-induced oral mucositis, a randomized double blinded placebo controlled clinical trial | IRCT20220213054015N1 |
| AMUM trial -Adjuvant Melatonin for Uveal Melanoma: A randomized open Phase III Study | AMUM trial -Adjuvant Melatonin for Uveal Melanoma: A randomized open Phase III Study | CTIS2022-500307-49-00 |
| Melatonin Pharmacokinetics in Dialysis Patients | Melatonin Pharmacokinetics in Dialysis Patients - Melatonin kinetics in dialysis / MEKDIP | NL-OMON40235 |
| Melatonin and Cognitive-Behaviour Therapy for the treatment of insomnia in individuals with schizophrenia | For individuals with schizophrenia and insomnia, can melatonin and CBT improve sleep, symptoms, functioning and cognitive functions | ACTRN12613000970741 |
| efficacy of oral gabapentin and melatonin on post operative delirium | The efficacy of oral Gabapentin with Melatonin on post operative delirium in patients undergoing major non-cardiac surgery under entropy guided general anaesthesia | CTRI/2022/02/039963 |
| The Analgesic Effects of Melatonin | The Analgesic Effects of Melatonin: A Randomized, Placebo-controlled, Double-blinded Study on Healthy Volunteers | NCT01923974 |
| Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders | A Randomized, Prospective, Double Blind, Placebo-Controlled Trial of Two Different Doses of Oral Melatonin Supplements in Chronic Kidney Disease (CKD)-Associated Sleep Disorders | NCT01922999 |
| Melatonin Treatment for Newborn Infants With Moderate to Severe Hypoxic Ischemic Encephalopathy | Melatonin Treatment for Newborn Infants With Moderate to Severe Hypoxic Ischemic Encephalopathy | NCT01904786 |
| The effect of melatonin supplementation on obesity management | The effects of melatonin supplementation on nutritional status, oxidative stress, metabolic and inflammatory parameters in obese women undergoing weight loss diet | IRCT2012122411867N1 |
| comparison of the melatonin effect in irritable bowel syndrome patients | Determination of the melatonin effect on gastrointestinal symptoms and quality of life in patients with irritable bowel syndrome with and without sleep disorders | IRCT20220104053626N2 |
| Adjustment and improvement of metabolic control in night shift workers after administration of melatonin | Multicenter, randomized, double-blind, placebo controlled trial of 2 mg melatonin for circadian phase adjustment and improvement of metabolic control in night shift workers | EUCTR2012-005254-30-DE |
| Efficacy of melatonin in rapid eye movement (REM sleep) behaviour disorder with coexisting Parkinsonism | Efficacy of melatonin in rapid eye movement (REM) sleep behaviour disorder with coexisting Parkinsonism: A double-blind, randomised controlled trial | ACTRN12613000648729 |
| Efficacy of melatonin in idiopathic rapid eye movement (REM) sleep behaviour disorder | Efficacy of melatonin in idiopathic rapid eye movement (REM) sleep behaviour disorder: A double-blind, randomised controlled trial | ACTRN12613000647730 |
| PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin | PLAY GAME: Post-concussion Syndrome Affecting Youth: GABAergic Effects of Melatonin. A Randomized Double-blind Placebo-controlled Trial of MELATONIN | NCT01874847 |
| The Effect of Melatonin on Osseointegration Of immediate Loading Implant supported Mandibular Overdentures | The Effect of Melatonin on Osseointegration Of immediate Loading Implant supported Mandibular Overdentures | PACTR201307000557125 |
| Investigating The effect of melatonin on serum changes of Adropin in patients with diabetic retinopathy | Investigating The effect of melatonin on serum changes of Adropin in patients with diabetic retinopathy | IRCT20211222053481N1 |
| The effect of melatonin on circadian rest-activity rhythms | The effect of melatonin on circadian rest-activity rhythms during benzodiazepine tapering in patients with bipolar disorder and comparing it with the control group | IRCT20200913048705N1 |
| Evaluation of the effect of melatonin with N-acetylcysteine in reducing liver injury caused by Remdesivir injection | The effect of melatonin with N-acetylcysteine in reducing liver injury caused by Remdesivir injection in Covid 19 patients | IRCT20210926052586N2 |
| To study effectiveness of Drug Melatonin for pain after surgery, in patients of cancer of head and neck region. | Efficacy of Melatonin on post operative pain reduction in patients undergoing Head and Neck cancer surgery under General Anaesthesia- Prospective Randomized double blind controlled study. | CTRI/2022/03/040841 |
| Melatonin-Micronutrients for Osteopenia Treatment Study | Phase 1 Study of Combination Strontium, Melatonin and Nutritional Co-factors on Bone Health and Quality of Life in Postmenopausal Women With Osteopenia | NCT01870115 |
| Effects of melatonin on salivary stress markers | The effects of melatonin supplement on salivary cortisol and amylase | TCTR20220310009 |
| Identification and Clinical Relevance of an Oxytocin Deficient State (Melatonin Study) | Identification and Clinical Relevance of an Oxytocin Deficient State Following Melatonin Administration in Patients With Hypopituitarism: a Proof-of-concept, Physiopathological Study With a Control Group | NCT05319301 |
| Extended-Release Melatonin in Patients With Rapid Eye Movement Sleep Behavior Disorder | Randomized, Double-Blind, Cross-Over Study Comparing the Efficacy of Immediate and Extended-Release Melatonin as a Supplement Affecting the Sleep Cycle in Patients With Parkinson Disease and Rapid Eye Movement Sleep Behavior Disorder | NCT05307770 |
| Safety Study of Melatonin in Stroke Patients | A Double Blind, Placebo Controlled Study to Evaluate the Efficacy of Melatonin in Acute Ischemic Stroke. | NCT01863277 |
| A prospective, randomized, controlled study of preoperative oral melatonin to reduce the incidence of postoperative delirium in elderly spinal surgery patients | A prospective, randomized, controlled study of preoperative oral melatonin to reduce the incidence of postoperative delirium in elderly spinal surgery patients | ChiCTR2200058039 |
| Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock | Phase III, Prospective, Randomized, Double-blind Clinical Trial to Evaluate the Efficacy of Melatonin in Patients With Severe Sepsis or Septic Shock | NCT01858909 |
| ACUMEN: Acute High Dose Melatonin for Encephalopathy of the Newborn | ACUMEN: Phase I Dose Escalation and Cohort Expansion study to affirm the safety of pharmacological doses of a novel formulation of intravenous melatonin in babies with hypoxic-ischaemic encephalopathy (HIE) to augment therapeutic hypothermia (HT) treatment; to reduce the incidence and severity of disability in babies with moderate-severe HIE. - 146647 | CTIS2025-520538-49-00 |
| To compare the effects of two drugs - T. Zolpidem and T. Melatonin in reducing anxiety during surgical period. | Comparitive study on oral Melatonin and oral Zolpidem on perioperative anxiety in surgeries done under regional anaesthesia. A randomised double blinded study. | CTRI/2022/03/041514 |
| Melatonin Levels in Smith Magenis Syndrome (SMS) | Melatonin Levels in Sleep-disordered Smith-Magenis Syndrome: a Pilot Study | NCT00691574 |
| The effect of melatonin cream on dermatitis | The investigation of the effect of melatonin topical cream on the lesions of patients with dermatitis | IRCT20220403054394N1 |
| Oral Bioavailability of Melatonin nano-emulsion tablets | An Open Label Balanced Randomized Single Dose Two Treatment Two Sequence Two Period Two Way Crossover Oral Bioavailability Study Of Melatonin 5 Mg In 1 Ml Nano Emulsion (Liquid) Manufactured By Tiny Technologies Kleiner Kielort 6-8 20144 Hamburg Federal Republic Of Germany With Melatonin 5 Mg Sublingual Tablets Manufactured By Vision Healthcare B V Postbus 5038 2000 GA Haarlem The Netherlands In Healthy Adult Human Subjects Under Fasting Conditions | CTRI/2022/06/043163 |
| Evaluation of melatonin therapy on sleep and delirium in intensive care patients | ISRCTN47578325 | |
| Study of the Bioavailability of a Food Supplement Rich in Melatonin Administered Sublingually and Orally (MELATONIN) | Study of the Bioavailability of a Food Supplement Rich in Melatonin Administered Sublingually Compared to Its Oral Administration. Randomized, Crossover, Single-blind Study | NCT03951025 |
| Melatonin in Intensive Therapy Unit (ITU) patients | ISRCTN23173759 | |
| Double-blind randomised controlled cross-over trial to determine the effect of low dose melatonin on sleep disorders in the elderly | ISRCTN14134844 | |
| Effects of melatonin treatment, light therapy, and sleep improvement on psychosocial, cognitive, and behavioural outcomes in children with Delayed Sleep Phase Syndrome and their parents | Effects of melatonin treatment, light therapy, and sleep improvement on psychosocial, cognitive, and behavioural outcomes in children with Delayed Sleep Phase Syndrome and their parents - Melatonin treatment, light therapy, and sleep improvement in children | NL-OMON39468 |
| Randomised Controlled Trial of Melatonin for Delayed Sleep Phase Disorder | The effect of melatonin on sleep onset time, sleep efficiency in the first third of the sleep episode, and sleep-related daytime impairments in people with delayed sleep phase disorder: a randomised controlled trial | ACTRN12612000425897 |
| An open-label study followed by a double-blind randomised comparison of the effect of sedation versus melatonin combined with sedation in children undergoing magnetic resonance imaging (MRI) | ISRCTN13459412 | |
| IMPROVEMENT IN PAIN CONTROL AND NUMBNESS FOLLOWING FACIAL FRACTURES WITH THE USE OF MELATONIN TABLETS | â??EFFECTS OF MELATONIN ON POSTOPERATIVE PAIN AND SENSORY RECOVERY FOLLOWING ZYGOMATICOMAXILLARY COMPLEX FRACTURES - A RANDOMIZED CONTROLLED TRIALâ?? | CTRI/2022/07/043630 |
| The melatonin analgesic effect in a human pain model | The melatonin analgesic effect in a human nociceptive and inflammatory pain model. | RBR-7m3mnd |
| Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study | Melatonin Associated to Acid Inhibition for Chemoprevention in Barret Esophagus: a Pilot Study | NCT01566474 |
| Effects of Hydrocortisone, Melatonin, and Placebo on Jet Lag | The Effects of Hydrocortisone, Melatonin, and Placebo on Symptoms of Jet Lag | NCT00097474 |
| Effekt af melatonin på forekomsten af postoperativ træthed og søvnforstyrrelser efter laparoskopisk kolecystektomi. En randomiseret dobbelt-blindet placebo kontrolleret undersøgelse. - MEL-MIS | Effekt af melatonin på forekomsten af postoperativ træthed og søvnforstyrrelser efter laparoskopisk kolecystektomi. En randomiseret dobbelt-blindet placebo kontrolleret undersøgelse. - MEL-MIS | EUCTR2004-003796-37-DK |
| A double-blind placebo-controlled cross-over study to determine if melatonin can improve the length of day time sleep in subjects with transient misalignment of the sleep-wake cycle as a result of working permanent night shifts. | A double-blind placebo-controlled cross-over study to determine if melatonin can improve the length of day time sleep in subjects with transient misalignment of the sleep-wake cycle as a result of working permanent night shifts. | EUCTR2005-000120-17-GB |
| The effect of light and/or melatonin on sleep, mood, cognition and behavior in demented elderly. | The effect of light and/or melatonin on sleep, mood, cognition and behavior in demented elderly. | NL-OMON28032 |
| The efficacy and safety of melatonin treatment in children with ADHD and chronic sleep onset insomnia. | The efficacy and safety of melatonin treatment in children with ADHD and chronic sleep onset insomnia. | NL-OMON25413 |
| Melatonin for children with idiopathic chronic sleep onset insomnia, with or without attention deficit hyperkinesia disorder - A dosefinding trial.A randomised placebo-controlled double-blind parallel group trial. | Melatonin for children with idiopathic chronic sleep onset insomnia, with or without attention deficit hyperkinesia disorder - A dosefinding trial.A randomised placebo-controlled double-blind parallel group trial. | NL-OMON19948 |
| Effects of Melatonin on Insomnia Symptoms in Older Adults | Melatonin Randomized Trial for Insomnia in the Elderly | NCT00230737 |
| Melatonin Supplements for Improving Sleep in Individuals With Hypertension | Melatonin Supplementation in Hypertensive Patients | NCT00238108 |
| The Contribution of Melatonin Vs. Placebo in Benzodiazepine Withdrawal in Methadone Maintenance Treatment Patients | NCT00261183 | |
| Melatonin Effects on Luteinizing Hormone | Melatonin Effects on Luteinizing Hormone | NCT00288262 |
| Melatonin Treatment and Inflammation, Oxidative Stress and Autonomic Function in Connection With Surgery | NCT00311259 | |
| The effect of oral melatonin on vision improvement in methanol poisoning | Evaluation of the role of oral melatonin in improving vision in methanol poisoning | IRCT20200507047344N3 |
| Melatonin and Cardiac Outcome After Major Surgery | Melatonin and Cardiac Morbidity After Elective Abdominal Aortic Aneurism Repair | NCT00315926 |
| Melatonin and Quality of Life in Dialysis Patients | Double Blind Placebo-controlled Study on the Efficacy of Melatonin on Sleep, Resulting in an Improved Quality of Life in Hemodialysis Patients | NCT00388661 |
| Double blind placebo controlled study on the efficacy of melatonin on sleep parameters and quality of life in hemodialysis patients - Melody | Double blind placebo controlled study on the efficacy of melatonin on sleep parameters and quality of life in hemodialysis patients - Melody | EUCTR2006-005719-89-NL |
| A blinded randomised cross-over study of the effect of melatonin treatment of sleep disturbances on hypothalamic-pituitary-gonadal axis and leptin in pubertal children | A blinded randomised cross-over study of the effect of melatonin treatment of sleep disturbances on hypothalamic-pituitary-gonadal axis and leptin in pubertal children | ISRCTN31542578 |
| Comparing use of melatonin with alprazolam in patient having surgery for breast cancer | Melatonin versus Alprazolam as a Premedicant in Breast Cancer Surgeries: A Randomized, Double-Blind Clinical Trial | CTRI/2022/06/043021 |
| Is melatonin a natural sleep promoter and antidepressant? | ISRCTN82912246 | |
| Melatonin associated to acid inhibition for chemoprevention in Barret esophagus (Melatonina asociada a inhibición ácida como estrategia de quimiprevención en esófago de Barrett) | Melatonin associated to acid inhibition for chemoprevention in Barret esophagus: a pilot study | ISRCTN95230916 |
| The effect of demlatonin on the treatment of sleep disorders in hemodialysis patients | Comparision the effect of 3 & 6 mg melatonin on the treatment of sleep disorders in patients undergoing hemodialysis; Randomised clinical trial | IRCT20220112053698N1 |
| Melatonin Intervention For Neurocognitive Deficits in the St. Jude Lifetime Cohort | Melatonin Intervention For Neurocognitive Deficits in the St. Jude Lifetime Cohort | NCT01700959 |
| Open label, Single Ascending Dose, Cross-over Study to Assess the Pharmacokinetics of Circadin® (Prolonged-Release Melatonin) Mini tablets in Children with Neurodevelopmental disorders and Sleep Disturbances. | Open label, Single Ascending Dose, Cross-over Study to Assess the Pharmacokinetics of Circadin® (Prolonged-Release Melatonin) Mini tablets in Children with Neurodevelopmental disorders and Sleep Disturbances. - PK study of Circadin® mini-tablets in children. | NL-OMON39955 |
| Exogenous Melatonin in Postmenopausal Women with Insomnia | Sleep and Circadian Rhythms in Men and Women - Protocol 4 | NCT05440734 |
| Effect of melatonin and clonidine on postoperative delirium | Comparison of the effects of melatonin and clonidine in the prevention of postoperative delirium in patients undergoing major orthopedic surgeries | IRCT20170316033099N7 |
| Melatonin versus placebo for prevention of delirium in inpatients with advanced cancer | Randomised double blind placebo controlled pilot phase II trial of oral melatonin for the prevention of delirium in hospital in people with advanced cancer | ACTRN12612000931875 |
| The effect of melatonin supplementation with progesterone on the improvement and level of inflammatory factors in patients with endometrial hyperplasia | The effect of melatonin supplementation with progesterone on the improvement and level of inflammatory factors in patients with endometrial hyperplasia | IRCT20220116053735N1 |
| The effect of melatonin on postoperative pain | Evaluation of preoperative administration of the oral melatonin on postoperative pain in lumbar spinal surgeries | IRCT20220613055157N1 |
| Effect of Melatonin on the components of metabolic syndrome in adolescent bipolarpatients taking risperidone plus lithium carbonate | Effect of Melatonin on the components of metabolic syndrome in adolescent bipolarpatients taking risperidone plus lithium carbonate: a randomized,double blind, placebo-controlled clinical trial | IRCT201208071556N44 |
| Getting SMART for Pediatric Epilepsy | Getting SMART for Pediatric Epilepsy (Sleep, Melatonin, and Research Trial, SMART) | NCT05439876 |
| Melatonin to prevent brain injury in unborn growth restricted babies | A pilot study of maternally administered melatonin to decrease the level of oxidative stress in human pregnancies affected by intrauterine growth restriction. | ACTRN12612000858897 |
| Efficacy of melatonin for the treatment of moderate to severe vincristine-induced neuropathy in pediatric malignancies | Efficacy of melatonin for the treatment of moderate to severe vincristine-induced neuropathy in pediatric malignancies | IRCT20200710048068N1 |
| The effect of Melatonin on climactric symptoms and sexual disfunction | Investigation of the effect of melatonin on the climacteric symptoms and sexual disfunction in menopausal woman attending in selected Gynecology Clinics of Shiraz University of medical sciences, 1390 | IRCT201201041548N13 |
| Effects of CoQ10, melatonin, vitamin B groups, vitamin D. and probiotic on reducing COVID-19 symptoms during recovery | Evaluating the Effects of CoQ10, melatonin, vitamin B groups, vitamin D. and probiotic on reducing COVID-19 symptoms during recovery- A randomized double blind controlled Clinical Trial | IRCT20140804018677N21 |
| Study of Melatonin: Sleep Problems in Alzheimer's Disease | NCT00000171 | |
| Effectiveness of Melatonin for Sleep Disturbances in Children With Atopic Dermatitis | Effectiveness of Melatonin Supplement in the Management of Sleep Disturbances in Children With Atopic Dermatitis | NCT01638234 |
| The effects of melatonin on glucose and lipids profile in type II diabetic patients | The effects of melatonin on glucose and lipids profile in type II diabetic patients | IRCT2012062610115N1 |
| Treatment of Osteopenia With Melatonin | Treatment of Osteopenia With Melatonin: Effects on BMD, Muscle Strength and Quality of Life | NCT01690000 |
| Melatonin in Healthy Volunteers | A Dose Escalation Study of Melatonin in Healthy Volunteers as a Potential Treatment for Sepsis | NCT01724424 |
| Randomized Controlled Trial to Assess Efficacy of Melatonin for Children During Burn Rehabilitation | Randomized Controlled Trial to Assess Efficacy of Melatonin for Children During Burn Rehabilitation | NCT01598259 |
| Altered Circadian Rhythm of Melatonin Secretion and Circadian Gene Expression in the Early Stage of Sepsis | In sepsis patients, do melatonin secretion and circadian gene expression compared to non-septic patients alter from their normal rhythm? | ACTRN12612000494831 |
| Melatonin for Prevention of Metabolic Side Effects of Olanzapine | Phase 2 Study of Melatonin Adjunct to Olanzapine for Prevention of Olanzapine-associated Metabolic Side Effects. | NCT01593774 |
| Treatment of osteopenia with melatonin: Effects on bone mineral density, muscle strength, and quality of life | Treatment of osteopenia with melatonin: Effects on BMD, muscle strength and quality of life - MelaOst | EUCTR2011-004670-28-DK |
| Dose escAlation study of Melatonin in Sepsis: healthy voLunteers | A dose escalation study of melatonin in healthy volunteers as a potential treatment for sepsis | ISRCTN17088991 |
| Melatonin and Radiation Therapy in Treating Patients With Brain Metastases | A Randomized Phase II Study of A.M. and P.M. Melatonin for Brain Metastasis in RPA Class II Patients | NCT00031967 |
| Effects of melatonin treatment, light therapy, and sleep improvement in children with sleep onset problems | Effects of melatonin treatment, light therapy, and sleep improvement on psychosocial, cognitive, and behavioural outcomes in children with Delayed Sleep Phase Syndrome and their parents - Melatonin treatment, light therapy, and sleep improvement in children | EUCTR2012-000220-18-NL |
| Young Blind Child Melatonin Treatment Study | Identification of Free-Running Rhythms in Blind Children | NCT00688935 |
