IMPPAT Phytochemical information: 
Histamine

Histamine
Clinical trials
Public title (as per ICTRP)Scientific title (as per ICTRP)Trial identifier
In Vivo Assessment of Histamine PharmacodynamicsIn Vivo Functional Assessment of Histamine Pharmacodynamics in ChildrenNCT00809692
Apitox, Honeybee Toxin for Pain and Inflammation of OsteoarthritisA Multicenter, Randomized, Double Blind, Active Controlled, Parallel Group, Clinical Study, to Evaluate the Safety and Efficacy of Apitox vs Histamine in Subjects With Refractory Osteoarthritis Pain and Inflammation of the KneeNCT01112722
A clinical trial to determine the effects of an oral anti-histamine drug on nocturnal scratching behavior in atopic dermatitis patientsA clinical trial to determine the effects of an oral anti-histamine drug on nocturnal scratching behavior in atopic dermatitis patients - Nocturnal scratching behavior in atopic dermatitis patientsJPRN-UMIN000003424
Efficacy of N-Alpha Methyl Histamine versus Propranolol in prevention of miigraine.Efficacy of N alpha Methyl histamine versus propranolol in migraine prophylaxisACTRN12610000126011
A Study to Assess the Effects of Remission Maintenance Therapy with Ceplene®, Given with Low-Dose Interleukin-2 (IL-2, Proleukin®), on Immune Response and Minimal Residual Disease (MRD) in Adult Patients with Acute Myeloid Leukemia (AML) in First Complete Remission (CR1)An Open-Label, Multicenter Study of the Effects of Remission Maintenance Therapy with Ceplene® (Histamine Dihydrochloride), Given in Conjunction with Low-Dose Interleukin-2 (IL-2, Proleukin®), on Immune Response and Minimal Residual Disease (MRD) in Adult Patients with Acute Myeloid Leukemia (AML) in First Complete Remission (CR1)EUCTR2009-012083-14-GB
A Study to Assess the Effects of Remission Maintenance Therapy with Ceplene®, Given with Low-Dose Interleukin-2 (IL-2, Proleukin®), on Immune Response and Minimal Residual Disease (MRD) in Adult Patients with Acute Myeloid Leukemia (AML) in First Complete Remission (CR1)An Open-Label, Multicenter Study of the Effects of Remission Maintenance Therapy with Ceplene® (Histamine Dihydrochloride), Given in Conjunction with Low-Dose Interleukin-2 (IL-2, Proleukin®), on Immune Response and Minimal Residual Disease (MRD) in Adult Patients with Acute Myeloid Leukemia (AML) in First Complete Remission (CR1)EUCTR2009-012083-14-SE
Interleukin-2 With or Without Histamine Dihydrochloride in Treating Patients With Metastatic Kidney CancerA Randomized Phase II Study to Evaluate the Efficacy of Combined Immunotherapy With Subcutaneous Interleukin-2 and Maxamine in Patients With Metastatic Renal Cell CarcinomaNCT00005038
A randomised controlled placebo based trial to determine the efficacy of a prophylactic dose of hydrocortisone and anti histamine in preventing reactions to anti snake venom (ASV)ISRCTN29425449
Assessment of changes in ventilation following induced bronchoconstriction with inhaled histamine in normal subjects using Krypton-81m ventilation scintigraphyAssessment of changes in ventilation following induced bronchoconstriction with inhaled histamine in normal subjects using Krypton-81m ventilation scintigraphyISRCTN70267623
Interleukin-2 With or Without Histamine Dihydrochloride in Treating Patients With Stage IV Melanoma Metastatic to the LiverA Phase III, Multi-Center Controlled Trial With Stratified Randomization Comparing The Efficacy Of Interleukin-2 (IL-2) Plus Histamine Dihydrochloride (HDC) Versus IL-2 Alone To Increase The Duration Of Survival In Patients With AJCC Stage IV Malignant Melanoma With Hepatic MetastasisNCT00039234
BIOLOGICAL STANDARDISATION OF ALLERGENIC EXTRACTS OF MITES TO DETERMINE BIOLOGICAL ACTIVITY (IN HEP UNITS) IN SENSITIVISED PATIENTS.BIOLOGICAL STANDARDISATION OF ALLERGENIC EXTRACTS OF MITES (Dermatophagoides pteronyssinus, Dermatophagoides farinae, Blomia tropicalis and Lepidoglyphus destructor) TO DETERMINE BIOLOGICAL ACTIVITY IN HISTAMINE EQUIVALENT UNITS (HEP) IN SENSITIVISED PATIENTS. - DIA-STA04080912-0124CTIS2024-513834-40-01
Interleukin-2 Plus Histamine Dihydrochloride in Treating Patients With Acute Myeloid LeukemiaMulti-Center, Randomized Open-Label Study to Evaluate the Safety and Efficacy of Immunotherapy With Subcutaneous Maxamine (Histamine Dihydrochloride) Plus Proleukin (Interleukin-2) Versus No Treatment (Standard of Care) in Patients With Acute Myeloid Leukemia in First or Subsequent Complete Remission (CR)NCT00003991
Evaluation of Histamine, CGRP and VIP as Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers"Evaluation of Histamine, CGRP and VIP as Biological Markers for Activation of Trigeminal and Parasympathetic Nerve Fibers in Response to ""Sinus"" Symptoms"NCT00208065
Study to Evaluate the Effect of the Coadministration of SCH 497079 (a Histamine 3 [H3] Receptor Antagonist) Plus Desloratadine on Nasal Congestion in Subjects With Seasonal Allergic Rhinitis Who Have Been Exposed to Pollen in the Vienna Challenge Chamber (VCC) - H3 POCStudy to Evaluate the Effect of the Coadministration of SCH 497079 (a Histamine 3 [H3] Receptor Antagonist) Plus Desloratadine on Nasal Congestion in Subjects With Seasonal Allergic Rhinitis Who Have Been Exposed to Pollen in the Vienna Challenge Chamber (VCC) - H3 POCEUCTR2004-001883-39-AT
A Trial of Camrelizumab Plus Nab-paclitaxel and Levocetirizine in Metastatic or Recurrent TNBCCamrelizumab Plus Nab-paclitaxel and Anti-histamine Drug Levocetirizine in Metastatic or Recurrent Triple-negative Breast Cancer: a Randomized, Double-arm, Phase 2 Randomized Controlled TrialNCT06632405
Relationship between sensory qualities and emotions (itch induction by means of histamine-iontophoresis)Relationship between sensory qualities and emotions (itch induction by means of histamine-iontophoresis) - JRS-HDRKS00005381
Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic ItchThe Role of Pre-established Skin Inflammation on the Susceptibility to Histamine and Cowhage-induced Itch in Healthy HumansNCT02769910
ALAP-1 for the attenuation of nasal provocation with histamine in seasonal allergic rhinitis: a randomised, double-blind, placebo-controlled, three-day dosing, cross-over study and dose finding one month cross-over studyISRCTN83077547
The Impact of Dietary Histamine in Chronic Pain – Pilot StudyAssessing the impact of an exogenous histamine-reducing dietary intervention on pain as measured by the Brief Pain Inventory (BPI) in adults.ACTRN12624000643572
Effects of mometazone furoate hydrate on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen.Effects of mometazone furoate hydrate on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen. - Effects of mometazone furoate hydrate on up-regulation of histamine H1 receptor mRNA in the nasal mucosa induced by artificial exposure of Japanese cedar pollen in patients with allergic rhinitis to cedar pollen.JPRN-UMIN000008952
Assessment of the effects of topical sodium cromoglicate on itch and flare in human skinTo assess the effects of topical sodium cromoglicate on itch and flare in human skin induced by intradermal histamine: a randomised double-blind vehicle controlled intra-subject design trialISRCTN35671014
Dietary Treatment for Chronic UrticariaCan Low Histamine Diet Reduce Symptoms of Patients With Idiopathic Urticaria?NCT02047136
To determine the minimum amount of Alternaria alternata allergenextract producing a positive skin reaction.Biological standardization of Alternaria alternata allergen extract todetermine the biological activity in histamine equivalent units (HEP).EUCTR2013-001308-13-ES
Proton Pump Inhibitor Versus Histamine-2 Receptor Antagonist for the Prevention of Recurrent Peptic UlcersPantoprazole Versus Famotidine for the Prevention of Recurrent Peptic Ulcers in Thienopyridine Users - a Double-blind Randomized Controlled TrialNCT02551744
Proton Pump Inhibitors vs. Histamine-2 REceptor Blockers for Ulcer Prophylaxis Therapy in the Intensive Care UnitA multi-centre, cluster randomised, crossover, registry trial comparing the safety and efficacy of proton pump inhibitors with histamine-2 receptor blockers for ulcer prophylaxis in intensive care patients requiring invasive mechanical intervention.ACTRN12616000481471
A study to evaluate safety and efficiency of treatment with histamine andinterleukin-2 in chronic myelomonocytic leukemia (CMML)Safety, Efficacy and Immune Response of Histamine Dihydrochloride andLow-dose Interleukin-2 in Chronic Myelomonocytic Leukemia (CMML)EUCTR2014-004874-41-SE
The examination of the effect of intranasal anti-histamine on intranasal corticosteroid in Japanese cedar pollinosisThe examination of the effect of intranasal anti-histamine on intranasal corticosteroid in Japanese cedar pollinosis - The examination of the effect of intranasal anti-histamine on intranasal corticosteroid in Japanese cedar pollinosisJPRN-UMIN000025508
The effect of histamine on acethylcholine-mediated sweatingThe effect of histamine on acethylcholine-mediated sweating - The effect of histamine on sweatingJPRN-UMIN000010077
Effect of anti-histamine and oral corticosteroid for symptoms in oral food challengeEffect of anti-histamine and oral corticosteroid for symptoms in oral food challenge - Anti-histamine and oral corticosteroid for symptoms in OFCJPRN-UMIN000033584
Dermal Blood Flow Response to Escalating Doses of Histamine, Administered by a Skin PrickDermal Blood Flow Response to Escalating Doses of Histamine, Administered by a Skin PrickNCT04399213
A Multicenter, Randomized, Double-blind, Placebo-Controlled Parallel Study:Clinical Study of Efficacy and Safety of Histamine Human Immunoglobulin (ShuYangMinNing) in the Treatment of Chronic Spontaneous Urticaria (CSU)A Multicenter, Randomized, Double-blind, Placebo-Controlled Parallel Study:Clinical Study of Efficacy and Safety of Histamine Human Immunoglobulin (ShuYangMinNing) in the Treatment of Chronic Spontaneous Urticaria (CSU)ChiCTR2400081126
Role of the Central Nervous System in Allergic RhinitisRole of the Central Nervous System in Allergic Rhinitis: Activation of Different Brain Regions After a Nasal Histamine Provocation in Healthy and Allergic PatientsNCT01777464
A randomized, single-blind, saline-controlled, dose-finding, study to characterize the pruritus and inflammatory response to intradermal histamine in healthy volunteers and patients with atopic dermatitisA randomized, single-blind, saline-controlled, dose-finding, study to characterize the pruritus and inflammatory response to intradermal histamine in healthy volunteers and patients with atopic dermatitis - Characterization of a pruritus challenge modelNL-OMON54996
SCS in ItchThe effect of spinal cord stimulation and dorsal root ganglion stimulation on histamine induced itch: an experimental pilot study.NL-OMON23833
The effect of spinal cord stimulation and dorsal root ganglion stimulation on histamine induced itch: an experimental pilot studyThe effect of spinal cord stimulation and dorsal root ganglion stimulation on histamine induced itch: an experimental pilot study - SCS in itchNL-OMON49164
Inter-arm and Inter-period Reproducability of the Dermal Blood Flow Response After a Histamine Skin Prick.Inter-arm and Inter-period Reproducability of the Dermal Blood Flow Response After a Histamine Skin Prick.NCT04396977
To determine the minimum amount of Dermatophagoides pteronyssinus allergen extract producing a positive skin reaction.Biological standardization of Dermatophagoides pteronyssinus allergen extract to determine the biological activity in histamine equivalent units (HEP).EUCTR2012-001939-31-ES
The effect of histamine on sudomotor functionThe effect of histamine on sudomotor function - The effect of histamine on sudomotor functionJPRN-UMIN000009247
A clinical trial to study the effectiveness of Dermacyte® A clinical trial to study the effectiveness of Dermacyte® Cosmetic Cream in reducing itching, redness and swelling due to Histamine.A Prospective, Randomized, Double-blind, Placebo-controlled Study to Determine the Efficacy of Dermacyte® Cosmetic Cream in Relieving Histamine-induced Pruritus and Wheal & Flare Reaction - NilCTRI/2012/01/002360
A comparative study on action of Homoeopathic Medicines Dysenteric co and Histamine on blood values and stool culture of allergic rhinitis patientsA comparative study on action of Bowel Nosode Dysenteric co and Homoeopathic Medicine Histamine in intestinal flora of patients with allergic rhinitisCTRI/2022/08/044753
Study on the effectiveness of a low histamine diet and diamino oxidase enzyme supplementation in patients with histamine intoleranceLow histamine diet and diamino oxidase enzyme supplementationISRCTN64888465
Biological standarization of pollen of Phleum pratense, Lolium perenne, Poa pratensis y Dactylis glomerata and its mixture to obtain extracts of these pollens with a potency provokes the same skin reaction in sensitive patients that the reaction the histamine produces in the subjects.Biological standarization of allergic extracts of will grasses: Phleum pratense, Lolium perenne, Poa pratensis y Dactylis glomerata and its mixture to determinate their biological activity, the In House Reference Preparation, measures in histamine unit equivalents (HEP) in sensitized patientsEUCTR2019-002644-24-ES
Histamine Dihydrochloride and Interleukin-2 in Primary Resectable Pancreatic CancerA Phase I/II Trial of Peri- and Postoperative Treatment With Histamine Dihydrochloride and Low-dose Interleukin-2 in Patients With Primary Resectable Pancreatic CancerNCT05810792
To determine the minimum amount of Artemisia vulgaris allergen extract producing a positive skin reaction.Biological standardization of Artemisia vulgaris allergen extract to determine the biological activity in histamine equivalent units (HEP).EUCTR2013-001310-15-ES
Effects of mometazone furoate hydrate on expression of histamine H1 receptor and allergy-related cytokines of nasal mucosa in healthy volunteers.Effects of mometazone furoate hydrate on expression of histamine H1 receptor and allergy-related cytokines of nasal mucosa in healthy volunteers. - Effects of mometazone furoate hydrate on expression of histamine H1 receptor and allergy-related cytokines of nasal mucosa in healthy volunteers.JPRN-UMIN000006094
Bronchial Hyperreactivity During Histamine Passive ExposureAre Technicians Showing Bronchial Hyperreactivity Able to Safely Perform Bronchial Provocation Tests?NCT01937494
Dietary Intervention for EczemaEfficacy of Food Intervention Targeting Salicylates, Histamine and Allergens (FISHA) for Symptom Control in Adults with Moderate-to-Severe Atopic Dermatitis: A Randomised Controlled TrialACTRN12624001394538
Histamine H1/H2 Receptors and Training AdaptationsRole of Histamine H1/H2 Receptors in the Health- and Performance-promoting Adaptations to High-intensity Interval TrainingNCT04450134