| Safety & Efficacy of Pilocarpine Ophthalmic Spray for Temporary Improvement of Near Vision in Presbyopic Adults | A Phase 3 Study of the Safety and Efficacy of 2% Pilocarpine Ophthalmic Spray Administered With the Optejet® Microdose Dispenser for Temporary Improvement of Near Vision in Adults With Presbyopia | NCT05114486 |
| The Safety and Efficacy of THVD-102, a combination of Oxybutynin and Pilocarpine, in Subjects with Primary Focal Hyperhidrosis. | A Phase 2a Study Evaluating the Safety and Efficacy of THVD-102, a combination of Oxybutynin and Pilocarpine, in Subjects with Primary Focal Hyperhidrosis. | ACTRN12615000873527 |
| Morphological Changes of Ciliary Body and Trabecular Meshwork | In Vivo Morphological Changes of Ciliary Body and Trabecular Meshwork in High Myopia Eyes With Open-angle Glaucoma in Their Accommodation Induced by Pilocarpine | NCT05352854 |
| Pharmacological Treatment of Presbyopia | Pharmacological Treatment of Presbyopia by Pilocarpine 1.25% Eye Drops | NCT05564832 |
| Efficacy of Pilocarpine 1% in Presbyopia | Efficacy of Pilocarpine 1% in Pseudophakia Individuals With Presbyopia | NCT05578001 |
| Efficacy of As-Needed Pilocarpine for the Treatment of Radiation-Induced Xerostomia: A Double-Blind, Randomized, Placebo-Controlled, Crossover Study | Efficacy of As-Needed Pilocarpine for the Treatment of Radiation-Induced Xerostomia: A Double-Blind, Randomized, Placebo-Controlled, Crossover Study | TCTR20221130004 |
| A Study to Investigate the Effect of Oral Doses of Pilocarpine on Salivary Secretion and Static Pupillometry in Healthy Subjects | A Phase 1 Study to Investigate the Effect of Oral Doses of Pilocarpine on Salivary Secretion and Static Pupillometry in Healthy Subjects | NCT02447315 |
| The Effect of pilocarpine mouthwash on measure saliva | Evaluation of the effect pilocarpine mouthwash and saline on the amount saliva in students in ahwaz jundi shspur university of medical scieces | IRCT2014102719698N1 |
| The effect of Pilocarpine on absorbed salivary gland dose in patients on radioiodine therapy. | Studying the effect of using oral pilocarpine on absorbed salivary gland dose and side effects in patients on radioiodine therapy | IRCT2014060917684N3 |
| Safety and Efficacy of Nyxol Eye Drops as a Single Agent and With Adjunctive Low-Dose Pilocarpine Eye Drops in Subjects With Presbyopia | Randomized, Double-Masked, Placebo-Controlled, Multicenter, Phase 3 Study of the Safety and Efficacy of Nyxol (Phentolamine Ophthalmic Solution 0.75%) as a Single Agent and With Adjunctive Low-Dose Pilocarpine Hydrochloride Ophthalmic Solution 0.4% in Subjects With Presbyopia | NCT05646719 |
| A clinical trial to study the effect of drug pilocarpine in radiation induced dryness of mouth among patients with head and neck cancers | A prospective study to evaluate the efficacy of oral pilocarpine in radiation induced Xerostomia among patients with head and neck squamous cell carcinoma - PRIX | CTRI/2023/04/051712 |
| The effect of Pilocarpine and omega-3 emulsion combined mouthwash on oral symptoms of Sjogren's syndrome | Evaluation the effectiveness of a combined mouthwash of pilocarpine and omega-3 emulsion with placebo on oral symptoms of patients with Sjögren syndrome | IRCT20230419057964N1 |
| Effect of pilocarpine mouthwash on symptoms and salivary flow rate | The evaluation of the dose-related effect of pilocarpine mouthwash on symptoms and salivary flow rate in patients with xerostomia | IRCT20200108046050N1 |
| Effect of Pilocarpine mouthwash on diabetic patients xerostomia | Evaluation of the effect of 0/3% Pilocarpine mouthwash on xerostomia in diabetic patients with xerostomia | IRCT20220930056061N1 |
| Evaluation of the effects of Pilocarpine gum on saliva secretion | Preparation of Pilocarpine gum formulation and its effect on saliva secretion | IRCT20191106045356N19 |
| Impact of CYP2A6 and CHRM3 genetic polymorphisms on the PK/PD of pilocarpine in Japanese healthy volunteers | Impact of CYP2A6 and CHRM3 genetic polymorphisms on the PK/PD of pilocarpine in Japanese healthy volunteers - Impact of CYP2A6 and CHRM3 polymorphisms on the PK/PD of pilocarpine | JPRN-UMIN000010796 |
| The efficacy of pilocarpine for xerostomia induced by radiation therapy at different administration timing. | The efficacy of pilocarpine for xerostomia induced by radiation therapy at different administration timing. - The efficacy of pilocarpine for xerostomia induced by radiation therapy at different administration timing. | JPRN-UMIN000010288 |
| Effect of 0.1% Pilocarpine Mouthwash on Xerostomia | Effect of 0.1% Pilocarpine Mouthwash on Xerostomia : Double-blind, Randomized Controlled Trial | NCT01627626 |
| A Study to Evaluate the Efficacy and Safety of Pilocarpine Hydrochloride Ophthalmic Solution for the Treatment of Presbyopia. | A Multi-Center, Double-blind, Randomized, Placebo-controlled, Parallel-Group, Phase III Clinical Study to Evaluate the Efficacy and Safety of Pilocarpine Hydrochloride Ophthalmic Solution USP 1.25% w/v Versus Placebo Ophthalmic Solution for the Treatment of Presbyopia - Nil | CTRI/2023/08/057127 |
| The effect of drop pilocarpine on oral lesions in pemphigus vulgaris | Effectiveness of topical pilocarpine as a cholinomimetic on refractory oral lesions :a single blinded, randomized controlled trial | IRCT20221002056070N1 |
| Effect of sialendoscopy with intraductal steroid plus pilocarpine for treatment of sialadenitis associated with Sjogren syndrome | Effect of sialendoscopy with intraductal steroid alone versus intraductal steroid plus pilocarpine therapy for sialadenitis associated with Sjogren syndrome : a 8-week follow-up, double-blind, randomized, controlled trial | TCTR20240214001 |
| Can eye drops safely replace reading glasses in older adults? | Investigating the effects of long-term pilocarpine use for presbyopia treatment on posterior ocular structures | ACTRN12624000383561 |
| Measurement of Sweat Sodium Concentration in Patients With Chronic Kidney Disease | Application of Pilocarpine Iontophoresis in Patients With Chronic Kidney Disease: a Feasibility Study | NCT06354842 |
| Comparing the effectiveness of electric stimulation therapy and pilocarpine mouthwash on salivary flow in patients with dry mouth: clinical trial | Comparing the effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) and Pilocarpine mouthwash with standard care on salivary flow in patients with radiation-induced xerostomia: a randomized controlled trial - NIL | CTRI/2024/04/065408 |
| The use of a laser and pilocarpine in improving saliva secretion in patients with head and neck cancer who have undergone radiochemotherapy | The synergistic effect of low-level laser and pilocarpine hydrochloride on saliva in patients with head and neck cancer who receive radiochemotherapy: Clinical randomized controlled study | ISRCTN56133161 |
| Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Presbyopia | Multicenter, Randomized, Double-Masked, Placebo-Controlled, Parallel Group Phase 2 Trial Evaluating the Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream BID for the Treatment of Presbyopia | NCT05124275 |
| Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream for the Treatment of Dry Eye Disease | Multicenter, Randomized, Double-Masked, Placebo-Controlled, Parallel Group Phase 2 Trial Evaluating the Safety and Efficacy of Pilocarpine Ophthalmic Topical Cream BID for the Treatment of Signs and Symptoms of Dry Eye Disease | NCT05119920 |
| The effect of 1% pilocarpine mouthwash on salivation in patients undergoing head and neck radiotherapy: a double-blind randomized clinical trial | The effect of 1% pilocarpine mouthwash on salivation in patients undergoing head and neck radiotherapy: a double-blind randomized clinical trial | IRCT20210830052335N1 |
| Oral Pilocarpine in the Treatment of the Dry Eye of Patients With Sjogrens Syndrome | Oral Pilocarpine in the Treatment of the Dry Eye of Patients With Sjogrens Syndrome | NCT04470479 |
| The Effects of Pilocarpine Hydrochloride Granules on Oral Status of Post Hematopoietic Stem Cell Transplantation | The Effects of Pilocarpine Hydrochloride Granules on Oral Status of Post Hematopoietic Stem Cell Transplantation - The Effects of Pilocarpine Hydrochloride Granules on Oral Status of Post Hematopoietic Stem Cell Transplantation | JPRN-UMIN000036666 |
| Pilocarpine After Combined Cataract/Trabectome Surgery | A Prospective Randomized Control Trial of Pilocarpine Use After Combined Cataract/Trabectome Surgery | NCT04005079 |
| Clinical research on the efficacy of pilocarpine hydrochloride administration from the early stage of treatment for the reduction of oral mucositis in oral cancer radiation therapy. | Clinical research on the efficacy of pilocarpine hydrochloride administration from the early stage of treatment for the reduction of oral mucositis in oral cancer radiation therapy. - Clinical research on the efficacy of pilocarpine hydrochloride administration. | JPRN-UMIN000036529 |
| Oral Pilocarpine tablets for advanced cancer patients with dry mouth. | Oral Pilocarpine tablets for Xerostomia in patients with advanced cancer – an N-of-1 feasibility pilot study | ACTRN12619000697189 |
| Pilocarpine Use After Kahook Goniotomy | A Prospective Randomized Control Trial of Pilocarpine Use After Combined Cataract/Kahook Dual Blade Surgery | NCT03933631 |
| Treatment of dry mouth with local pilocarpine drops | Local Application of Pilocarpine for Relieving Dry Mouth Complaints: A randomized controlled pilot trial - xero2019 | EUCTR2018-004352-38-NL |
| Local Application of Pilocarpine for Relieving Dry Mouth Complaints: A randomized controlled pilot trial | Local Application of Pilocarpine for Relieving Dry Mouth Complaints: A randomized controlled pilot trial - Pilocarpine drops for xerostomia. | NL-OMON48076 |
| Pilocarpine and Brimonidine in Patients With Monofocal Lenses | Effectiveness of Pilocarpine and Brimonidine to Improve Near Visual Acuity in Patients With Monofocal Intraocular Lenses | NCT03825081 |
| Clinical evaluation of drugs in people with dry mouth | clinical evaluation of Pilocarpine release systems in individuals with hyposalivation | RBR-9qdnws |
| 0.5% Pilocarpine in the Treatment of High Hyperopia | 0.5% Pilocarpine in the Treatment of High Hyperopia: A Prospective Randomized Controlled Trial | ChiCTR1800016564 |
| Effect of pilocarpine 2% eye drops on treatment resistant oral erosions of pemphigus. | Assessment of efficacy of topical pilocarpine 2% eye-drops in treatment of refractory/ persistent oral lesions of pemphigus vulgaris- a pilot study | CTRI/2017/11/010445 |
| Efficacy and safety of pilocarpine / sodium alginate formulation for dry mouth in Sjogren's syndrome patients | Efficacy and safety of pilocarpine / sodium alginate formulation for dry mouth in Sjogren's syndrome patients - Efficacy and safety of pilocarpine / sodium alginate formulation for dry mouth in Sjogren's syndrome patients | JPRN-UMIN000029307 |
| Pilocarpine Microneedles for Sweat Induction (PMN-SI) | A Pilot Study to Compare the Efficacy of Pilocarpine Microneedles With Iontophoresis Method for Sweat Induction in Healthy Human Subjects | NCT04732195 |
| Effect of Effect of Combined Administration of Pilocarpine and Herbal medicine (Baekhogainsa m-Tang Ext. Granule) on frequent intractable dry mouth: A randomized, open-label, parallel, m ulti-center trial | Effect of Effect of Combined Administration of Pilocarpine and Herbal medicine (Baekhogainsa m-Tang Ext. Granule) on frequent intractable dry mouth: A randomized, open-label, parallel, m ulti-center trial | KCT0005982 |
| Single patient multiple cross-over trials to determine the efficacy of pilocarpine 5 mg orally dissolving tablets in patients suffering from dry mouth. | Single patient multiple cross-over trials to determine the efficacy of pilocarpine 5 mg orally dissolving tablets in relieving xerostomia | ACTRN12617001067369 |
| Effects of intraocular pressure reduction in combined use with ripasudil and brimonidine, or pilocarpine in healthy adult volunteers. | Effects of intraocular pressure reduction in combined use with ripasudil and brimonidine, or pilocarpine in healthy adult volunteers. - Effects of IOP reduction in combined use with ripasudil and brimonidine, or pilocarpine. | JPRN-UMIN000027065 |
| Effect of Pilocarpine in Patients With Xerostomia | Effect of Pilocarpine in Patients With Xerostomia | NCT02982577 |
| The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure | The Diurnal and Nocturnal Effect of Pilocarpine on Intraocular Pressure and Ocular Perfusion Pressure | NCT02754570 |
| Effect of oral pilocarpine in severe dry eye syndrome | Effect of oral pilocarpine in severe dry eye syndrome - Effect of oral pilocarpine in severe dry eye syndrome | JPRN-UMIN000021268 |
| Pilocarpine, Brimonidine, Oxymetazoline (PBO) Compound to Control Presbyopia Symptoms | Pilocarpine, Brimonidine, Oxymetazoline Ophthalmic Compound Safety and Efficacy in Patients With Presbyopia | NCT05006911 |
| Study of the efficacy and safety of pilocarpine hydrochloride for vaginal dryness symptoms associated with atrophic vaginitis | Study of the efficacy and safety of pilocarpine hydrochloride for vaginal dryness symptoms associated with atrophic vaginitis - Study of the efficacy and safety of pilocarpine hydrochloride for vaginal dryness symptoms associated with atrophic vaginitis | JPRN-UMIN000017282 |
| Comparison of a Compound With Pilocarpine and Brimonidine to Improve Near Vision in Healthy Presbyopic Patients | Comparison of Pilocarpine, Brimonidine, Oxymetazoline, Hialuronic Acid, Bromfenac Ophthalmic Compound With Pilocarpine and Brimonidine to Improve Uncorrected Visual Acuity in Healthy Presbyopic Individuals | NCT05001243 |
| the effect of pilocarpine 1% eye drop on the relative improvement of presbyopia | the effect of pilocarpine 1% eye drop on the relative improvement of presbyopia | IRCT20240325061363N1 |
| Efficacy and Safety of two artificial saliva base polymers containing with 0.1% pilocarpine for Treatment of xerostomia: A Randomized Clinical Trial | Comparison of the Efficiency of Artificial Saliva with Pilocarpine in Management of Xerostomia | TCTR20200902001 |
| Safety and Efficacy Study of Pilocarpine HCl Ophthalmic Solution in Participants With Presbyopia | A Phase 3, Multicenter, Double-Masked, Randomized, Vehicle-Controlled Study Evaluating the Safety and Efficacy of Pilocarpine HCl in Participants With Presbyopia | NCT06451666 |
| Efficacy of Pilocarpine As a Secretagogue Versus Artificial Tears for the Treatment of Dry Eye | Efficacy of Pilocarpine As a Secretagogue Versus Artificial Tears for the Treatment of Dry Eye | NCT06752278 |
| Comparison of the effect of oral gel pilocarpine 2% and ginger 25% in patients with dry mouth after radiotherapy | Comparison of the effect of oral gel pilocarpine 2% and ginger 25% in patients with dry mouth after radiotherapy | IRCT20240502061625N1 |
| Pilocarpine in Preventing Mucositis and Dry Mouth in Patients Receiving Radiation Therapy for Head and Neck Cancer | A Phase III Study to Test the Efficacy of the Prophylactic Use of Oral Pilocarpine to Reduce Hyposalivation and Mucositis Associated With Curative Radiation Therapy in Head and Neck Cancer Patients | NCT00003139 |
| Pilocarpine in Treating Patients With Dry Mouth Caused by Opioids | A Double Blind Phase III Study of Oral Pilocarpine for Opioid-Induced Dry Mouth | NCT00003686 |
| Assessment of controlled release buccal inserts containing pilocarpine hydrochloride: a multi-centre, double-blind, placebo-controlled, randomised, cross-over study in patients diagnosed with Sjögren's Syndrome | Assessment of controlled release buccal inserts containing pilocarpine hydrochloride: a multi-centre, double-blind, placebo-controlled, randomised, cross-over study in patients diagnosed with Sjögren's Syndrome | ISRCTN80708834 |
| Decreased salivary flow rate as a dipsogenic factor in haemodialysis patients: a pilocarpine clinical trial | | ISRCTN41671411 |
| This study is a clinical trial comparing salivary gland function by measuring the salivary flow rate in patients of head and cancer on parotid sparing radiotherapy using VMAT technique who are receiving either Transcutaneous Electric Nerve Stimulation (TENS) or pilocarpine | Phase III RCT comparing salivary flow rate of Transcutaneous Electrical Nerve Stimulation (TENS) versus Pilocarpine in patients who are receiving parotid sparing VMAT in Head and Neck Cancer patients - Nil | CTRI/2024/10/074850 |
| Pilocarpine in Treating Vaginal Dryness in Patients With Breast Cancer | Pilocarpine for Vaginal Dryness: A Phase III Randomized, Double Blind, Placebo-Controlled Study | NCT00343382 |
| A Comparison of Orally Pilocarpine and Artificial Saliva in Xerostomy Treatment | Xerostomy Treatment in Patients With Sjogren's Syndrome in Chile :A Double Blind Control Trial Comparing Orally Pilocarpine Drops and Artificial Saliva | NCT00438048 |
| Bioequivalency Study of 7.5 mg Pilocarpine Under Fed Conditions | A Single Dose, Two-Period, Two-Treatment, 2-Sequence Crossover Bioequivalency Study of 7.5 mg Pilocarpine Tablets Under Fed Conditions | NCT00618059 |
| Bioequivalency Study of 7.5 mg Pilocarpine Tablets Under Fasting Conditions | A Single Dose, Two-Period, Two-Treatment, 2-Sequence Crossover Bioequivalency Study of 7.5 mg Pilocarpine Tablets Under Fasting Conditions | NCT00602524 |
| Bioequivalency Study of 5 mg Pilocarpine Tablets Under Fasting Conditions | A Single Dose, Two-Treatment, Two-Period, Two Sequence Crossover Bioequivalency Study of 5 mg Pilocarpine Tablets Under Fasting Conditions | NCT00601874 |
| Bioequivalency Study of 5 mg Piolocarpine Tablets Under Fed Conditions | A Single Dose, Two-Treatment, Two-Period, Two Sequence Crossover Bioequivalency Study of 5 mg Pilocarpine Tablets Under Fed Conditions | NCT00601211 |
| Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer | A Phase II/III Study Comparing Acupuncture-like Transcutaneous Electrical Nerve Stimulation (ALTENS) Versus Pilocarpine in Treating Early Radiation-Induced Xerostomia | NCT00656513 |
| Travoprost 0.004% Versus Pilocarpine 1% in Patients With Chronic Angle Closure Glaucoma (CACG) | A Twelve-Week, Double Masked, Parallel Group, Primary-Therapy Pilot Study of the Safety and Efficacy of Travoprost 0.004% Compared to Pilocarpine 1% in Patients With Chronic Angle-Closure Glaucoma | NCT00762645 |
| Dose, Effects and Characteristics of Pilocarpine | Dose, Effects and Characteristics of Pilocarpine | NCT00803803 |
| Safety & Efficacy of Pilocarpine Eye Solutions for Temporary Improvement of Near Vision in Presbyopic Adults | A Phase 3 Study of the Safety and Efficacy of 1% and 2% Pilocarpine Ophthalmic Solutions Administered With the Optejet® Microdose Dispenser for Temporary Improvement of Near Vision in Adults With Presbyopia | NCT04657172 |
| Efficacy of Cevimeline Versus Pilocarpine in the Secretion of Saliva | Efficacy of Cevimeline vs. Pilocarpine in the Secretion of Saliva | NCT01690052 |
| A multicenter, randomized, double-blind, placebo-controlled phase III clinical study evaluating the efficacy and safety of pilocarpine hydrochloride ophthalmic solution in the treatment of presbyopia | A multicenter, randomized, double-blind, placebo-controlled phase III clinical study evaluating the efficacy and safety of pilocarpine hydrochloride ophthalmic solution in the treatment of presbyopia | ChiCTR2500098056 |
| Oral pilocarpine for treatment in patients with xerotic keratoconjunctivitis | Oral pilocarpine for treatment in patients with xerotic keratoconjunctivitis - Oral Pilocarpine for treatment in patients with dry eye | JPRN-UMIN000002200 |
| Single Patient Multiple Cross-Over Trials To Determine The Efficacy Of Pilocarpine In Relieving Dry Mouth In Patients With Cancer | Single Patient Multiple Cross-Over Trials To Determine The Efficacy Of Pilocarpine In Relieving Dry Mouth In Patients With Cancer | ACTRN12610000840088 |
| Evaluation of NV701 (Pilocarpine 1.25%) Compared with Vuity (Pilocarpine 1.25%) on Pupil Size in Subjects with Presbyopia | Effect on Pupil Size After One-time Administration of NV701 (Pilocarpine 1.25%) Vs. Vuity (Pilocarpine 1.25%) | NCT06783686 |
| Efficacy of a new formulation of 0.2% pilocarpine spray in patients with hyposalivation | Efficacy of a new formulation of 0.2% pilocarpine spray in patients with hyposalivation | TCTR20250309013 |
| Can eye drops safely replace reading glasses in older adults? A short-term study. | Investigating the physiological effects of acute pilocarpine use for presbyopia treatment on posterior ocular structures | ACTRN12625000542493 |
| Effects of Novel Combinations of Tolterodine/Pilocarpine on Pharmacokinetics (PK) and Pharmacodynamics (PD) of Tolterodine in Healthy Subjects | Effects of THVD-201 on Pharmacokinetics and Pharmacodynamics of Tolterodine in Healthy Subjects | NCT01036035 |
| Low-Dose Pilocarpine for Prevention of Radiation-Induced Xerostomia in Head and Neck Cancer Patients : A Randomized, Double blind, Placebo-Controlled Trial | Low-Dose Pilocarpine for Prevention of Radiation-Induced Xerostomia in Head and Neck Cancer Patients : A Randomized, Double blind, Placebo-Controlled Trial | TCTR20250618006 |
