Sodium chlorite

Predicted ADME Properties
TypePropertyToolInterpretationProbability/Value
AbsorptionCaco-2 permeabilityadmetSARYes-
pkCSMNANA cm/s
Human Intestinal AbsorptionadmetSARYes-
pkCSMNANA %
SwissADMENA-
Human Oral BioavailabilityadmetSARYes-
Log Kp (Skin permeation)pkCSMNANA cm/h
SwissADME-NA cm/s
DistributionP-glycoprotein substrateadmetSARNo-
pkCSMNA-
SwissADMENA-
vNNNo Prediction-
P-glycoprotein inhibitoradmetSARNo-
vNNNo Prediction-
P-glycoprotein inhibitor IpkCSMNA-
P-glycoprotein inhibitor IIpkCSMNA-
Blood Brain BarrieradmetSARYes-
pkCSMNANA logBB
SwissADMENA-
vNNNo Prediction-
CNS permeabilitypkCSMNANA logPS
Fraction unbound in humanpkCSM-NA
Plasma protein bindingadmetSARModerate0.413
Subcellular localizationadmetSARMitochondria-
Steady state volume of distribution (VDss)pkCSMNANA L/Kg
MetabolismCYP1A2 inhibitoradmetSARNo
pkCSMNA-
SwissADMENA-
vNNNo Prediction-
CYP2C19 inhibitoradmetSARNo-
pkCSMNA-
SwissADMENA-
vNNNo Prediction-
CYP2C9 inhibitoradmetSARNo-
pkCSMNA-
SwissADMENA-
vNNNo Prediction-
CYP2C9 substrateadmetSARNo-
CYP2D6 inhibitoradmetSARNo-
pkCSMNA-
SwissADMENA-
vNNNo Prediction-
CYP2D6 substrateadmetSARNo-
pkCSMNA-
CYP3A4 inhibitoradmetSARNo-
pkCSMNA-
SwissADMENA-
vNNNo-
CYP3A4 substrateadmetSARNo-
pkCSMNA-
CYP inhibitory promiscuityadmetSARNo-
Human Liver Microsomal (HLM) stability assayvNNNo Prediction-
OATP2B1 inhibitoradmetSARNo-
OATP1B1 inhibitoradmetSARYes-
OATP1B3 inhibitoradmetSARYes-
MATE1 inhibitoradmetSARNo-
BSEP inhibitoradmetSARNo-
UGT catalysisadmetSARNo-
ExcretionRenal OCT2 inhibitoradmetSARNo-
Renal OCT2 substratepkCSMNA-
Total clearancepkCSM-NA ml/min/kg
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Predicted Toxicity properties
PropertyToolInterpretationProbability/Value
Acute oral toxicityadmetSAR-3.215 kg/mol
ProTox-352 mg/kg
Acute oral toxicity classadmetSARIII-
ProTox4-
BiodegradationadmetSARYes-
ToxtreeClass 3 (unknown biodegradability)-
Carcinogenicity (Three class)admetSARNon-required-
CarcinogensadmetSARYes-
ToxtreeNo-
Cramer's ruleToxtreeHigh (Class III)-
CytotoxicityvNNNoPrediction-
Genotoxic carcinogenityToxtreeNo-
HepatotoxicityadmetSARNo-
pkCSMNA-
vNNNoPrediction-
Human Ether-a-go-go-Related Gene InhibitoradmetSARNo
vNNNoPrediction-
Human Ether-a-go-go-Related Gene Inhibitor IpkCSMNA-
Human Ether-a-go-go-Related Gene Inhibitor IIpkCSMNA-
Mitochondrial Membrane Potential (MMP)vNNNo-
Maximum Recommended Tolerated Dose (MRTD)pkCSMNANA mg/kg/day
vNN-NoPrediction mg/day
Non-Genotoxic carcinogenicityToxtreeNo-
Oral rat acute toxicitypkCSM-NA mol/kg (LD50)
pkCSM-NA mg/kg_bw/day (LOAEL)
MicronucleusadmetSARYes-
Skin sensitisationpkCSMNA-
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Predicted Toxicity properties
PropertyToolInterpretationProbability/Value
Acute oral toxicityadmetSAR-3.215 kg/mol
ProTox-352 mg/kg
Acute oral toxicity classadmetSARIII-
ProTox4-
BiodegradationadmetSARYes-
ToxtreeClass 3 (unknown biodegradability)-
Carcinogenicity (Three class)admetSARNon-required-
CarcinogensadmetSARYes-
ToxtreeNo-
Cramer's ruleToxtreeHigh (Class III)-
CytotoxicityvNNNo Prediction-
Genotoxic carcinogenityToxtreeNo-
HepatotoxicityadmetSARNo-
pkCSMNA-
vNNNo Prediction-
Human Ether-a-go-go-Related Gene InhibitoradmetSARNo
vNNNo Prediction-
Human Ether-a-go-go-Related Gene Inhibitor IpkCSMNA-
Human Ether-a-go-go-Related Gene Inhibitor IIpkCSMNA-
Mitochondrial Membrane Potential (MMP)vNNNo-
Maximum Recommended Tolerated Dose (MRTD)pkCSMNANA mg/kg/day
vNN-No Prediction mg/day
Non-Genotoxic carcinogenicityToxtreeNo-
Oral rat acute toxicitypkCSM-NA mol/kg (LD50)
pkCSM-NA mg/kg_bw/day (LOAEL)
MicronucleusadmetSARYes-
Skin sensitisationpkCSMNA-
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