Spironolactone


Curated chemical-disease associations from CTD
Disease IDDisease nameReference
MESH:D000141 Acidosis, Renal Tubular PMID:9148232
MESH:D000860 Hypoxia PMID:20228418; PMID:21263376
MESH:D001919 Bradycardia PMID:2126792
MESH:D003681 Dehydration PMID:4740303
MESH:D003866 Depressive Disorder PMID:15949161
MESH:D003967 Diarrhea PMID:11250985
MESH:D005767 Gastrointestinal Diseases PMID:4740303
MESH:D006177 Gynecomastia PMID:17309946; PMID:21130975; PMID:22074142; PMID:4739107
MESH:D006261 Headache PMID:15949161
MESH:D006323 Heart Arrest PMID:15912333; PMID:2849806
MESH:D006331 Heart Diseases PMID:19913415
MESH:D006501 Hepatic Encephalopathy PMID:600713
MESH:D006505 Hepatitis PMID:11488711; PMID:7305153
MESH:D006929 Hyperaldosteronism PMID:1103606
MESH:D006947 Hyperkalemia PMID:1103606; PMID:11250985; PMID:12869459; PMID:15632880; PMID:15811903; PMID:16286062; PMID:17309946; PMID:20859899; PMID:21130975; PMID:2849806; PMID:2993981; PMID:4740303; PMID:4814187; PMID:4951338; PMID:7433326
MESH:D007008 Hypokalemia PMID:15811903; PMID:2264472
MESH:D007010 Hyponatremia PMID:4740303
MESH:D007172 Erectile Dysfunction PMID:22074142; PMID:4739107
MESH:D007673 Kidney Cortex Necrosis PMID:15245572
MESH:D007674 Kidney Diseases PMID:1064790; PMID:11776407
MESH:D008113 Liver Neoplasms PMID:25058030
MESH:D008599 Menstruation Disturbances PMID:22074142
MESH:D009461 Neurologic Manifestations PMID:4740303
MESH:D011507 Proteinuria PMID:15983956
MESH:D011782 Quadriplegia PMID:2993981
MESH:D013262 Stevens-Johnson Syndrome PMID:25811541
MESH:D022124 Hyperammonemia PMID:600713
MESH:D051437 Renal Insufficiency PMID:15632880
MESH:D053565 Hypercalciuria PMID:3411401; PMID:4558012
MESH:D056486 Chemical and Drug Induced Liver Injury PMID:11488711; PMID:33814510
MESH:D064420 Drug-Related Side Effects and Adverse Reactions PMID:5130149

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.